desipramine has been researched along with Sleep Apnea, Obstructive in 4 studies
Desipramine: A tricyclic dibenzazepine compound that potentiates neurotransmission. Desipramine selectively blocks reuptake of norepinephrine from the neural synapse, and also appears to impair serotonin transport. This compound also possesses minor anticholinergic activity, through its affinity to muscarinic receptors.
desipramine : A dibenzoazepine consisting of 10,11-dihydro-5H-dibenzo[b,f]azepine substituted on nitrogen with a 3-(methylamino)propyl group.
Sleep Apnea, Obstructive: A disorder characterized by recurrent apneas during sleep despite persistent respiratory efforts. It is due to upper airway obstruction. The respiratory pauses may induce HYPERCAPNIA or HYPOXIA. Cardiac arrhythmias and elevation of systemic and pulmonary arterial pressures may occur. Frequent partial arousals occur throughout sleep, resulting in relative SLEEP DEPRIVATION and daytime tiredness. Associated conditions include OBESITY; ACROMEGALY; MYXEDEMA; micrognathia; MYOTONIC DYSTROPHY; adenotonsilar dystrophy; and NEUROMUSCULAR DISEASES. (From Adams et al., Principles of Neurology, 6th ed, p395)
| Excerpt | Relevance | Reference |
|---|---|---|
| "Obstructive sleep apnea is a state-dependent disease." | 2.82 | Desipramine Increases Genioglossus Activity and Reduces Upper Airway Collapsibility during Non-REM Sleep in Healthy Subjects. ( Eckert, DJ; Edwards, BA; Marques, M; Sands, SA; Taranto-Montemurro, L; Wellman, A; White, DP, 2016) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 4 (100.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Taranto-Montemurro, L | 3 |
| Edwards, BA | 3 |
| Sands, SA | 3 |
| Marques, M | 2 |
| Eckert, DJ | 3 |
| White, DP | 3 |
| Wellman, A | 3 |
| Azarbarzin, A | 1 |
| de Melo, C | 1 |
| Jaffuel, D | 1 |
| Mallet, JP | 1 |
| Dauvilliers, Y | 1 |
| Bourdin, A | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| The Effect of Desipramine on Genioglossus Muscle Activity During Sleep in Healthy Control Subjects[NCT02428478] | Phase 2 | 17 participants (Actual) | Interventional | 2015-03-31 | Completed | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
Participants were connected to a modified continuous positive airway pressure (CPAP) machine (Pcrit3000, Respironics) which provided a wide range of pressures between 20 and -20 cm H2O in order to modify upper airway pressure. Following a baseline recording period of 5 minutes, the CPAP level was reduced to varying suboptimal pressures. Change in Pcrit was used to determine the collapsibility of the upper airway under both passive and active conditions, and is expressed as Passive Pcrit: ventilation at a nasal pressure of 0 cm H2O when pharyngeal muscles are passive; Active Pcrit: ventilation at a nasal pressure of 0 cm H2O when pharyngeal muscles are active. Improved=more negative Pcrit. (NCT02428478)
Timeframe: 1 night
| Intervention | cm H2O (Median) | |
|---|---|---|
| Passive Pcrit | Active Pcrit | |
| Desipramine | -10.0 | -14.9 |
| Placebo | -8.1 | -10.5 |
Electromyography (EMG) was used to analyze genioglossus (GG) [EMG GG] muscle movement. EMG GG activity was recorded via standard needle electrodes inserted into the genioglossus (tongue) muscle. Activity of EMG GG was measured during wakefulness and sleep as % of maximum activation obtained pushing the tongue against closed teeth during wakefulness (GG%max). Sleep values were then expressed as %wakefulness value for tonic and phasic EMG GG activity. Tonic activity was defined as the lowest EMG GG value during expiration, phasic activity was calculated as the peak value during inspiration minus the tonic value. (NCT02428478)
Timeframe: 1 night
| Intervention | percent wakefulness (Median) | |
|---|---|---|
| Tonic | Phasic | |
| Desipramine | 96 | 84 |
| Placebo | 75 | 93 |
2 trials available for desipramine and Sleep Apnea, Obstructive
| Article | Year |
|---|---|
Desipramine Increases Genioglossus Activity and Reduces Upper Airway Collapsibility during Non-REM Sleep in Healthy Subjects.
Topics: Adrenergic Uptake Inhibitors; Adult; Continuous Positive Airway Pressure; Cross-Over Studies; Desipr | 2016 |
Desipramine improves upper airway collapsibility and reduces OSA severity in patients with minimal muscle compensation.
Topics: Adrenergic Neurons; Adrenergic Uptake Inhibitors; Adult; Aged; Anthropometry; Continuous Positive Ai | 2016 |
2 other studies available for desipramine and Sleep Apnea, Obstructive
| Article | Year |
|---|---|
Is the Muscle the Only Potential Target of Desipramine in Obstructive Sleep Apnea Syndrome?
Topics: Desipramine; Humans; Polysomnography; Sleep Apnea, Obstructive | 2017 |
Reply: Is the Muscle the Only Potential Target of Desipramine in Obstructive Sleep Apnea Syndrome?
Topics: Desipramine; Humans; Polysomnography; Sleep Apnea, Obstructive | 2017 |