desipramine and Trichotillomania studies

Desipramine: A tricyclic dibenzazepine compound that potentiates neurotransmission. Desipramine selectively blocks reuptake of norepinephrine from the neural synapse, and also appears to impair serotonin transport. This compound also possesses minor anticholinergic activity, through its affinity to muscarinic receptors.
desipramine : A dibenzoazepine consisting of 10,11-dihydro-5H-dibenzo[b,f]azepine substituted on nitrogen with a 3-(methylamino)propyl group.

Research Excerpts

Excerpt	Relevance	Reference
"Treatment with clomipramine resulted in significantly greater improvement in symptoms than desipramine, as indicated by physicians' ratings of the women's clinical progress on a scale in which lower scores indicate improvement (mean [+/- SD] scores: at base line, 10."	6.66	A double-blind comparison of clomipramine and desipramine in the treatment of trichotillomania (hair pulling) ( Cheslow, DL; Goldberger, EL; Lenane, MC; Leonard, HL; Rapoport, JL; Swedo, SE, 1989)
"Twenty-five adult subjects with severe morbid onychophagia (nail biting) and no history of obsessive-compulsive disorder were enrolled in a 10-week double-blind cross-over trial of clomipramine hydrochloride and desipramine hydrochloride."	5.07	A double-blind comparison of clomipramine and desipramine treatment of severe onychophagia (nail biting). ( Lenane, MC; Leonard, HL; Rapoport, JL; Rettew, DC; Swedo, SE, 1991)
"Trichotillomania is a neglected neuropsychiatric disorder that only recently has received research attention."	2.67	Trichotillomania. An obsessive compulsive spectrum disorder? ( Leonard, HL; Swedo, SE, 1992)
"Treatment with clomipramine resulted in significantly greater improvement in symptoms than desipramine, as indicated by physicians' ratings of the women's clinical progress on a scale in which lower scores indicate improvement (mean [+/- SD] scores: at base line, 10."	2.66	A double-blind comparison of clomipramine and desipramine in the treatment of trichotillomania (hair pulling) ( Cheslow, DL; Goldberger, EL; Lenane, MC; Leonard, HL; Rapoport, JL; Swedo, SE, 1989)

Research

Studies (4)

Authors

Clinical Trials (3)

Trial Overview

Trial Outcomes

NIMH Trichotillomania Symptom Severity Scale (NIMH-TSS)

Timeframe	Studies, this research(%)	All Research%
pre-1990	1 (25.00)	18.7374
1990's	3 (75.00)	18.2507
2000's	0 (0.00)	29.6817
2010's	0 (0.00)	24.3611
2020's	0 (0.00)	2.80

Authors	Studies
Stein, DJ	1
Bouwer, C	1
Niehaus, DJ	1
Swedo, SE	3
Leonard, HL	3
Lenane, MC	2
Rettew, DC	1
Rapoport, JL	2
Goldberger, EL	1
Cheslow, DL	1

Trial	Phase	Enrollment	Study Type	Start Date	Status
Single-Group Crossover Trial Comparing Behavioral Treatment to Memantine in Body Focused Repetitive Behaviors[NCT05796752]	Phase 2/Phase 3	28 participants (Anticipated)	Interventional	2023-06-01	Not yet recruiting
A Double-Blind, Placebo Controlled Study of Aripiprazole in Body Focused Repetitive Behaviors[NCT05545891]	Phase 2	100 participants (Anticipated)	Interventional	2023-12-31	Not yet recruiting
A Double-Blind, Placebo-Controlled Study of Dronabinol in Trichotillomania and Other Body Focused Repetitive Behaviors[NCT03530800]	Phase 2/Phase 3	50 participants (Actual)	Interventional	2018-10-01	Completed
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

The entire study lasts 10 weeks. Every two weeks subjects will take the NIMH-TSS. The change in scores from baseline to after 10 weeks will be assessed. The scale itself assesses severity of trichotillomania symptoms. The NIMH-TSS score ranges from 0 to 20, with 0 being no symptoms and 20 being the most severe. (NCT03530800)
Timeframe: Assessed every two weeks up to 10 weeks, baseline data reported

