desipramine has been researched along with Chronic Illness in 30 studies
Desipramine: A tricyclic dibenzazepine compound that potentiates neurotransmission. Desipramine selectively blocks reuptake of norepinephrine from the neural synapse, and also appears to impair serotonin transport. This compound also possesses minor anticholinergic activity, through its affinity to muscarinic receptors.
desipramine : A dibenzoazepine consisting of 10,11-dihydro-5H-dibenzo[b,f]azepine substituted on nitrogen with a 3-(methylamino)propyl group.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Doxepin and desipramine at final doses of 188 and 173 mg/day, respectively, were compared in 36 volunteers with major affective or dysthymic disorder and chronic back pain." | 9.05 | Antidepressants in concomitant chronic back pain and depression: doxepin and desipramine compared. ( Benedetti, C; Bokan, JA; Butler, S; Phillips, M; Spengler, D; Ward, N, 1984) |
| "This single-center, 12-week, double-blind, prospective, controlled-concentration study randomized 121 chronic back pain patients without major depression to active placebo (benztropine mesylate) or to predetermined low, medium, or high concentrations of desipramine (targets were 50, 110, and 150 ng/mL, respectively) or fluoxetine (targets were 100, 200, and 400 ng/mL, respectively)." | 5.12 | Efficacy of noradrenergic and serotonergic antidepressants in chronic back pain: a preliminary concentration-controlled trial. ( Abramson, I; Atkinson, JH; Capparelli, EV; Garfin, SR; Matthews, SC; Slater, MA; Wallace, MS; Zisook, S, 2007) |
| "Patients with chronic low-back pain and depression were treated double blind with desipramine or doxepin." | 5.06 | Tricyclic antidepressants for chronic low-back pain. Mechanisms of action and predictors of response. ( Ward, NG, 1986) |
| "Doxepin and desipramine at final doses of 188 and 173 mg/day, respectively, were compared in 36 volunteers with major affective or dysthymic disorder and chronic back pain." | 5.05 | Antidepressants in concomitant chronic back pain and depression: doxepin and desipramine compared. ( Benedetti, C; Bokan, JA; Butler, S; Phillips, M; Spengler, D; Ward, N, 1984) |
| " The degree of anorexia and plasma corticosterone elevation in response to the stress was measured." | 3.67 | The effect of acute and chronic administration of desmethylimipramine on responses to stress in rats. ( Platt, JE; Stone, EA; Trullas, R, 1984) |
| "Desipramine has an antiarrhythmic effect in patients with chronic ventricular ectopy, but its clinical utility is limited by adverse effects." | 2.66 | Antiarrhythmic efficacy of desipramine. ( Bressler, R; Fenster, PE; Kipps, J, 1989) |
| "CD-1 mice were dosed with Bacille Calmette-Guérin (BCG) and measures of body weight, locomotor activity, and immobility in the tail suspension test (TST) were made." | 1.39 | A depressive phenotype induced by Bacille Calmette Guérin in 'susceptible' animals: sensitivity to antidepressants. ( Clark, JA; Klee, N; Nizami, M; Platt, B; Schulenberg, J, 2013) |
| " Unpredictable chronic mild stress induced a degradation of coat state and decreased grooming behaviour in the splash test, which was reversed by the chronic administration of tramadol (20 mg/kg) and desipramine (10 mg/kg)." | 1.34 | Antidepressant-like effect of tramadol in the unpredictable chronic mild stress procedure: possible involvement of the noradrenergic system. ( Aksu, F; Belzung, C; Bodard, S; Chalon, S; Yalcin, I, 2007) |
| " In this study, we examined the interaction between prolonged exposure to either repeated restraint stress or chronic mild stress with the chronic administration of the antidepressant desipramine on two spontaneous behaviours, in which an involvement of the mesolimbic dopamine system has been suggested: novelty-induced exploratory activity and grooming." | 1.31 | Exploratory behaviour and grooming after repeated restraint and chronic mild stress: effect of desipramine. ( Carboni, V; D'Aquila, PS; Peana, AT; Serra, G, 2000) |
