desipramine has been researched along with Neuroleptic Malignant Syndrome in 2 studies
Desipramine: A tricyclic dibenzazepine compound that potentiates neurotransmission. Desipramine selectively blocks reuptake of norepinephrine from the neural synapse, and also appears to impair serotonin transport. This compound also possesses minor anticholinergic activity, through its affinity to muscarinic receptors.
desipramine : A dibenzoazepine consisting of 10,11-dihydro-5H-dibenzo[b,f]azepine substituted on nitrogen with a 3-(methylamino)propyl group.
Neuroleptic Malignant Syndrome: A potentially fatal syndrome associated primarily with the use of neuroleptic agents (see ANTIPSYCHOTIC AGENTS) which are in turn associated with dopaminergic receptor blockade (see RECEPTORS, DOPAMINE) in the BASAL GANGLIA and HYPOTHALAMUS, and sympathetic dysregulation. Clinical features include diffuse MUSCLE RIGIDITY; TREMOR; high FEVER; diaphoresis; labile blood pressure; cognitive dysfunction; and autonomic disturbances. Serum CPK level elevation and a leukocytosis may also be present. (From Adams et al., Principles of Neurology, 6th ed, p1199; Psychiatr Serv 1998 Sep;49(9):1163-72)
| Excerpt | Relevance | Reference |
|---|---|---|
| "We report the lst case of neuroleptic malignant syndrome occurring in a patient receiving desipramine, a tricyclic antidepressant, with no exposure to neuroleptics." | 3.68 | Neuroleptic malignant syndrome: a unique association with a tricyclic antidepressant. ( Baca, L; Martinelli, L, 1990) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 2 (100.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Squires, LA | 1 |
| Neumeyer, AM | 1 |
| Bloomberg, J | 1 |
| Krishnamoorthy, KS | 1 |
| Baca, L | 1 |
| Martinelli, L | 1 |
2 other studies available for desipramine and Neuroleptic Malignant Syndrome
| Article | Year |
|---|---|
Hyperpyrexia in an adolescent on desipramine treatment.
Topics: Adolescent; Alanine Transaminase; Aspartate Aminotransferases; Creatine Kinase; Creatinine; Depressi | 1992 |
Neuroleptic malignant syndrome: a unique association with a tricyclic antidepressant.
Topics: Bromocriptine; Dantrolene; Desipramine; Dopamine; Drug Therapy, Combination; Female; Humans; Middle | 1990 |