desipramine has been researched along with Hypothermia in 20 studies
Desipramine: A tricyclic dibenzazepine compound that potentiates neurotransmission. Desipramine selectively blocks reuptake of norepinephrine from the neural synapse, and also appears to impair serotonin transport. This compound also possesses minor anticholinergic activity, through its affinity to muscarinic receptors.
desipramine : A dibenzoazepine consisting of 10,11-dihydro-5H-dibenzo[b,f]azepine substituted on nitrogen with a 3-(methylamino)propyl group.
Hypothermia: Lower than normal body temperature, especially in warm-blooded animals.
| Excerpt | Relevance | Reference |
|---|---|---|
| "The reversal of hypothermia, induced by reserpine or by a high (16 mg) dose of apomorphine, in male Swiss mice, does not seem to utilize a common mechanism." | 7.68 | Desipramine and nortriptyline antagonize apomorphine and reserpine hypothermia by a different mechanism. ( Borsini, F; Lecci, A; Meli, A; Volterra, G, 1990) |
| "This study examined the effects of acute and chronic desipramine, 24-h total sleep deprivation (TSD) and 96-h REM sleep deprivation (REMSD) on physostigmine-induced hypothermia, analgesia and behaviour." | 3.72 | Functional reactivity of central cholinergic systems following desipramine treatments and sleep deprivation. ( Murugaiah, KD; Ukponmwan, OE, 2003) |
| ") with 6-hydroxydopamine (6OHDA) (50 micrograms per mouse), as soon as the hypothermia elicited by the neurotoxin had vanished (3 hr), the hypothermic effect induced by the direct D2 dopamine receptor agonist RU 24926 (1 mg/kg, s." | 3.69 | Rapid and long lasting reduction of the hypothermic effect of a D2 dopamine agonist after an intracerebroventricular injection of 6-hydroxydopamine. ( Costentin, J; Dourmap, N; Suaudeau, C, 1995) |
| " Potential antidepressant activity in this subset was assayed in three rodent models--the antagonism of reserpine-induced hypothermia, the antagonism of histamine-induced ACTH release, and the ability to reduce noradrenergic responsiveness in the rat pineal gland." | 3.68 | 2-Phenyl-2-(1-hydroxycycloalkyl)ethylamine derivatives: synthesis and antidepressant activity. ( Andree, T; Bicksler, J; Butch, J; Fletcher, H; Husbands, GE; James, MN; Moyer, JA; Muth, EA; Stack, G; Yardley, JP, 1990) |
| "The reversal of hypothermia, induced by reserpine or by a high (16 mg) dose of apomorphine, in male Swiss mice, does not seem to utilize a common mechanism." | 3.68 | Desipramine and nortriptyline antagonize apomorphine and reserpine hypothermia by a different mechanism. ( Borsini, F; Lecci, A; Meli, A; Volterra, G, 1990) |
| " On the contrary, the hypothermia is partly antagonized by norepinephrine uptake inhibitors (desipramine, nomifensine, viloxazine, maprotiline, protryptiline), as well as amfonelic acid." | 3.67 | Involvement of norepinephrine neurons in the hypothermia induced by intracerebroventricular administration of 6-hydroxydopamine in mice, evidenced by antidepressants. ( Costentin, J; Leroux-Nicollet, I; Panissaud, C, 1988) |
