desipramine and Mental Disorders studies

Desipramine: A tricyclic dibenzazepine compound that potentiates neurotransmission. Desipramine selectively blocks reuptake of norepinephrine from the neural synapse, and also appears to impair serotonin transport. This compound also possesses minor anticholinergic activity, through its affinity to muscarinic receptors.
desipramine : A dibenzoazepine consisting of 10,11-dihydro-5H-dibenzo[b,f]azepine substituted on nitrogen with a 3-(methylamino)propyl group.

Mental Disorders: Psychiatric illness or diseases manifested by breakdowns in the adaptational process expressed primarily as abnormalities of thought, feeling, and behavior producing either distress or impairment of function.

Research Excerpts

Excerpt	Relevance	Reference
"Twenty-five adult subjects with severe morbid onychophagia (nail biting) and no history of obsessive-compulsive disorder were enrolled in a 10-week double-blind cross-over trial of clomipramine hydrochloride and desipramine hydrochloride."	5.07	A double-blind comparison of clomipramine and desipramine treatment of severe onychophagia (nail biting). ( Lenane, MC; Leonard, HL; Rapoport, JL; Rettew, DC; Swedo, SE, 1991)
"Clomipramine was superior to desipramine in the acute treatment of body dysmorphic disorder symptoms as measured by assessment of patients' obsessive preoccupation with perceived body defects, repetitive behaviors in response to this preoccupation, and global ratings of symptom severity."	2.69	Clomipramine vs desipramine crossover trial in body dysmorphic disorder: selective efficacy of a serotonin reuptake inhibitor in imagined ugliness. ( Allen, A; Aronowitz, B; Hollander, E; Kwon, J; Schmeidler, J; Simeon, D; Wong, C, 1999)
"Treatment with desipramine results in differing degrees of subjective side effects and changes in vital signs across the life cycle."	2.41	Side effects of desipramine and age. ( Bilich, C; Galanter, CA; Walsh, BT, 2002)
"Four cases of sudden death in children 12 years or younger during desipramine treatment were identified between 1986 and 1992."	1.29	Estimation of the association between desipramine and the risk for sudden death in 5- to 14-year-old children. ( Biederman, J; Greenhill, LL; Ryan, ND; Thisted, RA, 1995)

Timeframe	Studies, this research(%)	All Research%
pre-1990	27 (67.50)	18.7374
1990's	9 (22.50)	18.2507
2000's	3 (7.50)	29.6817
2010's	1 (2.50)	24.3611
2020's	0 (0.00)	2.80

Authors	Studies
Preskorn, SH	1
Galanter, CA	1
Bilich, C	1
Walsh, BT	1
Danhauer, SC	1
Miller, CS	1
Rhodus, NL	1
Carlson, CR	1
KRAKOWSKI, AJ	2
HAASE, HJ	1
KOESTER, H	1
KOENIG, M	1
BLEKER, A	1
CMYRAL, K	1
HOFMANN, G	1
VOLTERRA, V	1
GUERMANI, M	1
TOFTE, F	1
LEHMANN, HE	2
HORDERN, A	1
LAPOLLA, A	1
Zorc, JJ	1
Ludwig, S	1
Moody, JP	1
Tait, AC	1
Todrick, A	1
Hertrich, O	1
Enna, SJ	1
Rapoport, JL	3
Mikkelsen, EJ	1
Zavadil, A	1
Nee, L	1
Gruenau, C	1
Mendelson, W	1
Gillin, JC	1
Biederman, J	4
Thisted, RA	1
Greenhill, LL	1
Ryan, ND	1
Szarek, BL	1
Brandt, DM	1
Appelbaum, PS	1
Wilens, TE	2
Prince, J	1
Spencer, TJ	1
Faraone, SV	3
Warburton, R	1
Schleifer, D	1
Harding, M	1
Linehan, C	1
Geller, D	1
Baldessarini, RJ	1
Flood, J	1
Meyer, M	1
Wilens, T	1
Spencer, T	2
Chen, L	1
Weber, W	1
Hollander, E	1
Allen, A	1
Kwon, J	1
Aronowitz, B	1
Schmeidler, J	1
Wong, C	1
Simeon, D	1
Woodward, JA	1
Henry, BW	1
Overall, JE	1
Leonard, HL	1
Lenane, MC	1
Swedo, SE	1
Rettew, DC	1
Pohl, R	1
Balon, R	1
Berchou, R	1
Yeragani, VK	1
Esche, I	1
Joffe, RT	1
Blank, DW	1
Barnes, DM	1
Vessell, ES	1
Passananti, GT	1
Mandell, AJ	1
Schmutz, J	1
Glassman, AH	1
Perel, JM	1
Alexander, L	1
Roberts, CD	1
Roberts, EN	1
Milner, G	1
Hills, NF	1
Arbitman, R	1
Yurtcu, A	1
Sterlin, C	1
Ban, TA	1
Jarrold, L	1
Fischer, E	1
Spatz, H	1
Saavedra, JM	1
Reggiani, H	1
Miró, AH	1
Heller, B	1
Webb, WL	1

