desipramine has been researched along with Long QT Syndrome in 7 studies
Desipramine: A tricyclic dibenzazepine compound that potentiates neurotransmission. Desipramine selectively blocks reuptake of norepinephrine from the neural synapse, and also appears to impair serotonin transport. This compound also possesses minor anticholinergic activity, through its affinity to muscarinic receptors.
desipramine : A dibenzoazepine consisting of 10,11-dihydro-5H-dibenzo[b,f]azepine substituted on nitrogen with a 3-(methylamino)propyl group.
Long QT Syndrome: A condition that is characterized by episodes of fainting (SYNCOPE) and varying degree of ventricular arrhythmia as indicated by the prolonged QT interval. The inherited forms are caused by mutation of genes encoding cardiac ion channel proteins. The two major forms are ROMANO-WARD SYNDROME and JERVELL-LANGE NIELSEN SYNDROME.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Desipramine is a tricyclic antidepressant for psychiatric disorders that can induce QT prolongation, which may lead to torsades de pointes." | 1.36 | Block of the human ether-a-go-go-related gene (hERG) K+ channel by the antidepressant desipramine. ( Hong, HK; Jo, SH; Lee, BH; Park, MH, 2010) |
| "No significant arrhythmias or tachycardias were observed." | 1.29 | ECG changes in pediatric patients on tricyclic antidepressants, desipramine, and imipramine. ( Giuffre, RM; Johnson, A; O'Malley, K, 1996) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 5 (71.43) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 2 (28.57) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Hong, HK | 1 |
| Park, MH | 1 |
| Lee, BH | 1 |
| Jo, SH | 1 |
| Dennis, AT | 1 |
| Nassal, D | 1 |
| Deschenes, I | 1 |
| Thomas, D | 1 |
| Ficker, E | 1 |
| Waslick, B | 1 |
| Alderton, HR | 1 |
| Oesterheld, J | 1 |
| Johnson, A | 1 |
| Giuffre, RM | 1 |
| O'Malley, K | 1 |
| Smith, RH | 1 |
1 review available for desipramine and Long QT Syndrome
| Article | Year |
|---|---|
Tricyclic medication in children and the QT interval: case report and discussion.
Topics: Amitriptyline; Antidepressive Agents, Tricyclic; Attention Deficit Disorder with Hyperactivity; Chil | 1995 |
6 other studies available for desipramine and Long QT Syndrome
| Article | Year |
|---|---|
Block of the human ether-a-go-go-related gene (hERG) K+ channel by the antidepressant desipramine.
Topics: Animals; Antidepressive Agents, Tricyclic; Desipramine; ERG1 Potassium Channel; Ether-A-Go-Go Potass | 2010 |
Antidepressant-induced ubiquitination and degradation of the cardiac potassium channel hERG.
Topics: Animals; Antidepressive Agents, Tricyclic; Desipramine; Endocytosis; Endoplasmic Reticulum; ERG1 Pot | 2011 |
Cardiac effects of desipramine.
Topics: Adolescent; Cardiac Complexes, Premature; Child; Desipramine; Electrocardiography; Humans; Long QT S | 1995 |
TCA cardiotoxicity: the latest.
Topics: Adolescent; Antidepressive Agents, Tricyclic; Biotransformation; Child; Clomipramine; Desipramine; D | 1996 |
ECG changes in pediatric patients on tricyclic antidepressants, desipramine, and imipramine.
Topics: Adolescent; Alberta; Antidepressive Agents, Tricyclic; Arrhythmias, Cardiac; Attention Deficit Disor | 1996 |
Desipramine and the EKG.
Topics: Adolescent; Depressive Disorder; Desipramine; Dose-Response Relationship, Drug; Electrocardiography; | 1992 |