desipramine has been researched along with Osteosarcoma in 2 studies
Desipramine: A tricyclic dibenzazepine compound that potentiates neurotransmission. Desipramine selectively blocks reuptake of norepinephrine from the neural synapse, and also appears to impair serotonin transport. This compound also possesses minor anticholinergic activity, through its affinity to muscarinic receptors.
desipramine : A dibenzoazepine consisting of 10,11-dihydro-5H-dibenzo[b,f]azepine substituted on nitrogen with a 3-(methylamino)propyl group.
Osteosarcoma: A sarcoma originating in bone-forming cells, affecting the ends of long bones. It is the most common and most malignant of sarcomas of the bones, and occurs chiefly among 10- to 25-year-old youths. (From Stedman, 25th ed)
| Excerpt | Relevance | Reference |
|---|---|---|
| "In human osteosarcoma MG63 cells, the effect of desipramine, an antidepressant, on intracellular Ca(2+) concentration ([Ca(2+)](i)) was measured by using fura-2." | 7.72 | Effect of the antidepressant desipramine on cytosolic Ca(2+) movement and proliferation in human osteosarcoma cells. ( Chang, HT; Chen, WC; Huang, JK; Jan, CR; Jiann, BP; Lu, YC; Tseng, LL; Wang, JL, 2003) |
| "In human osteosarcoma MG63 cells, the effect of desipramine, an antidepressant, on intracellular Ca(2+) concentration ([Ca(2+)](i)) was measured by using fura-2." | 3.72 | Effect of the antidepressant desipramine on cytosolic Ca(2+) movement and proliferation in human osteosarcoma cells. ( Chang, HT; Chen, WC; Huang, JK; Jan, CR; Jiann, BP; Lu, YC; Tseng, LL; Wang, JL, 2003) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 2 (100.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Lu, T | 1 |
| Huang, CC | 1 |
| Lu, YC | 2 |
| Lin, KL | 1 |
| Liu, SI | 1 |
| Wang, BW | 1 |
| Chang, PM | 1 |
| Chen, IS | 1 |
| Chen, SS | 1 |
| Tsai, JY | 1 |
| Chou, CT | 1 |
| Jan, CR | 2 |
| Tseng, LL | 1 |
| Jiann, BP | 1 |
| Chang, HT | 1 |
| Wang, JL | 1 |
| Chen, WC | 1 |
| Huang, JK | 1 |
2 other studies available for desipramine and Osteosarcoma
| Article | Year |
|---|---|
Desipramine-induced Ca-independent apoptosis in Mg63 human osteosarcoma cells: dependence on P38 mitogen-activated protein kinase-regulated activation of caspase 3.
Topics: Antidepressive Agents, Tricyclic; Antineoplastic Agents; Apoptosis; Calcium; Caspase 3; Cell Line, T | 2009 |
Effect of the antidepressant desipramine on cytosolic Ca(2+) movement and proliferation in human osteosarcoma cells.
Topics: Antidepressive Agents; Calcium; Calcium Signaling; Desipramine; Enzyme Inhibitors; Enzyme-Linked Imm | 2003 |