desipramine has been researched along with Niemann-Pick Diseases in 4 studies
Desipramine: A tricyclic dibenzazepine compound that potentiates neurotransmission. Desipramine selectively blocks reuptake of norepinephrine from the neural synapse, and also appears to impair serotonin transport. This compound also possesses minor anticholinergic activity, through its affinity to muscarinic receptors.
desipramine : A dibenzoazepine consisting of 10,11-dihydro-5H-dibenzo[b,f]azepine substituted on nitrogen with a 3-(methylamino)propyl group.
Niemann-Pick Diseases: A group of autosomal recessive disorders in which harmful quantities of lipids accumulate in the viscera and the central nervous system. They can be caused by deficiencies of enzyme activities (SPHINGOMYELIN PHOSPHODIESTERASE) or defects in intracellular transport, resulting in the accumulation of SPHINGOMYELINS and CHOLESTEROL. There are various subtypes based on their clinical and genetic differences.
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (25.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 1 (25.00) | 29.6817 |
| 2010's | 2 (50.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Perry, DM | 1 |
| Newcomb, B | 1 |
| Adada, M | 1 |
| Wu, BX | 1 |
| Roddy, P | 1 |
| Kitatani, K | 1 |
| Siskind, L | 1 |
| Obeid, LM | 1 |
| Hannun, YA | 1 |
| Tam, C | 1 |
| Idone, V | 1 |
| Devlin, C | 1 |
| Fernandes, MC | 1 |
| Flannery, A | 1 |
| He, X | 1 |
| Schuchman, E | 1 |
| Tabas, I | 1 |
| Andrews, NW | 1 |
| Arena, S | 1 |
| Pattarozzi, A | 1 |
| Thellung, S | 1 |
| Villa, V | 1 |
| Corsaro, A | 1 |
| Massa, A | 1 |
| Diana, F | 1 |
| Spoto, G | 1 |
| Forcella, S | 1 |
| Damonte, G | 1 |
| Filocamo, M | 1 |
| Benatti, U | 1 |
| Schettini, G | 1 |
| Florioa, T | 1 |
| Albouz, S | 1 |
| Le Saux, F | 1 |
| Wenger, D | 1 |
| Hauw, JJ | 1 |
| Baumann, N | 1 |
4 other studies available for desipramine and Niemann-Pick Diseases
| Article | Year |
|---|---|
Defining a role for acid sphingomyelinase in the p38/interleukin-6 pathway.
Topics: Cell Line, Tumor; Cells, Cultured; Desipramine; Enzyme Inhibitors; Gene Knockdown Techniques; HeLa C | 2014 |
Exocytosis of acid sphingomyelinase by wounded cells promotes endocytosis and plasma membrane repair.
Topics: Animals; Cell Line; Cell Membrane; Ceramides; Desipramine; Endocytosis; Endosomes; Enzyme Inhibitors | 2010 |
Nitric oxide production stimulated by the basic fibroblast growth factor requires the synthesis of ceramide.
Topics: Animals; Bridged-Ring Compounds; Cells, Cultured; Ceramides; CHO Cells; Cricetinae; Cyclic GMP; Desi | 2002 |
Modifications of sphingomyelin and phosphatidylcholine metabolism by tricyclic antidepressants and phenothiazines.
Topics: Animals; Antidepressive Agents, Tricyclic; Cell Line; Chlorpromazine; Desipramine; Dose-Response Rel | 1986 |