desipramine has been researched along with Obsessive-Compulsive Disorder in 39 studies
Desipramine: A tricyclic dibenzazepine compound that potentiates neurotransmission. Desipramine selectively blocks reuptake of norepinephrine from the neural synapse, and also appears to impair serotonin transport. This compound also possesses minor anticholinergic activity, through its affinity to muscarinic receptors.
desipramine : A dibenzoazepine consisting of 10,11-dihydro-5H-dibenzo[b,f]azepine substituted on nitrogen with a 3-(methylamino)propyl group.
Obsessive-Compulsive Disorder: An anxiety disorder characterized by recurrent, persistent obsessions or compulsions. Obsessions are the intrusive ideas, thoughts, or images that are experienced as senseless or repugnant. Compulsions are repetitive and seemingly purposeful behavior which the individual generally recognizes as senseless and from which the individual does not derive pleasure although it may provide a release from tension.
| Excerpt | Relevance | Reference |
|---|---|---|
| "In a double-blind study, desipramine or placebo was added for 6 or 10 weeks to the treatment of 30 patients with obsessive-compulsive disorder whose symptoms were refractory to SSRI treatment (fluvoxamine, fluoxetine, or sertraline) alone." | 9.08 | Addition of desipramine to serotonin reuptake inhibitors in treatment-resistant obsessive-compulsive disorder. ( Anand, A; Barr, LC; Goodman, WK; McDougle, CJ; Price, LH, 1997) |
| "To determine whether clomipramine hydrochloride, a serotonin reuptake blocker with unique anti-obsessional properties, is differentially effective for obsessive-compulsive and stereotyped motor behaviors in autistic disorder compared with placebo and with the noradrenergic tricyclic antidepressant agent, desipramine hydrochloride." | 9.07 | A double-blind comparison of clomipramine, desipramine, and placebo in the treatment of autistic disorder. ( Gordon, CT; Hamburger, SD; Nelson, JE; Rapoport, JL; State, RC, 1993) |
| "Twenty-six children and adolescents with severe primary obsessive-compulsive disorder receiving long-term clomipramine hydrochloride maintenance treatment (mean +/- SD, 17." | 9.07 | A double-blind desipramine substitution during long-term clomipramine treatment in children and adolescents with obsessive-compulsive disorder. ( Cheslow, DL; Hamburger, SD; Lenane, MC; Leonard, HL; Rapoport, JL; Rettew, DC; Swedo, SE, 1991) |
| "To evaluate whether serotonin reuptake inhibition is critical to the treatment of obsessive-compulsive disorder, 40 outpatients with a principal diagnosis of obsessive-compulsive disorder were randomized in a double-blind fashion to 8 weeks of treatment with either the serotonin reuptake inhibitor fluvoxamine maleate (n = 21) or the norepinephrine reuptake inhibitor desipramine hydrochloride (n = 19)." | 9.06 | Specificity of serotonin reuptake inhibitors in the treatment of obsessive-compulsive disorder. Comparison of fluvoxamine and desipramine. ( Charney, DS; Delgado, PL; Goodman, WK; Heninger, GR; Krystal, JH; Nagy, LM; Palumbo, J; Price, LH; Rasmussen, SA, 1990) |
| "Forty-eight children and adolescents with severe primary obsessive-compulsive disorder completed a 10-week double-blind crossover trial of clomipramine hydrochloride (mean dose [+/- SD], 150 +/- 53 mg/d) and desipramine hydrochloride (mean dose [+/- SD], 153 +/- 55 mg/d)." | 9.06 | Treatment of obsessive-compulsive disorder with clomipramine and desipramine in children and adolescents. A double-blind crossover comparison. ( Cheslow, DL; Hamburger, SD; Koby, EV; Lenane, MC; Leonard, HL; Rapoport, JL; Swedo, SE, 1989) |
| "Ten patients with DSM-III-R obsessive-compulsive disorder (OCD) underwent the desipramine (DMI) growth hormone (GH) stimulation test as well as the dexamethasone suppression test (DST)." | 7.68 | The desipramine-induced growth hormone response and the dexamethasone suppression test in obsessive-compulsive disorder. ( Barry, S; Dinan, TG; Lucey, JV; Webb, MG, 1992) |
