desipramine has been researched along with Drug Withdrawal Symptoms in 49 studies
Desipramine: A tricyclic dibenzazepine compound that potentiates neurotransmission. Desipramine selectively blocks reuptake of norepinephrine from the neural synapse, and also appears to impair serotonin transport. This compound also possesses minor anticholinergic activity, through its affinity to muscarinic receptors.
desipramine : A dibenzoazepine consisting of 10,11-dihydro-5H-dibenzo[b,f]azepine substituted on nitrogen with a 3-(methylamino)propyl group.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Nicotine withdrawal is characterized by depression-like symptomatology that may be mediated by dysregulations in norepinephrine transmission." | 3.74 | The effects of chronic versus acute desipramine on nicotine withdrawal and nicotine self-administration in the rat. ( Markou, A; Paterson, NE; Semenova, S, 2008) |
| " Our study indicates that the discontinuation of diazepam, even when given in moderate dosage over a relatively short period of time, may cause withdrawal reactions in combined antidepressant/diazepam treatment." | 2.66 | Withdrawal reactions to diazepam in combined imipramine/diazepam treatment of primary nonagitated depressed outpatients. ( Feet, PO; Larsen, S; Lillevold, PE; Robak, OH, 1988) |
| "Treatment with desipramine was significantly more effective than placebo in alleviating abstinence symptoms." | 2.66 | Space-based abstinence: alleviation of withdrawal symptoms in combinative cocaine-phencyclidine abuse. ( Giannini, AJ; Giannini, MC; Loiselle, RH, 1987) |
| "Research has shown that enhancement of cannabinoid CB(1) receptor activity elicits an antidepressant-like response in the forced swim test (FST); however, the effects of chronic administration of cannabinoid agents in the FST are not well characterized." | 1.35 | Protracted cannabinoid administration elicits antidepressant behavioral responses in rats: role of gender and noradrenergic transmission. ( Gorzalka, BB; Hill, MN; Morrish, AC; Riebe, CJ, 2009) |
| "The literature is devoid of reports indicating that a reduction in the dosage or discontinuation of antidepressants of any chemical class produces symptoms of major depression within 2-4 d." | 1.28 | Symptoms of major depression: acute effect of withdrawing antidepressants. ( Del Medico, VJ; Dilsaver, SC; Halle, MH, 1991) |
| "Desipramine was compared with a placebo under double-blind conditions to determine if it is effective treatment for withdrawal from cocaine dependence." | 1.27 | Double-blind comparison of desipramine and placebo in withdrawal from cocaine dependence. ( Tarver, AL; Tennant, FS, 1984) |
| "Desipramine quickly reversed the withdrawal symptoms in both patients, although it did not prevent their future use of cocaine." | 1.27 | Desipramine in the treatment of hypersomnolence following abrupt cessation of cocaine use. ( Baxter, LR, 1983) |
| "Desipramine treatment instituted at a daily dosage of 75 mg for depressive equivalents of head, chest, and abdominal pain was increased to 1,000 mg daily over a 12-year interval with minimal side effects." | 1.26 | Withdrawal from long-term high-dose desipramine therapy. Clinical and biological changes. ( Brown, GM; Gupta, RN; Harman, J; Moldofsky, H; Murphy, JT; Stancer, HC, 1978) |
