desipramine has been researched along with Hypotension in 9 studies
Desipramine: A tricyclic dibenzazepine compound that potentiates neurotransmission. Desipramine selectively blocks reuptake of norepinephrine from the neural synapse, and also appears to impair serotonin transport. This compound also possesses minor anticholinergic activity, through its affinity to muscarinic receptors.
desipramine : A dibenzoazepine consisting of 10,11-dihydro-5H-dibenzo[b,f]azepine substituted on nitrogen with a 3-(methylamino)propyl group.
Hypotension: Abnormally low BLOOD PRESSURE that can result in inadequate blood flow to the brain and other vital organs. Common symptom is DIZZINESS but greater negative impacts on the body occur when there is prolonged depravation of oxygen and nutrients.
| Excerpt | Relevance | Reference |
|---|---|---|
| " Administration of the nitric oxide synthase (NOS) inhibitor NG-nitro-L-arginine methyl ester-(L-NAME) 15 min after DMI reversed hypotension within 5 min (P < 0." | 7.69 | Nitric oxide contributes to desipramine-induced hypotension in rats. ( Keyler, DE; Pentel, PR; Scarlett, W; Wananukul, W, 1996) |
| "The effect of drug-specific antibody Fab' fragment on desipramine (DMI) toxicity was studied in anesthetized rats to determine 1) whether DMI-induced hypotension can be reversed, and 2) whether the effect of this Fab' fragment can be enhanced by the concurrent administration of hypertonic NaHCO3." | 7.68 | Reversal of desipramine toxicity in rats using drug-specific antibody Fab' fragment: effects on hypotension and interaction with sodium bicarbonate. ( Brunn, GJ; Keyler, DE; Pentel, PR; Pond, SM, 1992) |
| "The administration of CaCl2 or 4-aminopyridine did not reverse tricyclic antidepressant-induced hypotension in rats." | 3.69 | Effect of calcium chloride and 4-aminopyridine therapy on desipramine toxicity in rats. ( Keyler, DE; Pentel, PR; Wananukul, W, 1996) |
| " Administration of the nitric oxide synthase (NOS) inhibitor NG-nitro-L-arginine methyl ester-(L-NAME) 15 min after DMI reversed hypotension within 5 min (P < 0." | 3.69 | Nitric oxide contributes to desipramine-induced hypotension in rats. ( Keyler, DE; Pentel, PR; Scarlett, W; Wananukul, W, 1996) |
| "The effect of drug-specific antibody Fab' fragment on desipramine (DMI) toxicity was studied in anesthetized rats to determine 1) whether DMI-induced hypotension can be reversed, and 2) whether the effect of this Fab' fragment can be enhanced by the concurrent administration of hypertonic NaHCO3." | 3.68 | Reversal of desipramine toxicity in rats using drug-specific antibody Fab' fragment: effects on hypotension and interaction with sodium bicarbonate. ( Brunn, GJ; Keyler, DE; Pentel, PR; Pond, SM, 1992) |
| "Correction of respiratory acidosis by discontinuation of inhaled CO2 did not improve QRS duration or mean arterial pressure." | 1.27 | Efficacy and mechanism of action of sodium bicarbonate in the treatment of desipramine toxicity in rats. ( Benowitz, N; Pentel, P, 1984) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 5 (55.56) | 18.7374 |
| 1990's | 4 (44.44) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Pentel, P | 1 |
| Benowitz, N | 1 |
| Marshall, JB | 1 |
| Forker, AD | 1 |
| Carpenter, P | 1 |
| Gobel, FL | 1 |
| Hulsing, DJ | 1 |
| Wananukul, W | 2 |
| Keyler, DE | 3 |
| Pentel, PR | 3 |
| Scarlett, W | 1 |
| Benazzi, F | 1 |
| Brunn, GJ | 1 |
| Pond, SM | 1 |
| Schuckit, M | 1 |
| Robins, E | 1 |
| Feighner, J | 1 |
| Tissot, R | 1 |
| Gaillard, JM | 1 |
| Guggisberg, M | 1 |
| Gauthier, G | 1 |
| de Ajuriaguerra, J | 1 |
1 review available for desipramine and Hypotension
| Article | Year |
|---|---|
Cardiovascular effects of tricyclic antidepressant drugs: therapeutic usage, overdose, and management of complications.
Topics: Adult; Aged; Amitriptyline; Antidepressive Agents, Tricyclic; Arrhythmias, Cardiac; Cardiovascular S | 1982 |
8 other studies available for desipramine and Hypotension
| Article | Year |
|---|---|
Efficacy and mechanism of action of sodium bicarbonate in the treatment of desipramine toxicity in rats.
Topics: Acidosis, Respiratory; Animals; Bicarbonates; Blood Pressure; Desipramine; Electrocardiography; Hear | 1984 |
Desipramine cardiac toxicity.
Topics: Adult; Bretylium Tosylate; Depressive Disorder; Desipramine; Heart Ventricles; Humans; Hypotension; | 1982 |
Effect of calcium chloride and 4-aminopyridine therapy on desipramine toxicity in rats.
Topics: 4-Aminopyridine; Animals; Antidepressive Agents, Tricyclic; Arrhythmias, Cardiac; Blood Pressure; Br | 1996 |
Nitric oxide contributes to desipramine-induced hypotension in rats.
Topics: Animals; Antidepressive Agents, Tricyclic; Arginine; Desipramine; Drug Interactions; Hemodynamics; H | 1996 |
Dangerous interaction with nefazodone added to fluoxetine, desipramine, venlafaxine, valproate and clonazepam combination therapy.
Topics: Adult; Antidepressive Agents; Clonazepam; Cyclohexanols; Depressive Disorder; Desipramine; Drug Ther | 1997 |
Reversal of desipramine toxicity in rats using drug-specific antibody Fab' fragment: effects on hypotension and interaction with sodium bicarbonate.
Topics: Animals; Bicarbonates; Desipramine; Drug Synergism; Electrocardiography; Hypotension; Immunoglobulin | 1992 |
Tricyclic antidepressants and monoamine oxidase inhibitors.
Topics: Administration, Oral; Adolescent; Adult; Aged; Amitriptyline; Animals; Depression; Desipramine; Drug | 1971 |
[Treatment of Parkinsonism with oral L-DOPA combined with a decarboxylase inhibitor (Ro IV 46.02)].
Topics: Adult; Aged; Anemia, Hemolytic; Aromatic Amino Acid Decarboxylase Inhibitors; Blood Cell Count; Carb | 1969 |