| "If sinusitis is not found to be present, the otolaryngologist must help the patient understand this point, reassure him or her that the otolaryngologist will still be vigilant for the development of sinusitis, and refocus the history and workup for some other cause of the recurrent and persistent paranasal pain." | 1.29 | Treatment of chronic paranasal sinus pain with minimal sinus disease. ( Acquadro, MA; Montgomery, WW, 1996) |
| "The literature is devoid of reports indicating that a reduction in the dosage or discontinuation of antidepressants of any chemical class produces symptoms of major depression within 2-4 d." | 1.28 | Symptoms of major depression: acute effect of withdrawing antidepressants. ( Del Medico, VJ; Dilsaver, SC; Halle, MH, 1991) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 8 (26.67) | 18.7374 |
| 1990's | 7 (23.33) | 18.2507 |
| 2000's | 11 (36.67) | 29.6817 |
| 2010's | 4 (13.33) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Listowska, M | 1 |
| Glac, W | 1 |
| Grembecka, B | 1 |
| Grzybowska, M | 1 |
| Wrona, D | 1 |
| Yalcin, I | 3 |
| Belzung, C | 3 |
| Surget, A | 1 |
| Bachis, A | 1 |
| Cruz, MI | 1 |
| Nosheny, RL | 1 |
| Mocchetti, I | 1 |
| Stone, EA | 2 |
| Lin, Y | 1 |
| Quartermain, D | 1 |
| Jiang, WG | 1 |
| Li, SX | 1 |
| Zhou, SJ | 1 |
| Sun, Y | 1 |
| Shi, J | 1 |
| Lu, L | 1 |
| Tomii, T | 1 |
| Honjo, O | 1 |
| Matsumoto, T | 1 |
| Tachibana, H | 1 |
| Fujii, Y | 1 |
| Ishino, K | 1 |
| Ogasawara, Y | 1 |
| Sano, S | 1 |
| Platt, B | 1 |
| Schulenberg, J | 1 |
| Klee, N | 1 |
| Nizami, M | 1 |
| Clark, JA | 1 |
| Danhauer, SC | 1 |
| Miller, CS | 1 |
| Rhodus, NL | 1 |
| Carlson, CR | 1 |
| Matuszewich, L | 1 |
| Yamamoto, BK | 1 |
| Aksu, F | 2 |
| Basile, AS | 1 |
| Janowsky, A | 1 |
| Golembiowska, K | 1 |
| Kowalska, M | 1 |
| Tam, E | 1 |
| Benveniste, M | 1 |
| Popik, P | 1 |
| Nikiforuk, A | 1 |
| Krawczyk, M | 1 |
| Nowak, G | 1 |
| Krieter, PA | 1 |
| Lippa, AS | 1 |
| Skolnick, P | 1 |
| Koustova, E | 1 |
| Atkinson, JH | 1 |
| Slater, MA | 1 |
| Capparelli, EV | 1 |
| Wallace, MS | 1 |
| Zisook, S | 1 |
| Abramson, I | 1 |
| Matthews, SC | 1 |
| Garfin, SR | 1 |
| Bodard, S | 1 |
| Chalon, S | 1 |
| Ward, N | 1 |
| Bokan, JA | 1 |
| Phillips, M | 1 |
| Benedetti, C | 1 |
| Butler, S | 1 |
| Spengler, D | 1 |
| Trullas, R | 1 |
| Platt, JE | 1 |
| Acquadro, MA | 1 |
| Montgomery, WW | 1 |
| Kocsis, JH | 2 |
| Friedman, RA | 2 |
| Markowitz, JC | 2 |
| Leon, AC | 1 |
| Miller, NL | 1 |
| Gniwesch, L | 1 |
| Parides, M | 1 |
| Miller, N | 1 |
| Spielman, LA | 1 |
| Moran, ME | 1 |
| Detke, MJ | 1 |
| Johnson, J | 1 |
| Lucki, I | 1 |
| D'Aquila, PS | 1 |
| Peana, AT | 1 |
| Carboni, V | 1 |
| Serra, G | 1 |
| Schenck, CH | 1 |
| Bundlie, SR | 1 |
| Ettinger, MG | 1 |
| Mahowald, MW | 1 |
| Saltz, BL | 1 |
| Nakamura, S | 1 |
| Halle, MH | 1 |
| Del Medico, VJ | 1 |
| Dilsaver, SC | 1 |
| Fenster, PE | 1 |
| Bressler, R | 1 |
| Kipps, J | 1 |
| Ward, NG | 1 |
| Cohen, BM | 1 |
| Baldessarini, RJ | 1 |
| Berner, P | 1 |
| Kryspin-Exner, K | 1 |
| Poeldinger, W | 1 |
| Morselli, PL | 1 |
| Rizzo, M | 1 |
| Zaccala, M | 1 |
| Garattini, S | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Efficacy of Antidepressants in Chronic Back Pain[NCT00018200] | Phase 2 | 130 participants (Actual) | Interventional | 1999-04-30 | Completed | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
1 review available for desipramine and Chronic Illness
| Article | Year |
|---|---|
Axonal sprouting of noradrenergic locus coeruleus neurons following repeated stress and antidepressant treatment.
