desmethylclomipramine has been researched along with Drug-Overdose* in 1 studies
1 other study(ies) available for desmethylclomipramine and Drug-Overdose
Article | Year |
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Biphasic time-course of serum concentrations of clomipramine and desmethylclomipramine after a near-fatal overdose.
A 27-y-old male was admitted deeply comatosed 5-6 h after taking approximately 15 g clomipramine. The prominent feature of the case was a biphasic course of clomipramine and desmethylclomipramine serum concentrations, possibly caused by delayed drug absorption. Clinically, 2 serious episodes requiring mechanical ventilation and aggressive pressor agent infusions occurred as the serum concentrations declined. However, the severe adult respiratory distress syndrome--related inflammatory process that required 4 w of intensive care may also be an explanation, although blood cultures were negative and neither liver nor renal functions were severely compromised. Topics: Adult; Chromatography, High Pressure Liquid; Clomipramine; Drug Overdose; Half-Life; Humans; Male | 1994 |