desipramine has been researched along with Sensitivity and Specificity in 30 studies
Desipramine: A tricyclic dibenzazepine compound that potentiates neurotransmission. Desipramine selectively blocks reuptake of norepinephrine from the neural synapse, and also appears to impair serotonin transport. This compound also possesses minor anticholinergic activity, through its affinity to muscarinic receptors.
desipramine : A dibenzoazepine consisting of 10,11-dihydro-5H-dibenzo[b,f]azepine substituted on nitrogen with a 3-(methylamino)propyl group.
Sensitivity and Specificity: Binary classification measures to assess test results. Sensitivity or recall rate is the proportion of true positives. Specificity is the probability of correctly determining the absence of a condition. (From Last, Dictionary of Epidemiology, 2d ed)
| Excerpt | Relevance | Reference |
|---|---|---|
| "Desipramine treatment was associated with decreased 6-(18)F-fluorodopamine-derived radioactivity in the heart, renal cortex, and thyroid gland but not in the liver, spleen, renal pelvis, or salivary glands." | 2.71 | Cardiac and extracardiac sympathetic denervation in Parkinson's disease with orthostatic hypotension and in pure autonomic failure. ( Goldstein, DS; Tipre, DN, 2005) |
| "Ethyl chloroformate was employed as derivatizing agent producing symmetrical peaks." | 1.35 | Determination of fluoxetine in plasma by gas chromatography-mass spectrometry using stir bar sorptive extraction. ( Fernandes, C; Lanças, FM; Sandra, P; Van Hoeck, E, 2008) |
| " In our search for a reporter gene that lacks these limitations, we have evaluated the feasibility of the human norepinephrine transporter (hNET) as a reporter gene in combination with the reporter probe 11C-m-hydroxyephedrine (mHED) for PET." | 1.33 | The human norepinephrine transporter in combination with 11C-m-hydroxyephedrine as a reporter gene/reporter probe for PET of gene therapy. ( Beerens, AM; Buursma, AR; de Vries, EF; Haisma, HJ; Hospers, GA; Rots, MG; Vaalburg, W; van Waarde, A, 2005) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 14 (46.67) | 18.2507 |
| 2000's | 16 (53.33) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Li, H | 1 |
| Sun, J | 1 |
| Sui, X | 1 |
| Liu, J | 1 |
| Yan, Z | 1 |
| Liu, X | 1 |
| Sun, Y | 1 |
| He, Z | 1 |
| Foster, DC | 1 |
| Beth Kotok, M | 1 |
| Huang, LS | 1 |
| Watts, A | 1 |
| Oakes, D | 1 |
| Howard, FM | 1 |
| Stodgell, CJ | 1 |
| Dworkin, RH | 1 |
| Fujiki, N | 1 |
| Cheng, T | 1 |
| Yoshino, F | 1 |
| Nishino, S | 1 |
| Bose, D | 1 |
| Martinavarro-Domínguez, A | 1 |
| Gil-Agustí, M | 1 |
| Carda-Broch, S | 1 |
| Durgbanshi, A | 1 |
| Capella-Peiró, ME | 1 |
| Esteve-Romero, J | 1 |
| Martínez-Mota, L | 1 |
| López-Rubalcava, C | 1 |
| Rodríguez-Manzo, G | 1 |
| Ordway, GA | 1 |
| Jia, W | 1 |
| Li, J | 1 |
| Zhu, MY | 1 |
| Mandela, P | 1 |
| Pan, J | 1 |
| Tipre, DN | 1 |
| Goldstein, DS | 1 |
| Buursma, AR | 1 |
| Beerens, AM | 1 |
| de Vries, EF | 1 |
| van Waarde, A | 1 |
| Rots, MG | 1 |
| Hospers, GA | 1 |
| Vaalburg, W | 1 |
| Haisma, HJ | 1 |
| Cantú, MD | 1 |
| Toso, DR | 1 |
| Lacerda, CA | 1 |
| Lanças, FM | 2 |
| Carrilho, E | 1 |
| Queiroz, ME | 1 |
| Paine, TA | 1 |
| Tomasiewicz, HC | 1 |
| Zhang, K | 1 |
| Carlezon, WA | 1 |
| Matsumoto, T | 1 |
| Asano, T | 1 |
| Takemoto, M | 1 |
| Tachibana, H | 1 |
| Ogasawara, Y | 1 |
| Kajiya, F | 1 |
| Fernandes, C | 1 |