Article	Year
Clinical psychopharmacology and medical malpractice: the four Ds. Journal of psychiatric practice, 2014, Volume: 20, Issue:5 Topics: Adult; Antidepressive Agents; Antipsychotic Agents; Attention Deficit Disorder with Hyperactivity; C	2014
Side effects of desipramine and age. Journal of child and adolescent psychopharmacology, 2002,Summer, Volume: 12, Issue:2 Topics: Adolescent; Adult; Age Factors; Appetite; Blood Pressure; Child; Constipation; Desipramine; Female;	2002
THE PHARMACOTHERAPY OF THE DEPRESSIVE SYNDROME. Canadian Medical Association journal, 1965, Apr-10, Volume: 92 Topics: Amitriptyline; Antidepressive Agents; Convulsive Therapy; Depression; Depressive Disorder; Desiprami	1965
THE ANTIDEPRESSANT DRUGS. The New England journal of medicine, 1965, Jun-03, Volume: 272 Topics: Amitriptyline; Antidepressive Agents; Central Nervous System Stimulants; Depression; Depressive Diso	1965
Adults with attention-deficit/hyperactivity disorder: a controversial diagnosis. The Journal of clinical psychiatry, 1998, Volume: 59 Suppl 7 Topics: Adolescent; Adult; Age Factors; Antidepressive Agents; Atomoxetine Hydrochloride; Attention Deficit	1998
Utility of clinical chemical determinations of drug concentrations in biological fluids. Clinical chemistry, 1971, Volume: 17, Issue:9 Topics: Adult; Allopurinol; Antipyrine; Ataxia; Chemistry, Clinical; Chromatography, Gas; Coffee; Desipramin	1971
[Intention and incident in drug research, demonstrated on the example of tricyclic psychopharmacologic agents]. Pharmaceutica acta Helvetiae, 1973, Volume: 48, Issue:3 Topics: Amitriptyline; Antidepressive Agents; Antipsychotic Agents; Azepines; Chemical Phenomena; Chemistry;	1973
The clinical pharmacology of imipramine. Implications for therapeutics. Archives of general psychiatry, 1973, Volume: 28, Issue:5 Topics: Administration, Oral; Barbiturates; Cell Membrane Permeability; Depression; Desipramine; Drug Intera	1973

Article	Year
Impact of criteria-based diagnosis of burning mouth syndrome on treatment outcome. Journal of orofacial pain, 2002,Fall, Volume: 16, Issue:4 Topics: Adult; Aged; Aged, 80 and over; Anti-Anxiety Agents; Anticonvulsants; Burning Mouth Syndrome; Carbam	2002
Childhood enuresis. II. Psychopathology, tricyclic concentration in plasma, and antienuretic effect. Archives of general psychiatry, 1980, Volume: 37, Issue:10 Topics: Child; Clinical Trials as Topic; Desipramine; Double-Blind Method; Enuresis; Humans; Imipramine; Mal	1980
Six-week, double-blind, placebo-controlled study of desipramine for adult attention deficit hyperactivity disorder. The American journal of psychiatry, 1996, Volume: 153, Issue:9 Topics: Adolescent; Adult; Age Factors; Ambulatory Care; Anxiety Disorders; Attention Deficit Disorder with	1996
Clomipramine vs desipramine crossover trial in body dysmorphic disorder: selective efficacy of a serotonin reuptake inhibitor in imagined ugliness. Archives of general psychiatry, 1999, Volume: 56, Issue:11 Topics: Adrenergic Uptake Inhibitors; Adult; Clomipramine; Comorbidity; Cross-Over Studies; Delusions; Desip	1999
A double-blind comparison of clomipramine and desipramine treatment of severe onychophagia (nail biting). Archives of general psychiatry, 1991, Volume: 48, Issue:9 Topics: Adult; Ambulatory Care; Clomipramine; Desipramine; Dose-Response Relationship, Drug; Double-Blind Me	1991
A double-blind assessment of antidepressants in the treatment of 212 enuretic patients. The Medical journal of Australia, 1968, Jun-01, Volume: 1, Issue:22 Topics: Clinical Trials as Topic; Desipramine; Enuresis; Epilepsy; Female; Humans; Humidity; Imipramine; Mal	1968
Protrptyline in the treatment of chronic schizophrenic patients. Current therapeutic research, clinical and experimental, 1970, Volume: 12, Issue:3 Topics: Adolescent; Adult; Clinical Trials as Topic; Desipramine; Dibenzocycloheptenes; Female; Humans; Male	1970

