desipramine has been researched along with Recrudescence in 20 studies
Desipramine: A tricyclic dibenzazepine compound that potentiates neurotransmission. Desipramine selectively blocks reuptake of norepinephrine from the neural synapse, and also appears to impair serotonin transport. This compound also possesses minor anticholinergic activity, through its affinity to muscarinic receptors.
desipramine : A dibenzoazepine consisting of 10,11-dihydro-5H-dibenzo[b,f]azepine substituted on nitrogen with a 3-(methylamino)propyl group.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Twenty-six children and adolescents with severe primary obsessive-compulsive disorder receiving long-term clomipramine hydrochloride maintenance treatment (mean +/- SD, 17." | 9.07 | A double-blind desipramine substitution during long-term clomipramine treatment in children and adolescents with obsessive-compulsive disorder. ( Cheslow, DL; Hamburger, SD; Lenane, MC; Leonard, HL; Rapoport, JL; Rettew, DC; Swedo, SE, 1991) |
| "Forty-eight children and adolescents with severe primary obsessive-compulsive disorder completed a 10-week double-blind crossover trial of clomipramine hydrochloride (mean dose [+/- SD], 150 +/- 53 mg/d) and desipramine hydrochloride (mean dose [+/- SD], 153 +/- 55 mg/d)." | 9.06 | Treatment of obsessive-compulsive disorder with clomipramine and desipramine in children and adolescents. A double-blind crossover comparison. ( Cheslow, DL; Hamburger, SD; Koby, EV; Lenane, MC; Leonard, HL; Rapoport, JL; Swedo, SE, 1989) |
| "This study examined the relative effectiveness of desipramine, cognitive-behavioral therapy, and their combination in the treatment of bulimia nervosa, together with the effects of withdrawing medication after two different lengths of treatment." | 5.07 | Pharmacologic and cognitive-behavioral treatment for bulimia nervosa: a controlled comparison. ( Agras, WS; Arnow, B; Bruce, B; Koran, LM; Perl, M; Raeburn, SD; Rossiter, EM; Schneider, JA; Telch, CF, 1992) |
| "The study documents a beneficial effect of desipramine in the treatment of bulimia nervosa when compared to placebo." | 5.07 | Long-term outcome of antidepressant treatment for bulimia nervosa. ( Devlin, MJ; Gladis, M; Hadigan, CM; Roose, SP; Walsh, BT, 1991) |
| "Twenty-six children and adolescents with severe primary obsessive-compulsive disorder receiving long-term clomipramine hydrochloride maintenance treatment (mean +/- SD, 17." | 5.07 | A double-blind desipramine substitution during long-term clomipramine treatment in children and adolescents with obsessive-compulsive disorder. ( Cheslow, DL; Hamburger, SD; Lenane, MC; Leonard, HL; Rapoport, JL; Rettew, DC; Swedo, SE, 1991) |
| "Forty-eight children and adolescents with severe primary obsessive-compulsive disorder completed a 10-week double-blind crossover trial of clomipramine hydrochloride (mean dose [+/- SD], 150 +/- 53 mg/d) and desipramine hydrochloride (mean dose [+/- SD], 153 +/- 55 mg/d)." | 5.06 | Treatment of obsessive-compulsive disorder with clomipramine and desipramine in children and adolescents. A double-blind crossover comparison. ( Cheslow, DL; Hamburger, SD; Koby, EV; Lenane, MC; Leonard, HL; Rapoport, JL; Swedo, SE, 1989) |
