desipramine has been researched along with Myocardial Ischemia in 22 studies
Desipramine: A tricyclic dibenzazepine compound that potentiates neurotransmission. Desipramine selectively blocks reuptake of norepinephrine from the neural synapse, and also appears to impair serotonin transport. This compound also possesses minor anticholinergic activity, through its affinity to muscarinic receptors.
desipramine : A dibenzoazepine consisting of 10,11-dihydro-5H-dibenzo[b,f]azepine substituted on nitrogen with a 3-(methylamino)propyl group.
Myocardial Ischemia: A disorder of cardiac function caused by insufficient blood flow to the muscle tissue of the heart. The decreased blood flow may be due to narrowing of the coronary arteries (CORONARY ARTERY DISEASE), to obstruction by a thrombus (CORONARY THROMBOSIS), or less commonly, to diffuse narrowing of arterioles and other small vessels within the heart. Severe interruption of the blood supply to the myocardial tissue may result in necrosis of cardiac muscle (MYOCARDIAL INFARCTION).
| Excerpt | Relevance | Reference |
|---|---|---|
| " This study investigated whether the norepinephrine transporter inhibitor, desipramine, can modulate sympathetic remodeling and ventricular fibrillation threshold (VFT) after myocardial ischemia-reperfusion." | 7.78 | Desipramine pretreatment improves sympathetic remodeling and ventricular fibrillation threshold after myocardial ischemia. ( Hu, X; Jiang, H; Liu, W; Wu, X; Yu, L, 2012) |
| " This study investigated whether the norepinephrine transporter inhibitor, desipramine, can modulate sympathetic remodeling and ventricular fibrillation threshold (VFT) after myocardial ischemia-reperfusion." | 3.78 | Desipramine pretreatment improves sympathetic remodeling and ventricular fibrillation threshold after myocardial ischemia. ( Hu, X; Jiang, H; Liu, W; Wu, X; Yu, L, 2012) |
| "Cardiac ischemia and anoxia induce massive norepinephrine (NE) release, which is mediated by a reverse operation of uptake-1 and can be suppressed by uptake-1 inhibitors." | 1.30 | Protection of neuronal uptake-1 inhibitors in ischemic and anoxic hearts by norepinephrine-dependent and -independent mechanisms. ( Dart, AM; Du, XJ; Esler, MD; Little, PJ; Woodcock, EA, 1998) |
| "Myocardial ischemia was caused by interruption of perfusion flow in rat heart and simulated by anoxic and glucose-free incubation in human and rat atrial tissue." | 1.29 | Two different mechanisms of noradrenaline release during normoxia and simulated ischemia in human cardiac tissue. ( Hagl, S; Kurz, T; Richardt, G; Schömig, A; Seyfarth, M, 1995) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 11 (50.00) | 18.2507 |
| 2000's | 8 (36.36) | 29.6817 |
| 2010's | 3 (13.64) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Naumenko, SE | 1 |
| Latysheva, TV | 1 |
| Gilinskii, MA | 1 |
| Jozwiak, J | 1 |
| Dietze, A | 1 |
| Grover, R | 1 |
| Savtschenko, A | 1 |
| Etz, C | 1 |
| Mohr, FW | 1 |
| Dhein, S | 1 |
| Wu, X | 1 |
| Jiang, H | 1 |
| Yu, L | 1 |
