Page last updated: 2024-10-25

desipramine and Chemical Dependence

desipramine has been researched along with Chemical Dependence in 82 studies

Desipramine: A tricyclic dibenzazepine compound that potentiates neurotransmission. Desipramine selectively blocks reuptake of norepinephrine from the neural synapse, and also appears to impair serotonin transport. This compound also possesses minor anticholinergic activity, through its affinity to muscarinic receptors.
desipramine : A dibenzoazepine consisting of 10,11-dihydro-5H-dibenzo[b,f]azepine substituted on nitrogen with a 3-(methylamino)propyl group.

Research Excerpts

ExcerptRelevanceReference
"Thirteen patients meeting DSM-III-R criteria for panic disorder with or without agoraphobia that started during or shortly after cocaine exposure were treated in the UCLA Anxiety Disorders Program (Los Angeles, CA)."7.68Low dose desipramine treatment of cocaine-related panic attacks. ( Ackerman, DL; Bystritsky, A; Pasnau, RO, 1991)
"Desipramine has been added to methadone maintenance in an attempt to reduce dependence on both substances."3.76Pharmacological and behavioral treatments of cocaine dependence: controlled studies. ( Arndt, IO; Childress, AR; Maany, I; McLellan, AT; O'Brien, CP; Woody, GE, 1988)
"Thirteen patients meeting DSM-III-R criteria for panic disorder with or without agoraphobia that started during or shortly after cocaine exposure were treated in the UCLA Anxiety Disorders Program (Los Angeles, CA)."3.68Low dose desipramine treatment of cocaine-related panic attacks. ( Ackerman, DL; Bystritsky, A; Pasnau, RO, 1991)
"Concerning the comorbid substance use, all the studies have included patients with alcohol use, none of them have dealt with cocaine, cannabis or nicotine use."2.82Clinical practice guideline on pharmacological and psychological management of adult patients with an anxiety disorder and comorbid substance use. ( Arranz, B; Arrojo, M; Becoña, E; Bernardo, M; Castells, X; Cunill, R; Flórez, G; Fonseca, F; Garriga, M; Goikolea, JM; González-Pinto, A; López, A; Sáiz, PA; San, L; Tirado-Muñoz, J; Torrens, M; Zorrilla, I, 2022)
"Desipramine was an effective antidepressant in this sample and was associated with significantly greater reduction in depressive symptoms than was placebo; however, desipramine treatment was not associated with greater reductions in cocaine use for either the depressed or euthymic subgroup."2.68Differential symptom reduction in depressed cocaine abusers treated with psychotherapy and pharmacotherapy. ( Carroll, KM; Nich, C; Rounsaville, BJ, 1995)
"Although patients with a history of substance abuse reported higher levels of anxiety and depression at presentation for treatment than patients without such histories, the two groups reported a similar age of onset of their bulimia nervosa and similar severity of eating pathology with regards to binge and vomit frequencies and measures of concern about body shape and weight."2.67The impact of prior substance abuse on treatment outcome for bulimia nervosa. ( Pike, KM; Strasser, TJ; Walsh, BT, 1992)
