desipramine has been researched along with Tachyarrhythmia in 16 studies
Desipramine: A tricyclic dibenzazepine compound that potentiates neurotransmission. Desipramine selectively blocks reuptake of norepinephrine from the neural synapse, and also appears to impair serotonin transport. This compound also possesses minor anticholinergic activity, through its affinity to muscarinic receptors.
desipramine : A dibenzoazepine consisting of 10,11-dihydro-5H-dibenzo[b,f]azepine substituted on nitrogen with a 3-(methylamino)propyl group.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Invasive electrophysiologic studies were performed before and during treatment with imipramine in 18 patients with inducible ventricular tachycardia (VT)." | 7.67 | Clinical efficacy and electrophysiology of imipramine for ventricular tachycardia. ( Connolly, SJ; Mason, JW; Mitchell, LB; Swerdlow, CD; Winkle, RA, 1984) |
| "We report a case of variant ventricular tachycardia induced by desipramine toxicity." | 7.66 | Variant ventricular tachycardia in desipramine toxicity. ( Covarrubias, EA; Lee, WR; Sheikh, MU; Slotkoff, LM, 1981) |
| "Desipramine treatment produced significant NE uptake inhibition as evidence by an exaggerated pressor response and a greater increase of myocardial interstitial NE in response to intravenous NE infusion but no significant effects on cardiac function or hemodynamics in sham-operated or CHF animals." | 5.33 | Cardiac sympathetic neuroprotective effect of desipramine in tachycardia-induced cardiomyopathy. ( Fukuoka, S; Iwai, C; Liang, CS; Mao, W; Stevens, SY, 2006) |
| "Continuous infusions of 5-hydroxytryptamine (5-HT) inhibit the tachycardiac responses to preganglionic (C7-T1) sympathetic stimulation in pithed rats pretreated with desipramine." | 3.72 | Pharmacological profile of the 5-HT-induced inhibition of cardioaccelerator sympathetic outflow in pithed rats: correlation with 5-HT1 and putative 5-ht5A/5B receptors. ( Arulmani, U; Centurión, D; Sánchez-Lopez, A; Saxena, PR; Vázquez, E; Villalón, CM, 2003) |
| "Invasive electrophysiologic studies were performed before and during treatment with imipramine in 18 patients with inducible ventricular tachycardia (VT)." | 3.67 | Clinical efficacy and electrophysiology of imipramine for ventricular tachycardia. ( Connolly, SJ; Mason, JW; Mitchell, LB; Swerdlow, CD; Winkle, RA, 1984) |
| "We report a case of variant ventricular tachycardia induced by desipramine toxicity." | 3.66 | Variant ventricular tachycardia in desipramine toxicity. ( Covarrubias, EA; Lee, WR; Sheikh, MU; Slotkoff, LM, 1981) |
| "Tachycardia was the most common change (36%)." | 2.68 | Electrocardiographic changes during desipramine and clomipramine treatment in children and adolescents. ( Allen, AJ; Hamburger, SD; Leonard, HL; Meyer, MC; Rapoport, JL; Richter, D; Swedo, SE; Tucker, E, 1995) |
| "Desipramine treatment produced significant NE uptake inhibition as evidence by an exaggerated pressor response and a greater increase of myocardial interstitial NE in response to intravenous NE infusion but no significant effects on cardiac function or hemodynamics in sham-operated or CHF animals." | 1.33 | Cardiac sympathetic neuroprotective effect of desipramine in tachycardia-induced cardiomyopathy. ( Fukuoka, S; Iwai, C; Liang, CS; Mao, W; Stevens, SY, 2006) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 7 (43.75) | 18.7374 |
| 1990's | 5 (31.25) | 18.2507 |
| 2000's | 4 (25.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Carson, RP | 1 |
| Diedrich, A | 1 |
| Robertson, D | 1 |
| FEKETE, M | 1 |
| BORSY, J | 1 |
| Sánchez-Lopez, A | 2 |
| Centurión, D | 2 |
| Vázquez, E | 1 |
| Arulmani, U | 1 |
| Saxena, PR | 1 |
| Villalón, CM | 2 |
| Flores, DL | 1 |
| Alvarado, I | 1 |
| Wong, ML | 1 |
| Licinio, J | 1 |
| Flockhart, D | 1 |
| Liang, CS | 1 |
| Mao, W | 1 |
| Iwai, C | 1 |
| Fukuoka, S | 1 |
| Stevens, SY | 1 |
| Connolly, SJ | 1 |
| Mitchell, LB | 1 |
| Swerdlow, CD | 1 |
| Mason, JW | 1 |
| Winkle, RA | 1 |
| Carpenter, P | 1 |
| Gobel, FL | 1 |
| Hulsing, DJ | 1 |
| Lee, WR | 1 |
| Sheikh, MU | 1 |
| Covarrubias, EA | 1 |
| Slotkoff, LM | 1 |
| Leonard, HL | 1 |
| Meyer, MC | 1 |
| Swedo, SE | 1 |
| Richter, D | 1 |
| Hamburger, SD | 1 |
| Allen, AJ | 1 |
| Rapoport, JL | 1 |
| Tucker, E | 1 |
| del Mar Fernández, M | 1 |
| Morán, A | 1 |
| Mosholder, A | 1 |
| Bates, C | 1 |
| Giesler, J | 1 |
| Reeve, E | 1 |
| Borchardt, CM | 1 |
| Wilens, TE | 1 |
| Stern, TA | 1 |
| Tribble, J | 1 |
| Weinhouse, E | 1 |
| Garland, J | 1 |
| Wendelberger, K | 1 |
| Casazza, F | 1 |
| Fiorista, F | 1 |
| Rustici, A | 1 |
| Brambilla, G | 1 |
| Alnaes, R | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| [NCT00265291] | Phase 2 | 700 participants (Actual) | Interventional | 1999-11-30 | Completed | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
1 trial available for desipramine and Tachyarrhythmia
| Article | Year |
|---|---|
Electrocardiographic changes during desipramine and clomipramine treatment in children and adolescents.
