desipramine has been researched along with Nerve Degeneration in 13 studies
Desipramine: A tricyclic dibenzazepine compound that potentiates neurotransmission. Desipramine selectively blocks reuptake of norepinephrine from the neural synapse, and also appears to impair serotonin transport. This compound also possesses minor anticholinergic activity, through its affinity to muscarinic receptors.
desipramine : A dibenzoazepine consisting of 10,11-dihydro-5H-dibenzo[b,f]azepine substituted on nitrogen with a 3-(methylamino)propyl group.
Nerve Degeneration: Loss of functional activity and trophic degeneration of nerve axons and their terminal arborizations following the destruction of their cells of origin or interruption of their continuity with these cells. The pathology is characteristic of neurodegenerative diseases. Often the process of nerve degeneration is studied in research on neuroanatomical localization and correlation of the neurophysiology of neural pathways.
| Excerpt | Relevance | Reference |
|---|---|---|
| "When desipramine (5mM) was added in order to block neuronal uptake the corresponding figures were 4." | 1.27 | Reduced uptake of noradrenaline into storage vesicles from the pregnant uterus. ( Dahlin, I; Fried, G; Hammarström, M, 1985) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 10 (76.92) | 18.7374 |
| 1990's | 2 (15.38) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 1 (7.69) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| McCaughey-Chapman, A | 1 |
| Connor, B | 1 |
| Jakab, RL | 1 |
| Leranth, C | 1 |
| Jonsson, G | 3 |
| Buisson, A | 1 |
| Pateau, V | 1 |
| Plotkine, M | 1 |
| Boulu, RG | 1 |
| Fried, G | 1 |
| Hammarström, M | 1 |
| Dahlin, I | 1 |
| Tajti, J | 1 |
| Luthman, J | 1 |
| Lachenmayer, L | 1 |
| Groth, HP | 1 |
| Sachs, C | 2 |
| Thoa, NB | 1 |
| Eichelman, B | 1 |
| Ng, LK | 1 |
| de Champlain, J | 1 |
| Corrodi, H | 1 |
| Masuoka, DT | 1 |
| Clark, WG | 1 |
13 other studies available for desipramine and Nerve Degeneration
| Article | Year |
|---|---|
Rat brain sagittal organotypic slice cultures as an ex vivo dopamine cell loss system.
Topics: Adrenergic Uptake Inhibitors; Animals; Animals, Newborn; Brain; Cell Death; Desipramine; Dopaminergi | 2017 |
Presence of somatostatin or neurotensin in lateral septal dopaminergic axon terminals of distinct hypothalamic and midbrain origins: convergence on the somatospiny neurons.
Topics: Animals; Axons; Desipramine; Dopamine; Female; Horseradish Peroxidase; Hypothalamus; Immunohistochem | 1993 |
Studies on the mechanisms of 6-hydroxydopamine cytotoxicity.
Topics: Adrenergic Fibers; Animals; Axons; Cell Membrane; Cytoplasm; Desipramine; Dopamine; Humans; Hydrogen | 1976 |
Nigrostriatal pathway modulates striatum vulnerability to quinolinic acid.
Topics: Animals; Corpus Striatum; Desipramine; Dopamine; Male; Nerve Degeneration; Neural Pathways; Oxidopam | 1991 |
Reduced uptake of noradrenaline into storage vesicles from the pregnant uterus.
Topics: Adenosine Triphosphate; Animals; Desipramine; Female; Guinea Pigs; Magnesium; Nerve Degeneration; No | 1985 |
Calmodulin inhibitors induce wallerian degeneration of mammalian peripheral nerves.
Topics: Amitriptyline; Animals; Calmodulin; Desipramine; Female; Male; Nerve Degeneration; Rats; Rats, Inbre | 1988 |
Effects of the parkinsonism-inducing neurotoxin MPTP and its metabolite MPP+ on sympathetic adrenergic nerves in mouse iris and atrium.
Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; 1-Methyl-4-phenylpyridinium; Adrenergic Fibers; Animal | 1986 |
Degeneration and regeneration of the adrenergic nerves in the rat iris induced by dihydroxytryptamines.
Topics: Animals; Anterior Chamber; Desipramine; Female; Fluorescence; Hydroxydopamines; Iris; Male; Nerve De | 1973 |
6-Aminodopamine-induced degeneration of catecholamine neurons.
Topics: Animals; Axons; Blood-Brain Barrier; Brain; Caudate Nucleus; Cerebral Cortex; Desipramine; Dopamine; | 1973 |
Shock-induced aggression: effects of 6-hydroxydopamine and other pharmacological agents.
Topics: Aggression; Amphetamine; Animals; Apomorphine; Brain; Catecholamines; Desipramine; Dihydroxyphenylal | 1972 |
Degeneration and regrowth of adrenergic nerve fibers in the rat peripheral tissues after 6-hydroxydopamine.
Topics: Animals; Arteries; Desipramine; Dopamine; Heart Atria; Histocytochemistry; Iris; Kidney; Male; Micro | 1971 |
Effect of 6-hydroxydopamine on rat heart noradrenaline.
Topics: Animals; Desipramine; Dopamine; Drug Interactions; Male; Monoamine Oxidase Inhibitors; Myocardium; N | 1971 |
Degeneration of adrenergic nerves produced by 6-hydroxydopamine.
Topics: Animals; Bretylium Compounds; Catecholamines; Desipramine; Dopamine; Ganglia, Autonomic; Heart Atria | 1968 |