desipramine has been researched along with Neuroblastoma in 25 studies
Desipramine: A tricyclic dibenzazepine compound that potentiates neurotransmission. Desipramine selectively blocks reuptake of norepinephrine from the neural synapse, and also appears to impair serotonin transport. This compound also possesses minor anticholinergic activity, through its affinity to muscarinic receptors.
desipramine : A dibenzoazepine consisting of 10,11-dihydro-5H-dibenzo[b,f]azepine substituted on nitrogen with a 3-(methylamino)propyl group.
Neuroblastoma: A common neoplasm of early childhood arising from neural crest cells in the sympathetic nervous system, and characterized by diverse clinical behavior, ranging from spontaneous remission to rapid metastatic progression and death. This tumor is the most common intraabdominal malignancy of childhood, but it may also arise from thorax, neck, or rarely occur in the central nervous system. Histologic features include uniform round cells with hyperchromatic nuclei arranged in nests and separated by fibrovascular septa. Neuroblastomas may be associated with the opsoclonus-myoclonus syndrome. (From DeVita et al., Cancer: Principles and Practice of Oncology, 5th ed, pp2099-2101; Curr Opin Oncol 1998 Jan;10(1):43-51)
| Excerpt | Relevance | Reference |
|---|---|---|
| "Neuroprotective effects of melatonin against oxidative stress-induced neuronal cell degeneration in human SH-SY5Y neuroblastoma cells were investigated in this report." | 7.75 | Protection against cell death and sustained tyrosine hydroxylase phosphorylation in hydrogen peroxide- and MPP-treated human neuroblastoma cells with melatonin. ( Chetsawang, B; Chetsawang, J; Govitrapong, P, 2009) |
| "Several studies demonstrated that methamphetamine (MA)-treated human neuroblastoma cells exhibit increased oxidative stress, which regulates intracellular signaling cascades leading to cell death." | 7.75 | Melatonin reduces induction of Bax, caspase and cell death in methamphetamine-treated human neuroblastoma SH-SY5Y cultured cells. ( Chetsawang, B; Govitrapong, P; Phansuwan-Pujito, P; Wisessmith, W, 2009) |
| " We examined effects of the selective norepinephrine-transporter (NET) inhibitor antidepressant desipramine (DMI) on expression of TH in human neuroblastoma cells (SK-N-BE[2]M17) and in rat brain regions." | 7.73 | Effects of desipramine treatment on tyrosine hydroxylase gene expression in cultured neuroblastoma cells and rat brain tissue. ( Baldessarini, RJ; Kim, KS; Wang, WP; Zhu, MY, 2005) |
| "SH-SY5Y and HTLA230 neuroblastoma cells were treated with fenretinide in the presence or absence of inhibitors of enzymes important in ceramide metabolism (fumonisin B1, inhibitor of ceramide synthase; desipramine, inhibitor of acidic and neutral sphingomyelinases; and PDMP, inhibitor of glucosylceramide)." | 7.72 | Gangliosides link the acidic sphingomyelinase-mediated induction of ceramide to 12-lipoxygenase-dependent apoptosis of neuroblastoma in response to fenretinide. ( Corazzari, M; Di Sano, F; Donnorso, RP; Fazi, B; Hall, AG; Lovat, PE; Pearson, AD; Piacentini, M; Redfern, CP, 2004) |
| "Incubation for 48 hours of C6 glioma cell cultures with 10(-4)M tricyclic antidepressant desipramine gave rise to a quantitative increase of total lipids and to qualitative modifications of glycosphinegolipids involving detection by thin-layer chromatography of spots migrating according to cerebroside and sulfatide and presence of an abnormal ganglioside pattern." | 7.66 | Tricyclic antidepressant desipramine induces stereospecific opiate binding and lipid modifications in rat glioma C6 cells. ( Albouz, S; Baumann, N; Bourdon, R; Boutry, JM; Hauw, JJ; Le Saux, F; Tocqué, B, 1982) |