" Mean plasma concentration of desipramine in a subsample of our subjects was less than that recommended for treatment of depression, thus the dosage of desipramine may have been subtherapeutic."2.67Comparison of amantadine and desipramine combined with psychotherapy for treatment of cocaine dependence. ( Brown, BS; Haertzen, CA; Hess, JM; Jaffe, JH; Kolar, AF; Mahaffey, JR; Weddington, WW, 1991)
"Informing drug abusers in treatment regarding positive HIV-serostatus was not associated with a lower treatment-retention rate or adverse psychological reactions when counseling regarding HIV issues was integrated with drug abuse treatment."2.67Psychological reactions and retention by cocaine addicts during treatment according to HIV-serostatus: a matched-control study. ( Brown, BS; Haertzen, CA; Hess, JM; Weddington, WW, 1991)
"Desipramine blood levels were taken at weeks 2 (inpatient), 3, and 8."2.67Continuity of care and desipramine in primary cocaine abusers. ( Banys, P; Clark, HW; Hall, SM; Presti, D; Stewart, P; Triffleman, E; Tunis, S; Tusel, D, 1994)
"Thus, antisocial personality disorder was a poor prognostic factor for treatment retention and continued cocaine abuse, and medication did not improve treatment outcome for the ASP patients, but did for the non-ASP patients."2.67Antisocial personality disorder as a prognostic factor for pharmacotherapy of cocaine dependence. ( Kosten, T; Leal, J; Ziedonis, D, 1994)
"Desipramine-treated subjects attained contiguous periods of abstinence substantially more frequently than subjects receiving lithium or placebo."2.66Desipramine facilitation of initial cocaine abstinence. ( Byck, R; Gawin, FH; Jatlow, PI; Kleber, HD; Kosten, TR; Morgan, C; Rounsaville, BJ, 1989)
"Treatment with bromocriptine was significantly more effective than placebo in alleviating withdrawal symptoms."2.66Bromocriptine-desipramine protocol in treatment of cocaine addiction. ( Billett, W; Giannini, AJ, 1987)
"Lithium carbonate was effective only in cyclothymic subjects."2.65Cocaine abuse treatment. Open pilot trial with desipramine and lithium carbonate. ( Gawin, FH; Kleber, HD, 1984)
"Pretreatment with bromocriptine (0."1.30Effects of proposed treatments for cocaine addiction on hemodynamic responsiveness to cocaine in conscious rats. ( Gan, Q; Knuepfer, MM, 1997)
"Desipramine treatment (3."1.28Desipramine effects on cocaine self-administration by rhesus monkeys. ( Bree, MP; Lukas, SE; Mello, NK; Mendelson, JH, 1990)
" Chronic administration of desipramine may have therapeutic efficacy in treating cocaine abuse only in subjects attempting to refrain from cocaine who are aided in their passage through a withdrawal phase by desipramine."1.28Schedule-induced oral self-administration of cocaine and ethanol solutions: lack of effect of chronic desipramine. ( Falk, JL; Tang, M, 1990)
"Desipramine was administered to 8 amphetamine- and 14 cocaine-dependent persons to assist withdrawal."1.27Cocaine and amphetamine dependence treated with desipramine. ( Rawson, RA; Tennant, FS, 1983)
"Desipramine quickly reversed the withdrawal symptoms in both patients, although it did not prevent their future use of cocaine."1.27Desipramine in the treatment of hypersomnolence following abrupt cessation of cocaine use. ( Baxter, LR, 1983)

