desipramine has been researched along with Ventricular Fibrillation in 9 studies
Desipramine: A tricyclic dibenzazepine compound that potentiates neurotransmission. Desipramine selectively blocks reuptake of norepinephrine from the neural synapse, and also appears to impair serotonin transport. This compound also possesses minor anticholinergic activity, through its affinity to muscarinic receptors.
desipramine : A dibenzoazepine consisting of 10,11-dihydro-5H-dibenzo[b,f]azepine substituted on nitrogen with a 3-(methylamino)propyl group.
Ventricular Fibrillation: A potentially lethal cardiac arrhythmia that is characterized by uncoordinated extremely rapid firing of electrical impulses (400-600/min) in HEART VENTRICLES. Such asynchronous ventricular quivering or fibrillation prevents any effective cardiac output and results in unconsciousness (SYNCOPE). It is one of the major electrocardiographic patterns seen with CARDIAC ARREST.
| Excerpt | Relevance | Reference |
|---|---|---|
| " This study investigated whether the norepinephrine transporter inhibitor, desipramine, can modulate sympathetic remodeling and ventricular fibrillation threshold (VFT) after myocardial ischemia-reperfusion." | 7.78 | Desipramine pretreatment improves sympathetic remodeling and ventricular fibrillation threshold after myocardial ischemia. ( Hu, X; Jiang, H; Liu, W; Wu, X; Yu, L, 2012) |
| " This study investigated whether the norepinephrine transporter inhibitor, desipramine, can modulate sympathetic remodeling and ventricular fibrillation threshold (VFT) after myocardial ischemia-reperfusion." | 3.78 | Desipramine pretreatment improves sympathetic remodeling and ventricular fibrillation threshold after myocardial ischemia. ( Hu, X; Jiang, H; Liu, W; Wu, X; Yu, L, 2012) |
| "Cardiac ischemia and anoxia induce massive norepinephrine (NE) release, which is mediated by a reverse operation of uptake-1 and can be suppressed by uptake-1 inhibitors." | 1.30 | Protection of neuronal uptake-1 inhibitors in ischemic and anoxic hearts by norepinephrine-dependent and -independent mechanisms. ( Dart, AM; Du, XJ; Esler, MD; Little, PJ; Woodcock, EA, 1998) |
| "There have been additional reports of sudden death in children." | 1.28 | Sudden death in children receiving Norpramin: a review of three reported cases and commentary. ( Cohen, DJ; King, RA; Kleinman, CS; Leckman, JF; Nelson, JC; Rasmusson, A; Riddle, MA, 1991) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (11.11) | 18.7374 |
| 1990's | 4 (44.44) | 18.2507 |
| 2000's | 3 (33.33) | 29.6817 |
| 2010's | 1 (11.11) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Levy, O | 1 |
| Erez, M | 2 |
| Varon, D | 2 |
| Keinan, E | 1 |
| Wu, X | 1 |
| Jiang, H | 1 |
| Yu, L | 1 |
| Hu, X | 1 |
| Liu, W | 1 |
| FEKETE, M | 1 |
| BORSY, J | 1 |
| Chow, BJ | 1 |
| Gollob, M | 1 |
| Birnie, D | 1 |
| Akhtar, M | 1 |
| Goldschlager, NF | 1 |
| Kurz, T | 1 |
| Offner, B | 1 |
| Schreieck, J | 1 |
| Richardt, G | 1 |
| Tölg, R | 1 |
| Schömig, A | 1 |
| Du, XJ | 1 |
| Woodcock, EA | 1 |
| Little, PJ | 1 |
| Esler, MD | 1 |
| Dart, AM | 1 |
| Manoach, M | 1 |
| Wozner, D | 1 |
| Riddle, MA | 1 |
| Nelson, JC | 1 |
| Kleinman, CS | 1 |
| Rasmusson, A | 1 |
| Leckman, JF | 1 |
| King, RA | 1 |
| Cohen, DJ | 1 |
9 other studies available for desipramine and Ventricular Fibrillation
| Article | Year |
|---|---|
A new class of antiarrhythmic-defibrillatory agents.
Topics: Animals; Anti-Arrhythmia Agents; Cats; Dibenzazepines; Structure-Activity Relationship; Ventricular | 2001 |
Desipramine pretreatment improves sympathetic remodeling and ventricular fibrillation threshold after myocardial ischemia.
Topics: Adrenergic Uptake Inhibitors; Animals; Desipramine; Male; Myocardial Ischemia; Premedication; Rats; | 2012 |
ON THE ANTIARRHYTHMIC EFFECT OF SOME THYMOLEPTICS (AMITRIPTYLINE, IMIPRAMINE, TRIMEPROPIMINE AND DESMETHYLIMIPRAMINE).
Topics: Aconitum; Amitriptyline; Antidepressive Agents; Atrial Fibrillation; Bradycardia; Bretylium Compound | 1964 |
Brugada syndrome precipitated by a tricyclic antidepressant.
Topics: Adult; Antidepressive Agents, Tricyclic; Depressive Disorder; Desipramine; Electrocardiography; Huma | 2005 |
Brugada electrocardiographic pattern due to tricyclic antidepressant overdose.
Topics: Adult; Antidepressive Agents, Tricyclic; Bundle-Branch Block; Clonazepam; Desipramine; Drug Combinat | 2006 |
Nonexocytotic noradrenaline release and ventricular fibrillation in ischemic rat hearts.
Topics: Adrenergic Uptake Inhibitors; Animals; Anti-Arrhythmia Agents; Carrier Proteins; Desipramine; Exocyt | 1995 |
Protection of neuronal uptake-1 inhibitors in ischemic and anoxic hearts by norepinephrine-dependent and -independent mechanisms.
Topics: Adrenergic Uptake Inhibitors; Animals; Cocaine; Desipramine; Dopamine Uptake Inhibitors; Drug Intera | 1998 |
Ventricular defibrillating properties of catecholamine uptake inhibitors.
Topics: Amphetamine; Animals; Antidepressive Agents, Tricyclic; Cats; Cocaine; Desipramine; Electrocardiogra | 1992 |
Sudden death in children receiving Norpramin: a review of three reported cases and commentary.
Topics: Attention Deficit Disorder with Hyperactivity; Child; Death, Sudden; Depressive Disorder; Desipramin | 1991 |