desipramine has been researched along with Neuralgia in 14 studies
Desipramine: A tricyclic dibenzazepine compound that potentiates neurotransmission. Desipramine selectively blocks reuptake of norepinephrine from the neural synapse, and also appears to impair serotonin transport. This compound also possesses minor anticholinergic activity, through its affinity to muscarinic receptors.
desipramine : A dibenzoazepine consisting of 10,11-dihydro-5H-dibenzo[b,f]azepine substituted on nitrogen with a 3-(methylamino)propyl group.
Neuralgia: Intense or aching pain that occurs along the course or distribution of a peripheral or cranial nerve.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Amitriptyline, a non-selective noradrenaline (NA) and 5-hydroxytryptamine (5-HT) reuptake inhibitor, has recently been demonstrated to produce a peripheral antinociceptive action in an inflammatory (formalin test) and a neuropathic pain model (spinal nerve ligation)." | 7.70 | Peripheral antinociceptive actions of desipramine and fluoxetine in an inflammatory and neuropathic pain test in the rat. ( Esser, MJ; Reid, AR; Sawynok, J, 1999) |
| "Desipramine has the least anticholinergic and sedative effects of the first generation tricyclic antidepressant agents, but its pain-relieving potential has received little study." | 6.67 | Desipramine relieves postherpetic neuralgia. ( Dubner, R; Gaughan, AM; Gracely, RH; Kishore-Kumar, R; Max, MB; Schafer, SC; Smoller, B, 1990) |
| "(1) Postherpetic pain is infrequent, but the incidence increases with age." | 5.31 | Gabapentin: new indication. In postherpetic neuralgia when amitriptyline fails. ( , 2002) |
| " We have used an integrative approach combining behavioural pharmacology with functional magnetic resonance imaging (fMRI) to investigate the effects of chronic treatment with the TCA desipramine, on touch-evoked pain (mechanical allodynia) and brain regional activity in the selective spinal nerve ligation (SNL) model of neuropathic pain." | 3.75 | Identification of discrete sites of action of chronic treatment with desipramine in a model of neuropathic pain. ( Chapman, V; Finn, DP; Governo, RJ; Jones, KL; Kendall, DA; Marsden, CA; Morris, PG; Prior, MJ, 2009) |
| "Amitriptyline, a non-selective noradrenaline (NA) and 5-hydroxytryptamine (5-HT) reuptake inhibitor, has recently been demonstrated to produce a peripheral antinociceptive action in an inflammatory (formalin test) and a neuropathic pain model (spinal nerve ligation)." | 3.70 | Peripheral antinociceptive actions of desipramine and fluoxetine in an inflammatory and neuropathic pain test in the rat. ( Esser, MJ; Reid, AR; Sawynok, J, 1999) |
| "Desipramine has the least anticholinergic and sedative effects of the first generation tricyclic antidepressant agents, but its pain-relieving potential has received little study." | 2.67 | Desipramine relieves postherpetic neuralgia. ( Dubner, R; Gaughan, AM; Gracely, RH; Kishore-Kumar, R; Max, MB; Schafer, SC; Smoller, B, 1990) |
| "Patients with neuropathic pain often experience depression and anxiety both of which are known to be temporally correlated with noradrenergic dysfunction in the locus coeruleus (LC) as pain becomes chronic." | 1.48 | The onset of treatment with the antidepressant desipramine is critical for the emotional consequences of neuropathic pain. ( Alba-Delgado, C; Berrocoso, E; Llorca-Torralba, M; Mico, JA, 2018) |