Research

Studies (82)

TimeframeStudies, this research(%)All Research%
pre-199031 (37.80)18.7374
1990's46 (56.10)18.2507
2000's4 (4.88)29.6817
2010's0 (0.00)24.3611
2020's1 (1.22)2.80

Authors

AuthorsStudies
Sáiz, PA1
Flórez, G1
Arrojo, M1
Bernardo, M1
González-Pinto, A1
Goikolea, JM1
Zorrilla, I1
Cunill, R1
Castells, X1
Becoña, E1
López, A1
Torrens, M1
Fonseca, F1
Tirado-Muñoz, J1
Arranz, B1
Garriga, M1
San, L1
Gasior, M1
Bergman, J1
Kallman, MJ1
Paronis, CA1
Amitai, Y1
Frischer, H1
Jasinski, DR1
Faries, DE1
Moore, RJ1
Schuh, LM1
Allen, AJ1
Tennant, FS3
Rawson, RA3
Gawin, FH9
Kleber, HD3
Baxter, LR1
McCann, M1
Vasiliades, J1
Carroll, KM4
Nich, C4
Rounsaville, BJ5
Shoptaw, S1
McCann, MJ1
Obert, JL1
Campbell, JL1
Thomas, HM1
Gabrielli, W1
Liskow, BI1
Powell, BJ1
Piotrowski, NA1
Clark, HW2
Hall, SM2
Tunis, S1
Triffleman, E1
Banys, P1
Tusel, D1
Stewart, P1
Presti, D1
Gordon, LT2
Wirtz, PW1
Gawin, F2
Kaminer, Y2
Leal, J1
Ziedonis, D2
Kosten, T4
Arndt, IO4
McLellan, AT5
Dorozynsky, L3
Woody, GE3
O'Brien, CP6
Jatlow, P4
Bisighini, RM1
Kosten, TR8
Johnson, DN1
Vocci, FJ1
Rowe, JB1
Sullivan, PF1
Mulder, RT1
Joyce, PR1
Foltin, RW3
Fischman, MW3
Schottenfeld, RS3
Higgins, ST1
Budney, AJ1
Knuepfer, MM1
Gan, Q1
Fuchs, RA1
Tran-Nguyen, LT1
Specio, SE1
Groff, RS1
Neisewander, JL1
Treisman, GJ1
Angelino, AF1
Hutton, HE1
Petit, JM1
Biggs, JT1
Kolar, AF3
Brown, BS4
Weddington, WW5
Haertzen, CC1
Michaelson, BS1
Jaffe, JH2
Brooke, D1
Fudala, PJ1
Johnson, RE1
See, RE1
Adams-Curtis, L1
Chapman, MA1
Silverman, DG1
Fleming, J2
Compton, M1
Byck, R4
Morgan, CM1
Falcione, J1
Meyer, RE1
Delucchi, KL1
Richardson, T1
Lee, E1
Petrakis, I1
Strasser, TJ1
Pike, KM1
Walsh, BT1
Bystritsky, A1
Ackerman, DL1
Pasnau, RO1
Ziedonis, DM1
Levin, FR1
Lehman, AF1
Giannini, AJ3
Haertzen, CA3
Hess, JM3
Mahaffey, JR2
Pickett, G1
Silverman, D1
Kosten, TA1
Morgan, CH1
Goeders, NE1
Bienvenu, OJ1
De Souza, EB1
Mello, NK4
Lukas, SE1
Bree, MP1
Mendelson, JH4
Teoh, SK2
Weiss, R1
McElroy, S1
McAfee, B2
Morgan, C2
Nelson, JC1
Tang, M1
Falk, JL1
Maany, I2
Dhopesh, V1
Burke, W1
Woody, G2
Jatlow, PI1
Arndt, I1
McElroy, SL1
Weiss, RD2
Alterman, A1
Walter, D1
Childress, AR2
Clark, RJ1
Dackis, CA2
Gold, MS2
Pottash, AL1
Bozarth, MA1
Wise, RA1
Tarver, A1
Pumphrey, E1
Seecof, R1
Schumann, B2
Millman, RB1
Billett, W1
Tennant, F1
Berman, ML1
Barnes, DM1
Malone, DA1
Giannini, MC1
Price, WA1
Loiselle, RH1
Wright, D1
Carney, MK1
Liu, SJ1
Wang, RI1
Milner, G1

Clinical Trials (1)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
Four Models of Telephone Support for Stimulant Recovery[NCT00744068]302 participants (Actual)Interventional2006-04-30Completed
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Reviews

11 reviews available for desipramine and Chemical Dependence

ArticleYear
Clinical practice guideline on pharmacological and psychological management of adult patients with an anxiety disorder and comorbid substance use.
    Adicciones, 2022, Apr-01, Volume: 34, Issue:2

    Topics: Adult; Anxiety Disorders; Desipramine; Humans; Naltrexone; Paroxetine; Substance-Related Disorders

2022
Clinical and research perspectives on cocaine abuse: the pharmacotherapy of cocaine abuse.
    NIDA research monograph, 1993, Volume: 135

    Topics: Buprenorphine; Clinical Trials as Topic; Cocaine; Desipramine; Humans; Substance-Related Disorders

1993
Medications development at the National Institute on Drug Abuse: focus on cocaine.
    NIDA research monograph, 1993, Volume: 135

    Topics: Bromocriptine; Cocaine; Desipramine; Humans; Substance Withdrawal Syndrome; Substance-Related Disord

1993
Cocaine self-administration research: treatment implications.
    NIDA research monograph, 1994, Volume: 145

    Topics: Animals; Choice Behavior; Clinical Trials as Topic; Cocaine; Desipramine; Dose-Response Relationship

1994
From the initial clinic contact to aftercare: a brief review of effective strategies for retaining cocaine abusers in treatment.
    NIDA research monograph, 1997, Volume: 165

    Topics: Antidepressive Agents; Appointments and Schedules; Clinical Trials as Topic; Cocaine; Desipramine; F

1997
New pharmacotherapies for cocaine dependence ... revisited.
    Archives of general psychiatry, 1992, Volume: 49, Issue:11

    Topics: Alcoholism; Cocaine; Desipramine; Disease Models, Animal; Double-Blind Method; Heroin Dependence; Hu

1992
Meta-analysis of desipramine as an adjunct in the treatment of cocaine addiction.
    Journal of clinical psychopharmacology, 1991, Volume: 11, Issue:6