| "The chronic administration of several psychoactive drugs has been suggested to produce behavioral withdrawal syndromes in the absence of physical withdrawal." | 1.26 | Behavioral withdrawal following several psychoactive drugs. ( Annau, Z; Simpson, DM, 1977) |
| ") + DMI treated controls were equally suppressed by various acute doses of morphine, but the DA-depleted group appeared to develop tolerance to the higher morphine dosage regimen (120 mg/kg, b." | 1.26 | Morphine-induced behavioral disruption in rats chronically depleted of brain dopamine. ( Chance, WT; Kallman, MJ; Rosecrans, JA; Spencer, RM; White, AT, 1979) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 29 (59.18) | 18.7374 |
| 1990's | 17 (34.69) | 18.2507 |
| 2000's | 3 (6.12) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Morrish, AC | 1 |
| Hill, MN | 1 |
| Riebe, CJ | 1 |
| Gorzalka, BB | 1 |
| Martijena, ID | 2 |
| Bustos, SG | 2 |
| Bertotto, ME | 1 |
| Molina, VA | 2 |
| Paterson, NE | 1 |
| Semenova, S | 1 |
| Markou, A | 2 |
| McWilliam, JR | 1 |
| Meldrum, BS | 1 |
| Checkley, SA | 1 |
| Janowsky, DS | 1 |
| Byerley, B | 1 |
| Tennant, FS | 2 |
| Tarver, AL | 1 |
| Baxter, LR | 1 |
| Charney, DS | 1 |
| Heninger, GR | 1 |
| Sternberg, DE | 1 |
| Willner, P | 4 |
| Montgomery, T | 3 |
| Bird, D | 1 |
| Nelson, JC | 1 |
| Schottenfeld, RS | 1 |
| Conrad, CD | 1 |
| Rawson, RA | 2 |
| McCann, M | 1 |
| Shoptaw, S | 1 |
| McCann, MJ | 1 |
| Obert, JL | 1 |
| Kaminer, Y | 1 |
| Cannizzaro, G | 1 |
| Flugy, A | 1 |
| Cannizzaro, C | 1 |
| Gagliano, M | 1 |
| Sabatino, M | 1 |
| Walsh, BT | 1 |
| Giardina, EG | 1 |
| Sloan, RP | 1 |
| Greenhill, L | 1 |
| Goldfein, J | 1 |
| Johnson, DN | 1 |
| Vocci, FJ | 1 |
| Landry, P | 1 |
| Roy, L | 1 |
| Benazzi, F | 1 |
| Wang, Y | 1 |
| Freund, RK | 1 |
| Palmer, MR | 1 |
| Lacerra, C | 1 |
| Brown, GM | 1 |
| Stancer, HC | 1 |
| Moldofsky, H | 1 |
| Harman, J | 1 |
| Murphy, JT | 1 |
| Gupta, RN | 1 |
| Simpson, DM | 1 |
| Annau, Z | 1 |
| Kallman, MJ | 1 |
| Spencer, RM | 1 |
| White, AT | 1 |
| Chance, WT | 1 |
| Rosecrans, JA | 1 |
| Kolar, AF | 1 |
| Brown, BS | 1 |
| Weddington, WW | 1 |
| Haertzen, CC | 1 |
| Michaelson, BS | 1 |
| Jaffe, JH | 1 |
| Hauger, RL | 1 |
| Koob, GF | 1 |
| Harris, GC | 1 |
| Williams, JT | 1 |
| Van Ameringen, M | 1 |
| Mancini, C | 1 |
| Sansone, M | 1 |
| Battaglia, M | 1 |
| Ekblom, J | 1 |
| Nalepa, I | 1 |
| Vetulani, J | 1 |
| Sharpe, LG | 1 |
| Pilotte, NS | 1 |
| Mitchell, WM | 1 |
| De Souza, EB | 1 |
| Halle, MH | 1 |
| Del Medico, VJ | 1 |
| Dilsaver, SC | 2 |
| Babb, SV | 1 |
| Dunlop, SR | 1 |
| Hoffmann, MA | 1 |
| Dackis, CA | 2 |
| Gold, MS | 2 |
| Pottash, AL | 1 |
| Feet, PO | 1 |
| Larsen, S | 1 |
| Lillevold, PE | 1 |
| Robak, OH | 1 |
| Towell, A | 1 |
| Muscat, R | 1 |
| Tennant, F | 1 |
| Berman, ML | 1 |
| Barnes, DM | 1 |
| Corral, M | 1 |
| Sivertz, K | 1 |
| Jones, BD | 1 |
| Giannini, AJ | 2 |
| Loiselle, RH | 2 |
| Giannini, MC | 2 |
| Malone, DA | 1 |
| Price, WA | 1 |
| Hoffman, LJ | 1 |
| Weiss, JM | 1 |
| Webster, PA | 1 |
| Bläsig, J | 3 |
| Papeschi, R | 2 |
| Herz, A | 3 |
| Stern, P | 1 |
| Hadzović, J | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Four Models of Telephone Support for Stimulant Recovery[NCT00744068] | 302 participants (Actual) | Interventional | 2006-04-30 | Completed | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
5 reviews available for desipramine and Drug Withdrawal Symptoms
| Article | Year |
|---|---|
Desipramine: an overview.
