desipramine has been researched along with Depressive Disorder, Major in 44 studies
Desipramine: A tricyclic dibenzazepine compound that potentiates neurotransmission. Desipramine selectively blocks reuptake of norepinephrine from the neural synapse, and also appears to impair serotonin transport. This compound also possesses minor anticholinergic activity, through its affinity to muscarinic receptors.
desipramine : A dibenzoazepine consisting of 10,11-dihydro-5H-dibenzo[b,f]azepine substituted on nitrogen with a 3-(methylamino)propyl group.
Depressive Disorder, Major: Disorder in which five (or more) of the following symptoms have been present during the same 2-week period and represent a change from previous functioning; at least one of the symptoms is either (1) depressed mood or (2) loss of interest or pleasure. Symptoms include: depressed mood most of the day, nearly every daily; markedly diminished interest or pleasure in activities most of the day, nearly every day; significant weight loss when not dieting or weight gain; Insomnia or hypersomnia nearly every day; psychomotor agitation or retardation nearly every day; fatigue or loss of energy nearly every day; feelings of worthlessness or excessive or inappropriate guilt; diminished ability to think or concentrate, or indecisiveness, nearly every day; or recurrent thoughts of death, recurrent suicidal ideation without a specific plan, or a suicide attempt. (DSM-5)
| Excerpt | Relevance | Reference |
|---|---|---|
| "This study compared the efficacy and safety of paroxetine and desipramine with those of placebo in the treatment of depressive disorders in adult women with breast cancer, stages I-IV." | 9.12 | A double-blind, multicenter, parallel-group study of paroxetine, desipramine, or placebo in breast cancer patients (stages I, II, III, and IV) with major depression. ( Evans, DL; Goodkin, R; Guo, Y; Lawson, D; Lawson, K; Lewison, B; Manatunga, AK; Musselman, DL; Nemeroff, CB; Penna, S; Porter, M; Somerset, WI, 2006) |
| "Considering the gene X environment hypothesis of depression, the present study investigated the effect of chronic ozone inhalation on depression and anxiety-related behavior, cognition, and brain markers of oxidative stress in the Flinders Sensitive Line (FSL) rat." | 7.81 | Ozone exposure of Flinders Sensitive Line rats is a rodent translational model of neurobiological oxidative stress with relevance for depression and antidepressant response. ( Brink, CB; Ellis, SM; Harvey, BH; Mokoena, ML; Viljoen, F, 2015) |
| "This study compared the efficacy and safety of paroxetine and desipramine with those of placebo in the treatment of depressive disorders in adult women with breast cancer, stages I-IV." | 5.12 | A double-blind, multicenter, parallel-group study of paroxetine, desipramine, or placebo in breast cancer patients (stages I, II, III, and IV) with major depression. ( Evans, DL; Goodkin, R; Guo, Y; Lawson, D; Lawson, K; Lewison, B; Manatunga, AK; Musselman, DL; Nemeroff, CB; Penna, S; Porter, M; Somerset, WI, 2006) |