| " In the present study, we show that the glucocorticoid receptor (GR) agonist dexamethasone (DEX) increased MAPK/ERK1/2 signaling in the presence of the noradrenergic antidepressant, desipramine (DMI), while no such effect was induced by DEX or DMI alone in human neuroblastoma SH-SY5Y cells." | 3.80 | Dexamethasone in the presence of desipramine enhances MAPK/ERK1/2 signaling possibly via its interference with β-arrestin. ( Ben-Shachar, D; Karry, R; Klein, E; Lucki, A, 2014) |
| " Also inhibited peroxynitrite-mediated tyrosine nitration of alpha-synuclein in vitro and protected human neuroblastoma (SH-SY5Y) cells against SIN-1 and 6-OHDA toxicity when micromolar concentrations were used." | 3.78 | Microwave-assisted synthesis of hydroxyphenyl nitrones with protective action against oxidative stress. ( Alonso-Gil, S; Chavarría, C; Gil, C; Morales Garcia, JA; Pérez, C; Perez, DI; Pérez-Castillo, A; Porcal, W; Souza, JM, 2012) |
| "Neuroprotective effects of melatonin against oxidative stress-induced neuronal cell degeneration in human SH-SY5Y neuroblastoma cells were investigated in this report." | 3.75 | Protection against cell death and sustained tyrosine hydroxylase phosphorylation in hydrogen peroxide- and MPP-treated human neuroblastoma cells with melatonin. ( Chetsawang, B; Chetsawang, J; Govitrapong, P, 2009) |
| "Several studies demonstrated that methamphetamine (MA)-treated human neuroblastoma cells exhibit increased oxidative stress, which regulates intracellular signaling cascades leading to cell death." | 3.75 | Melatonin reduces induction of Bax, caspase and cell death in methamphetamine-treated human neuroblastoma SH-SY5Y cultured cells. ( Chetsawang, B; Govitrapong, P; Phansuwan-Pujito, P; Wisessmith, W, 2009) |
| "SH-SY5Y and HTLA230 neuroblastoma cells were treated with fenretinide in the presence or absence of inhibitors of enzymes important in ceramide metabolism (fumonisin B1, inhibitor of ceramide synthase; desipramine, inhibitor of acidic and neutral sphingomyelinases; and PDMP, inhibitor of glucosylceramide)." | 3.72 | Gangliosides link the acidic sphingomyelinase-mediated induction of ceramide to 12-lipoxygenase-dependent apoptosis of neuroblastoma in response to fenretinide. ( Corazzari, M; Di Sano, F; Donnorso, RP; Fazi, B; Hall, AG; Lovat, PE; Pearson, AD; Piacentini, M; Redfern, CP, 2004) |
| "Human neuroblastoma cells of sympathetic origin have been used for studying the effects of diosmin and its metabolite diosmetin (vasotonic agent) on amine reuptake systems." | 3.68 | Amine uptake inhibition by diosmin and diosmetin in human neuronal and neuroendocrine cell lines. ( Biancardi, E; Clementi, F; Codignola, A; Cova, D; Sher, E, 1992) |
| "NCB-20 cells (neuroblastoma X fetal Chinese hamster brain hybrids) are equipped with a [3H]5-hydroxytryptamine [( 3H]5-HT) uptake system and [3H]imipramine recognition sites." | 3.67 | 5-Hydroxytryptamine uptake and imipramine binding sites in neurotumor NCB-20 cells. ( Chuang, DM; Costa, E; Nakaki, T; Roth, BL, 1985) |
| "Tricyclic antidepressants (imipramine and desipramine) gave rise to an important decrease of sphingomyelinase activity in murine neuroblastoma and human fibroblast cell cultures." | 3.66 | Tricyclic antidepressants induce sphingomyelinase deficiency in fibroblast and neuroblastoma cell cultures. ( Albouz, S; Baumann, N; Berwald-Netter, Y; Bourdon, R; Boutry, JM; Hauw, JJ, 1981) |
