desipramine has been researched along with Sepsis in 3 studies
Desipramine: A tricyclic dibenzazepine compound that potentiates neurotransmission. Desipramine selectively blocks reuptake of norepinephrine from the neural synapse, and also appears to impair serotonin transport. This compound also possesses minor anticholinergic activity, through its affinity to muscarinic receptors.
desipramine : A dibenzoazepine consisting of 10,11-dihydro-5H-dibenzo[b,f]azepine substituted on nitrogen with a 3-(methylamino)propyl group.
Sepsis: Systemic inflammatory response syndrome with a proven or suspected infectious etiology. When sepsis is associated with organ dysfunction distant from the site of infection, it is called severe sepsis. When sepsis is accompanied by HYPOTENSION despite adequate fluid infusion, it is called SEPTIC SHOCK.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Here we show that patients with severe sepsis exhibit an enhanced sphingolytic activity in comparison with controls [262 pmol/(mlxh) vs." | 1.33 | Role of increased sphingomyelinase activity in apoptosis and organ failure of patients with severe sepsis. ( Bockmeyer, CL; Brunkhorst, FM; Bunck, AC; Claus, RA; Deigner, HP; Kinscherf, R; Lösche, W, 2005) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 1 (33.33) | 29.6817 |
| 2010's | 2 (66.67) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Chung, HY | 2 |
| Kollmey, AS | 1 |
| Schrepper, A | 1 |
| Kohl, M | 1 |
| Bläss, MF | 1 |
| Stehr, SN | 1 |
| Lupp, A | 2 |
| Gräler, MH | 2 |
| Claus, RA | 3 |
| Witt, CJ | 1 |
| Jbeily, N | 1 |
| Hurtado-Oliveros, J | 1 |
| Giszas, B | 1 |
| Bruns, T | 1 |
| Stallmach, A | 1 |
| Gonnert, FA | 1 |
| Bunck, AC | 1 |
| Bockmeyer, CL | 1 |
| Brunkhorst, FM | 1 |
| Lösche, W | 1 |
| Kinscherf, R | 1 |
| Deigner, HP | 1 |
3 other studies available for desipramine and Sepsis
| Article | Year |
|---|---|
Adjustment of Dysregulated Ceramide Metabolism in a Murine Model of Sepsis-Induced Cardiac Dysfunction.
Topics: Animals; Biomarkers; Cardiac Output; Ceramides; Desipramine; Disease Models, Animal; Female; Gene Ex | 2017 |
Acid Sphingomyelinase Inhibition Prevents Development of Sepsis Sequelae in the Murine Liver.
Topics: Animals; Apoptosis; Cell Line; Desipramine; Disease Models, Animal; Drug Evaluation, Preclinical; Fe | 2017 |
Role of increased sphingomyelinase activity in apoptosis and organ failure of patients with severe sepsis.
Topics: Adult; Aged; Animals; Apoptosis; Ascorbic Acid; Blood Chemical Analysis; Ceramides; Desipramine; Dis | 2005 |