| "Considering the gene X environment hypothesis of depression, the present study investigated the effect of chronic ozone inhalation on depression and anxiety-related behavior, cognition, and brain markers of oxidative stress in the Flinders Sensitive Line (FSL) rat." | 3.81 | Ozone exposure of Flinders Sensitive Line rats is a rodent translational model of neurobiological oxidative stress with relevance for depression and antidepressant response. ( Brink, CB; Ellis, SM; Harvey, BH; Mokoena, ML; Viljoen, F, 2015) |
| "59 moderate Alzheimer patients with major depressive disorder were randomly divided into 3 groups (sertraline, venlafaxine and desipramine), treated for 12 weeks (150 mg maximum dose) and assessed by the Hamilton Depression Test (HRSD), the Mini Mental State Examination (MMSE) and the Barthel index at the week 0 and the 2(nd), 4(th), 8(th), 12(th) weeks thereafter." | 2.79 | Comparison of sertraline, venlafaxine and desipramine effects on depression, cognition and the daily living activities in Alzheimer patients. ( Abdollahian, E; Azarpazhooh, A; Haghighi, MB; Mokhber, N; Saghebi, A; Samadi, R; Soltanifar, A, 2014) |
| "We identified 101 outpatients with major depressive disorder (52 men and 49 women; mean age, 41." | 2.70 | Double-blind study of high-dose fluoxetine versus lithium or desipramine augmentation of fluoxetine in partial responders and nonresponders to fluoxetine. ( Alpert, J; Baer, L; Fava, M; Lagomasino, I; Nierenberg, A; Rosenbaum, JF; Sonawalla, S; Tedlow, J; Worthington, J, 2002) |
| " The combined therapies were most effective in patients who were more severely depressed, particularly when desipramine was at or above recommended stable dosage levels." | 2.70 | Comparison of desipramine and cognitive/behavioral therapy in the treatment of elderly outpatients with mild-to-moderate depression. ( Coon, DW; Gallagher-Thompson, D; Koin, D; Sommer, BR; Thompson, LW, 2001) |
| "The PKC activity of the major depressive disorder subjects and healthy volunteers was inhibited by desipramine, whereas that of the bipolar disorder subjects showed both inhibition and activation." | 2.69 | Different effect of desipramine on protein kinase C in platelets between bipolar and major depressive disorders. ( Aoki, S; Morishita, S; Watanabe, S, 1999) |
| "Relapse was defined as a 50% increase in HDRS with total < or = 17." | 2.69 | Tryptophan-depletion challenge in depressed patients treated with desipramine or fluoxetine: implications for the role of serotonin in the mechanism of antidepressant action. ( Charney, DS; Delgado, PL; Heninger, GR; Krystal, JH; Licinio, J; Miller, HL; Moreno, FA; Salomon, RM, 1999) |
| "Major depressive disorder is one of the most common mental disorders in children and adolescents." | 2.53 | Comparative efficacy and tolerability of antidepressants for major depressive disorder in children and adolescents: a network meta-analysis. ( Cipriani, A; Coghill, D; Cohen, D; Cuijpers, P; Del Giovane, C; Hazell, P; Hetrick, SE; Leucht, S; Liu, L; Liu, Y; Michael, KD; Pu, J; Qin, B; Ravindran, AV; Whittington, C; Xie, P; Yang, L; Zhang, Y; Zhou, X, 2016) |
| "Desipramine treatment appeared to result in decreases in alcohol consumption in nonalcoholic patients with depression." | 1.32 | Depressive symptoms and alcohol consumption among nonalcoholic depression patients treated with desipramine. ( Bagby, RM; Goldstein, BI; Joffe, RT; Levitt, A; Schaffer, A; Wesson, V; Zaretsky, A, 2004) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 7 (15.91) | 18.7374 |