| "Previous findings suggest that neuropathic pain induces characteristic changes in the noradrenergic system that may modify the sensorial and affective dimensions of pain." | 1.43 | Effect of DSP4 and desipramine in the sensorial and affective component of neuropathic pain in rats. ( Berrocoso, E; Bravo, L; Camarena-Delgado, C; Mico, JA; Rey-Brea, R, 2016) |
| "The management of neuropathic pain has two distinct goals-prevention of development and control of established neuropathic pain." | 1.43 | Prophylactic treatment with the tricyclic antidepressant desipramine prevents development of paclitaxel-induced neuropathic pain through activation of endogenous analgesic systems. ( Deng, L; Hohmann, AG; Lee, WH; Makriyannis, A; Xu, Z, 2016) |
| "Peripheral neuropathic pain is a chronic condition that may produce plastic changes in several brain regions." | 1.38 | The function of alpha-2-adrenoceptors in the rat locus coeruleus is preserved in the chronic constriction injury model of neuropathic pain. ( Alba-Delgado, C; Berrocoso, E; Borges, G; Horrillo, I; Meana, JJ; Mico, JA; Neto, F; Ortega, JE; Sánchez-Blázquez, P, 2012) |
| " 10b was additionally bioavailable following oral dosing and demonstrated efficacy in rat models of acute, inflammatory, and neuropathic pain." | 1.37 | Discovery of novel selective norepinephrine inhibitors: 1-(2-morpholin-2-ylethyl)-3-aryl-1,3-dihydro-2,1,3-benzothiadiazole 2,2-dioxides (WYE-114152). ( Adedoyin, A; Bray, JA; Deecher, DC; Fensome, A; Goldberg, JA; Harrison, J; Leventhal, L; Mann, C; Mark, L; Nogle, L; O'Neill, DJ; Spangler, TB; Sullivan, NR; Terefenko, EA; Trybulski, EJ; Uveges, AJ; Vu, A; Whiteside, GT; Zhang, P, 2011) |
| "(1) Postherpetic pain is infrequent, but the incidence increases with age." | 1.31 | Gabapentin: new indication. In postherpetic neuralgia when amitriptyline fails. ( , 2002) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 4 (28.57) | 18.2507 |
| 2000's | 3 (21.43) | 29.6817 |
| 2010's | 7 (50.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| O'Neill, DJ | 1 |
| Adedoyin, A | 1 |
| Bray, JA | 1 |
| Deecher, DC | 1 |
| Fensome, A | 1 |
| Goldberg, JA | 1 |
| Harrison, J | 1 |
| Leventhal, L | 1 |
| Mann, C | 1 |
| Mark, L | 1 |
| Nogle, L | 1 |
| Sullivan, NR | 1 |
| Spangler, TB | 1 |
| Terefenko, EA | 1 |
| Trybulski, EJ | 1 |
| Uveges, AJ | 1 |
| Vu, A | 1 |
| Whiteside, GT | 1 |
| Zhang, P | 1 |
| Alba-Delgado, C | 2 |
| Llorca-Torralba, M | 1 |
| Mico, JA | 3 |
| Berrocoso, E | 3 |
| Stratinaki, M | 1 |
| Varidaki, A | 1 |
| Mitsi, V | 1 |
| Ghose, S | 1 |
| Magida, J | 1 |
| Dias, C | 1 |
| Russo, SJ | 1 |
| Vialou, V | 1 |
| Caldarone, BJ | 1 |
| Tamminga, CA | 1 |
| Nestler, EJ | 1 |
| Zachariou, V | 1 |
| Bravo, L | 1 |
| Rey-Brea, R | 1 |
| Camarena-Delgado, C | 1 |
| Deng, L | 1 |
| Lee, WH | 1 |
| Xu, Z | 1 |
| Makriyannis, A | 1 |
| Hohmann, AG | 1 |
| Jones, KL | 1 |
| Finn, DP | 1 |
| Governo, RJ | 1 |
| Prior, MJ | 1 |
| Morris, PG | 1 |
| Kendall, DA | 1 |
| Marsden, CA | 1 |
| Chapman, V | 1 |
| Hu, B | 1 |
| Doods, H | 1 |
| Treede, RD | 1 |
| Ceci, A | 1 |
| Borges, G | 1 |
| Sánchez-Blázquez, P | 1 |
| Ortega, JE | 1 |
| Horrillo, I | 1 |
| Meana, JJ | 1 |
| Neto, F | 1 |
| Farghaly, HS | 1 |
| Abdel-Zaher, AO | 1 |
| Mostafa, MG | 1 |
| Kotb, HI | 1 |
| Rudra, A | 1 |
| Mitra, A | 1 |
| Pan, AK | 1 |
| Roy, M | 1 |
| Chasuk, R | 1 |
| Sawynok, J | 1 |
| Esser, MJ | 1 |
| Reid, AR | 1 |
| Kishore-Kumar, R | 1 |
| Max, MB | 1 |
| Schafer, SC | 1 |
| Gaughan, AM | 1 |
| Smoller, B | 1 |
| Gracely, RH | 1 |
| Dubner, R | 1 |
1 review available for desipramine and Neuralgia
| Article | Year |
|---|---|
Postherpetic neuralgia and its managements.