    Topics: Cocaine; Combined Modality Therapy; Desipramine; Humans; Meta-Analysis as Topic; Substance-Related D

1991
Clinical investigations of drug effects in women.
    NIDA research monograph, 1986, Volume: 65

    Topics: Buprenorphine; Cocaine; Desipramine; Female; Heroin Dependence; Humans; Male; Naltrexone; Opioid-Rel

1986
Pharmacological and behavioral treatments of cocaine dependence: controlled studies.
    The Journal of clinical psychiatry, 1988, Volume: 49 Suppl

    Topics: Animals; Behavior Therapy; Clinical Trials as Topic; Cocaine; Conditioning, Classical; Desipramine;

1988
Evaluation and clinical management of cocaine abusers.
    The Journal of clinical psychiatry, 1988, Volume: 49 Suppl

    Topics: Acquired Immunodeficiency Syndrome; Antidepressive Agents, Tricyclic; Cocaine; Desipramine; Humans;

1988
Pharmacological approaches to cocaine addiction.
    Journal of substance abuse treatment, 1985, Volume: 2, Issue:3

    Topics: Brain Chemistry; Bromocriptine; Cocaine; Desipramine; Dopamine; Euphoria; Humans; Receptors, Dopamin

1985

Trials

33 trials available for desipramine and Chemical Dependence

ArticleYear
Abuse liability assessment of atomoxetine in a drug-abusing population.
    Drug and alcohol dependence, 2008, May-01, Volume: 95, Issue:1-2

    Topics: Adrenergic Uptake Inhibitors; Adult; Arousal; Atomoxetine Hydrochloride; Central Nervous System Stim

2008
Cocaine abuse treatment. Open pilot trial with desipramine and lithium carbonate.
    Archives of general psychiatry, 1984, Volume: 41, Issue:9

    Topics: Adult; Clinical Trials as Topic; Cocaine; Cyclothymic Disorder; Desipramine; Female; Humans; Lithium

1984
Differential symptom reduction in depressed cocaine abusers treated with psychotherapy and pharmacotherapy.
    The Journal of nervous and mental disease, 1995, Volume: 183, Issue:4

    Topics: Adult; Cocaine; Cognitive Behavioral Therapy; Combined Modality Therapy; Comorbidity; Depressive Dis

1995
The Matrix model of outpatient stimulant abuse treatment: evidence of efficacy.
    Journal of addictive diseases, 1994, Volume: 13, Issue:4

    Topics: Adult; Ambulatory Care; Cocaine; Combined Modality Therapy; Desipramine; Double-Blind Method; Female

1994
Impact of desipramine or carbamazepine on patient retention in outpatient cocaine treatment: preliminary findings.
    Journal of addictive diseases, 1994, Volume: 13, Issue:4

    Topics: Ambulatory Care; Antisocial Personality Disorder; Anxiety Disorders; Carbamazepine; Cocaine; Combine

1994
Treatment research with crack-cocaine-dependent male veterans: the efficacy of different recruitment strategies.
    The American journal of drug and alcohol abuse, 1994, Volume: 20, Issue:4

    Topics: Adolescent; Adult; Aged; Ambulatory Care; Combined Modality Therapy; Crack Cocaine; Desipramine; Hum

1994
Continuity of care and desipramine in primary cocaine abusers.
    The Journal of nervous and mental disease, 1994, Volume: 182, Issue:10

    Topics: Adult; Ambulatory Care; Cocaine; Continuity of Patient Care; Costs and Cost Analysis; Counseling; De

1994
One-year follow-up of psychotherapy and pharmacotherapy for cocaine dependence. Delayed emergence of psychotherapy effects.
    Archives of general psychiatry, 1994, Volume: 51, Issue:12

    Topics: Adaptation, Psychological; Adult; Ambulatory Care; Behavior Therapy; Cocaine; Cognitive Behavioral T

1994
Antisocial personality disorder as a prognostic factor for pharmacotherapy of cocaine dependence.
    Drug and alcohol dependence, 1994, Volume: 35, Issue:1

    Topics: Adult; Amantadine; Antisocial Personality Disorder; Cocaine; Combined Modality Therapy; Comorbidity;

1994
Desipramine treatment for cocaine dependence. Role of antisocial personality disorder.
    The Journal of nervous and mental disease, 1994, Volume: 182, Issue:3

    Topics: Adult; Antisocial Personality Disorder; Cocaine; