desipramine has been researched along with Sexual Dysfunction, Physiological in 2 studies
Desipramine: A tricyclic dibenzazepine compound that potentiates neurotransmission. Desipramine selectively blocks reuptake of norepinephrine from the neural synapse, and also appears to impair serotonin transport. This compound also possesses minor anticholinergic activity, through its affinity to muscarinic receptors.
desipramine : A dibenzoazepine consisting of 10,11-dihydro-5H-dibenzo[b,f]azepine substituted on nitrogen with a 3-(methylamino)propyl group.
Sexual Dysfunction, Physiological: Physiological disturbances in normal sexual performance in either the male or the female.
| Excerpt | Relevance | Reference |
|---|---|---|
| "This single-center, 12-week, double-blind, prospective, controlled-concentration study randomized 121 chronic back pain patients without major depression to active placebo (benztropine mesylate) or to predetermined low, medium, or high concentrations of desipramine (targets were 50, 110, and 150 ng/mL, respectively) or fluoxetine (targets were 100, 200, and 400 ng/mL, respectively)." | 5.12 | Efficacy of noradrenergic and serotonergic antidepressants in chronic back pain: a preliminary concentration-controlled trial. ( Abramson, I; Atkinson, JH; Capparelli, EV; Garfin, SR; Matthews, SC; Slater, MA; Wallace, MS; Zisook, S, 2007) |
| " Twenty-seven men were dosed with 100 mg desipramine (a weak base) and 975 mg aspirin (a weak acid) and ejaculated their semen in 1 pass across 5 compartments of a collection device 2." | 1.35 | Noninvasive quantitation of drug concentration in prostate and seminal vesicles: improvement and validation with desipramine and aspirin. ( Caffo, B; Cao, YJ; Choi, L; Fuchs, EJ; Hendrix, CW; Radebaugh, CL, 2008) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 2 (100.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Atkinson, JH | 1 |
| Slater, MA | 1 |
| Capparelli, EV | 1 |
| Wallace, MS | 1 |
| Zisook, S | 1 |
| Abramson, I | 1 |
| Matthews, SC | 1 |
| Garfin, SR | 1 |
| Cao, YJ | 1 |
| Caffo, B | 1 |
| Choi, L | 1 |
| Radebaugh, CL | 1 |
| Fuchs, EJ | 1 |
| Hendrix, CW | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Efficacy of Antidepressants in Chronic Back Pain[NCT00018200] | Phase 2 | 130 participants (Actual) | Interventional | 1999-04-30 | Completed | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
1 trial available for desipramine and Sexual Dysfunction, Physiological
| Article | Year |
|---|---|
Efficacy of noradrenergic and serotonergic antidepressants in chronic back pain: a preliminary concentration-controlled trial.
Topics: Adrenergic Uptake Inhibitors; Adult; Aged; Back Pain; Capsules; Chronic Disease; Constipation; Desip | 2007 |
1 other study available for desipramine and Sexual Dysfunction, Physiological
| Article | Year |
|---|---|
Noninvasive quantitation of drug concentration in prostate and seminal vesicles: improvement and validation with desipramine and aspirin.
Topics: Administration, Oral; Adolescent; Adult; Algorithms; Aspirin; Bayes Theorem; Biomarkers, Pharmacolog | 2008 |