| Hu, X | 1 |
| Liu, W | 1 |
| Yamamoto, S | 1 |
| Tamai, I | 1 |
| Takaoka, M | 1 |
| Matsumura, Y | 1 |
| Richardt, D | 1 |
| Dendorfer, A | 1 |
| Tölg, R | 3 |
| Dominiak, P | 1 |
| Richardt, G | 4 |
| Kuroko, Y | 1 |
| Yamazaki, T | 6 |
| Tokunaga, N | 1 |
| Akiyama, T | 6 |
| Kitagawa, H | 2 |
| Ishino, K | 1 |
| Sano, S | 1 |
| Mori, H | 2 |
| Xing, J | 1 |
| Koba, S | 1 |
| Kehoe, V | 1 |
| Gao, Z | 1 |
| Rice, K | 1 |
| King, N | 1 |
| Sinoway, L | 1 |
| Li, J | 1 |
| Kurz, T | 3 |
| Hagl, S | 2 |
| Seyfarth, M | 1 |
| Schömig, A | 2 |
| Shindo, T | 1 |
| Ninomiya, I | 2 |
| Offner, B | 1 |
| Schreieck, J | 1 |
| Hatta, E | 1 |
| Yasuda, K | 1 |
| Levi, R | 2 |
| Du, XJ | 1 |
| Woodcock, EA | 1 |
| Little, PJ | 1 |
| Esler, MD | 1 |
| Dart, AM | 1 |
| Gerber, SH | 1 |
| Heyer, C | 1 |
| Krüger, C | 1 |
| Kübler, W | 1 |
| Haass, M | 1 |
| Schneider, I | 1 |
| Smith, NC | 1 |
| Schaefer, S | 1 |
| Wang, LF | 1 |
| van der Vliet, A | 1 |
| Hristova, M | 1 |
| Vulliet, PR | 1 |
| Fan, SD | 1 |
| Yahagi, N | 2 |
| Seya, K | 1 |
| Daitoku, K | 1 |
| Motomura, S | 1 |
| Miura, T | 1 |
| Kawamura, S | 1 |
| Tatsuno, H | 1 |
| Ikeda, Y | 1 |
| Mikami, S | 1 |
| Iwamoto, H | 1 |
| Okamura, T | 1 |
| Iwatate, M | 1 |
| Kimura, M | 1 |
| Dairaku, Y | 1 |
| Maekawa, T | 1 |
| Matsuzaki, M | 1 |
| Kawada, T | 1 |
| Sunagawa, K | 1 |
22 other studies available for desipramine and Myocardial Ischemia
| Article | Year |
|---|---|
Inhibition of norepinephrine reuptake and size of myocardial infarction during focal ischemia and after preconditioning.
Topics: Animals; Desipramine; Ischemic Preconditioning, Myocardial; Male; Myocardial Infarction; Myocardial | 2010 |
Desipramine prevents cardiac gap junction uncoupling.
Topics: Acidosis; Animals; Anti-Arrhythmia Agents; Antidepressive Agents, Tricyclic; Blotting, Western; Conn | 2012 |
Desipramine pretreatment improves sympathetic remodeling and ventricular fibrillation threshold after myocardial ischemia.
Topics: Adrenergic Uptake Inhibitors; Animals; Desipramine; Male; Myocardial Ischemia; Premedication; Rats; | 2012 |
Role of histamine H3 receptors during ischemia/reperfusion in isolated rat hearts.
Topics: Adrenergic Uptake Inhibitors; Animals; Chromatography, High Pressure Liquid; Desipramine; Histamine | 2004 |
Inhibition of nonexocytotic norepinephrine release by desipramine reduces myocardial infarction size.
Topics: Adrenergic Uptake Inhibitors; Animals; Chromatography, High Pressure Liquid; Coronary Vessels; Desip | 2006 |
Cardiac epinephrine synthesis and ischemia-induced myocardial epinephrine release.
Topics: Adrenergic Uptake Inhibitors; Animals; Blood Pressure; Desipramine; Dialysis; Enzyme Inhibitors; Epi | 2007 |
Interstitial norepinephrine concentrations in skeletal muscle of ischemic heart failure.
Topics: Adrenergic Uptake Inhibitors; Animals; Cardiac Output, Low; Chromatography, High Pressure Liquid; Co | 2007 |
Two different mechanisms of noradrenaline release during normoxia and simulated ischemia in human cardiac tissue.
