desipramine has been researched along with Hypothyroidism in 11 studies
Desipramine: A tricyclic dibenzazepine compound that potentiates neurotransmission. Desipramine selectively blocks reuptake of norepinephrine from the neural synapse, and also appears to impair serotonin transport. This compound also possesses minor anticholinergic activity, through its affinity to muscarinic receptors.
desipramine : A dibenzoazepine consisting of 10,11-dihydro-5H-dibenzo[b,f]azepine substituted on nitrogen with a 3-(methylamino)propyl group.
Hypothyroidism: A syndrome that results from abnormally low secretion of THYROID HORMONES from the THYROID GLAND, leading to a decrease in BASAL METABOLIC RATE. In its most severe form, there is accumulation of MUCOPOLYSACCHARIDES in the SKIN and EDEMA, known as MYXEDEMA. It may be primary or secondary due to other pituitary disease, or hypothalamic dysfunction.
| Excerpt | Relevance | Reference |
|---|---|---|
| " Experimental hypothyroidism (28-day propylthiouracil treatment) has no significant effect on System L-like transport of the amino acid tryptophan in adipocytes." | 7.71 | Effect of hypothyroidism on pathways for iodothyronine and tryptophan uptake into rat adipocytes. ( Collingwood, CJ; Ritchie, JW; Taylor, PM, 2001) |
| "05) decrease in brain uptake of both labeled T3 (T3) and labeled thyroxine (T4) across the spectrum of thyroid states from hypothyroid (HYPO) to euthyroid to T4-induced hyperthyroid." | 7.69 | An acute dose of desmethylimipramine inhibits brain uptake of [125I]3,3',5-triiodothyronine (T3) in thyroxine-induced but not T3-induced hyperthyroid rats: implications for tricyclic antidepressant therapy. ( Dratman, MB; Gordon, JT; Greenberg, J; Tomlinson, EE, 1994) |
| " Experimental hypothyroidism (28-day propylthiouracil treatment) has no significant effect on System L-like transport of the amino acid tryptophan in adipocytes." | 3.71 | Effect of hypothyroidism on pathways for iodothyronine and tryptophan uptake into rat adipocytes. ( Collingwood, CJ; Ritchie, JW; Taylor, PM, 2001) |
| "05) decrease in brain uptake of both labeled T3 (T3) and labeled thyroxine (T4) across the spectrum of thyroid states from hypothyroid (HYPO) to euthyroid to T4-induced hyperthyroid." | 3.69 | An acute dose of desmethylimipramine inhibits brain uptake of [125I]3,3',5-triiodothyronine (T3) in thyroxine-induced but not T3-induced hyperthyroid rats: implications for tricyclic antidepressant therapy. ( Dratman, MB; Gordon, JT; Greenberg, J; Tomlinson, EE, 1994) |
| " We examined effects of thyroid hormone administration or production of hypothyroidism with methimazole on receptors associated with regulation of noradrenergic function." | 3.67 | Thyroid hormone and norepinephrine: effects on alpha-2, beta, and reuptake sites in cerebral cortex and heart. ( Swann, AC, 1988) |
| "A 24-year-old woman with a unipolar depression had an augmented thyroid-stimulating hormone response to thyrotropin-releasing hormone (TRH), suggesting subclinical hypothyroidism." | 1.26 | Does subclinical hypothyroidism predispose to tricyclic-induced rapid mood cycles? ( Extein, I; Gold, MS; Pottash, AL, 1982) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 8 (72.73) | 18.7374 |
| 1990's | 2 (18.18) | 18.2507 |
| 2000's | 1 (9.09) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Schwarcz, G | 1 |
| Halaris, A | 1 |
| Baxter, L | 1 |
| Escobar, J | 1 |
| Thompson, M | 1 |
| Young, M | 1 |
| Sternbach, HA | 1 |
| Pottash, AL | 2 |
| Extein, I | 2 |
| Gold, MS | 2 |
| Gordon, JT | 2 |
| Tomlinson, EE | 2 |
| Greenberg, J | 2 |
| Dratman, MB | 2 |
| Martens, DA | 1 |
| Ritchie, JW | 1 |
| Collingwood, CJ | 1 |
| Taylor, PM | 1 |
| Rastogi, RB | 1 |
| Singhal, RL | 1 |
| Hrdina, PD | 1 |
| Mason, GA | 1 |
| Bondy, SC | 1 |
| Nemeroff, CB | 1 |
| Walker, CH | 1 |
| Prange, AJ | 1 |
| Swann, AC | 1 |
| Martin, P | 1 |
| Massol, J | 1 |
| Belon, JP | 1 |
| Gaudel, G | 1 |
| Soubrié, P | 1 |
| Avni, J | 1 |
| Edelstein, EL | 1 |
| Khazan, N | 1 |
| Sulman, FG | 1 |
11 other studies available for desipramine and Hypothyroidism
| Article | Year |
|---|---|
Normal thyroid function in desipramine nonresponders converted to responders by the addition of L-triiodothyronine.