| Van Hoeck, E | 1 |
| Sandra, P | 1 |
| Snyder, DL | 1 |
| Gayheart, P | 1 |
| Johnson, MD | 1 |
| Gurdal, H | 1 |
| Roberts, J | 1 |
| Elm, T | 1 |
| Hansen, EL | 1 |
| Perry, PJ | 1 |
| Zeilmann, C | 1 |
| Arndt, S | 1 |
| Fujii, T | 1 |
| Kurihara, Y | 1 |
| Arimoto, H | 1 |
| Mitsutsuka, Y | 1 |
| Koyama, E | 1 |
| Kikuchi, Y | 1 |
| Echizen, H | 1 |
| Chiba, K | 1 |
| Ishizaki, T | 1 |
| Adamczyk, M | 1 |
| Fishpaugh, J | 1 |
| Harrington, C | 1 |
| Johnson, D | 1 |
| Vanderbilt, A | 1 |
| Lahmame, A | 1 |
| Armario, A | 1 |
| Chen, AG | 1 |
| Wing, YK | 1 |
| Chiu, H | 1 |
| Lee, S | 1 |
| Chen, CN | 1 |
| Chan, K | 1 |
| Pommier, F | 1 |
| Sioufi, A | 1 |
| Godbillon, J | 1 |
| de la Torre, R | 1 |
| Ortuño, J | 1 |
| Pascual, JA | 1 |
| González, S | 1 |
| Ballesta, J | 1 |
| Kimura, H | 1 |
| Mukaida, M | 1 |
| Wang, G | 1 |
| Yuan, J | 1 |
| Matsumoto, K | 1 |
| Syed, AA | 1 |
| Khatoon, BA | 1 |
| Silwadi, MF | 1 |
| Simeon, D | 1 |
| Guralnik, O | 1 |
| Schmeidler, J | 1 |
| Heard, K | 1 |
| Cain, BS | 1 |
| Dart, RC | 1 |
| Cairns, CB | 1 |
| Probst, BD | 1 |
| Cetta, F | 1 |
| Michael-Hepp, J | 1 |
| Blum, B | 1 |
| Bönisch, H | 1 |
| Durlach-Misteli, C | 1 |
| Van Ree, JM | 1 |
| Pepin, MC | 1 |
| Govindan, MV | 1 |
| Barden, N | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Vulvar Vestibulitis Trial: Desipramine-Lidocaine[NCT00276068] | 128 participants (Anticipated) | Interventional | 2002-08-31 | Completed | |||
| Is Low Level Laser Therapy (LLLT) Effective for Reducing Pain Experienced by Women With Provoked Vestibulodynia?[NCT04234542] | 28 participants (Actual) | Interventional | 2021-02-18 | Completed | |||
| Effectiveness and Cost-utility of Somatocognitive Therapy Versus Treatment as Usual for Provoked (Localized) Vestibulodynia - a Randomized Clinical Trial (ProLoVe Study)[NCT04613713] | 128 participants (Anticipated) | Interventional | 2021-01-01 | Recruiting | |||
| The Effects of Supplementing Tyrosine on Blood Pressure in Parkinson's Disease[NCT01676103] | Phase 1/Phase 2 | 40 participants (Actual) | Interventional | 2012-09-30 | Completed | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
1 review available for desipramine and Sensitivity and Specificity
| Article | Year |
|---|---|
Tricyclic antidepressant concentrations in plasma: an estimate of their sensitivity and specificity as a predictor of response.
Topics: Adolescent; Adult; Amitriptyline; Antidepressive Agents, Tricyclic; Clinical Trials as Topic; Depres | 1994 |
2 trials available for desipramine and Sensitivity and Specificity
| Article | Year |
|---|---|
The tampon test for vulvodynia treatment outcomes research: reliability, construct validity, and responsiveness.
Topics: Adrenergic Uptake Inhibitors; Adult; Anesthetics, Local; Coitus; Desipramine; Diagnostic Techniques, | 2009 |
The tampon test for vulvodynia treatment outcomes research: reliability, construct validity, and responsiveness.
Topics: Adrenergic Uptake Inhibitors; Adult; Anesthetics, Local; Coitus; Desipramine; Diagnostic Techniques, | 2009 |
The tampon test for vulvodynia treatment outcomes research: reliability, construct validity, and responsiveness.
Topics: Adrenergic Uptake Inhibitors; Adult; Anesthetics, Local; Coitus; Desipramine; Diagnostic Techniques, | 2009 |
The tampon test for vulvodynia treatment outcomes research: reliability, construct validity, and responsiveness.
