desipramine has been researched along with Hypotension, Orthostatic in 11 studies
Desipramine: A tricyclic dibenzazepine compound that potentiates neurotransmission. Desipramine selectively blocks reuptake of norepinephrine from the neural synapse, and also appears to impair serotonin transport. This compound also possesses minor anticholinergic activity, through its affinity to muscarinic receptors.
desipramine : A dibenzoazepine consisting of 10,11-dihydro-5H-dibenzo[b,f]azepine substituted on nitrogen with a 3-(methylamino)propyl group.
Hypotension, Orthostatic: A significant drop in BLOOD PRESSURE after assuming a standing position. Orthostatic hypotension is a finding, and defined as a 20-mm Hg decrease in systolic pressure or a 10-mm Hg decrease in diastolic pressure 3 minutes after the person has risen from supine to standing. Symptoms generally include DIZZINESS, blurred vision, and SYNCOPE.
| Excerpt | Relevance | Reference |
|---|---|---|
| "The use of desipramine in treating major depressive disorder in the hospitalized medically ill patient is described." | 3.67 | Use of desipramine in the medically ill. ( Cavanaugh, SV, 1984) |
| "All patients with PD and orthostatic hypotension had abnormal blood pressure responses to the Valsalva maneuver and septal and lateral ventricular myocardial concentrations of 6-[(18)F]fluorodopamine-derived radioactivity >2 SD below the normal mean." | 2.70 | Orthostatic hypotension from sympathetic denervation in Parkinson's disease. ( Bruce, SR; Dendi, R; Goldstein, DS; Holmes, CS; Li, ST, 2002) |
| "Symptomatic orthostatic hypotension, the most common side effect encountered, occurred early in treatment at low desipramine plasma concentrations." | 1.26 | Major adverse reactions during desipramine treatment: relationship to plasma drug concentrations, concomitant antipsychotic treatment, and patient characteristics. ( Bock, J; Bowers, MB; Jatlow, PI; Nelson, JC; Quinlan, DM, 1982) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 7 (63.64) | 18.7374 |
| 1990's | 2 (18.18) | 18.2507 |
| 2000's | 2 (18.18) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Flores, DL | 1 |
| Alvarado, I | 1 |
| Wong, ML | 1 |
| Licinio, J | 1 |
| Flockhart, D | 1 |
| Nelson, JC | 3 |
| Jatlow, PI | 1 |
| Bock, J | 1 |
| Quinlan, DM | 1 |
| Bowers, MB | 1 |
| Rosenbaum, JF | 1 |
| Cavanaugh, SV | 1 |
| Kaminer, Y | 1 |
| Goldstein, DS | 1 |
| Holmes, CS | 1 |
| Dendi, R | 1 |
| Bruce, SR | 1 |
| Li, ST | 1 |
| Esler, M | 1 |
| Jackman, G | 1 |
| Bobik, A | 1 |
| Kelleher, D | 1 |
| Jennings, G | 1 |
| Leonard, P | 1 |
| Skews, H | 1 |
| Korner, P | 1 |
| Price, LH | 1 |
| Heninger, GR | 1 |
| Pals, DT | 1 |
| DeGraaf, GL | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| [NCT00265291] | Phase 2 | 700 participants (Actual) | Interventional | 1999-11-30 | Completed | ||
| The Effects of Supplementing Tyrosine on Blood Pressure in Parkinson's Disease[NCT01676103] | Phase 1/Phase 2 | 40 participants (Actual) | Interventional | 2012-09-30 | Completed | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
2 reviews available for desipramine and Hypotension, Orthostatic
| Article | Year |
|---|---|
Use of desipramine in depressed inpatients.
Topics: Age Factors; Clinical Trials as Topic; Delusions; Depressive Disorder; Desipramine; Dose-Response Re | 1984 |
Treatment of outpatients with desipramine.
Topics: Ambulatory Care; Anxiety Disorders; Body Weight; Depressive Disorder; Desipramine; Drug Administrati | 1984 |
2 trials available for desipramine and Hypotension, Orthostatic
| Article | Year |
|---|---|
Use of desipramine in depressed inpatients.
Topics: Age Factors; Clinical Trials as Topic; Delusions; Depressive Disorder; Desipramine; Dose-Response Re | 1984 |
Orthostatic hypotension from sympathetic denervation in Parkinson's disease.
Topics: Adrenergic Uptake Inhibitors; Aged; Autonomic Nervous System Diseases; Brain; Catecholamines; Desipr | 2002 |
8 other studies available for desipramine and Hypotension, Orthostatic
| Article | Year |
|---|---|
Clinical implications of genetic polymorphism of CYP2D6 in Mexican Americans.
Topics: Adult; Cytochrome P-450 CYP2D6; Depression; Desipramine; Double-Blind Method; Fluoxetine; Humans; Hy | 2004 |
Major adverse reactions during desipramine treatment: relationship to plasma drug concentrations, concomitant antipsychotic treatment, and patient characteristics.
Topics: Adult; Age Factors; Aged; Antipsychotic Agents; Constipation; Delirium; Depressive Disorder; Desipra | 1982 |
Use of desipramine in the medically ill.
Topics: Arrhythmias, Cardiac; Cardiovascular System; Depressive Disorder; Desipramine; Disease; Drug Adminis | 1984 |
Cocaine craving.
Topics: Adolescent; Amitriptyline; Cocaine; Desipramine; Humans; Hypotension, Orthostatic; Male; Risk Factor | 1994 |
Initiation of tricyclic treatment at full dose.
Topics: Amitriptyline; Antidepressive Agents, Tricyclic; Depressive Disorder; Desipramine; Drug Administrati | 1994 |
Determination of norepinephrine apparent release rate and clearance in humans.
Topics: Catechol O-Methyltransferase; Desipramine; Humans; Hypotension, Orthostatic; Male; Metabolic Clearan | 1979 |
Can yohimbine be used to treat orthostatic hypotension associated with the use of desipramine and other antidepressants? What general and/or specific strategy do you recommend for treating orthostatic hypotension?
Topics: Desipramine; Humans; Hypotension, Orthostatic; Yohimbine | 1988 |
Cardiovascular effects of losulazine hydrochloride, a peripheral norepinephrine-depleting agent, in nonhuman primates.
Topics: Animals; Antihypertensive Agents; Blood Pressure; Cardiac Output; Chlorisondamine; Desipramine; Dose | 1985 |