desipramine has been researched along with Glioma in 22 studies
Desipramine: A tricyclic dibenzazepine compound that potentiates neurotransmission. Desipramine selectively blocks reuptake of norepinephrine from the neural synapse, and also appears to impair serotonin transport. This compound also possesses minor anticholinergic activity, through its affinity to muscarinic receptors.
desipramine : A dibenzoazepine consisting of 10,11-dihydro-5H-dibenzo[b,f]azepine substituted on nitrogen with a 3-(methylamino)propyl group.
Glioma: Benign and malignant central nervous system neoplasms derived from glial cells (i.e., astrocytes, oligodendrocytes, and ependymocytes). Astrocytes may give rise to astrocytomas (ASTROCYTOMA) or glioblastoma multiforme (see GLIOBLASTOMA). Oligodendrocytes give rise to oligodendrogliomas (OLIGODENDROGLIOMA) and ependymocytes may undergo transformation to become EPENDYMOMA; CHOROID PLEXUS NEOPLASMS; or colloid cysts of the third ventricle. (From Escourolle et al., Manual of Basic Neuropathology, 2nd ed, p21)
| Excerpt | Relevance | Reference |
|---|---|---|
| " In the present study, desipramine (DMI), a representative of TCAs, was examined with respect to its apoptosis-inducing activity in rat C6 glioma cells and the underlying mechanism of action." | 7.77 | Desipramine induces apoptosis in rat glioma cells via endoplasmic reticulum stress-dependent CHOP pathway. ( Chen, HZ; Fang, C; Hou, LN; Ma, J; Peng, L; Qi, H; Qiu, Y; Xia, Z; Yang, L, 2011) |
| "To study desipramine (Des)-induced apoptosis and regulation of caspase 3 gene expression and [Ca2+]i homeostasis in rat glioma C6 cells." | 7.71 | Caspase 3 gene expression and [Ca2+]i homeostasis underlying desipramine-induced C6 glioma cell apoptosis. ( Chen, HZ; Jin, ZJ; Qi, H, 2002) |
| "Treatment of rat C6 glioma cells with the tricyclic antidepressant desipramine induces opioid binding." | 7.69 | A monoclonal anti-idiotypic antibody to opioid receptors labels desipramine-induced opioid binding sites on rat C6 glioma cells and attenuates thymidine incorporation into DNA. ( Barg, J; Belcheva, MM; Coscia, CJ; Johnson, FE; Levy, R; McHale, RJ; McLachlan, JA; Vogel, Z, 1994) |
| "The tricyclic antidepressant desipramine, when added to culture medium, gave rise in C6 rat glioma cells to a decrease of the activity of the enzyme asialofetuin sialyltransferase." | 7.68 | Effect of desipramine on a glycoprotein sialyltransferase activity in C6 cultured glioma cells. ( Baubichon-Cortay, H; Broquet, P; George, P; Louisot, P; Peschard, MJ, 1990) |
| "The effects of chlorpromazine (CPZ), desmethylimipramine (DMI) and propranolol (PRO) on phospholipid metabolism in C6 glioma cells were studied by following the incorporation of 32Pi, [U-14C]glycerol, [2-3H]glycerol and [1-14C]oleate into lipids." | 7.67 | Modifications of phospholipid metabolism induced by chlorpromazine, desmethylimipramine and propranolol in C6 glioma cells. ( Hauser, G; Leli, U, 1987) |
| "Rat glioma C6 cells, cultured in the presence of the tricyclic antidepressant desipramine, lost a significant number of beta-adrenergic receptors in a time- and dose-dependent manner." | 7.67 | Effect of the tricyclic antidepressant desipramine on beta-adrenergic receptors in cultured rat glioma C6 cells. ( Finberg, JP; Fishman, PH, 1987) |
| "Incubation for 48 hours of C6 glioma cell cultures with 10(-4)M tricyclic antidepressant desipramine gave rise to a quantitative increase of total lipids and to qualitative modifications of glycosphinegolipids involving detection by thin-layer chromatography of spots migrating according to cerebroside and sulfatide and presence of an abnormal ganglioside pattern." | 7.66 | Tricyclic antidepressant desipramine induces stereospecific opiate binding and lipid modifications in rat glioma C6 cells. ( Albouz, S; Baumann, N; Bourdon, R; Boutry, JM; Hauw, JJ; Le Saux, F; Tocqué, B, 1982) |
| " In the present study, desipramine (DMI), a representative of TCAs, was examined with respect to its apoptosis-inducing activity in rat C6 glioma cells and the underlying mechanism of action." | 3.77 | Desipramine induces apoptosis in rat glioma cells via endoplasmic reticulum stress-dependent CHOP pathway. ( Chen, HZ; Fang, C; Hou, LN; Ma, J; Peng, L; Qi, H; Qiu, Y; Xia, Z; Yang, L, 2011) |
| "To study desipramine (Des)-induced apoptosis and regulation of caspase 3 gene expression and [Ca2+]i homeostasis in rat glioma C6 cells." | 3.71 | Caspase 3 gene expression and [Ca2+]i homeostasis underlying desipramine-induced C6 glioma cell apoptosis. ( Chen, HZ; Jin, ZJ; Qi, H, 2002) |
| "Previous studies have demonstrated that chronic treatment of C6 glioma cells with the antidepressants desipramine and fluoxetine increases the Triton X-100 solubility of the G protein Gsalpha (Toki et al." | 3.71 | Chronic treatment of C6 glioma cells with antidepressant drugs results in a redistribution of Gsalpha. ( Donati, RJ; Rasenick, MM; Thukral, C, 2001) |
| "Opioid agonists inhibit DNA synthesis in C6 rat glioma cells that express opioid receptors, induced by desipramine (DMI)." | 3.69 | Opioids inhibit endothelin-mediated DNA synthesis, phosphoinositide turnover, and Ca2+ mobilization in rat C6 glioma cells. ( Barg, J; Belcheva, MM; Coscia, CJ; Johnson, FE; Levy, R; McHale, RJ; Saya, D; Vogel, Z; Zimlichman, R, 1994) |
| "Treatment of rat C6 glioma cells with the tricyclic antidepressant desipramine induces opioid binding." | 3.69 | A monoclonal anti-idiotypic antibody to opioid receptors labels desipramine-induced opioid binding sites on rat C6 glioma cells and attenuates thymidine incorporation into DNA. ( Barg, J; Belcheva, MM; Coscia, CJ; Johnson, FE; Levy, R; McHale, RJ; McLachlan, JA; Vogel, Z, 1994) |
| "The tricyclic antidepressant desipramine, when added to culture medium, gave rise in C6 rat glioma cells to a decrease of the activity of the enzyme asialofetuin sialyltransferase." | 3.68 | Effect of desipramine on a glycoprotein sialyltransferase activity in C6 cultured glioma cells. ( Baubichon-Cortay, H; Broquet, P; George, P; Louisot, P; Peschard, MJ, 1990) |
| "The effects of chlorpromazine (CPZ), desmethylimipramine (DMI) and propranolol (PRO) on phospholipid metabolism in C6 glioma cells were studied by following the incorporation of 32Pi, [U-14C]glycerol, [2-3H]glycerol and [1-14C]oleate into lipids." | 3.67 | Modifications of phospholipid metabolism induced by chlorpromazine, desmethylimipramine and propranolol in C6 glioma cells. ( Hauser, G; Leli, U, 1987) |
| "Rat glioma C6 cells, cultured in the presence of the tricyclic antidepressant desipramine, lost a significant number of beta-adrenergic receptors in a time- and dose-dependent manner." | 3.67 | Effect of the tricyclic antidepressant desipramine on beta-adrenergic receptors in cultured rat glioma C6 cells. ( Finberg, JP; Fishman, PH, 1987) |
| "Incubation for 48 hours of C6 glioma cell cultures with 10(-4)M tricyclic antidepressant desipramine gave rise to a quantitative increase of total lipids and to qualitative modifications of glycosphinegolipids involving detection by thin-layer chromatography of spots migrating according to cerebroside and sulfatide and presence of an abnormal ganglioside pattern." | 3.66 | Tricyclic antidepressant desipramine induces stereospecific opiate binding and lipid modifications in rat glioma C6 cells. ( Albouz, S; Baumann, N; Bourdon, R; Boutry, JM; Hauw, JJ; Le Saux, F; Tocqué, B, 1982) |
| " We report here an early and important decrease in sphingomyelinase activity in C6 glioma cells cultured in the presence of imipramine or desipramine at final concentrations of 0." | 3.66 | Effect of tricyclic antidepressants on sphingomyelinase and other sphingolipid hydrolases in C6 cultured glioma cells. ( Albouz, S; Baumann, N; Boutry, JM; Hauw, JJ; Le Saux, F; Vanier, MT, 1983) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 10 (45.45) | 18.7374 |
| 1990's | 7 (31.82) | 18.2507 |
| 2000's | 2 (9.09) | 29.6817 |
| 2010's | 3 (13.64) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Zou, F | 1 |
| Pusch, S | 1 |
| Hua, J | 1 |
| Ma, T | 1 |
| Yang, L | 2 |
| Zhu, Q | 1 |
| Xu, Y | 1 |
| Gu, Y | 1 |
| von Deimling, A | 1 |
| Zha, X | 1 |
| Ma, J | 2 |
| Qiu, Y | 1 |
| Peng, L | 1 |
| Xia, Z | 1 |
| Hou, LN | 2 |
| Fang, C | 2 |
| Qi, H | 3 |
| Chen, HZ | 3 |
| Rong, ZX | 1 |
| Liang, P | 1 |
| Li, HF | 1 |
| Jin, ZJ | 1 |
| Albouz, S | 5 |
| Tocqué, B | 2 |
| Hauw, JJ | 4 |
| Boutry, JM | 4 |
| Le Saux, F | 4 |
| Bourdon, R | 2 |
| Baumann, N | 5 |
| Vanier, MT | 1 |
| Zalc, B | 1 |
| Chen, J | 1 |
| Rasenick, MM | 3 |
| Barg, J | 2 |
| Belcheva, MM | 3 |
| Zimlichman, R | 1 |
| Levy, R | 2 |
| Saya, D | 1 |
| McHale, RJ | 2 |
| Johnson, FE | 2 |
| Coscia, CJ | 3 |
| Vogel, Z | 2 |
| McLachlan, JA | 1 |
| Bohn, LM | 1 |
| Toki, S | 1 |
| Donati, RJ | 2 |
| Thukral, C | 1 |
| Fowler, CJ | 1 |
| Brännström, G | 1 |
| Broquet, P | 1 |
| Baubichon-Cortay, H | 1 |
| George, P | 1 |
| Peschard, MJ | 1 |
| Louisot, P | 1 |
| Masson, M | 1 |
| Spezzatti, B | 1 |
| Castagna, M | 1 |
| Reggiani, A | 2 |
| Carenzi, A | 2 |
| Della Bella, D | 1 |
| Bella, DD | 1 |
| Leli, U | 2 |
| Hauser, G | 2 |
| Fishman, PH | 1 |
| Finberg, JP | 1 |
| Wenger, D | 1 |
22 other studies available for desipramine and Glioma
| Article | Year |
|---|---|
Identification of novel allosteric inhibitors of mutant isocitrate dehydrogenase 1 by cross docking-based virtual screening.
Topics: Allosteric Site; Blood-Brain Barrier; Brain Neoplasms; Dose-Response Relationship, Drug; Drug Evalua | 2018 |
Desipramine induces apoptosis in rat glioma cells via endoplasmic reticulum stress-dependent CHOP pathway.
Topics: Animals; Antidepressive Agents, Tricyclic; Apoptosis; Blotting, Western; Cell Line, Tumor; Desiprami | 2011 |
Antidepressant desipramine leads to C6 glioma cell autophagy: implication for the adjuvant therapy of cancer.
Topics: Animals; Antidepressive Agents; Autophagy; Cell Death; Chemotherapy, Adjuvant; Desipramine; Glioma; | 2013 |
Caspase 3 gene expression and [Ca2+]i homeostasis underlying desipramine-induced C6 glioma cell apoptosis.
Topics: Animals; Apoptosis; Biological Transport, Active; Brain; Calcium; Caspase 3; Caspases; Desipramine; | 2002 |
Tricyclic antidepressant desipramine induces stereospecific opiate binding and lipid modifications in rat glioma C6 cells.
Topics: Animals; Cell Transformation, Neoplastic; Desipramine; Dihydromorphine; Glioma; Lipid Metabolism; Ne | 1982 |
Effect of tricyclic antidepressants on sphingomyelinase and other sphingolipid hydrolases in C6 cultured glioma cells.