Topics: Adolescent; Antidepressive Agents, Tricyclic; Child; Clomipramine; Cross-Over Studies; Death, Sudden | 1995 |
15 other studies available for desipramine and Tachyarrhythmia
| Article | Year |
|---|---|
Autonomic control after blockade of the norepinephrine transporter: a model of orthostatic intolerance.
Topics: Adrenergic Uptake Inhibitors; Animals; Baroreflex; Blood Pressure; Body Weight; Desipramine; Female; | 2002 |
ON THE ANTIARRHYTHMIC EFFECT OF SOME THYMOLEPTICS (AMITRIPTYLINE, IMIPRAMINE, TRIMEPROPIMINE AND DESMETHYLIMIPRAMINE).
Topics: Aconitum; Amitriptyline; Antidepressive Agents; Atrial Fibrillation; Bradycardia; Bretylium Compound | 1964 |
Pharmacological profile of the 5-HT-induced inhibition of cardioaccelerator sympathetic outflow in pithed rats: correlation with 5-HT1 and putative 5-ht5A/5B receptors.
Topics: Animals; Autonomic Fibers, Preganglionic; Blood Pressure; Decerebrate State; Desipramine; Disease Mo | 2003 |
Clinical implications of genetic polymorphism of CYP2D6 in Mexican Americans.
Topics: Adult; Cytochrome P-450 CYP2D6; Depression; Desipramine; Double-Blind Method; Fluoxetine; Humans; Hy | 2004 |
Cardiac sympathetic neuroprotective effect of desipramine in tachycardia-induced cardiomyopathy.
Topics: Animals; Cardiac Pacing, Artificial; Cardiomyopathies; Desipramine; Heart; Neuroprotective Agents; N | 2006 |
Clinical efficacy and electrophysiology of imipramine for ventricular tachycardia.
Topics: Adult; Aged; Cardiac Pacing, Artificial; Desipramine; Electrocardiography; Electrophysiology; Female | 1984 |
Desipramine cardiac toxicity.
Topics: Adult; Bretylium Tosylate; Depressive Disorder; Desipramine; Heart Ventricles; Humans; Hypotension; | 1982 |
Variant ventricular tachycardia in desipramine toxicity.
Topics: Adult; Desipramine; Electrocardiography; Humans; Male; Tachycardia | 1981 |
5-Hydroxytryptamine inhibits the tachycardia induced by selective preganglionic sympathetic stimulation in pithed rats.
Topics: Animals; Autonomic Fibers, Preganglionic; Decerebrate State; Desipramine; Dose-Response Relationship | 1999 |
Desipramine side-effect.
Topics: Adolescent; Depressive Disorder; Desipramine; Dose-Response Relationship, Drug; Electrocardiography; | 1991 |
Low dose tricyclic tachycardia.
Topics: Adolescent; Depressive Disorder; Desipramine; Electrocardiography, Ambulatory; Female; Humans; Nortr | 1991 |
Ventricular tachycardia associated with desipramine and thioridazine.
Topics: Adult; Desipramine; Drug Interactions; Female; Heart Ventricles; Humans; Tachycardia; Thioridazine | 1990 |
Treatment of severe imipramine poisoning complicated by a negative history of drug ingestion.
Topics: Acute Disease; Desipramine; Electrocardiography; Emergencies; Female; Gastric Lavage; Humans; Imipra | 1989 |
[Torsade de pointes caused by tricyclic antidepressive agents. Description of a clinical case].
Topics: Antidepressive Agents, Tricyclic; Desipramine; Dothiepin; Electrocardiography; Female; Humans; Middl | 1986 |
[Desipramine (Sertofren) in the treatment of depression].
Topics: Aged; Asthenia; Depression; Desipramine; Electroconvulsive Therapy; Female; Humans; Middle Aged; Tac | 1967 |