| "Incubation for 48 hours of C6 glioma cell cultures with 10(-4)M tricyclic antidepressant desipramine gave rise to a quantitative increase of total lipids and to qualitative modifications of glycosphinegolipids involving detection by thin-layer chromatography of spots migrating according to cerebroside and sulfatide and presence of an abnormal ganglioside pattern." | 3.66 | Tricyclic antidepressant desipramine induces stereospecific opiate binding and lipid modifications in rat glioma C6 cells. ( Albouz, S; Baumann, N; Bourdon, R; Boutry, JM; Hauw, JJ; Le Saux, F; Tocqué, B, 1982) |
| "Successful imaging or treatment of neuroblastoma with 131I-meta-iodobenzylguanidine (131I-mIBG) depends on the selectivity of active (type 1) uptake of mIBG in neuroblastoma cells relative to passive (type 2) uptake present in most normal tissues." | 1.29 | Modification of meta-iodobenzylguanidine uptake in neuroblastoma cells by elevated temperature. ( Armour, A; Gaze, MN; Mairs, RJ; Wheldon, TE, 1994) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 5 (20.00) | 18.7374 |
| 1990's | 8 (32.00) | 18.2507 |
| 2000's | 8 (32.00) | 29.6817 |
| 2010's | 4 (16.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Chavarría, C | 1 |
| Perez, DI | 1 |
| Pérez, C | 1 |
| Morales Garcia, JA | 1 |
| Alonso-Gil, S | 1 |
| Pérez-Castillo, A | 1 |
| Gil, C | 1 |
| Souza, JM | 1 |
| Porcal, W | 1 |
| Lucki, A | 2 |
| Klein, E | 2 |
| Karry, R | 1 |
| Ben-Shachar, D | 2 |
| Chetsawang, B | 2 |
| Chetsawang, J | 1 |
| Govitrapong, P | 2 |
| Donnici, L | 1 |
| Tiraboschi, E | 1 |
| Tardito, D | 1 |
| Musazzi, L | 1 |
| Racagni, G | 1 |
| Popoli, M | 1 |
| Bayer, M | 1 |
| Kuçi, Z | 1 |
| Schömig, E | 1 |
| Gründemann, D | 1 |
| Dittmann, H | 1 |
| Handgretinger, R | 1 |
| Bruchelt, G | 1 |
| Wisessmith, W | 1 |
| Phansuwan-Pujito, P | 1 |
| Nothdurfter, C | 1 |
| Tanasic, S | 1 |
| Di Benedetto, B | 1 |
| Rammes, G | 1 |
| Wagner, EM | 1 |
| Kirmeier, T | 1 |
| Ganal, V | 1 |
| Kessler, JS | 1 |
| Rein, T | 1 |
| Holsboer, F | 1 |
| Rupprecht, R | 1 |
| Yaniv, SP | 1 |
| Lovat, PE | 1 |
| Di Sano, F | 1 |
| Corazzari, M | 1 |
| Fazi, B | 1 |
| Donnorso, RP | 1 |
| Pearson, AD | 1 |
| Hall, AG | 1 |
| Redfern, CP | 1 |
| Piacentini, M | 1 |
| Zhu, MY | 2 |
| Wang, WP | 1 |
| Baldessarini, RJ | 2 |
| Kim, KS | 2 |
| Saito, M | 2 |
| Cooper, TB | 1 |
| Vadasz, C | 1 |
| Albouz, S | 2 |
| Hauw, JJ | 2 |
| Berwald-Netter, Y | 1 |
| Boutry, JM | 2 |
| Bourdon, R | 2 |
| Baumann, N | 2 |
| Tocqué, B | 1 |
| Le Saux, F | 1 |
| Rana, B | 1 |
| McMorn, SO | 1 |
| Reeve, HL | 1 |
| Wyatt, CN | 1 |
| Vaughan, PF | 1 |
| Peers, C | 1 |
| Armour, A | 1 |
| Mairs, RJ | 2 |
| Gaze, MN | 2 |
| Wheldon, TE | 1 |
| Barden, N | 2 |
| Zavosh, A | 1 |
| Schaefer, J | 1 |
| Ferrel, A | 1 |
| Figlewicz, DP | 1 |
| Kim, CH | 1 |
| Hwang, DY | 1 |
| Richelson, E | 1 |
| Zwiller, J | 1 |
| Treska-Ciesielski, J | 1 |
| Mack, G | 1 |
| Mandel, P | 1 |
| Sher, E | 1 |
| Codignola, A | 1 |
| Biancardi, E | 1 |
| Cova, D | 1 |
| Clementi, F | 1 |
| Pepin, MC | 1 |
| Govindan, MV | 1 |
| Barrett, A | 1 |
| Lashford, LS | 1 |
| Hancock, JP | 1 |
| Kemshead, JT | 1 |
| Nakaki, T | 1 |
| Roth, BL | 1 |
| Chuang, DM | 1 |
| Costa, E | 1 |
25 other studies available for desipramine and Neuroblastoma
| Article | Year |
|---|---|
Microwave-assisted synthesis of hydroxyphenyl nitrones with protective action against oxidative stress.
