desipramine has been researched along with Rett Syndrome in 7 studies
Desipramine: A tricyclic dibenzazepine compound that potentiates neurotransmission. Desipramine selectively blocks reuptake of norepinephrine from the neural synapse, and also appears to impair serotonin transport. This compound also possesses minor anticholinergic activity, through its affinity to muscarinic receptors.
desipramine : A dibenzoazepine consisting of 10,11-dihydro-5H-dibenzo[b,f]azepine substituted on nitrogen with a 3-(methylamino)propyl group.
Rett Syndrome: An inherited neurological developmental disorder that is associated with X-LINKED INHERITANCE and may be lethal in utero to hemizygous males. The affected female is normal until the age of 6-25 months when progressive loss of voluntary control of hand movements and communication skills; ATAXIA; SEIZURES; autistic behavior; intermittent HYPERVENTILATION; and HYPERAMMONEMIA appear. (From Menkes, Textbook of Child Neurology, 5th ed, p199)
| Excerpt | Relevance | Reference |
|---|---|---|
| "Rett syndrome is a neurodevelopmental disease due to Mecp2 gene mutations that is associated to complex neurological symptoms, with bioaminergic deficits and life-threatening apneas related to sudden and unexpected death." | 7.74 | Oral treatment with desipramine improves breathing and life span in Rett syndrome mouse model. ( Dutschmann, M; Hilaire, G; Lajard, AM; Mebarek, S; Picard, N; Zanella, S, 2008) |
| "Mirtazapine was more effective than desipramine in restoring somatosensory cortex thickness by fully rescuing pyramidal neurons dendritic arborization and spine density." | 5.43 | Pharmacological treatment with mirtazapine rescues cortical atrophy and respiratory deficits in MeCP2 null mice. ( Baj, G; Bernareggi, A; Bittolo, T; Deiana, C; Ferrazzo, S; Raminelli, CA; Tongiorgi, E; Vaghi, V, 2016) |
| "Rett syndrome is a neurodevelopmental disease due to Mecp2 gene mutations that is associated to complex neurological symptoms, with bioaminergic deficits and life-threatening apneas related to sudden and unexpected death." | 3.74 | Oral treatment with desipramine improves breathing and life span in Rett syndrome mouse model. ( Dutschmann, M; Hilaire, G; Lajard, AM; Mebarek, S; Picard, N; Zanella, S, 2008) |
| "Mirtazapine was more effective than desipramine in restoring somatosensory cortex thickness by fully rescuing pyramidal neurons dendritic arborization and spine density." | 1.43 | Pharmacological treatment with mirtazapine rescues cortical atrophy and respiratory deficits in MeCP2 null mice. ( Baj, G; Bernareggi, A; Bittolo, T; Deiana, C; Ferrazzo, S; Raminelli, CA; Tongiorgi, E; Vaghi, V, 2016) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 5 (71.43) | 29.6817 |
| 2010's | 2 (28.57) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Bittolo, T | 1 |
| Raminelli, CA | 1 |
| Deiana, C | 1 |
| Baj, G | 1 |
| Vaghi, V | 1 |
| Ferrazzo, S | 1 |
| Bernareggi, A | 1 |
| Tongiorgi, E | 1 |
| Ricceri, L | 1 |
| De Filippis, B | 1 |
| Laviola, G | 1 |
| Zhang, X | 1 |
| Su, J | 1 |
| Cui, N | 1 |
| Gai, H | 1 |
| Wu, Z | 1 |
| Jiang, C | 1 |
| Roux, JC | 2 |
| Dura, E | 1 |
| Moncla, A | 1 |
| Mancini, J | 1 |
| Villard, L | 2 |
| Nau, JY | 1 |
| Zanella, S | 1 |
| Mebarek, S | 1 |
| Lajard, AM | 1 |
| Picard, N | 1 |
| Dutschmann, M | 1 |
| Hilaire, G | 1 |
1 review available for desipramine and Rett Syndrome
| Article | Year |
|---|---|
Mouse models of Rett syndrome: from behavioural phenotyping to preclinical evaluation of new therapeutic approaches.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Brain; Desipramine; Disease Model | 2008 |
6 other studies available for desipramine and Rett Syndrome
| Article | Year |
|---|---|
Pharmacological treatment with mirtazapine rescues cortical atrophy and respiratory deficits in MeCP2 null mice.
Topics: Animals; Antidepressive Agents; Atrophy; Breath Tests; Cerebral Cortex; Desipramine; GABAergic Neuro | 2016 |
The disruption of central CO2 chemosensitivity in a mouse model of Rett syndrome.
Topics: Action Potentials; Animals; Carbon Dioxide; Chemoreceptor Cells; Desipramine; Disease Models, Animal | 2011 |
Treatment with desipramine improves breathing and survival in a mouse model for Rett syndrome.
Topics: Adrenergic Uptake Inhibitors; Animals; Brain Stem; Cell Proliferation; Desipramine; Disease Models, | 2007 |
[Drug therapy for Rett syndrome].
Topics: Adrenergic Uptake Inhibitors; Desipramine; Humans; Rett Syndrome | 2007 |
Oral treatment with desipramine improves breathing and life span in Rett syndrome mouse model.
Topics: Animals; Antidepressive Agents, Tricyclic; Apnea; Desipramine; Female; Locomotion; Longevity; Medull | 2008 |
[Pharmacological treatment of Rett syndrome improves breathing and survival in a mouse model].
Topics: Adrenergic Uptake Inhibitors; Animals; Brain Stem; Cells, Cultured; Desipramine; Drug Evaluation, Pr | 2007 |