| "Relapse was defined as a 50% increase in HDRS with total < or = 17." | 2.69 | Tryptophan-depletion challenge in depressed patients treated with desipramine or fluoxetine: implications for the role of serotonin in the mechanism of antidepressant action. ( Charney, DS; Delgado, PL; Heninger, GR; Krystal, JH; Licinio, J; Miller, HL; Moreno, FA; Salomon, RM, 1999) |
| "Imipramine doses were individually adjusted until doses yielded plasma concentrations of imipramine plus desipramine that were well above 400 nmol/L or until all neuropathy symptoms had vanished." | 1.28 | Concentration-response relationship in imipramine treatment of diabetic neuropathy symptoms. ( Beck-Nielsen, H; Frøland, A; Gram, LF; Sindrup, SH; Skjold, T, 1990) |
| " Knowledge of the drug dose-response curve and its levels in blood may enable the physician to convert a patient from a "nonresponder" into a "responder." | 1.26 | High dose desipramine, plasma drug levels and clinical response. ( Amsterdam, J; Brunswick, DJ; Mendels, J, 1979) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 8 (40.00) | 18.7374 |
| 1990's | 12 (60.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Brown, WA | 1 |
| Qualls, CB | 1 |
| Friedman, RA | 2 |
| Markowitz, JC | 1 |
| Parides, M | 1 |
| Kocsis, JH | 2 |
| Mitchell, J | 1 |
| Carroll, KM | 1 |
| Rounsaville, BJ | 1 |
| Nich, C | 1 |
| Gordon, LT | 1 |
| Wirtz, PW | 1 |
| Gawin, F | 1 |
| Douglas, MB | 1 |
| Fleming, MF | 1 |
| Delgado, PL | 1 |
| Miller, HL | 1 |
| Salomon, RM | 1 |
| Licinio, J | 1 |
| Krystal, JH | 1 |
| Moreno, FA | 1 |
| Heninger, GR | 1 |
| Charney, DS | 1 |
| Swann, AC | 1 |
| Bowden, CL | 1 |
| Rush, AJ | 1 |
| Rhoades, H | 1 |
| Rose, R | 1 |
| Kobes, R | 1 |
| Amsterdam, J | 1 |
| Brunswick, DJ | 1 |
| Mendels, J | 1 |
| Agras, WS | 1 |
| Rossiter, EM | 1 |
| Arnow, B | 1 |
| Schneider, JA | 1 |
| Telch, CF | 1 |
| Raeburn, SD | 1 |
| Bruce, B | 1 |
| Perl, M | 1 |
| Koran, LM | 1 |
| Walsh, BT | 1 |
| Hadigan, CM | 1 |
| Devlin, MJ | 1 |
| Gladis, M | 1 |
| Roose, SP | 1 |
| Leonard, HL | 2 |
| Swedo, SE | 2 |
| Lenane, MC | 2 |
| Rettew, DC | 1 |
| Cheslow, DL | 2 |
| Hamburger, SD | 2 |
| Rapoport, JL | 2 |
| Teoh, SK | 2 |
| Mendelson, JH | 2 |
| Mello, NK | 2 |
| Weiss, R | 1 |
| McElroy, S | 1 |
| McAfee, B | 2 |
| Jarrett, DB | 1 |
| Miewald, JM | 1 |
| Kupfer, DJ | 1 |
| Sindrup, SH | 1 |
| Gram, LF | 1 |
| Skjold, T | 1 |
| Frøland, A | 1 |
| Beck-Nielsen, H | 1 |
| Koby, EV | 1 |
| McElroy, SL | 1 |
| Weiss, RD | 2 |
| Schweizer, E | 1 |
| Dever, A | 1 |
| Clary, C | 1 |
| Barnes, DM | 1 |
| Cohen, BM | 1 |
| Baldessarini, RJ | 1 |
10 trials available for desipramine and Recrudescence
| Article | Year |
|---|---|
Retreatment for relapse following desipramine discontinuation in dysthymia.
Topics: Adult; Aged; Depressive Disorder; Desipramine; Double-Blind Method; Drug Administration Schedule; Fe | 1995 |
One-year follow-up of psychotherapy and pharmacotherapy for cocaine dependence. Delayed emergence of psychotherapy effects.
Topics: Adaptation, Psychological; Adult; Ambulatory Care; Behavior Therapy; Cocaine; Cognitive Behavioral T | 1994 |
Tryptophan-depletion challenge in depressed patients treated with desipramine or fluoxetine: implications for the role of serotonin in the mechanism of antidepressant action.