| "Sertraline was also associated with a significantly greater number of patients who achieved a "robust" improvement in OCD symptoms (> or =40% reduction) compared with desipramine." | 6.69 | Multicenter double-blind comparison of sertraline and desipramine for concurrent obsessive-compulsive and major depressive disorders. ( Black, DW; Chapman, D; Clary, C; Greist, JH; Harrison, W; Hoehn-Saric, R; Lydiard, B; McElroy, S; Ninan, P; Stahl, S; Zajecka, J, 2000) |
| "Treatment with clomipramine resulted in significantly greater improvement in symptoms than desipramine, as indicated by physicians' ratings of the women's clinical progress on a scale in which lower scores indicate improvement (mean [+/- SD] scores: at base line, 10." | 6.66 | A double-blind comparison of clomipramine and desipramine in the treatment of trichotillomania (hair pulling) ( Cheslow, DL; Goldberger, EL; Lenane, MC; Leonard, HL; Rapoport, JL; Swedo, SE, 1989) |
| "In a double-blind study, desipramine or placebo was added for 6 or 10 weeks to the treatment of 30 patients with obsessive-compulsive disorder whose symptoms were refractory to SSRI treatment (fluvoxamine, fluoxetine, or sertraline) alone." | 5.08 | Addition of desipramine to serotonin reuptake inhibitors in treatment-resistant obsessive-compulsive disorder. ( Anand, A; Barr, LC; Goodman, WK; McDougle, CJ; Price, LH, 1997) |
| "To determine whether clomipramine hydrochloride, a serotonin reuptake blocker with unique anti-obsessional properties, is differentially effective for obsessive-compulsive and stereotyped motor behaviors in autistic disorder compared with placebo and with the noradrenergic tricyclic antidepressant agent, desipramine hydrochloride." | 5.07 | A double-blind comparison of clomipramine, desipramine, and placebo in the treatment of autistic disorder. ( Gordon, CT; Hamburger, SD; Nelson, JE; Rapoport, JL; State, RC, 1993) |
| "Twenty-six children and adolescents with severe primary obsessive-compulsive disorder receiving long-term clomipramine hydrochloride maintenance treatment (mean +/- SD, 17." | 5.07 | A double-blind desipramine substitution during long-term clomipramine treatment in children and adolescents with obsessive-compulsive disorder. ( Cheslow, DL; Hamburger, SD; Lenane, MC; Leonard, HL; Rapoport, JL; Rettew, DC; Swedo, SE, 1991) |
| "Twenty-five adult subjects with severe morbid onychophagia (nail biting) and no history of obsessive-compulsive disorder were enrolled in a 10-week double-blind cross-over trial of clomipramine hydrochloride and desipramine hydrochloride." | 5.07 | A double-blind comparison of clomipramine and desipramine treatment of severe onychophagia (nail biting). ( Lenane, MC; Leonard, HL; Rapoport, JL; Rettew, DC; Swedo, SE, 1991) |
| "To evaluate whether serotonin reuptake inhibition is critical to the treatment of obsessive-compulsive disorder, 40 outpatients with a principal diagnosis of obsessive-compulsive disorder were randomized in a double-blind fashion to 8 weeks of treatment with either the serotonin reuptake inhibitor fluvoxamine maleate (n = 21) or the norepinephrine reuptake inhibitor desipramine hydrochloride (n = 19)." | 5.06 | Specificity of serotonin reuptake inhibitors in the treatment of obsessive-compulsive disorder. Comparison of fluvoxamine and desipramine. ( Charney, DS; Delgado, PL; Goodman, WK; Heninger, GR; Krystal, JH; Nagy, LM; Palumbo, J; Price, LH; Rasmussen, SA, 1990) |
| "Forty-eight children and adolescents with severe primary obsessive-compulsive disorder completed a 10-week double-blind crossover trial of clomipramine hydrochloride (mean dose [+/- SD], 150 +/- 53 mg/d) and desipramine hydrochloride (mean dose [+/- SD], 153 +/- 55 mg/d)." | 5.06 | Treatment of obsessive-compulsive disorder with clomipramine and desipramine in children and adolescents. A double-blind crossover comparison. ( Cheslow, DL; Hamburger, SD; Koby, EV; Lenane, MC; Leonard, HL; Rapoport, JL; Swedo, SE, 1989) |