Topics: Clinical Trials as Topic; Depressive Disorder; Desipramine; Dose-Response Relationship, Drug; Drug U | 1984 |
Medications development at the National Institute on Drug Abuse: focus on cocaine.
Topics: Bromocriptine; Cocaine; Desipramine; Humans; Substance Withdrawal Syndrome; Substance-Related Disord | 1993 |
Pharmacologic induction of cholinergic system up-regulation and supersensitivity in affective disorders research.
Topics: Animals; Antidepressive Agents; Antidepressive Agents, Tricyclic; Bipolar Disorder; Brain; Depressio | 1986 |
Pharmacological approaches to cocaine addiction.
Topics: Brain Chemistry; Bromocriptine; Cocaine; Desipramine; Dopamine; Euphoria; Humans; Receptors, Dopamin | 1985 |
[Neurobiologic aspects of the morphine addictions].
Topics: Acetylcholine; Amphetamine; Animals; Apomorphine; Brain Chemistry; Catecholamines; Cocaine; Desipram | 1974 |
7 trials available for desipramine and Drug Withdrawal Symptoms
| Article | Year |
|---|---|
Desipramine: an overview.
Topics: Clinical Trials as Topic; Depressive Disorder; Desipramine; Dose-Response Relationship, Drug; Drug U | 1984 |
Serotonin function and mechanism of action of antidepressant treatment. Effects of amitriptyline and desipramine.
Topics: Aged; Amitriptyline; Animals; Brain Chemistry; Depressive Disorder; Desipramine; Female; Humans; Inf | 1984 |
The Matrix model of outpatient stimulant abuse treatment: evidence of efficacy.
Topics: Adult; Ambulatory Care; Cocaine; Combined Modality Therapy; Desipramine; Double-Blind Method; Female | 1994 |
Treatment of cocaine dependence in methadone maintenance clients: a pilot study comparing the efficacy of desipramine and amantadine.
Topics: Adolescent; Adult; Amantadine; Baltimore; Cocaine; Desipramine; Female; Follow-Up Studies; Humans; M | 1992 |
Withdrawal reactions to diazepam in combined imipramine/diazepam treatment of primary nonagitated depressed outpatients.
Topics: Clinical Trials as Topic; Depressive Disorder; Desipramine; Diazepam; Double-Blind Method; Drug Ther | 1988 |
Space-based abstinence: alleviation of withdrawal symptoms in combinative cocaine-phencyclidine abuse.
Topics: Adult; Cocaine; Desipramine; Double-Blind Method; Humans; Male; Phencyclidine; Psychotherapy, Brief; | 1987 |
Treatment of depression in chronic cocaine and phencyclidine abuse with desipramine.
Topics: Adult; Clinical Trials as Topic; Cocaine; Depression; Desipramine; Humans; Male; Phencyclidine; Plac | 1986 |
38 other studies available for desipramine and Drug Withdrawal Symptoms
| Article | Year |
|---|---|
Protracted cannabinoid administration elicits antidepressant behavioral responses in rats: role of gender and noradrenergic transmission.
Topics: Adrenergic alpha-Antagonists; Adrenergic beta-Antagonists; Animals; Antidepressive Agents; Antidepre | 2009 |
Antidepressants attenuate both the enhanced ethanol intake and ethanol-induced anxiolytic effects in diazepam withdrawn rats.
Topics: Alcohol Drinking; Analysis of Variance; Animals; Anti-Anxiety Agents; Antidepressive Agents; Anxiety | 2005 |
The effects of chronic versus acute desipramine on nicotine withdrawal and nicotine self-administration in the rat.
Topics: Animals; Antidepressive Agents, Tricyclic; Conditioning, Operant; Depression; Desipramine; Food; Inf | 2008 |
Changes in the sensitivity of the central alpha- and beta-adrenergic systems during desmethylimipramine treatment as assessed by plasma growth hormone response in the baboon.