| 1990's | 3 (6.82) | 18.2507 |
| 2000's | 22 (50.00) | 29.6817 |
| 2010's | 11 (25.00) | 24.3611 |
| 2020's | 1 (2.27) | 2.80 |
| Authors | Studies |
|---|---|
| Jaddoa, E | 1 |
| Masania, J | 1 |
| Masiero, E | 1 |
| Sgamma, T | 1 |
| Arroo, R | 1 |
| Sillence, D | 1 |
| Zetterström, T | 1 |
| Mokhber, N | 1 |
| Abdollahian, E | 1 |
| Soltanifar, A | 1 |
| Samadi, R | 1 |
| Saghebi, A | 1 |
| Haghighi, MB | 1 |
| Azarpazhooh, A | 1 |
| Wong, ML | 5 |
| Dong, C | 3 |
| Flores, DL | 2 |
| Ehrhart-Bornstein, M | 2 |
| Bornstein, S | 2 |
| Arcos-Burgos, M | 2 |
| Licinio, J | 6 |
| Uher, R | 1 |
| Ripke, S | 1 |
| Müller-Myhsok, B | 1 |
| Lewis, CM | 1 |
| Perlis, RH | 1 |
| Mokoena, ML | 1 |
| Harvey, BH | 1 |
| Viljoen, F | 1 |
| Ellis, SM | 1 |
| Brink, CB | 1 |
| Meylan, EM | 1 |
| Halfon, O | 1 |
| Magistretti, PJ | 1 |
| Cardinaux, JR | 1 |
| Cipriani, A | 1 |
| Zhou, X | 1 |
| Del Giovane, C | 1 |
| Hetrick, SE | 1 |
| Qin, B | 1 |
| Whittington, C | 1 |
| Coghill, D | 1 |
| Zhang, Y | 1 |
| Hazell, P | 1 |
| Leucht, S | 1 |
| Cuijpers, P | 1 |
| Pu, J | 1 |
| Cohen, D | 1 |
| Ravindran, AV | 1 |
| Liu, Y | 1 |
| Michael, KD | 1 |
| Yang, L | 1 |
| Liu, L | 1 |
| Xie, P | 1 |
| Hibicke, M | 1 |
| Graham, MA | 1 |
| Hayslett, RL | 1 |
| Preskorn, SH | 1 |
| Nichols, AI | 1 |
| Paul, J | 1 |
| Patroneva, AL | 1 |
| Helzner, EC | 1 |
| Guico-Pabia, CJ | 1 |
| Grigoriadis, S | 1 |
| Bouffard, BA | 1 |
| Kennedy, S | 1 |
| Bagby, RM | 3 |
| Joffe, RT | 3 |
| Souery, D | 1 |
| Serretti, A | 1 |
| Calati, R | 1 |
| Oswald, P | 1 |
| Massat, I | 1 |
| Konstantinidis, A | 1 |
| Linotte, S | 1 |
| Kasper, S | 1 |
| Montgomery, S | 1 |
| Zohar, J | 1 |
| Mendlewicz, J | 1 |
| Lopes Rocha, F | 1 |
| Fuzikawa, C | 1 |
| Riera, R | 1 |
| Ramos, MG | 1 |
| Hara, C | 1 |
| Fava, M | 3 |
| Alpert, J | 1 |
| Nierenberg, A | 1 |
| Lagomasino, I | 1 |
| Sonawalla, S | 1 |
| Tedlow, J | 1 |
| Worthington, J | 1 |
| Baer, L | 1 |
| Rosenbaum, JF | 2 |
| Levkovitz, Y | 1 |
| Caftori, R | 1 |
| Avital, A | 1 |
| Richter-Levin, G | 1 |
| Porter, RJ | 1 |
| Mulder, RT | 1 |
| Joyce, PR | 1 |
| Chen, B | 1 |
| Wang, JF | 1 |
| Sun, X | 1 |
| Young, LT | 1 |
| KRAKOWSKI, AJ | 2 |
| ALNAES, R | 1 |
| KRISTIANSEN, J | 1 |
| Gonzalez, G | 1 |
| Feingold, A | 1 |
| Oliveto, A | 1 |
| Gonsai, K | 1 |
| Kosten, TR | 1 |
| Katz, MM | 1 |
| Tekell, JL | 1 |
| Bowden, CL | 1 |
| Brannan, S | 1 |
| Houston, JP | 1 |
| Berman, N | 1 |
| Frazer, A | 1 |
| Papakostas, GI | 2 |
| Petersen, T | 2 |
| Denninger, JW | 1 |
| Tossani, E | 1 |
| Pava, JA | 1 |
| Alpert, JE | 2 |
| Nierenberg, AA | 2 |
| Iosifescu, DV | 1 |
| Burns, AM | 1 |
| Goldstein, BI | 1 |
| Schaffer, A | 1 |
| Levitt, A | 1 |
| Zaretsky, A | 1 |
| Wesson, V | 1 |
| Cai, W | 1 |
| Khaoustov, VI | 1 |
| Xie, Q | 1 |
| Pan, T | 1 |
| Le, W | 1 |
| Yoffe, B | 1 |
| Musselman, DL | 1 |
| Somerset, WI | 1 |
| Guo, Y | 1 |
| Manatunga, AK | 1 |
| Porter, M | 1 |
| Penna, S | 1 |
| Lewison, B | 1 |
| Goodkin, R | 1 |
| Lawson, K | 1 |
| Lawson, D | 1 |
