desipramine has been researched along with Hyperactivity, Motor in 11 studies
Desipramine: A tricyclic dibenzazepine compound that potentiates neurotransmission. Desipramine selectively blocks reuptake of norepinephrine from the neural synapse, and also appears to impair serotonin transport. This compound also possesses minor anticholinergic activity, through its affinity to muscarinic receptors.
desipramine : A dibenzoazepine consisting of 10,11-dihydro-5H-dibenzo[b,f]azepine substituted on nitrogen with a 3-(methylamino)propyl group.
| Excerpt | Relevance | Reference |
|---|---|---|
| "In the present study we have investigated the effects of compounds which increase synaptic levels of noradrenaline on cocaine-induced seizures and lethality in mice." | 7.68 | Noradrenergic mechanisms appear not to be involved in cocaine-induced seizures and lethality. ( Ball, DM; Jackson, HC; Nutt, DJ, 1990) |
| "In the present study we have investigated the effects of compounds which increase synaptic levels of noradrenaline on cocaine-induced seizures and lethality in mice." | 3.68 | Noradrenergic mechanisms appear not to be involved in cocaine-induced seizures and lethality. ( Ball, DM; Jackson, HC; Nutt, DJ, 1990) |
| " In the olfactory bulbectomized rat model of depression, chronic administration (14 days) of metyrapone (50 mg/kg b." | 1.30 | Metyrapone displays antidepressant-like properties in preclinical paradigms. ( Cryan, JF; Harkin, A; Healy, DG; Kelly, JP; Leonard, BE, 1999) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 7 (63.64) | 18.7374 |
| 1990's | 2 (18.18) | 18.2507 |
| 2000's | 1 (9.09) | 29.6817 |
| 2010's | 1 (9.09) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Tanaka, T | 1 |
| Ago, Y | 1 |
| Umehara, C | 1 |
| Imoto, E | 1 |
| Hasebe, S | 1 |
| Hashimoto, H | 1 |
| Takuma, K | 1 |
| Matsuda, T | 1 |
| Mahesh, R | 1 |
| Rajkumar, R | 1 |
| Minasri, B | 1 |
| Venkatesha Perumal, R | 1 |
| Speciale, SG | 1 |
| Karoum, F | 1 |
| Wyatt, RJ | 1 |
| Healy, DG | 1 |
| Harkin, A | 1 |
| Cryan, JF | 1 |
| Kelly, JP | 1 |
| Leonard, BE | 1 |
| Linnoila, M | 2 |
| Gualtieri, CT | 1 |
| Jobson, K | 1 |
| Staye, J | 1 |
| Roberts, DC | 1 |
| Zis, AP | 1 |
| Fibiger, HC | 1 |
| Jackson, HC | 1 |
| Ball, DM | 1 |
| Nutt, DJ | 1 |
| Donnelly, M | 1 |
| Zametkin, AJ | 1 |
| Rapoport, JL | 1 |
| Ismond, DR | 1 |
| Weingartner, H | 1 |
| Lane, E | 1 |
| Oliver, J | 1 |
| Potter, WZ | 1 |
| Olds, ME | 1 |
| Yuwiler, A | 1 |
| Ladisich, W | 2 |
| Volbehr, H | 2 |
| Matussek, N | 2 |
1 trial available for desipramine and Hyperactivity, Motor
| Article | Year |
|---|---|
Treatment of childhood hyperactivity with desipramine: plasma drug concentration, cardiovascular effects, plasma and urinary catecholamine levels, and clinical response.
Topics: Administration, Oral; Blood Pressure; Child; Clinical Trials as Topic; Cognition; Desipramine; Doubl | 1986 |
10 other studies available for desipramine and Hyperactivity, Motor
| Article | Year |
|---|---|
Role of Prefrontal Serotonergic and Dopaminergic Systems in Encounter-Induced Hyperactivity in Methamphetamine-Sensitized Mice.
Topics: 5,7-Dihydroxytryptamine; Animals; Central Nervous System Stimulants; Desipramine; Dopamine; Dopamine | 2017 |
Potential antidepressants: pharmacology of 2-(4-methyl piperazin-1-yl)-1,8-naphthyridine-3-carbonitrile in rodent behavioural models.
Topics: Animals; Antidepressive Agents; Antidepressive Agents, Second-Generation; Antidepressive Agents, Tri | 2007 |
Different effects of amphetamine and amfonelic acid on peripheral and central catecholamine metabolism.
Topics: 3,4-Dihydroxyphenylacetic Acid; 4-Butyrolactone; Amphetamine; Animals; Brain; Catecholamines; Caudat | 1980 |
Metyrapone displays antidepressant-like properties in preclinical paradigms.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Animals; Antidepressive Agents; Antidepressive Agents, Tricy | 1999 |
Characteristics of the therapeutic response to imipramine in hyperactive children.
Topics: Adolescent; Age Factors; Child; Child, Preschool; Desipramine; Drug Tolerance; Erythrocytes; Humans; | 1979 |
Ascending catecholamine pathways and amphetamine-induced locomotor activity: importance of dopamine and apparent non-involvement of norepinephrine.
Topics: Amphetamine; Animals; Caudate Nucleus; Cerebral Cortex; Desipramine; Dopamine; Habituation, Psychoph | 1975 |
Noradrenergic mechanisms appear not to be involved in cocaine-induced seizures and lethality.
Topics: Adrenergic alpha-Antagonists; Animals; Cocaine; Desipramine; Dioxanes; Hyperkinesis; Idazoxan; Injec | 1990 |
Comparison of hyperactivity in adult rats induced by neonatal intraventricular 6-hydroxydopamine following pargyline or desmethylimipramine treatment.
Topics: Age Factors; Animals; Animals, Newborn; Brain; Desipramine; Dopamine; Female; Hydroxydopamines; Hype | 1985 |
Biochemical and behavioural effect of amphetamine in DMI and Ro 4-1284 induced hyperactivity.
Topics: Amphetamine; Animals; Behavior; Desipramine; Humans; Hyperkinesis; Quinolizines; Rats | 1970 |
Paradoxical amphetamine effect in hyperactive rats in relation to norepinephrine metabolism.
Topics: Amino Acids; Amphetamine; Animals; Brain; Chlorine; Cocaine; Desipramine; Humans; Hyperkinesis; Ipro | 1970 |