desipramine has been researched along with Reperfusion Injury in 3 studies
Desipramine: A tricyclic dibenzazepine compound that potentiates neurotransmission. Desipramine selectively blocks reuptake of norepinephrine from the neural synapse, and also appears to impair serotonin transport. This compound also possesses minor anticholinergic activity, through its affinity to muscarinic receptors.
desipramine : A dibenzoazepine consisting of 10,11-dihydro-5H-dibenzo[b,f]azepine substituted on nitrogen with a 3-(methylamino)propyl group.
Reperfusion Injury: Adverse functional, metabolic, or structural changes in tissues that result from the restoration of blood flow to the tissue (REPERFUSION) following ISCHEMIA.
| Excerpt | Relevance | Reference |
|---|---|---|
| "In view of the importance of sympathetic nervous system in the genesis of cardiac arrhythmias during reperfusion following coronary occlusion, the role of noradrenaline uptake inhibitor desipramine in the prevention of reperfusion arrhythmias was investigated in intact rabbit heart and isolated rat heart." | 3.69 | Role of noradrenaline uptake inhibition and alpha-adrenoceptors in reperfusion ventricular arrhythmias in vivo and in vitro. ( Pandhi, P; Sharma, PL; Shekher, A; Singh, M, 1996) |
| "Cardiac ischemia and anoxia induce massive norepinephrine (NE) release, which is mediated by a reverse operation of uptake-1 and can be suppressed by uptake-1 inhibitors." | 1.30 | Protection of neuronal uptake-1 inhibitors in ischemic and anoxic hearts by norepinephrine-dependent and -independent mechanisms. ( Dart, AM; Du, XJ; Esler, MD; Little, PJ; Woodcock, EA, 1998) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 2 (66.67) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 1 (33.33) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Fan, J | 1 |
| Wu, BX | 1 |
| Crosson, CE | 1 |
| Shekher, A | 1 |
| Sharma, PL | 1 |
| Pandhi, P | 1 |
| Singh, M | 1 |
| Du, XJ | 1 |
| Woodcock, EA | 1 |
| Little, PJ | 1 |
| Esler, MD | 1 |
| Dart, AM | 1 |
3 other studies available for desipramine and Reperfusion Injury
| Article | Year |
|---|---|
Suppression of Acid Sphingomyelinase Protects the Retina from Ischemic Injury.
Topics: Animals; Apoptosis; Blotting, Western; Ceramides; Chromatography, High Pressure Liquid; Desipramine; | 2016 |
Role of noradrenaline uptake inhibition and alpha-adrenoceptors in reperfusion ventricular arrhythmias in vivo and in vitro.
Topics: Adrenergic Uptake Inhibitors; Animals; Arrhythmias, Cardiac; Desipramine; In Vitro Techniques; Male; | 1996 |
Protection of neuronal uptake-1 inhibitors in ischemic and anoxic hearts by norepinephrine-dependent and -independent mechanisms.
Topics: Adrenergic Uptake Inhibitors; Animals; Cocaine; Desipramine; Dopamine Uptake Inhibitors; Drug Intera | 1998 |