Topics: Adult; Aged; Amino Acids; Analysis of Variance; Antidepressive Agents, Second-Generation; Antidepres | 1999 |
Desipramine versus phenelzine in recurrent unipolar depression: clinical characteristics and treatment response.
Topics: Adolescent; Adult; Aged; Antidepressive Agents, Tricyclic; Depressive Disorder; Desipramine; Female; | 1997 |
Pharmacologic and cognitive-behavioral treatment for bulimia nervosa: a controlled comparison.
Topics: Adolescent; Adult; Aged; Ambulatory Care; Bulimia; Cognitive Behavioral Therapy; Combined Modality T | 1992 |
Long-term outcome of antidepressant treatment for bulimia nervosa.
Topics: Adult; Bulimia; Desipramine; Double-Blind Method; Female; Follow-Up Studies; Humans; Medical Records | 1991 |
A double-blind desipramine substitution during long-term clomipramine treatment in children and adolescents with obsessive-compulsive disorder.
Topics: Adolescent; Age Factors; Child; Clomipramine; Desipramine; Double-Blind Method; Drug Administration | 1991 |
Hyperprolactinemia and risk for relapse of cocaine abuse.
Topics: Adult; Cocaine; Desipramine; Double-Blind Method; Female; Humans; Hyperprolactinemia; Male; Prolacti | 1990 |
Treatment of obsessive-compulsive disorder with clomipramine and desipramine in children and adolescents. A double-blind crossover comparison.
Topics: Adolescent; Adult; Age Factors; Child; Clinical Trials as Topic; Clomipramine; Desipramine; Double-B | 1989 |
Desipramine treatment for relapse prevention in cocaine dependence.
Topics: Adult; Cocaine; Desipramine; Double-Blind Method; Female; Humans; Length of Stay; Male; Personality | 1989 |
10 other studies available for desipramine and Recrudescence
| Article | Year |
|---|---|
Pituitary-adrenal disinhibition in depression: marker of a subtype with characteristic clinical features and response to treatment?
Topics: Adult; Amitriptyline; Clomipramine; Depressive Disorder; Desipramine; Dexamethasone; Female; Humans; | 1981 |
Acute response of social functioning in dysthymic patients with desipramine.
Topics: Adult; Depressive Disorder; Desipramine; Dose-Response Relationship, Drug; Drug Administration Sched | 1995 |
Treating depression in alcoholics.
Topics: Alcoholism; Antidepressive Agents, Tricyclic; Depressive Disorder; Desipramine; Double-Blind Method; | 1996 |
High dose desipramine, plasma drug levels and clinical response.
Topics: Alanine Transaminase; Alkaline Phosphatase; Aspartate Aminotransferases; Cholestasis; Depression; De | 1979 |
Recurrent depression is associated with a persistent reduction in sleep-related growth hormone secretion.
Topics: Adult; Aged; Ambulatory Care; Biomarkers; Depressive Disorder; Desipramine; Electroencephalography; | 1990 |
Concentration-response relationship in imipramine treatment of diabetic neuropathy symptoms.
Topics: Adult; Desipramine; Diabetic Neuropathies; Dose-Response Relationship, Drug; Female; Humans; Imipram | 1990 |
Relapse to cocaine abuse after initiating desipramine treatment.
Topics: Adult; Bulimia; Cocaine; Depressive Disorder; Desipramine; Female; Humans; Male; Recurrence; Substan | 1988 |
Suicide upon recovery from depression. A clinical note.
Topics: Adult; Bipolar Disorder; Depressive Disorder; Desipramine; Electroconvulsive Therapy; Female; Humans | 1988 |
Breaking the cycle of addiction.
Topics: Behavior Therapy; Cocaine; Desipramine; Humans; Mental Disorders; Psychotherapy; Recurrence; Substan | 1988 |
Tolerance to therapeutic effects of antidepressants.
Topics: Adult; Aged; Amitriptyline; Antidepressive Agents; Chronic Disease; Depressive Disorder; Desipramine | 1985 |