Skin Picking Symptom Assessment Scale (SP-SAS)

Intervention	score on a scale (Mean)
Dronabinol	12.38
Placebo	10.63

The entire study lasts 10 weeks. Every two weeks subjects will take the SP-SAS. The change in scores from baseline to after 10 weeks will be assessed. The scale itself assesses severity of skin-picking symptoms. The SP-SAS score ranges from 0 to 48, with 0 being no symptoms and 48 being the most severe. (NCT03530800)
Timeframe: Assessed every two weeks up to 10 weeks, baseline reported

Article	Year
Trichotillomania. An obsessive compulsive spectrum disorder? The Psychiatric clinics of North America, 1992, Volume: 15, Issue:4 Topics: Adolescent; Adult; Child; Child, Preschool; Clomipramine; Combined Modality Therapy; Desipramine; Do	1992
A double-blind comparison of clomipramine and desipramine treatment of severe onychophagia (nail biting). Archives of general psychiatry, 1991, Volume: 48, Issue:9 Topics: Adult; Ambulatory Care; Clomipramine; Desipramine; Dose-Response Relationship, Drug; Double-Blind Me	1991
A double-blind comparison of clomipramine and desipramine in the treatment of trichotillomania (hair pulling) The New England journal of medicine, 1989, Aug-24, Volume: 321, Issue:8 Topics: Adolescent; Adult; Clomipramine; Desipramine; Double-Blind Method; Female; Humans; Obsessive-Compuls	1989
A double-blind comparison of clomipramine and desipramine in the treatment of trichotillomania (hair pulling) The New England journal of medicine, 1989, Aug-24, Volume: 321, Issue:8 Topics: Adolescent; Adult; Clomipramine; Desipramine; Double-Blind Method; Female; Humans; Obsessive-Compuls	1989
A double-blind comparison of clomipramine and desipramine in the treatment of trichotillomania (hair pulling) The New England journal of medicine, 1989, Aug-24, Volume: 321, Issue:8 Topics: Adolescent; Adult; Clomipramine; Desipramine; Double-Blind Method; Female; Humans; Obsessive-Compuls	1989
A double-blind comparison of clomipramine and desipramine in the treatment of trichotillomania (hair pulling) The New England journal of medicine, 1989, Aug-24, Volume: 321, Issue:8 Topics: Adolescent; Adult; Clomipramine; Desipramine; Double-Blind Method; Female; Humans; Obsessive-Compuls	1989
A double-blind comparison of clomipramine and desipramine in the treatment of trichotillomania (hair pulling) The New England journal of medicine, 1989, Aug-24, Volume: 321, Issue:8 Topics: Adolescent; Adult; Clomipramine; Desipramine; Double-Blind Method; Female; Humans; Obsessive-Compuls	1989
A double-blind comparison of clomipramine and desipramine in the treatment of trichotillomania (hair pulling) The New England journal of medicine, 1989, Aug-24, Volume: 321, Issue:8 Topics: Adolescent; Adult; Clomipramine; Desipramine; Double-Blind Method; Female; Humans; Obsessive-Compuls	1989
A double-blind comparison of clomipramine and desipramine in the treatment of trichotillomania (hair pulling) The New England journal of medicine, 1989, Aug-24, Volume: 321, Issue:8 Topics: Adolescent; Adult; Clomipramine; Desipramine; Double-Blind Method; Female; Humans; Obsessive-Compuls	1989
A double-blind comparison of clomipramine and desipramine in the treatment of trichotillomania (hair pulling) The New England journal of medicine, 1989, Aug-24, Volume: 321, Issue:8 Topics: Adolescent; Adult; Clomipramine; Desipramine; Double-Blind Method; Female; Humans; Obsessive-Compuls	1989
A double-blind comparison of clomipramine and desipramine in the treatment of trichotillomania (hair pulling) The New England journal of medicine, 1989, Aug-24, Volume: 321, Issue:8 Topics: Adolescent; Adult; Clomipramine; Desipramine; Double-Blind Method; Female; Humans; Obsessive-Compuls	1989

desipramine and Trichotillomania