Topics: Adrenergic Uptake Inhibitors; Adult; Anesthetics, Local; Coitus; Desipramine; Diagnostic Techniques, | 2009 |
The tampon test for vulvodynia treatment outcomes research: reliability, construct validity, and responsiveness.
Topics: Adrenergic Uptake Inhibitors; Adult; Anesthetics, Local; Coitus; Desipramine; Diagnostic Techniques, | 2009 |
The tampon test for vulvodynia treatment outcomes research: reliability, construct validity, and responsiveness.
Topics: Adrenergic Uptake Inhibitors; Adult; Anesthetics, Local; Coitus; Desipramine; Diagnostic Techniques, | 2009 |
The tampon test for vulvodynia treatment outcomes research: reliability, construct validity, and responsiveness.
Topics: Adrenergic Uptake Inhibitors; Adult; Anesthetics, Local; Coitus; Desipramine; Diagnostic Techniques, | 2009 |
The tampon test for vulvodynia treatment outcomes research: reliability, construct validity, and responsiveness.
Topics: Adrenergic Uptake Inhibitors; Adult; Anesthetics, Local; Coitus; Desipramine; Diagnostic Techniques, | 2009 |
The tampon test for vulvodynia treatment outcomes research: reliability, construct validity, and responsiveness.
Topics: Adrenergic Uptake Inhibitors; Adult; Anesthetics, Local; Coitus; Desipramine; Diagnostic Techniques, | 2009 |
Cardiac and extracardiac sympathetic denervation in Parkinson's disease with orthostatic hypotension and in pure autonomic failure.
Topics: Adult; Aged; Autonomic Nervous System; Autonomic Nervous System Diseases; Desipramine; Dopamine; Flu | 2005 |
27 other studies available for desipramine and Sensitivity and Specificity
| Article | Year |
|---|---|
First-principle, structure-based prediction of hepatic metabolic clearance values in human.
Topics: Computational Biology; Drug Discovery; Hepatocytes; Humans; Hydrogen-Ion Concentration; Liver; Metab | 2009 |
Specificity of direct transition from wake to REM sleep in orexin/ataxin-3 transgenic narcoleptic mice.
Topics: Analysis of Variance; Animals; Antidepressive Agents, Tricyclic; Ataxin-3; Benzhydryl Compounds; Cen | 2009 |
Therapeutic monitoring of imipramine and desipramine by micellar liquid chromatography with direct injection and electrochemical detection.
Topics: Antidepressive Agents, Tricyclic; Chromatography, Liquid; Desipramine; Electrochemistry; Humans; Hyd | 2005 |
Ejaculation induces long-lasting behavioural changes in male rats in the forced swimming test: evidence for an increased sensitivity to the antidepressant desipramine.
Topics: Analysis of Variance; Animals; Antidepressive Agents, Tricyclic; Behavior, Animal; Depression; Desip | 2005 |
Norepinephrine transporter function and desipramine: residual drug effects versus short-term regulation.
Topics: Adaptation, Physiological; Adrenergic Uptake Inhibitors; Animals; Artifacts; Desipramine; Dose-Respo | 2005 |
The human norepinephrine transporter in combination with 11C-m-hydroxyephedrine as a reporter gene/reporter probe for PET of gene therapy.
Topics: Adenoviridae; Animals; Carbon Radioisotopes; Cell Line; Cell Line, Tumor; Chlorocebus aethiops; Cont | 2005 |
Optimization of solid-phase microextraction procedures for the determination of tricyclic antidepressants and anticonvulsants in plasma samples by liquid chromatography.
Topics: Amitriptyline; Anticonvulsants; Antidepressive Agents, Tricyclic; Carbamazepine; Chromatography, Liq | 2006 |
Sensitivity of the five-choice serial reaction time task to the effects of various psychotropic drugs in Sprague-Dawley rats.
Topics: Animals; Attention; Behavior, Animal; Benzeneacetamides; Choice Behavior; Desipramine; Dizocilpine M | 2007 |
Microheterogeneity of regional myocardial blood flows in low-perfused rat hearts evaluated by double-tracer digital radiography.
Topics: Animals; Autoradiography; Coronary Circulation; Desipramine; Deuterium; Iodine Radioisotopes; Perfus | 2007 |
Determination of fluoxetine in plasma by gas chromatography-mass spectrometry using stir bar sorptive extraction.
