desipramine has been researched along with Malaria in 2 studies
Desipramine: A tricyclic dibenzazepine compound that potentiates neurotransmission. Desipramine selectively blocks reuptake of norepinephrine from the neural synapse, and also appears to impair serotonin transport. This compound also possesses minor anticholinergic activity, through its affinity to muscarinic receptors.
desipramine : A dibenzoazepine consisting of 10,11-dihydro-5H-dibenzo[b,f]azepine substituted on nitrogen with a 3-(methylamino)propyl group.
Malaria: A protozoan disease caused in humans by four species of the PLASMODIUM genus: PLASMODIUM FALCIPARUM; PLASMODIUM VIVAX; PLASMODIUM OVALE; and PLASMODIUM MALARIAE; and transmitted by the bite of an infected female mosquito of the genus ANOPHELES. Malaria is endemic in parts of Asia, Africa, Central and South America, Oceania, and certain Caribbean islands. It is characterized by extreme exhaustion associated with paroxysms of high FEVER; SWEATING; shaking CHILLS; and ANEMIA. Malaria in ANIMALS is caused by other species of plasmodia.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Desipramine was found to be one of the most effective compounds yet described for the reversal of chloroquine resistance both in vitro and in vivo." | 5.27 | Reversal of chloroquine resistance in malaria parasite Plasmodium falciparum by desipramine. ( Bitonti, AJ; Davidson, DE; Kyle, DE; McCann, PP; Milhous, WK; Oduola, AM; Rossan, RN; Sjoerdsma, A, 1988) |
| "Desipramine was found to be one of the most effective compounds yet described for the reversal of chloroquine resistance both in vitro and in vivo." | 1.27 | Reversal of chloroquine resistance in malaria parasite Plasmodium falciparum by desipramine. ( Bitonti, AJ; Davidson, DE; Kyle, DE; McCann, PP; Milhous, WK; Oduola, AM; Rossan, RN; Sjoerdsma, A, 1988) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (50.00) | 18.7374 |
| 1990's | 1 (50.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Miki, A | 1 |
| Tanabe, K | 1 |
| Nakayama, T | 1 |
| Kiryon, C | 1 |
| Ohsawa, K | 1 |
| Bitonti, AJ | 1 |
| Sjoerdsma, A | 1 |
| McCann, PP | 1 |
| Kyle, DE | 1 |
| Oduola, AM | 1 |
| Rossan, RN | 1 |
| Milhous, WK | 1 |
| Davidson, DE | 1 |
2 other studies available for desipramine and Malaria
| Article | Year |
|---|---|
Plasmodium chabaudi: association of reversal of chloroquine resistance with increased accumulation of chloroquine in resistant parasites.
Topics: Animals; Antidepressive Agents, Tricyclic; Calcium Channel Blockers; Chloroquine; Chlorpromazine; Ch | 1992 |
Reversal of chloroquine resistance in malaria parasite Plasmodium falciparum by desipramine.
Topics: Animals; Antidepressive Agents, Tricyclic; Aotus trivirgatus; Chloroquine; Desipramine; Dose-Respons | 1988 |