Topics: Animals; Antidepressive Agents; Axons; Chronic Disease; Desipramine; Electroconvulsive Therapy; Elec | 1991 |
7 trials available for desipramine and Chronic Illness
| Article | Year |
|---|---|
Impact of criteria-based diagnosis of burning mouth syndrome on treatment outcome.
Topics: Adult; Aged; Aged, 80 and over; Anti-Anxiety Agents; Anticonvulsants; Burning Mouth Syndrome; Carbam | 2002 |
Efficacy of noradrenergic and serotonergic antidepressants in chronic back pain: a preliminary concentration-controlled trial.
Topics: Adrenergic Uptake Inhibitors; Adult; Aged; Back Pain; Capsules; Chronic Disease; Constipation; Desip | 2007 |
Antidepressants in concomitant chronic back pain and depression: doxepin and desipramine compared.
Topics: Adult; Anxiety Disorders; Back Pain; beta-Endorphin; Chronic Disease; Clinical Trials as Topic; Depr | 1984 |
Maintenance therapy for chronic depression. A controlled clinical trial of desipramine.
Topics: Adult; Age of Onset; Chronic Disease; Depressive Disorder; Desipramine; Drug Administration Schedule | 1996 |
Antiarrhythmic efficacy of desipramine.
Topics: Adult; Aged; Aged, 80 and over; Arrhythmias, Cardiac; Chronic Disease; Clinical Trials as Topic; Des | 1989 |
Tricyclic antidepressants for chronic low-back pain. Mechanisms of action and predictors of response.
Topics: Adult; Back Pain; Chronic Disease; Clinical Trials as Topic; Depressive Disorder; Desipramine; Doubl | 1986 |
Therapy possibilities for therapy-resistant depressions.
Topics: Amitriptyline; Antidepressive Agents; Chronic Disease; Clinical Trials as Topic; Depression; Desipra | 1974 |
22 other studies available for desipramine and Chronic Illness
| Article | Year |
|---|---|
Changes in blood CD4+T and CD8+T lymphocytes in stressed rats pretreated chronically with desipramine are more pronounced after chronic open field stress challenge.
Topics: Animals; Antidepressive Agents, Tricyclic; Apoptosis; Body Weight; CD4-Positive T-Lymphocytes; CD8-P | 2015 |
Mouse strain differences in the unpredictable chronic mild stress: a four-antidepressant survey.
Topics: Animals; Animals, Outbred Strains; Antidepressive Agents; Antidepressive Agents, Second-Generation; | 2008 |
Chronic unpredictable stress promotes neuronal apoptosis in the cerebral cortex.
Topics: Animals; Antidepressive Agents, Tricyclic; Apoptosis; Caspase 3; Cerebral Cortex; Chronic Disease; C | 2008 |
Evaluation of the repeated open-space swim model of depression in the mouse.
Topics: Adaptation, Psychological; Animals; Antidepressive Agents; Antidepressive Agents, Second-Generation; | 2008 |
Chronic unpredictable stress induces a reversible change of PER2 rhythm in the suprachiasmatic nucleus.