Topics: Amitriptyline; Analgesics; Desipramine; Herpes Zoster; Humans; India; Neuralgia | 1993 |
1 trial available for desipramine and Neuralgia
| Article | Year |
|---|---|
Desipramine relieves postherpetic neuralgia.
Topics: Adult; Aged; Clinical Trials as Topic; Desipramine; Female; Herpes Zoster; Humans; Male; Middle Aged | 1990 |
12 other studies available for desipramine and Neuralgia
| Article | Year |
|---|---|
Discovery of novel selective norepinephrine inhibitors: 1-(2-morpholin-2-ylethyl)-3-aryl-1,3-dihydro-2,1,3-benzothiadiazole 2,2-dioxides (WYE-114152).
Topics: Acute Pain; Administration, Oral; Analgesics; Animals; Benzothiazoles; Biological Availability; Cell | 2011 |
The onset of treatment with the antidepressant desipramine is critical for the emotional consequences of neuropathic pain.
Topics: Action Potentials; Analysis of Variance; Animals; Antidepressive Agents, Tricyclic; CREB-Binding Pro | 2018 |
Regulator of G protein signaling 4 [corrected] is a crucial modulator of antidepressant drug action in depression and neuropathic pain models.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Animals; Antidepressive Agents; Behavior, Animal; Brain; | 2013 |
Effect of DSP4 and desipramine in the sensorial and affective component of neuropathic pain in rats.
Topics: Adrenergic Agents; Adrenergic Uptake Inhibitors; Analgesics; Animals; Antidepressive Agents; Avoidan | 2016 |
Prophylactic treatment with the tricyclic antidepressant desipramine prevents development of paclitaxel-induced neuropathic pain through activation of endogenous analgesic systems.
Topics: Animals; Antidepressive Agents, Tricyclic; Antineoplastic Agents, Phytogenic; Desipramine; Hyperalge | 2016 |
Identification of discrete sites of action of chronic treatment with desipramine in a model of neuropathic pain.
Topics: Animals; Brain; Brain Mapping; Desipramine; Disease Models, Animal; Drug Administration Schedule; En | 2009 |
Depression-like behaviour in rats with mononeuropathy is reduced by the CB2-selective agonist GW405833.
Topics: Animals; Antidepressive Agents; Antidepressive Agents, Tricyclic; Behavior, Animal; Depressive Disor | 2009 |
The function of alpha-2-adrenoceptors in the rat locus coeruleus is preserved in the chronic constriction injury model of neuropathic pain.
Topics: Action Potentials; Adrenergic alpha-2 Receptor Agonists; Adrenergic alpha-Antagonists; Adrenergic Up | 2012 |
Comparative evaluation of the effect of tricyclic antidepressants on inducible nitric oxide synthase expression in neuropathic pain model.
Topics: Amitriptyline; Analgesics; Analysis of Variance; Animals; Antidepressive Agents, Tricyclic; Behavior | 2012 |
Gabapentin: new indication. In postherpetic neuralgia when amitriptyline fails.
Topics: Acetates; Amitriptyline; Anticonvulsants; Desipramine; Drug Approval; France; Herpes Zoster; Humans; | 2002 |
Treatments for postherpetic neuralgia.
Topics: Amitriptyline; Antidepressive Agents, Tricyclic; Capsaicin; Desipramine; Herpes Zoster; Humans; Meta | 1997 |
Peripheral antinociceptive actions of desipramine and fluoxetine in an inflammatory and neuropathic pain test in the rat.
Topics: Adrenergic Uptake Inhibitors; Amitriptyline; Animals; Caffeine; Desipramine; Drug Evaluation, Precli | 1999 |