Topics: Adrenergic Uptake Inhibitors; Animals; Calcium; Calcium Channel Blockers; Calcium Channels; Cyanides | 1995 |
Increase in myocardial interstitial norepinephrine during a short period of coronary occlusion.
Topics: Animals; Cats; Chromatography, High Pressure Liquid; Desipramine; Dialysis; Electrochemistry; Extrac | 1994 |
Differential regional responses of myocardial interstitial noradrenaline levels to coronary occlusion.
Topics: Animals; Blood Pressure; Cats; Chromatography, High Pressure Liquid; Desipramine; Dialysis; Extracel | 1993 |
Nonexocytotic noradrenaline release and ventricular fibrillation in ischemic rat hearts.
Topics: Adrenergic Uptake Inhibitors; Animals; Anti-Arrhythmia Agents; Carrier Proteins; Desipramine; Exocyt | 1995 |
Activation of histamine H3 receptors inhibits carrier-mediated norepinephrine release in a human model of protracted myocardial ischemia.
Topics: Aged; Carrier Proteins; Desipramine; Female; Histamine Release; Humans; Hypoxia; Male; Middle Aged; | 1997 |
Protection of neuronal uptake-1 inhibitors in ischemic and anoxic hearts by norepinephrine-dependent and -independent mechanisms.
Topics: Adrenergic Uptake Inhibitors; Animals; Cocaine; Desipramine; Dopamine Uptake Inhibitors; Drug Intera | 1998 |
Influence of Bretschneider's cardioplegia on norepinephrine release from isolated perfused guinea-pig hearts.
Topics: Adrenergic Uptake Inhibitors; Amiloride; Animals; Desipramine; Dose-Response Relationship, Drug; Fev | 1999 |
Alpha 1-adrenergic receptor-mediated increase in the mass of phosphatidic acid and 1,2-diacylglycerol in ischemic rat heart.
Topics: Adrenergic alpha-Antagonists; Adrenergic beta-Antagonists; Adrenergic Uptake Inhibitors; Analysis of | 1999 |
LLC-PK(1) cells stably expressing the human norepinephrine transporter: A functional model of carrier-mediated norepinephrine release in protracted myocardial ischemia.
Topics: 1-Methyl-4-phenylpyridinium; Amiloride; Animals; Biological Transport, Active; Desipramine; Drug Int | 1999 |
Fasting limits norepinephrine release with myocardial ischemia and reperfusion.
Topics: Adrenergic Uptake Inhibitors; Animals; Blood Glucose; Creatine Kinase; Desipramine; Fasting; Food; H | 1999 |
Either desipramine or TMB-8 suppresses cyanide-induced norepinephrine efflux from in vivo cardiac sympathetic nerves of cats.
Topics: Animals; Antidepressive Agents, Tricyclic; Calcium Channel Blockers; Cats; Cyanides; Desipramine; Di | 2000 |
Norepinephrine measurement in the isolated, blood-perfused papillary muscle of the dog by using ex vivo microdialysis.
Topics: Animals; Chromatography, High Pressure Liquid; Desipramine; Dogs; Female; Male; Microdialysis; Myoca | 1999 |
Myocardial interstitial norepinephrine and dihydroxyphenylglycol levels during ischemia and reperfusion.
Topics: Animals; Blood Pressure; Calcium Channel Blockers; Cats; Desipramine; Dialysis; Female; Heart Rate; | 2001 |
Ischemic preconditioning attenuates cardiac sympathetic nerve injury via ATP-sensitive potassium channels during myocardial ischemia.
Topics: Adenosine Triphosphate; Animals; Coronary Circulation; Desipramine; Dialysis Solutions; Diltiazem; D | 2001 |
Modulatory effects of ketamine on catecholamine efflux from in vivo cardiac sympathetic nerve endings in cats.
Topics: Adrenergic Uptake Inhibitors; Animals; Calcium Channel Blockers; Catecholamines; Cats; Coronary Arte | 2002 |