Topics: Adult; Depressive Disorder; Desipramine; Drug Synergism; Drug Therapy, Combination; Female; Humans; | 1984 |
Identifying depression secondary to lithium-induced hypothyroidism.
Topics: Bipolar Disorder; Depressive Disorder; Desipramine; Dose-Response Relationship, Drug; Drug Therapy, | 1984 |
Does subclinical hypothyroidism predispose to tricyclic-induced rapid mood cycles?
Topics: Adult; Bipolar Disorder; Depressive Disorder; Desipramine; Female; Humans; Hypothyroidism; Lithium; | 1982 |
An acute dose of desmethylimipramine inhibits brain uptake of [125I]3,3',5-triiodothyronine (T3) in thyroxine-induced but not T3-induced hyperthyroid rats: implications for tricyclic antidepressant therapy.
Topics: Analysis of Variance; Animals; Antidepressive Agents, Tricyclic; Brain; Desipramine; Dose-Response R | 1994 |
Desmethylimipramine, a potent inhibitor of synaptosomal norepinephrine uptake, has diverse effects on thyroid hormone processing in rat brain. I. Effects on in vivo uptake of 125I-labeled thyroid hormones in rat brain.
Topics: Animals; Brain; Desipramine; Hyperthyroidism; Hypothyroidism; Iodine Radioisotopes; Kinetics; Male; | 1993 |
Effect of hypothyroidism on pathways for iodothyronine and tryptophan uptake into rat adipocytes.
Topics: Adipocytes; Amino Acids, Cyclic; Animals; Antigens, CD; Biological Transport; Carrier Proteins; Desi | 2001 |
Influence of desmethylimipramine on some neurochemical alterations during experimental hypothyroidism.
Topics: Acetylcholine; Animals; Brain; Brain Chemistry; Desipramine; Dopamine; Female; Hypothyroidism; Methi | 1975 |
The effects of thyroid state on beta-adrenergic and serotonergic receptors in rat brain.
Topics: Animals; Brain; Cerebellum; Corpus Striatum; Desipramine; Hippocampus; Hyperthyroidism; Hypothyroidi | 1987 |
Thyroid hormone and norepinephrine: effects on alpha-2, beta, and reuptake sites in cerebral cortex and heart.
Topics: Animals; Cerebral Cortex; Desipramine; Dihydroalprenolol; Heart; Hypothyroidism; Male; Methimazole; | 1988 |
Thyroid function and reversal by antidepressant drugs of depressive-like behavior (escape deficits) in rats.
Topics: Animals; Antidepressive Agents; Brain; Clomipramine; Desipramine; Dose-Response Relationship, Drug; | 1987 |
Comparative study of imipramine, amitriptyline and their desmethyl analogues in the hypothyroid rat.
Topics: Amitriptyline; Animals; Blepharoptosis; Desipramine; Exploratory Behavior; Female; Hypothyroidism; I | 1967 |