Topics: Analysis of Variance; Animals; Antidepressive Agents, Tricyclic; Chronic Disease; Circadian Rhythm; | 2011 |
Impact of chronic cyanosis and reoxygenation on the microheterogeneity of the myocardial blood flow: digital radiographic study in neonatal rats.
Topics: Age Factors; Aging; Animals; Animals, Newborn; Chronic Disease; Coronary Circulation; Cyanosis; Desi | 2011 |
A depressive phenotype induced by Bacille Calmette Guérin in 'susceptible' animals: sensitivity to antidepressants.
Topics: Animals; Antidepressive Agents; BCG Vaccine; Chronic Disease; Depression; Desipramine; Diazepam; Dis | 2013 |
Effects of chronic stress on methamphetamine-induced dopamine depletions in the striatum.
Topics: Animals; Antidepressive Agents, Tricyclic; Chronic Disease; Desipramine; Dopamine; Dopamine Uptake I | 2004 |
Effects of desipramine and tramadol in a chronic mild stress model in mice are altered by yohimbine but not by pindolol.
Topics: Adrenergic alpha-Antagonists; Adrenergic beta-Antagonists; Analgesics, Opioid; Animals; Antidepressi | 2005 |
Characterization of the antinociceptive actions of bicifadine in models of acute, persistent, and chronic pain.
Topics: Acute Disease; Analgesics; Animals; Brain; Bridged Bicyclo Compounds, Heterocyclic; Chronic Disease; | 2007 |
Antidepressant-like effect of tramadol in the unpredictable chronic mild stress procedure: possible involvement of the noradrenergic system.
Topics: Adrenergic beta-Antagonists; Animals; Antidepressive Agents; Behavior, Animal; Cerebellum; Chronic D | 2007 |
The effect of acute and chronic administration of desmethylimipramine on responses to stress in rats.
Topics: Acute Disease; Animals; Anorexia; Chronic Disease; Corticosterone; Depression; Desipramine; Electros | 1984 |
Treatment of chronic paranasal sinus pain with minimal sinus disease.
Topics: 1-Naphthylamine; Anti-Inflammatory Agents, Non-Steroidal; Antidepressive Agents, Tricyclic; Carbamaz | 1996 |
Interpersonal improvement in chronically depressed patients treated with desipramine.
Topics: Adult; Antidepressive Agents; Chronic Disease; Depressive Disorder; Desipramine; Female; Humans; Mal | 1996 |
Acute and chronic antidepressant drug treatment in the rat forced swimming test model of depression.
Topics: Acute Disease; Animals; Antidepressive Agents; Antidepressive Agents, Second-Generation; Antidepress | 1997 |
Exploratory behaviour and grooming after repeated restraint and chronic mild stress: effect of desipramine.
Topics: Animals; Antidepressive Agents, Tricyclic; Chronic Disease; Desipramine; Exploratory Behavior; Groom | 2000 |
Chronic behavioral disorders of human REM sleep: a new category of parasomnia. 1986 [classical article].
Topics: Aged; Anticonvulsants; Antidepressive Agents, Tricyclic; Brain; Chronic Disease; Clonazepam; Desipra | 2002 |
Tardive dyskinesia in the elderly patient.
Topics: Aged; Chlorpromazine; Chronic Disease; Clonazepam; Clozapine; Depressive Disorder; Desipramine; Diph | 1992 |
Symptoms of major depression: acute effect of withdrawing antidepressants.
Topics: Adult; Arousal; Chronic Disease; Depressive Disorder; Desipramine; Dose-Response Relationship, Drug; | 1991 |
The course of panic attacks and agoraphobia.
Topics: Agoraphobia; Anxiety; Chronic Disease; Desipramine; Fear; Follow-Up Studies; Humans; Panic; Phobic D | 1988 |
Tolerance to therapeutic effects of antidepressants.
Topics: Adult; Aged; Amitriptyline; Antidepressive Agents; Chronic Disease; Depressive Disorder; Desipramine | 1985 |
Haloperidol-desipramine interaction in mice, rats and man.
Topics: Animals; Basal Ganglia Diseases; Benperidol; Butyrophenones; Chronic Disease; Desipramine; Drug Anta | 1970 |