| "Alterations in arginine vasopressin regulation and secretion have been proposed as one possible biochemical abnormality in patients with obsessive-compulsive disorder." | 3.71 | Vasopressin-dependent flank marking in golden hamsters is suppressed by drugs used in the treatment of obsessive-compulsive disorder. ( Ferris, CF; Koppel, G; Messenger, T; Rasmussen, MF, 2001) |
| "Ten patients with DSM-III-R obsessive-compulsive disorder (OCD) underwent the desipramine (DMI) growth hormone (GH) stimulation test as well as the dexamethasone suppression test (DST)." | 3.68 | The desipramine-induced growth hormone response and the dexamethasone suppression test in obsessive-compulsive disorder. ( Barry, S; Dinan, TG; Lucey, JV; Webb, MG, 1992) |
| "Sertraline was also associated with a significantly greater number of patients who achieved a "robust" improvement in OCD symptoms (> or =40% reduction) compared with desipramine." | 2.69 | Multicenter double-blind comparison of sertraline and desipramine for concurrent obsessive-compulsive and major depressive disorders. ( Black, DW; Chapman, D; Clary, C; Greist, JH; Harrison, W; Hoehn-Saric, R; Lydiard, B; McElroy, S; Ninan, P; Stahl, S; Zajecka, J, 2000) |
| "Canine acral lick dermatitis is a naturally occurring disorder in which excessive licking of paws or flank can produce ulcers and infection that require medical treatment." | 2.67 | Drug treatment of canine acral lick. An animal model of obsessive-compulsive disorder. ( Kriete, M; Rapoport, JL; Ryland, DH, 1992) |
| "Trichotillomania is a neglected neuropsychiatric disorder that only recently has received research attention." | 2.67 | Trichotillomania. An obsessive compulsive spectrum disorder? ( Leonard, HL; Swedo, SE, 1992) |
| "Treatment with clomipramine resulted in significantly greater improvement in symptoms than desipramine, as indicated by physicians' ratings of the women's clinical progress on a scale in which lower scores indicate improvement (mean [+/- SD] scores: at base line, 10." | 2.66 | A double-blind comparison of clomipramine and desipramine in the treatment of trichotillomania (hair pulling) ( Cheslow, DL; Goldberger, EL; Lenane, MC; Leonard, HL; Rapoport, JL; Swedo, SE, 1989) |
| "Only for Tourette's Disorder, Trichotillomania and possibly Sydenham's Chorea have there been convincing biological evidence for continuity with OCD." | 2.39 | [The "obsessive-compulsive spectrum": a useful concept?]. ( Rapoport, JL, 1994) |
| "desipramine) treatment (both 10 mg/kg; 20 mg/kg x 21 days)." | 1.35 | Stereotypic behaviour in the deer mouse: pharmacological validation and relevance for obsessive compulsive disorder. ( Harvey, BH; Korff, S; Stein, DJ, 2008) |
| " Chronic administration of the selective serotonin re-uptake inhibitors fluoxetine and clomipramine (CMI) at 5 mg/kg per day and fluvoxamine at 10 mg/kg twice a day significantly decreased schedule-induced polydipsia (SIP) on day 15 and throughout the remainder of the study compared to control rats." | 1.29 | Selective serotonin re-uptake inhibitors decrease schedule-induced polydipsia in rats: a potential model for obsessive compulsive disorder. ( Corbett, R; Cornfeldt, M; Dunn, RW; Smith, C; Szewczak, M; Woods, A, 1993) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 13 (33.33) | 18.7374 |
| 1990's | 16 (41.03) | 18.2507 |
| 2000's | 7 (17.95) | 29.6817 |
| 2010's | 3 (7.69) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Thompson, SL | 2 |
| Welch, AC | 1 |
| Ho, EV | 2 |
| Bessa, JM | 1 |
| Portugal-Nunes, C | 1 |
| Morais, M | 1 |
| Young, JW | 1 |
| Knowles, JA | 2 |
| Dulawa, SC | 3 |
| Katzka, WR | 1 |
| Sharifi, MF | 1 |
| Shanahan, NA | 1 |
| Velez, LP | 1 |
| Masten, VL | 1 |
| Fernández-Guasti, A | 1 |
| Ulloa, RE | 1 |
| Nicolini, H | 1 |
| VOLTERRA, V | 1 |
| GUERMANI, M | 1 |
| SEGERS, J | 1 |