Topics: Animals; Brain; Brain Neoplasms; Culture Techniques; Desipramine; Dose-Response Relationship, Drug; | 1983 |
Desipramine elicits the expression of opiate receptors and sulfogalactosylceramide synthesis in rat C6 glioma cells.
Topics: Animals; Cerebrosides; Desipramine; Dihydromorphine; Fluorescent Antibody Technique; Galactosylceram | 1984 |
Chronic treatment of C6 glioma cells with antidepressant drugs increases functional coupling between a G protein (Gs) and adenylyl cyclase.
Topics: Adenylyl Cyclases; Animals; Antidepressive Agents; Cell Membrane; Cytosol; Desipramine; Dose-Respons | 1995 |
Opioids inhibit endothelin-mediated DNA synthesis, phosphoinositide turnover, and Ca2+ mobilization in rat C6 glioma cells.
Topics: Animals; Antibodies, Anti-Idiotypic; beta-Endorphin; Calcium; Desipramine; DNA, Neoplasm; Dose-Respo | 1994 |
A monoclonal anti-idiotypic antibody to opioid receptors labels desipramine-induced opioid binding sites on rat C6 glioma cells and attenuates thymidine incorporation into DNA.
Topics: Animals; Antibodies, Monoclonal; Brain Neoplasms; Cell Division; Cell Membrane; Colorimetry; Densito | 1994 |
Evidence for kappa- and mu-opioid receptor expression in C6 glioma cells.
Topics: Analgesics; Analgesics, Opioid; Animals; Benzeneacetamides; beta-Endorphin; Binding, Competitive; De | 1998 |
Treatment of C6 glioma cells and rats with antidepressant drugs increases the detergent extraction of G(s alpha) from plasma membrane.
Topics: Adenylyl Cyclases; Animals; Antidepressive Agents; Antidepressive Agents, Tricyclic; Cell Membrane; | 1999 |
Chronic treatment of C6 glioma cells with antidepressant drugs results in a redistribution of Gsalpha.
Topics: Animals; Antidepressive Agents; Chlorpromazine; Desipramine; Fluoxetine; Glioma; GTP-Binding Protein | 2001 |
Reduction in beta-adrenoceptor density in cultured rat glioma C6 cells after incubation with antidepressants is dependent upon the culturing conditions used.
Topics: Adrenergic beta-Antagonists; Animals; Antidepressive Agents; Cell Division; Desipramine; Glioma; Pro | 1990 |
Effect of desipramine on a glycoprotein sialyltransferase activity in C6 cultured glioma cells.
Topics: Animals; Desipramine; Glioma; Sialyltransferases; Solubility; Tumor Cells, Cultured | 1990 |
Calmodulin antagonist W-7 inhibits lysosomal sphingomyelinase activity in C6 glioma cells.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Calmodulin; Desipramine; Glioma; Isoquinolines; Lysos | 1989 |
Influence of opioids on beta-receptors down-regulation: studies in cultured C6 glioma cells.
Topics: Animals; Cell Line; Cell Membrane; Cyclic AMP; Desipramine; Glioma; Isoproterenol; Kinetics; Morphin | 1987 |
Opioids and beta-receptors interaction: further studies in cultured cells.
Topics: Aminopeptidases; Animals; Cell Line; Desipramine; Glioma; Receptors, Adrenergic, beta; Receptors, Op | 1986 |
Chlorpromazine induces accumulation of inositol phosphates in C6 glioma cells.
Topics: Animals; Cell Line; Chlorpromazine; Desipramine; Glioma; Inositol; Inositol Phosphates; Lysophosphol | 1986 |
Modifications of phospholipid metabolism induced by chlorpromazine, desmethylimipramine and propranolol in C6 glioma cells.
Topics: Animals; Cell Line; Chlorpromazine; Desipramine; Diglycerides; Dose-Response Relationship, Drug; Gli | 1987 |
Effect of the tricyclic antidepressant desipramine on beta-adrenergic receptors in cultured rat glioma C6 cells.
Topics: Adenylyl Cyclases; Alprenolol; Animals; Cells, Cultured; Cyclic AMP; Desipramine; Glioma; Isoprotere | 1987 |
Modifications of sphingomyelin and phosphatidylcholine metabolism by tricyclic antidepressants and phenothiazines.
Topics: Animals; Antidepressive Agents, Tricyclic; Cell Line; Chlorpromazine; Desipramine; Dose-Response Rel | 1986 |