| " Proadifen antagonized the action of IMI when investigated in reserpine hypothermia and ptosis and in the behavioral despair test." | 3.66 | Influence of proadifen, an inhibitor of the metabolism of drugs, on the action of imipramine and desipramine in rats. ( Daniel, W; Maj, J; Rogóz, Z; Skuza, G; Sowińska, H, 1981) |
| "3 A second cannabis extract (II) with a different ratio of cannabinoids (also administered in dosage equivalent to 10 mg Delta(9)-THC/kg) failed to affect pentobarbitone anaesthesia in mice." | 1.25 | Interaction of cannabis and general anaesthetic agents in mice. ( Chesher, GB; Jackson, DM; Starmer, GA, 1974) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 12 (60.00) | 18.7374 |
| 1990's | 4 (20.00) | 18.2507 |
| 2000's | 2 (10.00) | 29.6817 |
| 2010's | 2 (10.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Yardley, JP | 1 |
| Husbands, GE | 1 |
| Stack, G | 1 |
| Butch, J | 1 |
| Bicksler, J | 1 |
| Moyer, JA | 1 |
| Muth, EA | 1 |
| Andree, T | 1 |
| Fletcher, H | 1 |
| James, MN | 1 |
| Balsamo, A | 1 |
| Giorgi, I | 1 |
| Lapucci, A | 1 |
| Lucacchini, A | 1 |
| Macchia, B | 1 |
| Macchia, F | 1 |
| Martini, C | 1 |
| Rossi, A | 1 |
| Vacher, B | 1 |
| Funes, P | 1 |
| Chopin, P | 1 |
| Cussac, D | 1 |
| Heusler, P | 1 |
| Tourette, A | 1 |
| Marien, M | 1 |
| Overstreet, DH | 2 |
| Fredericks, K | 1 |
| Knapp, D | 1 |
| Breese, G | 1 |
| McMichael, J | 1 |
| Murugaiah, KD | 1 |
| Ukponmwan, OE | 1 |
| METYSOVA, J | 1 |
| METYS, J | 1 |
| Soliman, KF | 1 |
| Gabriel, NN | 1 |
| Maj, J | 1 |
| Daniel, W | 1 |
| Rogóz, Z | 1 |
| Skuza, G | 1 |
| Sowińska, H | 1 |
| Suaudeau, C | 1 |
| Dourmap, N | 1 |
| Costentin, J | 2 |
| Gerber, SH | 1 |
| Heyer, C | 1 |
| Krüger, C | 1 |
| Hagl, S | 1 |
| Kübler, W | 1 |
| Haass, M | 1 |
| Cousins, MS | 1 |
| Vosmer, G | 1 |
| Seiden, LS | 1 |
| Volterra, G | 1 |
| Borsini, F | 1 |
| Lecci, A | 1 |
| Meli, A | 1 |
| Okiyama, M | 1 |
| Ueno, K | 1 |
| Ohmori, S | 1 |
| Igarashi, T | 1 |
| Kitagawa, H | 1 |
| Leroux-Nicollet, I | 1 |
| Panissaud, C | 1 |
| Chesher, GB | 1 |
| Jackson, DM | 1 |
| Starmer, GA | 1 |
| Jori, A | 1 |
| Annoni, F | 1 |
| Bianchetti, A | 1 |
| Nakamura, K | 1 |
| Thoenen, H | 1 |
| Cooper, F | 2 |
| Leonard, BE | 1 |
| Schnieden, H | 2 |
| Zetler, G | 1 |
20 other studies available for desipramine and Hypothermia
| Article | Year |
|---|---|
2-Phenyl-2-(1-hydroxycycloalkyl)ethylamine derivatives: synthesis and antidepressant activity.
Topics: Adrenocorticotropic Hormone; Animals; Antidepressive Agents; Binding, Competitive; Biological Assay; | 1990 |
3-[(2-ethoxyphenoxy)methyl]piperidine derivatives. Synthesis and antidepressant activity.
Topics: Animals; Antidepressive Agents; Blepharoptosis; Brain; Desipramine; Dopamine; Drug Evaluation, Precl | 1987 |
Rigid analogues of the α2-adrenergic blocker atipamezole: small changes, big consequences.
Topics: Adrenergic alpha-2 Receptor Antagonists; Adrenergic alpha-Antagonists; Animals; Antihypertensive Age | 2010 |
Nerve growth factor (NGF) has novel antidepressant-like properties in rats.
Topics: Animals; Antidepressive Agents, Second-Generation; Antidepressive Agents, Tricyclic; Brain; Corticos | 2010 |
Functional reactivity of central cholinergic systems following desipramine treatments and sleep deprivation.