| NUYTS, JA | 1 |
| COLLARD, J | 1 |
| GERNAY, JM | 1 |
| MORMONT, C | 1 |
| Tsaltas, E | 1 |
| Kontis, D | 1 |
| Chrysikakou, S | 1 |
| Giannou, H | 1 |
| Biba, A | 1 |
| Pallidi, S | 1 |
| Christodoulou, A | 1 |
| Maillis, A | 1 |
| Rabavilas, A | 1 |
| Rojas-Corrales, MO | 1 |
| Gibert-Rahola, J | 1 |
| Mico, JA | 1 |
| Korff, S | 1 |
| Stein, DJ | 2 |
| Harvey, BH | 1 |
| Woods, A | 1 |
| Smith, C | 1 |
| Szewczak, M | 1 |
| Dunn, RW | 1 |
| Cornfeldt, M | 1 |
| Corbett, R | 1 |
| Rapoport, JL | 9 |
| Zohar, J | 2 |
| Kaplan, Z | 1 |
| Benjamin, J | 1 |
| Leonard, HL | 6 |
| Swedo, SE | 6 |
| Lenane, MC | 5 |
| McDougle, CJ | 2 |
| Goodman, WK | 3 |
| Price, LH | 3 |
| Sichel, DA | 1 |
| Cohen, LS | 1 |
| Dimmock, JA | 1 |
| Rosenbaum, JF | 1 |
| Gordon, CT | 1 |
| State, RC | 1 |
| Nelson, JE | 1 |
| Hamburger, SD | 3 |
| Bouwer, C | 1 |
| Niehaus, DJ | 1 |
| Barr, LC | 1 |
| Anand, A | 1 |
| Hoehn-Saric, R | 2 |
| Ninan, P | 1 |
| Black, DW | 1 |
| Stahl, S | 1 |
| Greist, JH | 1 |
| Lydiard, B | 1 |
| McElroy, S | 1 |
| Zajecka, J | 1 |
| Chapman, D | 1 |
| Clary, C | 1 |
| Harrison, W | 1 |
| Ferris, CF | 1 |
| Rasmussen, MF | 1 |
| Messenger, T | 1 |
| Koppel, G | 1 |
| Schlaepfer, TE | 1 |
| Greenberg, BD | 1 |
| McLeod, DR | 1 |
| Pearlson, GD | 1 |
| Wong, SH | 1 |
| Lucey, JV | 1 |
| Barry, S | 1 |
| Webb, MG | 1 |
| Dinan, TG | 1 |
| Ryland, DH | 1 |
| Kriete, M | 1 |
| Rettew, DC | 2 |
| Cheslow, DL | 3 |
| Delgado, PL | 1 |
| Palumbo, J | 1 |
| Krystal, JH | 1 |
| Nagy, LM | 1 |
| Rasmussen, SA | 1 |
| Heninger, GR | 1 |
| Charney, DS | 1 |
| DeMaso, DR | 1 |
| Hunter, TA | 1 |
| Insel, TR | 3 |
| Mueller, EA | 2 |
| Alterman, I | 1 |
| Linnoila, M | 1 |
| Murphy, DL | 2 |
| Koby, EV | 1 |
| Goldberger, EL | 1 |
| Esche, I | 1 |
| Joffe, RT | 1 |
| Blank, DW | 1 |
| Leonard, H | 1 |
| Swedo, S | 1 |
| Coffey, M | 1 |
| Cheslow, D | 1 |
| Baer, L | 1 |
| Minichiello, WE | 1 |
| Jenike, MA | 1 |
| Eisenberg, J | 1 |
| Asnis, G | 1 |
| Gillin, JC | 1 |
| Siever, LJ | 1 |
| Rose, JT | 1 |
| Maxwell, C | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Single-Group Crossover Trial Comparing Behavioral Treatment to Memantine in Body Focused Repetitive Behaviors[NCT05796752] | Phase 2/Phase 3 | 28 participants (Anticipated) | Interventional | 2023-06-01 | Not yet recruiting | ||
| A Double-Blind, Placebo Controlled Study of Aripiprazole in Body Focused Repetitive Behaviors[NCT05545891] | Phase 2 | 100 participants (Anticipated) | Interventional | 2023-12-31 | Not yet recruiting | ||
| A Double-Blind, Placebo-Controlled Study of Dronabinol in Trichotillomania and Other Body Focused Repetitive Behaviors[NCT03530800] | Phase 2/Phase 3 | 50 participants (Actual) | Interventional | 2018-10-01 | Completed | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
The entire study lasts 10 weeks. Every two weeks subjects will take the NIMH-TSS. The change in scores from baseline to after 10 weeks will be assessed. The scale itself assesses severity of trichotillomania symptoms. The NIMH-TSS score ranges from 0 to 20, with 0 being no symptoms and 20 being the most severe. (NCT03530800)
Timeframe: Assessed every two weeks up to 10 weeks, baseline data reported
| Intervention | score on a scale (Mean) |
|---|---|
| Dronabinol | 12.38 |
| Placebo | 10.63 |
The entire study lasts 10 weeks. Every two weeks subjects will take the SP-SAS. The change in scores from baseline to after 10 weeks will be assessed. The scale itself assesses severity of skin-picking symptoms. The SP-SAS score ranges from 0 to 48, with 0 being no symptoms and 48 being the most severe. (NCT03530800)
Timeframe: Assessed every two weeks up to 10 weeks, baseline reported
| Intervention | score on a scale (Mean) |
|---|---|
| Dronabinol | 24.44 |
| Placebo | 28.5 |
3 reviews available for desipramine and Obsessive-Compulsive Disorder
| Article | Year |
|---|---|
[The "obsessive-compulsive spectrum": a useful concept?].