| Evans, DL | 1 |
| Nemeroff, CB | 1 |
| Hill, MN | 1 |
| Ho, WS | 1 |
| Sinopoli, KJ | 1 |
| Viau, V | 1 |
| Hillard, CJ | 1 |
| Gorzalka, BB | 1 |
| Whelan, F | 2 |
| Deloukas, P | 1 |
| Whittaker, P | 1 |
| Delgado, M | 1 |
| Cantor, RM | 1 |
| McCann, SM | 1 |
| Sharma, A | 1 |
| Busnello, JV | 1 |
| Ribeiro, L | 1 |
| Thakur, S | 1 |
| Elashoff, RM | 1 |
| Wann, BP | 1 |
| Bah, TM | 1 |
| Boucher, M | 1 |
| Courtemanche, J | 1 |
| Le Marec, N | 1 |
| Rousseau, G | 1 |
| Godbout, R | 1 |
| Ward, NG | 1 |
| Lampe, TH | 1 |
| Morishita, S | 1 |
| Aoki, S | 1 |
| Watanabe, S | 1 |
| Delgado, PL | 1 |
| Miller, HL | 1 |
| Salomon, RM | 1 |
| Krystal, JH | 1 |
| Moreno, FA | 1 |
| Heninger, GR | 1 |
| Charney, DS | 1 |
| Levitan, RD | 1 |
| Kennedy, SH | 1 |
| Levitt, AJ | 1 |
| McDowell, DM | 1 |
| Levin, FR | 1 |
| Seracini, AM | 1 |
| Nunes, EV | 1 |
| Thompson, LW | 1 |
| Coon, DW | 1 |
| Gallagher-Thompson, D | 1 |
| Sommer, BR | 1 |
| Koin, D | 1 |
| Treisman, GJ | 1 |
| Angelino, AF | 1 |
| Hutton, HE | 1 |
| Hoehn-Saric, R | 1 |
| Schlaepfer, TE | 1 |
| Greenberg, BD | 1 |
| McLeod, DR | 1 |
| Pearlson, GD | 1 |
| Wong, SH | 1 |
| Pandey, GN | 1 |
| Ren, X | 1 |
| Pandey, SC | 1 |
| Dwivedi, Y | 1 |
| Sharma, R | 1 |
| Janicak, PG | 1 |
| Rodová, A | 1 |
| Svestka, J | 1 |
| Náhunek, K | 1 |
| Wolpowitz, B | 1 |
| Roux, JT | 1 |
| Margat, P | 1 |
| Broussot, T | 1 |
| Pouly, JP | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| [NCT00265291] | Phase 2 | 700 participants (Actual) | Interventional | 1999-11-30 | Completed | ||
| Sequenced Treatment Alternatives to Relieve Adolescent Depression (STAR-AD) a Multicentre Open-label Randomized Controlled Trial Protocol[NCT05814640] | Phase 1/Phase 2 | 520 participants (Anticipated) | Interventional | 2023-02-20 | Recruiting | ||
| Development and Evaluation of an Ecological Momentary Assessment (EMA) Baseline Screening System for Therapists Who Treat Youths With Depressive Symptoms[NCT04830527] | 60 participants (Actual) | Interventional | 2020-11-24 | Terminated (stopped due to The study was terminated early due to the difficulty in recruiting cases during a pandemic period.) | |||
| Efficacy Of Switching From SSRI to Desvenlafaxine on Cognitive Function In Patients With an Acute Episode of Major Depression[NCT03432221] | 36 participants (Anticipated) | Observational | 2018-04-03 | Recruiting | |||
| Model for Early Prediction of Clinical Response in Patients With Major Depression Receiving Fluoxetine[NCT01075529] | Phase 4 | 140 participants (Actual) | Interventional | 2007-03-31 | Completed | ||
| Prospective 24-week Study, Comparing Clinical Outcomes Between Switching Antidepressants and Maintaining the Same Antidepressant in Patients With Major Depressive Disorder Who do Not Show a 20% Reduction in Symptoms at Week 2[NCT00519012] | Phase 4 | 200 participants (Anticipated) | Interventional | 2007-08-31 | Recruiting | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
3 reviews available for desipramine and Depressive Disorder, Major
| Article | Year |
|---|---|
Comparative efficacy and tolerability of antidepressants for major depressive disorder in children and adolescents: a network meta-analysis.
Topics: Adolescent; Amitriptyline; Antidepressive Agents; Bayes Theorem; Child; Citalopram; Clomipramine; Co | 2016 |
Comparative efficacy and tolerability of antidepressants for major depressive disorder in children and adolescents: a network meta-analysis.
Topics: Adolescent; Amitriptyline; Antidepressive Agents; Bayes Theorem; Child; Citalopram; Clomipramine; Co | 2016 |
Comparative efficacy and tolerability of antidepressants for major depressive disorder in children and adolescents: a network meta-analysis.
Topics: Adolescent; Amitriptyline; Antidepressive Agents; Bayes Theorem; Child; Citalopram; Clomipramine; Co | 2016 |
Comparative efficacy and tolerability of antidepressants for major depressive disorder in children and adolescents: a network meta-analysis.
Topics: Adolescent; Amitriptyline; Antidepressive Agents; Bayes Theorem; Child; Citalopram; Clomipramine; Co | 2016 |
Effect of desvenlafaxine on the cytochrome P450 2D6 enzyme system.
Topics: Antidepressive Agents; Antidepressive Agents, Tricyclic; Cyclohexanols; Cytochrome P-450 CYP2D6; Dep | 2008 |
Antidepressant combination for major depression in incomplete responders--a systematic review.
Topics: Adult; Antidepressive Agents; Depressive Disorder, Major; Desipramine; Double-Blind Method; Drug The | 2013 |
20 trials available for desipramine and Depressive Disorder, Major
| Article | Year |
|---|---|
Comparison of sertraline, venlafaxine and desipramine effects on depression, cognition and the daily living activities in Alzheimer patients.
Topics: Activities of Daily Living; Aged; Alzheimer Disease; Antidepressive Agents; Cognition; Comorbidity; | 2014 |
Clinical outcomes and genome-wide association for a brain methylation site in an antidepressant pharmacogenetics study in Mexican Americans.
Topics: Adrenergic Uptake Inhibitors; Adult; Aged; Antidepressive Agents; Antidepressive Agents, Second-Gene | 2014 |
Novel sequence variations in the brain-derived neurotrophic factor gene and association with major depression and antidepressant treatment response.
Topics: Adult; Aged; Alleles; Antidepressive Agents; Brain-Derived Neurotrophic Factor; Case-Control Studies | 2009 |
Citalopram versus desipramine in treatment resistant depression: effect of continuation or switching strategies: a randomized open study.
Topics: Antidepressive Agents, Second-Generation; Antidepressive Agents, Tricyclic; Citalopram; Depressive D | 2011 |
Double-blind study of high-dose fluoxetine versus lithium or desipramine augmentation of fluoxetine in partial responders and nonresponders to fluoxetine.
Topics: Adult; Analysis of Variance; Antidepressive Agents, Second-Generation; Antidepressive Agents, Tricyc | 2002 |
The SSRIs drug Fluoxetine, but not the noradrenergic tricyclic drug Desipramine, improves memory performance during acute major depression.
Topics: Acute Disease; Adult; Analysis of Variance; Antidepressive Agents, Tricyclic; Depressive Disorder, M | 2002 |
Baseline prolactin and L-tryptophan availability predict response to antidepressant treatment in major depression.
Topics: Administration, Oral; Adolescent; Adult; Antidepressive Agents, Tricyclic; Biological Availability; | 2003 |
Comorbid major depressive disorder as a prognostic factor in cocaine-abusing buprenorphine-maintained patients treated with desipramine and contingency management.
Topics: Adult; Aged; Antidepressive Agents, Tricyclic; Buprenorphine; Cocaine-Related Disorders; Comorbidity | 2003 |
Onset and early behavioral effects of pharmacologically different antidepressants and placebo in depression.
Topics: Adult; Affect; Aged; Analysis of Variance; Antidepressive Agents; Chi-Square Distribution; Depressiv | 2004 |
Onset and early behavioral effects of pharmacologically different antidepressants and placebo in depression.
Topics: Adult; Affect; Aged; Analysis of Variance; Antidepressive Agents; Chi-Square Distribution; Depressiv | 2004 |
Onset and early behavioral effects of pharmacologically different antidepressants and placebo in depression.
