desipramine has been researched along with Endotoxin Shock in 3 studies
Desipramine: A tricyclic dibenzazepine compound that potentiates neurotransmission. Desipramine selectively blocks reuptake of norepinephrine from the neural synapse, and also appears to impair serotonin transport. This compound also possesses minor anticholinergic activity, through its affinity to muscarinic receptors.
desipramine : A dibenzoazepine consisting of 10,11-dihydro-5H-dibenzo[b,f]azepine substituted on nitrogen with a 3-(methylamino)propyl group.
| Excerpt | Relevance | Reference |
|---|---|---|
| "In the septic shock model, all three drugs given preventively markedly decreased circulating levels of TNF-alpha and mortality (50% mortality in fluoxetine treated group, 30% in desipramine and prednisolone treated groups versus 90% in controls)." | 1.34 | Anti-inflammatory properties of desipramine and fluoxetine. ( Bichon, F; Detoc, M; Henriquet, C; Jaffuel, D; Mathieu, M; Michel, A; Portet, K; Roumestan, C, 2007) |
| "Here we show that patients with severe sepsis exhibit an enhanced sphingolytic activity in comparison with controls [262 pmol/(mlxh) vs." | 1.33 | Role of increased sphingomyelinase activity in apoptosis and organ failure of patients with severe sepsis. ( Bockmeyer, CL; Brunkhorst, FM; Bunck, AC; Claus, RA; Deigner, HP; Kinscherf, R; Lösche, W, 2005) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (33.33) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 2 (66.67) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Claus, RA | 1 |
| Bunck, AC | 1 |
| Bockmeyer, CL | 1 |
| Brunkhorst, FM | 1 |
| Lösche, W | 1 |
| Kinscherf, R | 1 |
| Deigner, HP | 1 |
| Roumestan, C | 1 |
| Michel, A | 1 |
| Bichon, F | 1 |
| Portet, K | 1 |
| Detoc, M | 1 |
| Henriquet, C | 1 |
| Jaffuel, D | 1 |
| Mathieu, M | 1 |
| Pardini, BJ | 1 |
| Jones, SB | 1 |
| Filkins, JP | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Fluoxetine to Reduce Hospitalization From COVID-19 Infection (FloR COVID-19)[NCT04570449] | Early Phase 1 | 0 participants (Actual) | Interventional | 2020-11-30 | Withdrawn (stopped due to Study timeline is not feasible) | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
3 other studies available for desipramine and Endotoxin Shock
| Article | Year |
|---|---|
Role of increased sphingomyelinase activity in apoptosis and organ failure of patients with severe sepsis.
Topics: Adult; Aged; Animals; Apoptosis; Ascorbic Acid; Blood Chemical Analysis; Ceramides; Desipramine; Dis | 2005 |
Anti-inflammatory properties of desipramine and fluoxetine.
Topics: Animals; Anti-Inflammatory Agents; Antidepressive Agents; Asthma; Cells, Cultured; Cytokines; Desipr | 2007 |
Contribution of depressed reuptake to the depletion of norepinephrine from rat heart and spleen during endotoxin shock.
Topics: Animals; Blood Glucose; Desipramine; Male; Myocardium; Norepinephrine; Rats; Shock, Septic; Spleen; | 1982 |