desipramine has been researched along with Microcephaly in 1 studies
Desipramine: A tricyclic dibenzazepine compound that potentiates neurotransmission. Desipramine selectively blocks reuptake of norepinephrine from the neural synapse, and also appears to impair serotonin transport. This compound also possesses minor anticholinergic activity, through its affinity to muscarinic receptors.
desipramine : A dibenzoazepine consisting of 10,11-dihydro-5H-dibenzo[b,f]azepine substituted on nitrogen with a 3-(methylamino)propyl group.
Microcephaly: A congenital abnormality in which the CEREBRUM is underdeveloped, the fontanels close prematurely, and, as a result, the head is small. (Desk Reference for Neuroscience, 2nd ed.)
| Excerpt | Relevance | Reference |
|---|---|---|
| "Rett syndrome is a neurodevelopmental disease due to Mecp2 gene mutations that is associated to complex neurological symptoms, with bioaminergic deficits and life-threatening apneas related to sudden and unexpected death." | 7.74 | Oral treatment with desipramine improves breathing and life span in Rett syndrome mouse model. ( Dutschmann, M; Hilaire, G; Lajard, AM; Mebarek, S; Picard, N; Zanella, S, 2008) |
| "Rett syndrome is a neurodevelopmental disease due to Mecp2 gene mutations that is associated to complex neurological symptoms, with bioaminergic deficits and life-threatening apneas related to sudden and unexpected death." | 3.74 | Oral treatment with desipramine improves breathing and life span in Rett syndrome mouse model. ( Dutschmann, M; Hilaire, G; Lajard, AM; Mebarek, S; Picard, N; Zanella, S, 2008) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 1 (100.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Zanella, S | 1 |
| Mebarek, S | 1 |
| Lajard, AM | 1 |
| Picard, N | 1 |
| Dutschmann, M | 1 |
| Hilaire, G | 1 |
1 other study available for desipramine and Microcephaly
| Article | Year |
|---|---|
Oral treatment with desipramine improves breathing and life span in Rett syndrome mouse model.
Topics: Animals; Antidepressive Agents, Tricyclic; Apnea; Desipramine; Female; Locomotion; Longevity; Medull | 2008 |