desipramine has been researched along with Heroin Dependence in 7 studies
Desipramine: A tricyclic dibenzazepine compound that potentiates neurotransmission. Desipramine selectively blocks reuptake of norepinephrine from the neural synapse, and also appears to impair serotonin transport. This compound also possesses minor anticholinergic activity, through its affinity to muscarinic receptors.
desipramine : A dibenzoazepine consisting of 10,11-dihydro-5H-dibenzo[b,f]azepine substituted on nitrogen with a 3-(methylamino)propyl group.
Heroin Dependence: Strong dependence or addiction, both physiological and emotional, upon HEROIN.
| Excerpt | Relevance | Reference |
|---|---|---|
| "This 13-week, randomized, double-blind, placebo-controlled trial evaluated the efficacy of desipramine hydrochloride (0 or 150 mg/d) plus buprenorphine hydrochloride (12 mg/d) or methadone hydrochloride (65 mg/d) in 180 opioid-dependent cocaine abusers (124 men, 56 women)." | 9.09 | Desipramine in opioid-dependent cocaine abusers maintained on buprenorphine vs methadone. ( Feingold, A; Jatlow, P; Kosten, TR; Oliveto, AH; Schottenfeld, R, 1999) |
| "This 13-week, randomized, double-blind, placebo-controlled trial evaluated the efficacy of desipramine hydrochloride (0 or 150 mg/d) plus buprenorphine hydrochloride (12 mg/d) or methadone hydrochloride (65 mg/d) in 180 opioid-dependent cocaine abusers (124 men, 56 women)." | 5.09 | Desipramine in opioid-dependent cocaine abusers maintained on buprenorphine vs methadone. ( Feingold, A; Jatlow, P; Kosten, TR; Oliveto, AH; Schottenfeld, R, 1999) |
| "Thus, antisocial personality disorder was a poor prognostic factor for treatment retention and continued cocaine abuse, and medication did not improve treatment outcome for the ASP patients, but did for the non-ASP patients." | 2.67 | Antisocial personality disorder as a prognostic factor for pharmacotherapy of cocaine dependence. ( Kosten, T; Leal, J; Ziedonis, D, 1994) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 3 (42.86) | 18.7374 |
| 1990's | 3 (42.86) | 18.2507 |
| 2000's | 1 (14.29) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Oliveto, AH | 1 |
| Feingold, A | 1 |
| Schottenfeld, R | 1 |
| Jatlow, P | 1 |
| Kosten, TR | 1 |
| Tzschentke, TM | 1 |
| Magalas, Z | 1 |
| De Vry, J | 1 |
| Leal, J | 1 |
| Ziedonis, D | 1 |
| Kosten, T | 2 |
| Meyer, RE | 1 |
| Mendelson, JH | 1 |
| Mello, NK | 1 |
| Bozarth, MA | 1 |
| Wise, RA | 1 |
| Gawin, F | 1 |
| Schumann, B | 1 |
2 reviews available for desipramine and Heroin Dependence
| Article | Year |
|---|---|
New pharmacotherapies for cocaine dependence ... revisited.
Topics: Alcoholism; Cocaine; Desipramine; Disease Models, Animal; Double-Blind Method; Heroin Dependence; Hu | 1992 |
Clinical investigations of drug effects in women.
Topics: Buprenorphine; Cocaine; Desipramine; Female; Heroin Dependence; Humans; Male; Naltrexone; Opioid-Rel | 1986 |
2 trials available for desipramine and Heroin Dependence
| Article | Year |
|---|---|
Desipramine in opioid-dependent cocaine abusers maintained on buprenorphine vs methadone.
Topics: Adult; Analgesics, Opioid; Antidepressive Agents, Tricyclic; Buprenorphine; Cocaine-Related Disorder | 1999 |
Antisocial personality disorder as a prognostic factor for pharmacotherapy of cocaine dependence.
Topics: Adult; Amantadine; Antisocial Personality Disorder; Cocaine; Combined Modality Therapy; Comorbidity; | 1994 |
3 other studies available for desipramine and Heroin Dependence
| Article | Year |
|---|---|
Effects of venlafaxine and desipramine on heroin-induced conditioned place preference in the rat.
Topics: Animals; Antidepressive Agents, Second-Generation; Antidepressive Agents, Tricyclic; Association Lea | 2006 |
Involvement of the ventral tegmental dopamine system in opioid and psychomotor stimulant reinforcement.
Topics: Animals; Cocaine; Desipramine; Dopamine; Heroin; Heroin Dependence; Hydroxydopamines; Oxidopamine; P | 1986 |
Treating cocaine abusing methadone maintenance patients with desipramine.
Topics: Acquired Immunodeficiency Syndrome; Adult; Cocaine; Desipramine; Female; Heroin Dependence; Humans; | 1988 |