Topics: Animals; Brain; Clonidine; Desipramine; Female; Growth Hormone; Humans; Male; Papio; Propanolamines; | 1983 |
Double-blind comparison of desipramine and placebo in withdrawal from cocaine dependence.
Topics: Adolescent; Adult; Cocaine; Desipramine; Double-Blind Method; Female; Humans; Male; Norepinephrine; | 1984 |
Desipramine in the treatment of hypersomnolence following abrupt cessation of cocaine use.
Topics: Adult; Cocaine; Desipramine; Female; Humans; Sleep Wake Disorders; Substance Withdrawal Syndrome; Su | 1983 |
Behavioural changes during withdrawal from desmethylimipramine (DMI). I. Interactions with amphetamine.
Topics: Animals; Anorexia; Desipramine; Dextroamphetamine; Drug Interactions; Eating; Feeding and Eating Dis | 1981 |
Behavioural changes during withdrawal from desmethylimipramine (DMI). II. Increased resistance to extinction.
Topics: Animals; Conditioning, Operant; Desipramine; Extinction, Psychological; Hippocampus; Humans; Male; N | 1981 |
Hypomania after desipramine withdrawal.
Topics: Adolescent; Affective Disorders, Psychotic; Bipolar Disorder; Depressive Disorder; Desipramine; Huma | 1983 |
Effects of subchronic desmethylimipramine (DMI) treatment on the classically conditioned eyeblink response in rabbits.
Topics: Animals; Conditioning, Eyelid; Desipramine; Extinction, Psychological; Humans; Male; Mental Recall; | 1980 |
Withdrawal from chronic phencyclidine (PCP) dependence with desipramine.
Topics: Adolescent; Adult; Desipramine; Female; Humans; Male; Phencyclidine; Substance Withdrawal Syndrome; | 1981 |
Cocaine craving.
Topics: Adolescent; Amitriptyline; Cocaine; Desipramine; Humans; Hypotension, Orthostatic; Male; Risk Factor | 1994 |
Effects of desipramine and alprazolam in the forced swim test in rats after long-lasting termination of chronic exposure to picrotoxin and pentylenetetrazol.
Topics: Alprazolam; Animals; Chlordiazepoxide; Desipramine; GABA-A Receptor Antagonists; Male; Motor Activit | 1993 |
Effects of desipramine on autonomic control of the heart.
Topics: Adolescent; Adult; Arousal; Attention Deficit Disorder with Hyperactivity; Autonomic Nervous System; | 1994 |
Withdrawal hypomania associated with paroxetine.
Topics: Adult; Antidepressive Agents, Second-Generation; Antidepressive Agents, Tricyclic; Bipolar Disorder; | 1997 |
Dangerous interaction with nefazodone added to fluoxetine, desipramine, venlafaxine, valproate and clonazepam combination therapy.
Topics: Adult; Antidepressive Agents; Clonazepam; Cyclohexanols; Depressive Disorder; Desipramine; Drug Ther | 1997 |
Potentiation of ethanol effects in cerebellum by activation of endogenous noradrenergic inputs.
Topics: Adrenergic Uptake Inhibitors; Animals; Ataxia; Central Nervous System Depressants; Cerebellum; Depre | 1999 |
Benzodiazepine withdrawal facilitates the subsequent onset of escape failures and anhedonia: influence of different antidepressant drugs.
Topics: Amphetamine; Animals; Anti-Anxiety Agents; Antidepressive Agents; Avoidance Learning; Conditioning, | 1999 |
Withdrawal from long-term high-dose desipramine therapy. Clinical and biological changes.
Topics: Adult; Desipramine; Electrocardiography; Electroencephalography; Growth Hormone; Heart Block; Humans | 1978 |
Behavioral withdrawal following several psychoactive drugs.
Topics: Animals; Brain; Chlorpromazine; Desipramine; Dextroamphetamine; Electric Stimulation; Humans; Iproni | 1977 |
Morphine-induced behavioral disruption in rats chronically depleted of brain dopamine.
