desipramine has been researched along with Malaria, Falciparum in 5 studies
Desipramine: A tricyclic dibenzazepine compound that potentiates neurotransmission. Desipramine selectively blocks reuptake of norepinephrine from the neural synapse, and also appears to impair serotonin transport. This compound also possesses minor anticholinergic activity, through its affinity to muscarinic receptors.
desipramine : A dibenzoazepine consisting of 10,11-dihydro-5H-dibenzo[b,f]azepine substituted on nitrogen with a 3-(methylamino)propyl group.
Malaria, Falciparum: Malaria caused by PLASMODIUM FALCIPARUM. This is the severest form of malaria and is associated with the highest levels of parasites in the blood. This disease is characterized by irregularly recurring febrile paroxysms that in extreme cases occur with acute cerebral, renal, or gastrointestinal manifestations.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Control of falciparum malaria has become almost impossible in many areas due to the development of resistance to chloroquine and other antimalarial drugs." | 1.29 | Relationship of global chloroquine transport and reversal of resistance in Plasmodium falciparum. ( Boulter, MK; Bray, PG; Howells, RE; Ritchie, GY; Ward, SA, 1994) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 4 (80.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 1 (20.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Miller, ME | 1 |
| Parrott, EE | 1 |
| Singh, R | 1 |
| Nelson, SW | 1 |
| Cremer, G | 1 |
| Basco, LK | 2 |
| Le Bras, J | 2 |
| Camus, D | 1 |
| Slomianny, C | 1 |
| Andersen, SL | 1 |
| Milhous, WK | 1 |
| Vennerstrom, JL | 1 |
| Bray, PG | 2 |
| Boulter, MK | 1 |
| Ritchie, GY | 1 |
| Howells, RE | 2 |
| Ward, SA | 2 |
| Ndifor, AM | 1 |
| Ngu, JL | 1 |
5 other studies available for desipramine and Malaria, Falciparum
| Article | Year |
|---|---|
A High-Throughput Assay to Identify Inhibitors of the Apicoplast DNA Polymerase from Plasmodium falciparum.
Topics: Antimalarials; Apicoplasts; Chloroplasts; DNA; DNA-Directed DNA Polymerase; Drug Discovery; Exonucle | 2014 |
Plasmodium falciparum: detection of P-glycoprotein in chloroquine-susceptible and chloroquine-resistant clones and isolates.
Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 1; Biological Transport; Chloroquine; | 1995 |
In vitro activity of bisquinoline WR268,668 against African clones and isolates of Plasmodium falciparum.
Topics: Africa; Animals; Antimalarials; Chloroquine; Cyclohexylamines; Desipramine; Drug Interactions; Drug | 1994 |
Relationship of global chloroquine transport and reversal of resistance in Plasmodium falciparum.
Topics: Animals; Biological Transport, Active; Chloroquine; Desipramine; Drug Resistance; Humans; Hydrogen-I | 1994 |
Enhancement of drug susceptibility in Plasmodium falciparum in vitro and Plasmodium berghei in vivo by mixed-function oxidase inhibitors.
Topics: Adolescent; Animals; Child; Child, Preschool; Chloroquine; Cimetidine; Cytochrome P-450 Enzyme Inhib | 1993 |