Article	Year
TREATMENT OF SEVERE DEPRESSION WITH DESIPRAMINE, A METABOLITE OF IMIPRAMINE. The American journal of psychiatry, 1963, Volume: 120 Topics: Adolescent; Antidepressive Agents; Brain Diseases; Depression; Depressive Disorder; Depressive Disor	1963
[ON THE METHODOLOGY OF RESEARCH ON ANTIDEPRESSIVE DRUGS WITH SPECIAL REFERENCE TO IMIPRAMINE (TOFRANIL) AND DESMETHYLIMIPRAMINE (PERTOFRAN)]. Archiv fur Psychiatrie und Nervenkrankheiten, 1963, Sep-18, Volume: 204 Topics: Aging; Antidepressive Agents; Bipolar Disorder; Body Constitution; Desipramine; Humans; Imipramine;	1963
[RESULTS OF THE USE OF DESMETHYL-IMIPRAMINE (G-35020, PERTOFRAN) IN THE DEPRESSIVE SYNDROME]. Wiener medizinische Wochenschrift (1946), 1963, Dec-07, Volume: 113 Topics: Antidepressive Agents; Bipolar Disorder; Depressive Disorder; Desipramine; Humans; Imipramine; Menta	1963
[PRELIMINARY OBSERVATIONS ON THE CLINICAL USE OF A METABOLITE OF IMIPRAMINE: DESMETHYLIMIPRAMINE (G 35020)]. Rivista sperimentale di freniatria e medicina legale delle alienazioni mentali, 1963, Dec-31, Volume: 87 Topics: Antidepressive Agents; Depression; Depressive Disorder; Desipramine; Humans; Imipramine; Mental Diso	1963
[LONG-TERM DRUG TREATMENT OF CRIMINALS. PRELIMINARY EXPERIENCES]. Ugeskrift for laeger, 1964, Jan-09, Volume: 126 Topics: Antidepressive Agents; Chlordiazepoxide; Criminals; Criminology; Denmark; Desipramine; Humans; Imipr	1964
TREATMENT OF SEVERE DEPRESSION WITH DESIPRAMINE: LONG-TERM TRIAL AND FOLLOW-UP. Diseases of the nervous system, 1964, Volume: 25 Topics: Constipation; Depression; Depressive Disorder; Depressive Disorder, Major; Desipramine; Drug Hyperse	1964
CLINICAL TRIAL OF A NEW ANTIDEPRESSANT (DESIPRAMINE HYDROCHLORIDE) IN A HOSPITAL SETTING. The American journal of psychiatry, 1965, Volume: 121 Topics: Antidepressive Agents; Biomedical Research; Bipolar Disorder; Depression; Depressive Disorder; Desip	1965
A 12-year-old girl with altered mental status and a seizure. Pediatric emergency care, 2004, Volume: 20, Issue:9 Topics: Child; Desipramine; Female; Humans; Mental Disorders; Seizures	2004
Plasma levels of imipramine and desmethylimipramine during therapy. The British journal of psychiatry : the journal of mental science, 1967, Volume: 113, Issue:495 Topics: Adult; Aged; Chromatography; Chromatography, Thin Layer; Desipramine; Female; Humans; Imipramine; Ma	1967
[Ataractic treatment in psychiatry and general medicine. Survey of drugs, 4]. Fortschritte der Medizin, 1983, Jul-07, Volume: 101, Issue:25 Topics: Azepines; Chemical Phenomena; Chemistry; Clozapine; Desipramine; Diazepam; Dibenzazepines; Family Pr	1983
Brain serotonin receptors and neuropsychiatric disorders. Advances in experimental medicine and biology, 1981, Volume: 133 Topics: Animals; Brain; Desipramine; Fluoxetine; Humans; Imipramine; Kinetics; Lysergic Acid Diethylamide; M	1981
Estimation of the association between desipramine and the risk for sudden death in 5- to 14-year-old children. The Journal of clinical psychiatry, 1995, Volume: 56, Issue:3 Topics: Adolescent; Age Factors; Cause of Death; Child; Confidence Intervals; Death, Sudden; Desipramine; Dr	1995