Topics: Adolescent; Adult; Clinical Trials as Topic; Clomipramine; Desipramine; Female; Humans; Male; Neuroc | 1994 |
Obsessive compulsive disorder in children and adolescents: issues in management.
Topics: Adolescent; Age Factors; Behavior Therapy; Child; Child, Preschool; Clomipramine; Comorbidity; Couns | 1993 |
The pharmacotherapy of obsessive-compulsive disorder.
Topics: 1-Naphthylamine; Buspirone; Clomipramine; Desipramine; Fluoxetine; Fluvoxamine; Humans; Obsessive-Co | 1993 |
15 trials available for desipramine and Obsessive-Compulsive Disorder
| Article | Year |
|---|---|
A double-blind comparison of clomipramine, desipramine, and placebo in the treatment of autistic disorder.
Topics: Adolescent; Adult; Ambulatory Care; Autistic Disorder; Child; Clomipramine; Desipramine; Double-Blin | 1993 |
Addition of desipramine to serotonin reuptake inhibitors in treatment-resistant obsessive-compulsive disorder.
Topics: 1-Naphthylamine; Adrenergic Uptake Inhibitors; Adult; Clomipramine; Desipramine; Double-Blind Method | 1997 |
Multicenter double-blind comparison of sertraline and desipramine for concurrent obsessive-compulsive and major depressive disorders.
Topics: Adrenergic Uptake Inhibitors; Adult; Antidepressive Agents, Tricyclic; Comorbidity; Depressive Disor | 2000 |
Cerebral blood flow in obsessive-compulsive patients with major depression: effect of treatment with sertraline or desipramine on treatment responders and non-responders.
Topics: Adult; Aged; Blood Flow Velocity; Cerebral Cortex; Depressive Disorder, Major; Desipramine; Dominanc | 2001 |
Drug treatment of canine acral lick. An animal model of obsessive-compulsive disorder.
Topics: 1-Naphthylamine; Animals; Clomipramine; Dermatitis; Desipramine; Disease Models, Animal; Dog Disease | 1992 |
Trichotillomania. An obsessive compulsive spectrum disorder?
Topics: Adolescent; Adult; Child; Child, Preschool; Clomipramine; Combined Modality Therapy; Desipramine; Do | 1992 |
A double-blind desipramine substitution during long-term clomipramine treatment in children and adolescents with obsessive-compulsive disorder.
Topics: Adolescent; Age Factors; Child; Clomipramine; Desipramine; Double-Blind Method; Drug Administration | 1991 |
A double-blind comparison of clomipramine and desipramine treatment of severe onychophagia (nail biting).
Topics: Adult; Ambulatory Care; Clomipramine; Desipramine; Dose-Response Relationship, Drug; Double-Blind Me | 1991 |
Specificity of serotonin reuptake inhibitors in the treatment of obsessive-compulsive disorder. Comparison of fluvoxamine and desipramine.
Topics: Adult; Anxiety Disorders; Basal Ganglia; Depressive Disorder; Desipramine; Dopamine; Double-Blind Me | 1990 |
Obsessive-compulsive disorder and serotonin: is there a connection?