Topics: Anti-Inflammatory Agents; Antioxidants; Blood-Brain Barrier; Cell Survival; Dose-Response Relationsh | 2012 |
Dexamethasone in the presence of desipramine enhances MAPK/ERK1/2 signaling possibly via its interference with β-arrestin.
Topics: Adrenergic alpha-2 Receptor Antagonists; Antidepressive Agents, Tricyclic; Antineoplastic Agents, Ho | 2014 |
Protection against cell death and sustained tyrosine hydroxylase phosphorylation in hydrogen peroxide- and MPP-treated human neuroblastoma cells with melatonin.
Topics: 1-Methyl-4-phenylpyridinium; Analysis of Variance; Blotting, Western; Cell Death; Cell Line, Tumor; | 2009 |
Time-dependent biphasic modulation of human BDNF by antidepressants in neuroblastoma cells.
Topics: Antidepressive Agents; Antidepressive Agents, Second-Generation; Brain-Derived Neurotrophic Factor; | 2008 |
Uptake of mIBG and catecholamines in noradrenaline- and organic cation transporter-expressing cells: potential use of corticosterone for a preferred uptake in neuroblastoma- and pheochromocytoma cells.
Topics: 3-Iodobenzylguanidine; Animals; Biological Transport; Catecholamines; Cell Line, Tumor; Corticostero | 2009 |
Melatonin reduces induction of Bax, caspase and cell death in methamphetamine-treated human neuroblastoma SH-SY5Y cultured cells.
Topics: bcl-2-Associated X Protein; Caspase 3; Cell Count; Cell Death; Cell Line, Tumor; Cell Survival; Desi | 2009 |
Impact of lipid raft integrity on 5-HT3 receptor function and its modulation by antidepressants.
Topics: Animals; Anticholesteremic Agents; Antidepressive Agents; beta-Cyclodextrins; Biophysics; Cholestero | 2010 |
Dexamethasone enhances the norepinephrine-induced ERK/MAPK intracellular pathway possibly via dysregulation of the alpha2-adrenergic receptor: implications for antidepressant drug mechanism of action.
Topics: Antidepressive Agents; Butadienes; Cell Line, Tumor; Cyclic AMP Response Element-Binding Protein; De | 2010 |
Gangliosides link the acidic sphingomyelinase-mediated induction of ceramide to 12-lipoxygenase-dependent apoptosis of neuroblastoma in response to fenretinide.
Topics: Antineoplastic Agents; Apoptosis; Arachidonate 12-Lipoxygenase; Cell Line, Tumor; Ceramides; Desipra | 2004 |
Effects of desipramine treatment on tyrosine hydroxylase gene expression in cultured neuroblastoma cells and rat brain tissue.
