desipramine has been researched along with Death, Sudden in 9 studies
Desipramine: A tricyclic dibenzazepine compound that potentiates neurotransmission. Desipramine selectively blocks reuptake of norepinephrine from the neural synapse, and also appears to impair serotonin transport. This compound also possesses minor anticholinergic activity, through its affinity to muscarinic receptors.
desipramine : A dibenzoazepine consisting of 10,11-dihydro-5H-dibenzo[b,f]azepine substituted on nitrogen with a 3-(methylamino)propyl group.
Death, Sudden: The abrupt cessation of all vital bodily functions, manifested by the permanent loss of total cerebral, respiratory, and cardiovascular functions.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Tachycardia was the most common change (36%)." | 2.68 | Electrocardiographic changes during desipramine and clomipramine treatment in children and adolescents. ( Allen, AJ; Hamburger, SD; Leonard, HL; Meyer, MC; Rapoport, JL; Richter, D; Swedo, SE; Tucker, E, 1995) |
| "This case study describes the sudden deaths of two additional children treated with tricyclic antidepressants, one with desipramine, 3." | 1.30 | Case study: two additional sudden deaths with tricyclic antidepressants. ( McClellan, J; Varley, CK, 1997) |
| "Four cases of sudden death in children 12 years or younger during desipramine treatment were identified between 1986 and 1992." | 1.29 | Estimation of the association between desipramine and the risk for sudden death in 5- to 14-year-old children. ( Biederman, J; Greenhill, LL; Ryan, ND; Thisted, RA, 1995) |
| "There have been additional reports of sudden death in children." | 1.28 | Sudden death in children receiving Norpramin: a review of three reported cases and commentary. ( Cohen, DJ; King, RA; Kleinman, CS; Leckman, JF; Nelson, JC; Rasmusson, A; Riddle, MA, 1991) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 8 (88.89) | 18.2507 |
| 2000's | 1 (11.11) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Biederman, J | 1 |
| Thisted, RA | 1 |
| Greenhill, LL | 1 |
| Ryan, ND | 1 |
| Leonard, HL | 1 |
| Meyer, MC | 1 |
| Swedo, SE | 1 |
| Richter, D | 1 |
| Hamburger, SD | 1 |
| Allen, AJ | 1 |
| Rapoport, JL | 1 |
| Tucker, E | 1 |
| Varley, CK | 2 |
| McClellan, J | 1 |
| Swanson, JR | 1 |
| Jones, GR | 1 |
| Krasselt, W | 1 |
| Denmark, LN | 1 |
| Ratti, F | 1 |
| Geller, B | 1 |
| Tingelstad, JB | 1 |
| Riddle, MA | 1 |
| Nelson, JC | 1 |
| Kleinman, CS | 1 |
| Rasmusson, A | 1 |
| Leckman, JF | 1 |
| King, RA | 1 |
| Cohen, DJ | 1 |
2 reviews available for desipramine and Death, Sudden
| Article | Year |
|---|---|
Death of two subjects due to imipramine and desipramine metabolite accumulation during chronic therapy: a review of the literature and possible mechanisms.
Topics: Adult; Antidepressive Agents, Tricyclic; Child; Death, Sudden; Desipramine; Female; Humans; Imiprami | 1997 |
Sudden death related to selected tricyclic antidepressants in children: epidemiology, mechanisms and clinical implications.
Topics: Adolescent; Antidepressive Agents, Tricyclic; Child; Child Behavior Disorders; Death, Sudden; Desipr | 2001 |
1 trial available for desipramine and Death, Sudden
| Article | Year |
|---|---|
Electrocardiographic changes during desipramine and clomipramine treatment in children and adolescents.
Topics: Adolescent; Antidepressive Agents, Tricyclic; Child; Clomipramine; Cross-Over Studies; Death, Sudden | 1995 |
6 other studies available for desipramine and Death, Sudden
| Article | Year |
|---|---|
Estimation of the association between desipramine and the risk for sudden death in 5- to 14-year-old children.
Topics: Adolescent; Age Factors; Cause of Death; Child; Confidence Intervals; Death, Sudden; Desipramine; Dr | 1995 |
Case study: two additional sudden deaths with tricyclic antidepressants.
Topics: Antidepressive Agents, Tricyclic; Antipsychotic Agents; Child; Death, Sudden; Desipramine; Humans; I | 1997 |
Commentary on unexplained death of children on Norpramin.
Topics: Adolescent; Antidepressive Agents, Tricyclic; Child; Death, Sudden; Depressive Disorder; Desipramine | 1991 |
The cardiotoxicity of the tricyclics.
Topics: Antidepressive Agents, Tricyclic; Arrhythmias, Cardiac; Attention Deficit Disorder with Hyperactivit | 1991 |
Sudden death in children receiving Norpramin: a review of three reported cases and commentary.
Topics: Attention Deficit Disorder with Hyperactivity; Child; Death, Sudden; Depressive Disorder; Desipramin | 1991 |
Sudden death in children treated with a tricyclic antidepressant.
Topics: Attention Deficit Disorder with Hyperactivity; Child; Death, Sudden; Desipramine; Heart Diseases; Hu | 1990 |