Page last updated: 2024-10-25

desipramine and Sexual Dysfunction, Physiological

desipramine has been researched along with Sexual Dysfunction, Physiological in 2 studies

Desipramine: A tricyclic dibenzazepine compound that potentiates neurotransmission. Desipramine selectively blocks reuptake of norepinephrine from the neural synapse, and also appears to impair serotonin transport. This compound also possesses minor anticholinergic activity, through its affinity to muscarinic receptors.
desipramine : A dibenzoazepine consisting of 10,11-dihydro-5H-dibenzo[b,f]azepine substituted on nitrogen with a 3-(methylamino)propyl group.

Sexual Dysfunction, Physiological: Physiological disturbances in normal sexual performance in either the male or the female.

Research Excerpts

ExcerptRelevanceReference
"This single-center, 12-week, double-blind, prospective, controlled-concentration study randomized 121 chronic back pain patients without major depression to active placebo (benztropine mesylate) or to predetermined low, medium, or high concentrations of desipramine (targets were 50, 110, and 150 ng/mL, respectively) or fluoxetine (targets were 100, 200, and 400 ng/mL, respectively)."5.12Efficacy of noradrenergic and serotonergic antidepressants in chronic back pain: a preliminary concentration-controlled trial. ( Abramson, I; Atkinson, JH; Capparelli, EV; Garfin, SR; Matthews, SC; Slater, MA; Wallace, MS; Zisook, S, 2007)
" Twenty-seven men were dosed with 100 mg desipramine (a weak base) and 975 mg aspirin (a weak acid) and ejaculated their semen in 1 pass across 5 compartments of a collection device 2."1.35Noninvasive quantitation of drug concentration in prostate and seminal vesicles: improvement and validation with desipramine and aspirin. ( Caffo, B; Cao, YJ; Choi, L; Fuchs, EJ; Hendrix, CW; Radebaugh, CL, 2008)

Research

Studies (2)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's2 (100.00)29.6817
2010's0 (0.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Atkinson, JH1
Slater, MA1
Capparelli, EV1
Wallace, MS1
Zisook, S1
Abramson, I1
Matthews, SC1
Garfin, SR1
Cao, YJ1
Caffo, B1
Choi, L1
Radebaugh, CL1
Fuchs, EJ1
Hendrix, CW1

Clinical Trials (1)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
Efficacy of Antidepressants in Chronic Back Pain[NCT00018200]Phase 2130 participants (Actual)Interventional1999-04-30Completed
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Trials

1 trial available for desipramine and Sexual Dysfunction, Physiological

ArticleYear
Efficacy of noradrenergic and serotonergic antidepressants in chronic back pain: a preliminary concentration-controlled trial.
    Journal of clinical psychopharmacology, 2007, Volume: 27, Issue:2

    Topics: Adrenergic Uptake Inhibitors; Adult; Aged; Back Pain; Capsules; Chronic Disease; Constipation; Desip

2007

Other Studies

1 other study available for desipramine and Sexual Dysfunction, Physiological

ArticleYear
Noninvasive quantitation of drug concentration in prostate and seminal vesicles: improvement and validation with desipramine and aspirin.
    Journal of clinical pharmacology, 2008, Volume: 48, Issue:2

    Topics: Administration, Oral; Adolescent; Adult; Algorithms; Aspirin; Bayes Theorem; Biomarkers, Pharmacolog

2008