Topics: Adrenergic Uptake Inhibitors; Analysis of Variance; Animals; Blotting, Northern; Blotting, Western; | 2005 |
Ethanol-induced changes in the content of triglycerides, ceramides, and glucosylceramides in cultured neurons.
Topics: Animals; Apoptosis; Cell Line, Tumor; Cells, Cultured; Ceramides; Cerebellum; Desipramine; Enzyme In | 2005 |
Tricyclic antidepressants induce sphingomyelinase deficiency in fibroblast and neuroblastoma cell cultures.
Topics: Animals; Cells, Cultured; Desipramine; Fibroblasts; Humans; Imipramine; Mice; Neuroblastoma; Phospho | 1981 |
Tricyclic antidepressant desipramine induces stereospecific opiate binding and lipid modifications in rat glioma C6 cells.
Topics: Animals; Cell Transformation, Neoplastic; Desipramine; Dihydromorphine; Glioma; Lipid Metabolism; Ne | 1982 |
Inhibition of neuronal nicotinic acetylcholine receptors by imipramine and desipramine.
Topics: Desipramine; Dimethylphenylpiperazinium Iodide; Electrophysiology; Humans; Imipramine; Ion Channels; | 1993 |
Modification of meta-iodobenzylguanidine uptake in neuroblastoma cells by elevated temperature.
Topics: 3-Iodobenzylguanidine; Antineoplastic Agents; Desipramine; Female; Hot Temperature; Humans; Iodine R | 1994 |
Modulation of glucocorticoid receptor gene expression by antidepressant drugs.
Topics: Adrenal Cortex Hormones; Amitriptyline; Animals; Anti-Inflammatory Agents; Antidepressive Agents, Tr | 1996 |
Desipramine treatment decreases 3H-nisoxetine binding and norepinephrine transporter mRNA in SK-N-SHSY5Y cells.
Topics: Adrenergic Uptake Inhibitors; Carrier Proteins; Desipramine; Fluoxetine; Humans; Neuroblastoma; Nore | 1999 |
Effects of desipramine treatment on norepinephrine transporter gene expression in the cultured SK-N-BE(2)M17 cells and rat brain tissue.
Topics: Animals; Antidepressive Agents; Brain; Desipramine; Enzyme Inhibitors; Gene Expression; Humans; Locu | 2002 |
Tricyclic antidepressants and histamine H1 receptors.
Topics: Amitriptyline; Animals; Antidepressive Agents, Tricyclic; Atropine; Benztropine; Cells, Cultured; Cl | 1979 |
Uptake of noradrenaline by an adrenergic clone of neuroblastoma cells.
Topics: Amphetamine; Clone Cells; Desipramine; Imipramine; Kinetics; Neuroblastoma; Norepinephrine; Ouabain | 1975 |
Amine uptake inhibition by diosmin and diosmetin in human neuronal and neuroendocrine cell lines.
Topics: Biogenic Monoamines; Carcinoma, Small Cell; Cell Line; Cell Membrane; Desipramine; Diosmin; Dopamine | 1992 |
Increased glucocorticoid receptor gene promoter activity after antidepressant treatment.
Topics: Animals; Antidepressive Agents; Blotting, Northern; Chimera; Chloramphenicol O-Acetyltransferase; De | 1992 |
The uptake and retention of metaiodobenzyl guanidine by the neuroblastoma cell line NB1-G.
Topics: 3-Iodobenzylguanidine; Antineoplastic Agents; Biological Transport, Active; Desipramine; Humans; Iod | 1991 |
Meta-iodobenzylguanidine (mIBG) uptake and storage in the human neuroblastoma cell line SK-N-BE(2C).
Topics: 3-Iodobenzylguanidine; Antineoplastic Agents; Binding, Competitive; Biological Transport, Active; Ce | 1991 |
5-Hydroxytryptamine uptake and imipramine binding sites in neurotumor NCB-20 cells.
Topics: Animals; Binding Sites; Brain; Clomipramine; Cricetinae; Cricetulus; Desipramine; Fluoxetine; Hybrid | 1985 |