Topics: Adult; Affect; Aged; Analysis of Variance; Antidepressive Agents; Chi-Square Distribution; Depressiv | 2004 |
Onset and early behavioral effects of pharmacologically different antidepressants and placebo in depression.
Topics: Adult; Affect; Aged; Analysis of Variance; Antidepressive Agents; Chi-Square Distribution; Depressiv | 2004 |
Psychosocial functioning during the treatment of major depressive disorder with fluoxetine.
Topics: Activities of Daily Living; Adult; Ambulatory Care; Antidepressive Agents, Second-Generation; Antima | 2004 |
Obesity among outpatients with major depressive disorder.
Topics: Adult; Ambulatory Care; Antidepressive Agents, Second-Generation; Body Mass Index; Body Weight; Depr | 2005 |
A double-blind, multicenter, parallel-group study of paroxetine, desipramine, or placebo in breast cancer patients (stages I, II, III, and IV) with major depression.
Topics: Adult; Aged; Aged, 80 and over; Antidepressive Agents, Tricyclic; Breast; Breast Neoplasms; Comorbid | 2006 |
Phosphodiesterase genes are associated with susceptibility to major depression and antidepressant treatment response.
Topics: 3',5'-Cyclic-GMP Phosphodiesterases; Adult; Aged; Antidepressive Agents; Cyclic Nucleotide Phosphodi | 2006 |
Different effect of desipramine on protein kinase C in platelets between bipolar and major depressive disorders.
Topics: Adult; Aged; Antidepressive Agents, Tricyclic; Bipolar Disorder; Blood Platelets; Depressive Disorde | 1999 |
Tryptophan-depletion challenge in depressed patients treated with desipramine or fluoxetine: implications for the role of serotonin in the mechanism of antidepressant action.
Topics: Adult; Aged; Amino Acids; Analysis of Variance; Antidepressive Agents, Second-Generation; Antidepres | 1999 |
Selective alteration of personality in response to noradrenergic and serotonergic antidepressant medication in depressed sample: evidence of non-specificity.
Topics: Adolescent; Adrenergic Uptake Inhibitors; Aged; Antidepressive Agents; Depressive Disorder, Major; D | 1999 |
Venlafaxine treatment of cocaine abusers with depressive disorders.
Topics: Adult; Antidepressive Agents, Second-Generation; Cocaine-Related Disorders; Comorbidity; Cyclohexano | 2000 |
Comparison of desipramine and cognitive/behavioral therapy in the treatment of elderly outpatients with mild-to-moderate depression.
Topics: Aged; Ambulatory Care; Antidepressive Agents; Cognitive Behavioral Therapy; Depressive Disorder, Maj | 2001 |
Cerebral blood flow in obsessive-compulsive patients with major depression: effect of treatment with sertraline or desipramine on treatment responders and non-responders.
Topics: Adult; Aged; Blood Flow Velocity; Cerebral Cortex; Depressive Disorder, Major; Desipramine; Dominanc | 2001 |
[Clinical experience with desipramine in endogenous and involutional depressions].
Topics: Adult; Aged; Bipolar Disorder; Clinical Trials as Topic; Depression; Depressive Disorder, Major; Des | 1970 |
21 other studies available for desipramine and Depressive Disorder, Major
| Article | Year |
|---|---|
Effect of antidepressant drugs on the brain sphingolipid system.
Topics: Acid Ceramidase; Adrenergic Uptake Inhibitors; Animals; Brain; Depressive Disorder, Major; Desiprami | 2020 |
Association of a brain methylation site with clinical outcomes in depression does not replicate across populations.
Topics: Antidepressive Agents; Brain-Derived Neurotrophic Factor; Depressive Disorder, Major; Desipramine; F | 2015 |
Response to Uher et al.
Topics: Antidepressive Agents; Brain-Derived Neurotrophic Factor; Depressive Disorder, Major; Desipramine; F | 2015 |
Ozone exposure of Flinders Sensitive Line rats is a rodent translational model of neurobiological oxidative stress with relevance for depression and antidepressant response.
Topics: Animals; Antidepressive Agents; Behavior, Animal; Citalopram; Depression; Depressive Disorder, Major | 2015 |
The HDAC inhibitor SAHA improves depressive-like behavior of CRTC1-deficient mice: Possible relevance for treatment-resistant depression.