Topics: Adult; Blood Platelets; Central Nervous System; Clinical Trials as Topic; Desipramine; Female; Human | 1985 |
Treatment of obsessive-compulsive disorder with clomipramine and desipramine in children and adolescents. A double-blind crossover comparison.
Topics: Adolescent; Adult; Age Factors; Child; Clinical Trials as Topic; Clomipramine; Desipramine; Double-B | 1989 |
A double-blind comparison of clomipramine and desipramine in the treatment of trichotillomania (hair pulling)
Topics: Adolescent; Adult; Clomipramine; Desipramine; Double-Blind Method; Female; Humans; Obsessive-Compuls | 1989 |
A double-blind comparison of clomipramine and desipramine in the treatment of trichotillomania (hair pulling)
Topics: Adolescent; Adult; Clomipramine; Desipramine; Double-Blind Method; Female; Humans; Obsessive-Compuls | 1989 |
A double-blind comparison of clomipramine and desipramine in the treatment of trichotillomania (hair pulling)
Topics: Adolescent; Adult; Clomipramine; Desipramine; Double-Blind Method; Female; Humans; Obsessive-Compuls | 1989 |
A double-blind comparison of clomipramine and desipramine in the treatment of trichotillomania (hair pulling)
Topics: Adolescent; Adult; Clomipramine; Desipramine; Double-Blind Method; Female; Humans; Obsessive-Compuls | 1989 |
A double-blind comparison of clomipramine and desipramine in the treatment of trichotillomania (hair pulling)
Topics: Adolescent; Adult; Clomipramine; Desipramine; Double-Blind Method; Female; Humans; Obsessive-Compuls | 1989 |
A double-blind comparison of clomipramine and desipramine in the treatment of trichotillomania (hair pulling)
Topics: Adolescent; Adult; Clomipramine; Desipramine; Double-Blind Method; Female; Humans; Obsessive-Compuls | 1989 |
A double-blind comparison of clomipramine and desipramine in the treatment of trichotillomania (hair pulling)
Topics: Adolescent; Adult; Clomipramine; Desipramine; Double-Blind Method; Female; Humans; Obsessive-Compuls | 1989 |
A double-blind comparison of clomipramine and desipramine in the treatment of trichotillomania (hair pulling)
Topics: Adolescent; Adult; Clomipramine; Desipramine; Double-Blind Method; Female; Humans; Obsessive-Compuls | 1989 |
A double-blind comparison of clomipramine and desipramine in the treatment of trichotillomania (hair pulling)
Topics: Adolescent; Adult; Clomipramine; Desipramine; Double-Blind Method; Female; Humans; Obsessive-Compuls | 1989 |
Obsessive-compulsive disorder: psychobiological approaches to diagnosis, treatment, and pathophysiology.
Topics: Adult; Brain; Clomipramine; Depressive Disorder; Desipramine; Diagnosis, Differential; Female; Human | 1987 |
Treatment of childhood obsessive compulsive disorder with clomipramine and desmethylimipramine: a double-blind crossover comparison.
Topics: Adolescent; Adult; Child; Clinical Trials as Topic; Clomipramine; Desipramine; Double-Blind Method; | 1988 |
Depression: prognosis and drug treatment.
Topics: Adolescent; Adult; Age Factors; Aged; Clinical Trials as Topic; Depression; Desipramine; Female; Hum | 1969 |
21 other studies available for desipramine and Obsessive-Compulsive Disorder
| Article | Year |
|---|---|
Btbd3 expression regulates compulsive-like and exploratory behaviors in mice.
Topics: Animals; Antidepressive Agents; Behavior, Animal; Brain; Compulsive Behavior; Desipramine; Disease M | 2019 |
Clinically effective OCD treatment prevents 5-HT1B receptor-induced repetitive behavior and striatal activation.
Topics: Animals; Corpus Striatum; Desipramine; Exploratory Behavior; Female; Fluoxetine; Indoles; Mice; Mice | 2016 |
Essential role for orbitofrontal serotonin 1B receptors in obsessive-compulsive disorder-like behavior and serotonin reuptake inhibitor response in mice.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Acoustic Stimulation; Adrenergic beta-Antagonists; Adrenergi | 2011 |
Age differences in the sensitivity to clomipramine in an animal model of obsessive-compulsive disorder.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Aging; Animals; Antidepressive Agents, Tricyclic; Clomiprami | 2003 |
[PRELIMINARY OBSERVATIONS ON THE CLINICAL USE OF A METABOLITE OF IMIPRAMINE: DESMETHYLIMIPRAMINE (G 35020)].