A comparison of weight changes with fluoxetine, desipramine, and amitriptyline: a retrospective study of psychiatric inpatients. The Journal of nervous and mental disease, 1993, Volume: 181, Issue:11 Topics: Amitriptyline; Body Weight; Desipramine; Dose-Response Relationship, Drug; Drug Therapy, Combination	1993
Law & psychiatry. Who is responsible when a patient's insurance runs out? Psychiatric services (Washington, D.C.), 1996, Volume: 47, Issue:4 Topics: Adolescent; Cost Control; Depressive Disorder; Desipramine; Drug Overdose; Financing, Personal; Hosp	1996
Predicting desipramine levels in children and adolescents: a naturalistic clinical study. Journal of the American Academy of Child and Adolescent Psychiatry, 1997, Volume: 36, Issue:3 Topics: Adolescent; Antidepressive Agents, Tricyclic; Child; Child, Preschool; Desipramine; Female; Humans;	1997
Patterns of symptom change in anxious depressed outpatients treated with different drugs. Diseases of the nervous system, 1975, Volume: 36, Issue:3 Topics: Amitriptyline; Antidepressive Agents; Anxiety; Chlordiazepoxide; Chlorpromazine; Depression; Desipra	1975
Treatment of behavioral disorders in animals. The American journal of psychiatry, 1990, Volume: 147, Issue:9 Topics: Animal Diseases; Animals; Animals, Domestic; Clomipramine; Desipramine; Disease Models, Animal; Dog	1990
Allergy to tartrazine in antidepressants. The American journal of psychiatry, 1987, Volume: 144, Issue:2 Topics: Adult; Antidepressive Agents, Tricyclic; Azo Compounds; Desipramine; Drug Eruptions; Female; Humans;	1987
Erythrocyte electrolytes in psychiatric illness. Acta psychiatrica Scandinavica, 1988, Volume: 78, Issue:6 Topics: Adult; Bipolar Disorder; Depressive Disorder; Desipramine; Erythrocytes; Female; Humans; Male; Menta	1988
Breaking the cycle of addiction. Science (New York, N.Y.), 1988, Aug-26, Volume: 241, Issue:4869 Topics: Behavior Therapy; Cocaine; Desipramine; Humans; Mental Disorders; Psychotherapy; Recurrence; Substan	1988
The role of adaptive regulation in the pathophysiology of psychiatric disease. Journal of psychiatric research, 1974, Volume: 11 Topics: Axonal Transport; Binding Sites; Brain; Corpus Striatum; Desipramine; Dopamine; Enzyme Inhibitors; H	1974
Mind and body in biological psychiatry. Biological psychiatry, 1973, Volume: 5, Issue:3 Topics: Adult; Affect; Carbon Dioxide; Chlorpromazine; Conditioning, Classical; Depression; Desipramine; Ere	1973
An explanatory statistical model for plasma levels of imipramine and desmethylimipramine during long-term therapy. The British journal of psychiatry : the journal of mental science, 1973, Volume: 122, Issue:571 Topics: Desipramine; Dose-Response Relationship, Drug; Female; Humans; Imipramine; Male; Mental Disorders; M	1973
Urinary elimination of phenethylamine. Biological psychiatry, 1972, Volume: 5, Issue:2 Topics: Chromatography, Gas; Depression; Desipramine; Dibenzazepines; Epilepsy, Temporal Lobe; Humans; Menta	1972
The use of psychopharmacological drugs in the aged. Geriatrics, 1971, Volume: 26, Issue:6 Topics: Affective Symptoms; Aged; Antidepressive Agents; Anxiety; Barbiturates; Butyrophenones; Dementia; De	1971

desipramine and Mental Disorders

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