Topics: Animals; Brain; Conditioning, Operant; Desipramine; Dopamine; Drug Tolerance; Humans; Hydroxydopamin | 1979 |
Desmethylimipramine attenuates cocaine withdrawal in rats.
Topics: Analysis of Variance; Animals; Cocaine; Desipramine; Kinetics; Male; Predictive Value of Tests; Radi | 1992 |
Sensitization of locus ceruleus neurons during withdrawal from chronic stimulants and antidepressants.
Topics: Amphetamine; Animals; Cocaine; Desipramine; Electrophysiology; Injections, Intraperitoneal; Locus Co | 1992 |
Adverse effects of switching from fluoxetine to desipramine.
Topics: Adult; Depressive Disorder; Desipramine; Female; Fluoxetine; Humans; Metabolic Clearance Rate; Middl | 1992 |
Avoidance learning during antidepressant withdrawal in mice.
Topics: Animals; Avoidance Learning; Brain; Desipramine; Injections, Intraperitoneal; Male; Mianserin; Mice; | 1991 |
Withdrawal of repeated cocaine decreases autoradiographic [3H]mazindol-labelling of dopamine transporter in rat nucleus accumbens.
Topics: Animals; Autoradiography; Carrier Proteins; Cocaine; Corpus Striatum; Densitometry; Desipramine; Dop | 1991 |
Symptoms of major depression: acute effect of withdrawing antidepressants.
Topics: Adult; Arousal; Chronic Disease; Depressive Disorder; Desipramine; Dose-Response Relationship, Drug; | 1991 |
Protracted ventricular arrhythmias occurring after abrupt tricyclic antidepressant withdrawal.
Topics: Depressive Disorder; Desipramine; Electrocardiography; Humans; Imipramine; Male; Middle Aged; Substa | 1990 |
Central stimulant abuse: neurochemistry and pharmacotherapy.
Topics: Antipsychotic Agents; Brain; Bromocriptine; Cocaine; Desipramine; Dopamine; Euphoria; Humans; Recept | 1986 |
Dopamine autoreceptors in the ventral tegmental area show subsensitivity following withdrawal from chronic antidepressant drug treatment.
Topics: Animals; Antidepressive Agents; Apomorphine; Desipramine; Feeding Behavior; Male; Rats; Receptors, D | 1986 |
Stepwise detoxification from cocaine. A promising regimen.
Topics: Adolescent; Adult; Amantadine; Bromocriptine; Cocaine; Desipramine; Drug Therapy, Combination; Femal | 1988 |
Breaking the cycle of addiction.
Topics: Behavior Therapy; Cocaine; Desipramine; Humans; Mental Disorders; Psychotherapy; Recurrence; Substan | 1988 |
Transient mood elevation associated with antidepressant drug decrease.
Topics: Bipolar Disorder; Depressive Disorder; Desipramine; Emotions; Female; Humans; Middle Aged; Substance | 1987 |
Behavioral depression following clonidine withdrawal: a new animal model of long-lasting depression?
Topics: Animals; Clonidine; Depressive Disorder; Desipramine; Disease Models, Animal; Rats; Substance Withdr | 1986 |
Withdrawal symptoms in neonates associated with maternal antidepressant therapy.
Topics: Adult; Depression; Desipramine; Female; Fetus; Humans; Infant, Newborn; Infant, Newborn, Diseases; M | 1973 |
[Significance of catecholamines for the manifestation of morphine withdrawal in the rat].
Topics: Amphetamine; Animals; Apomorphine; Behavior, Animal; Brain Chemistry; Catecholamines; Desipramine; D | 1974 |
Role of catecholaminergic mechanisms in the expression of the morphine abstinence syndrome in rats.
Topics: Animals; Apomorphine; Behavior, Animal; Benserazide; Brain Chemistry; Catecholamines; Cocaine; Desip | 1974 |
Pharmacological analysis of central actions of synthetic substance P.
Topics: Aggression; Animals; Blood-Brain Barrier; Desipramine; Humans; Male; Mice; Morphine; Strychnine; Sub | 1973 |