Topics: Antidepressive Agents; Depression; Depressive Disorder; Desipramine; Humans; Imipramine; Mental Diso | 1963 |
[ACTION OF DESMETHYL-IMIPRAMINE (PERTOFRAN) IN DEPRESSIVE SYNDROMES].
Topics: Antidepressive Agents; Bipolar Disorder; Depressive Disorder; Desipramine; Humans; Imipramine; Neuro | 1964 |
[A CASE OF AUTOFELLATIO: PHENOMENOLOGICALLY-ORIENTATED PSYCHOTHERAPY WITH PERTOFRAN TREATMENT].
Topics: Desipramine; Drug Therapy; Humans; Masturbation; Neurotic Disorders; Obsessive-Compulsive Disorder; | 1964 |
Reinforced spatial alternation as an animal model of obsessive-compulsive disorder (OCD): investigation of 5-HT2C and 5-HT1D receptor involvement in OCD pathophysiology.
Topics: Animals; Anti-Anxiety Agents; Antidepressive Agents, Tricyclic; Desipramine; Diazepam; Disease Model | 2005 |
Role of atypical opiates in OCD. Experimental approach through the study of 5-HT(2A/C) receptor-mediated behavior.
Topics: 5-Hydroxytryptophan; Analgesics, Opioid; Animals; Clozapine; Desipramine; Disease Models, Animal; Do | 2007 |
Stereotypic behaviour in the deer mouse: pharmacological validation and relevance for obsessive compulsive disorder.
Topics: Animals; Antidepressive Agents, Tricyclic; Behavior, Animal; Desipramine; Disease Models, Animal; Do | 2008 |
Selective serotonin re-uptake inhibitors decrease schedule-induced polydipsia in rats: a potential model for obsessive compulsive disorder.
Topics: Animals; Clomipramine; Conditioning, Operant; Desipramine; Diazepam; Disease Models, Animal; Drinkin | 1993 |
Compulsive exhibitionism successfully treated with fluvoxamine: a controlled case study.
Topics: Adult; Desipramine; Exhibitionism; Fluvoxamine; Humans; Male; Masturbation; Obsessive-Compulsive Dis | 1994 |
Postpartum obsessive compulsive disorder: a case series.
Topics: Adult; Clomipramine; Desipramine; Diagnosis, Differential; Female; Fluoxetine; Follow-Up Studies; Hu | 1993 |
Stereotypic movement disorder.
Topics: Adult; Antipsychotic Agents; Clomipramine; Desipramine; Drug Therapy, Combination; Female; Humans; M | 1997 |
Vasopressin-dependent flank marking in golden hamsters is suppressed by drugs used in the treatment of obsessive-compulsive disorder.
Topics: Adrenergic Uptake Inhibitors; Aggression; Animals; Arginine Vasopressin; Behavior, Animal; Clomipram | 2001 |
The desipramine-induced growth hormone response and the dexamethasone suppression test in obsessive-compulsive disorder.
Topics: Adult; Aged; Desipramine; Dexamethasone; Female; Growth Hormone; Humans; Male; Middle Aged; Obsessiv | 1992 |
Combining fluoxetine with desipramine.
Topics: Adolescent; Desipramine; Drug Interactions; Female; Fluoxetine; Humans; Obsessive-Compulsive Disorde | 1990 |
Erythrocyte electrolytes in psychiatric illness.
Topics: Adult; Bipolar Disorder; Depressive Disorder; Desipramine; Erythrocytes; Female; Humans; Male; Menta | 1988 |
Behavioral treatment in two cases of obsessive-compulsive disorder with concomitant bipolar affective disorder.
Topics: Adult; Behavior Therapy; Bipolar Disorder; Desipramine; Female; Haloperidol; Humans; Lithium; Male; | 1985 |
Lithium as an adjunct treatment in obsessive-compulsive disorder.
Topics: Adult; Depression; Desipramine; Drug Therapy, Combination; Humans; Lithium; Male; Obsessive-Compulsi | 1985 |
Tricyclic response in obsessive compulsive disorder.
Topics: Adolescent; Adult; Clomipramine; Clorgyline; Desipramine; Dexamethasone; Double-Blind Method; Electr | 1985 |