Topics: Adrenergic Uptake Inhibitors; Analgesia; Animals; Body Temperature; Central Nervous System; Desipram | 2003 |
PHARMACOLOGICAL PROPERTIES OF THE DESMETHYL DERIVATIVES OF SOME ANTIDEPRESSANTS OF IMIPRAMINE TYPE.
Topics: Amitriptyline; Animals; Antidepressive Agents; Caffeine; Desipramine; Hypothermia; Hypothermia, Indu | 1965 |
Effect of biogenic amines reuptake inhibition on ethanol induced hypothermia.
Topics: Animals; Biogenic Amines; Clomipramine; Desipramine; Ethanol; Hypothermia; Male; Mice; Mice, Inbred | 1983 |
Influence of proadifen, an inhibitor of the metabolism of drugs, on the action of imipramine and desipramine in rats.
Topics: Animals; Blepharoptosis; Desipramine; Hypothermia; Imipramine; Male; Motor Activity; Proadifen; Rats | 1981 |
Rapid and long lasting reduction of the hypothermic effect of a D2 dopamine agonist after an intracerebroventricular injection of 6-hydroxydopamine.
Topics: Animals; Desipramine; Dose-Response Relationship, Drug; Hypothermia; Injections, Spinal; Male; Mice; | 1995 |
Influence of Bretschneider's cardioplegia on norepinephrine release from isolated perfused guinea-pig hearts.
Topics: Adrenergic Uptake Inhibitors; Amiloride; Animals; Desipramine; Dose-Response Relationship, Drug; Fev | 1999 |
Rats selectively bred for responsiveness to 5-hydroxytryptamine(1A) receptor stimulation: differences in differential reinforcement of low rate 72-second performance and response to serotonergic drugs.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Adrenergic Uptake Inhibitors; Age Factors; Animals; Behavior | 2000 |
Desipramine and nortriptyline antagonize apomorphine and reserpine hypothermia by a different mechanism.
Topics: Animals; Apomorphine; Body Temperature; Desipramine; Haloperidol; Hypothermia; Injections, Intraperi | 1990 |
Drug interactions between imipramine and benzodiazepines in rats.
Topics: Animals; Anti-Anxiety Agents; Blood Proteins; Brain; Chromatography, High Pressure Liquid; Desiprami | 1988 |
Involvement of norepinephrine neurons in the hypothermia induced by intracerebroventricular administration of 6-hydroxydopamine in mice, evidenced by antidepressants.
Topics: Animals; Antidepressive Agents; Brain; Desipramine; Dose-Response Relationship, Drug; Hydroxydopamin | 1988 |
Interaction of cannabis and general anaesthetic agents in mice.
Topics: Anesthesia, General; Animals; Cannabis; Desipramine; Dronabinol; Drug Synergism; Ethyl Ethers; Fencl | 1974 |
Metabolic effects induced by the interaction of reserpine with desipramine.
Topics: Adipose Tissue; Adipose Tissue, Brown; Animals; Blood Glucose; Body Temperature; Chlorpromazine; Des | 1968 |
Hypothermia induced by intraventricular administration of 6-hydroxydopamine in rats.
Topics: Adrenergic alpha-Antagonists; Adrenergic beta-Antagonists; Animals; Brain; Cocaine; Desipramine; Dop | 1971 |
The role of catecholamines in the reversal of reserpine-induced hypothermia in mice by desipramine and chlorpromazine.
Topics: Animals; Body Temperature; Catecholamines; Chlorpromazine; Desipramine; Dihydroxyphenylalanine; Dose | 1972 |
Study of the mechanisms of action of desipramine and chlorpromazine in reversing reserpine-induced hypothermia in mice.
Topics: Adrenalectomy; Animals; Chlorisondamine; Chlorpromazine; Desipramine; Hypothermia; Male; Mice; Reser | 1972 |
Cataleptic state and hypothermia in mice, caused by central cholinergic stimulation and antagonized by anticholinergic and antidepressant drugs.
Topics: Amitriptyline; Animals; Antidepressive Agents; Atropine; Catalepsy; Desipramine; Hexamethonium Compo | 1968 |