Topics: Adsorption; Antidepressive Agents; Desipramine; Fluoxetine; Formic Acid Esters; Gas Chromatography-M | 2008 |
Prenatal cocaine exposure alters norepinephrine release from cardiac adrenergic nerve terminals.
Topics: Adrenergic Fibers; Animals; Body Weight; Cocaine; Desipramine; Female; Heart; Ionomycin; Male; Myoca | 1995 |
Simultaneous determination of lofepramine and desipramine by a high-performance liquid chromatographic method used for therapeutic drug monitoring.
Topics: Chromatography, High Pressure Liquid; Desipramine; Drug Monitoring; Humans; Kinetics; Lofepramine; Q | 1995 |
Surface ionization organic mass spectrometry of imipramine, desipramine, clomipramine, and lidocaine.
Topics: Clomipramine; Desipramine; Humans; Imipramine; Lidocaine; Mass Spectrometry; Sensitivity and Specifi | 1994 |
Simultaneous high-performance liquid chromatography-electrochemical detection determination of imipramine, desipramine, their 2-hydroxylated metabolites, and imipramine N-oxide in human plasma and urine: preliminary application to oxidation pharmacogeneti
Topics: Arylsulfatases; Calibration; Chromatography, High Pressure Liquid; Debrisoquin; Desipramine; Electro | 1993 |
Immunoassay reagents for psychoactive drugs. II. The method for the development of antibodies specific to imipramine and desipramine.
Topics: Animals; Antibody Formation; Antibody Specificity; Antidepressive Agents, Tricyclic; Cross Reactions | 1993 |
Differential responsiveness of inbred strains of rats to antidepressants in the forced swimming test: are Wistar Kyoto rats an animal model of subsensitivity to antidepressants?
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Animals; Antidepressive Agents; Behavior, Animal; Desipramin | 1996 |
Simultaneous determination of imipramine, desipramine and their 2- and 10-hydroxylated metabolites in human plasma and urine by high-performance liquid chromatography.
Topics: Adult; Antidepressive Agents, Tricyclic; Chromatography, High Pressure Liquid; Desipramine; Female; | 1997 |
Simultaneous determination of imipramine and its metabolite desipramine in human plasma by capillary gas chromatography with mass-selective detection.
Topics: Administration, Oral; Antidepressive Agents, Tricyclic; Calibration; Chromatography, Gas; Circadian | 1997 |
Quantitative determination of tricyclic antidepressants and their metabolites in plasma by solid-phase extraction (Bond-Elut TCA) and separation by capillary gas chromatography with nitrogen-phosphorous detection.
Topics: Amitriptyline; Antidepressive Agents, Tricyclic; Chromatography, Gas; Clomipramine; Desipramine; Dru | 1998 |
Dual-label time-resolved fluoroimmunoassay of psychopharmaceuticals and stimulants in serum.
Topics: Animals; Antidepressive Agents, Tricyclic; Antipsychotic Agents; Calibration; Central Nervous System | 2000 |
New reagents for detection of faecal occult blood.
Topics: Alkanes; Desipramine; Edetic Acid; Humans; Hydrogen-Ion Concentration; Imipramine; Indicators and Re | 2001 |
Development of a depersonalization severity scale.
Topics: Adult; Antidepressive Agents, Second-Generation; Antidepressive Agents, Tricyclic; Clomipramine; Dep | 2001 |
Tricyclic antidepressants directly depress human myocardial mechanical function independent of effects on the conduction system.
Topics: Amitriptyline; Analysis of Variance; Antidepressive Agents, Tricyclic; Culture Techniques; Desiprami | 2001 |
The utility of a 12-lead electrocardiogram in diagnosing a suspected antidepressant overdose.
Topics: Adolescent; Bicarbonates; Desipramine; Drug Overdose; Electrocardiography; Emergency Service, Hospit | 1992 |
Characterization of the [3H]-desipramine binding site of the bovine adrenomedullary plasma membrane.
Topics: Adrenal Medulla; Animals; Binding Sites; Carrier Proteins; Cattle; Cell Membrane; Chlorides; Desipra | 1992 |
Dopamine and melatonin in the nucleus accumbens may be implicated in the mode of action of antidepressant drugs.
Topics: Animals; Antidepressive Agents; Apomorphine; Behavior, Animal; Desipramine; Dopamine; Dose-Response | 1992 |
Increased glucocorticoid receptor gene promoter activity after antidepressant treatment.
Topics: Animals; Antidepressive Agents; Blotting, Northern; Chimera; Chloramphenicol O-Acetyltransferase; De | 1992 |