Topics: Animals; Antidepressive Agents; Brain-Derived Neurotrophic Factor; Depressive Disorder, Major; Depre | 2016 |
Adolescent chronic restraint stress (aCRS) elicits robust depressive-like behavior in freely cycling, adult female rats without increasing anxiety-like behaviors.
Topics: Age Factors; Animals; Antidepressive Agents, Tricyclic; Behavior, Animal; Depression; Depressive Dis | 2017 |
A comparison of desipramine response in younger and older women.
Topics: Adult; Age Factors; Antidepressive Agents, Tricyclic; Depressive Disorder, Major; Desipramine; Femal | 2010 |
Regulation of GAP-43 expression by chronic desipramine treatment in rat cultured hippocampal cells.
Topics: Animals; Antidepressive Agents, Tricyclic; Blotting, Northern; Cells, Cultured; Depressive Disorder, | 2003 |
TREATMENT OF SEVERE DEPRESSION WITH DESIPRAMINE, A METABOLITE OF IMIPRAMINE.
Topics: Adolescent; Antidepressive Agents; Brain Diseases; Depression; Depressive Disorder; Depressive Disor | 1963 |
[DESMETHYLIMIPRAMINE (PERTOFRAN) IN THE TREATMENT OF DEPRESSIONS. A CLINICAL AND PSYCHODYNAMIC APPRAISAL].
Topics: Antidepressive Agents; Biomedical Research; Bipolar Disorder; Chlorpromazine; Depression; Depressive | 1963 |
TREATMENT OF SEVERE DEPRESSION WITH DESIPRAMINE: LONG-TERM TRIAL AND FOLLOW-UP.
Topics: Constipation; Depression; Depressive Disorder; Depressive Disorder, Major; Desipramine; Drug Hyperse | 1964 |
Depressive symptoms and alcohol consumption among nonalcoholic depression patients treated with desipramine.
Topics: Adult; Alcohol Drinking; Antidepressive Agents, Tricyclic; Depressive Disorder, Major; Desipramine; | 2004 |
Interferon-alpha-induced modulation of glucocorticoid and serotonin receptors as a mechanism of depression.
Topics: Antidepressive Agents, Second-Generation; Antidepressive Agents, Tricyclic; Antiviral Agents; Cell C | 2005 |
Involvement of the endocannabinoid system in the ability of long-term tricyclic antidepressant treatment to suppress stress-induced activation of the hypothalamic-pituitary-adrenal axis.
Topics: Animals; Antidepressive Agents, Tricyclic; Cannabinoid Receptor Modulators; Cortisone; Depressive Di | 2006 |
Suicidality scores during double-blind fluoxetine and desipramine treatment in Mexican Americans.
Topics: Antidepressive Agents, Tricyclic; Depressive Disorder, Major; Desipramine; Double-Blind Method; Fluo | 2007 |
Vulnerability for apoptosis in the limbic system after myocardial infarction in rats: a possible model for human postinfarct major depression.
Topics: Animals; Antidepressive Agents, Tricyclic; Apoptosis; Behavior, Animal; Depressive Disorder, Major; | 2007 |
A trial of dextroamphetamine in patients with involutional agitated depression.
Topics: Aged; Depressive Disorder, Major; Desipramine; Dextroamphetamine; Female; Humans; Middle Aged; Psych | 1982 |
Psychiatric issues in the management of patients with HIV infection.
Topics: Adult; Antidepressive Agents; Attention Deficit Disorder with Hyperactivity; Depressive Disorder, Ma | 2001 |
Hyperactive phosphoinositide signaling pathway in platelets of depressed patients: effect of desipramine treatment.
Topics: Adult; Blood Platelets; Cells, Cultured; Depressive Disorder, Major; Desipramine; Female; Humans; In | 2001 |
[Parenteral treatment of depressive diseases].
Topics: Antidepressive Agents; Bipolar Disorder; Dementia; Depression; Depressive Disorder, Major; Desiprami | 1970 |
[Trial of G. 35020 in 52 cases of depression].
Topics: Adult; Aged; Bipolar Disorder; Depression; Depressive Disorder, Major; Desipramine; Female; Humans; | 1968 |