desipramine has been researched along with Depressive Disorder, Treatment-Resistant in 4 studies
Desipramine: A tricyclic dibenzazepine compound that potentiates neurotransmission. Desipramine selectively blocks reuptake of norepinephrine from the neural synapse, and also appears to impair serotonin transport. This compound also possesses minor anticholinergic activity, through its affinity to muscarinic receptors.
desipramine : A dibenzoazepine consisting of 10,11-dihydro-5H-dibenzo[b,f]azepine substituted on nitrogen with a 3-(methylamino)propyl group.
Depressive Disorder, Treatment-Resistant: Failure to respond to two or more trials of antidepressant monotherapy or failure to respond to four or more trials of different antidepressant therapies. (Campbell's Psychiatric Dictionary, 9th ed.)
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 4 (100.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Hasegawa, S | 1 |
| Miyake, Y | 1 |
| Yoshimi, A | 1 |
| Mouri, A | 1 |
| Hida, H | 1 |
| Yamada, K | 1 |
| Ozaki, N | 1 |
| Nabeshima, T | 1 |
| Noda, Y | 1 |
| Guo, M | 1 |
| Lu, XY | 1 |
| Meylan, EM | 1 |
| Halfon, O | 1 |
| Magistretti, PJ | 1 |
| Cardinaux, JR | 1 |
| O'Leary, OF | 1 |
| Zandy, S | 1 |
| Dinan, TG | 1 |
| Cryan, JF | 1 |
4 other studies available for desipramine and Depressive Disorder, Treatment-Resistant
| Article | Year |
|---|---|
Dysfunction of Serotonergic and Dopaminergic Neuronal Systems in the Antidepressant-Resistant Impairment of Social Behaviors Induced by Social Defeat Stress Exposure as Juveniles.
Topics: Animals; Antidepressive Agents; Aripiprazole; Brain; Depressive Disorder, Treatment-Resistant; Desip | 2018 |
Leptin receptor deficiency confers resistance to behavioral effects of fluoxetine and desipramine via separable substrates.
Topics: Adrenergic Uptake Inhibitors; Animals; Behavior, Animal; Depressive Disorder, Treatment-Resistant; D | 2014 |
The HDAC inhibitor SAHA improves depressive-like behavior of CRTC1-deficient mice: Possible relevance for treatment-resistant depression.
Topics: Animals; Antidepressive Agents; Brain-Derived Neurotrophic Factor; Depressive Disorder, Major; Depre | 2016 |
Lithium augmentation of the effects of desipramine in a mouse model of treatment-resistant depression: a role for hippocampal cell proliferation.
Topics: Animals; Cell Proliferation; Depressive Disorder, Treatment-Resistant; Desipramine; Disease Models, | 2013 |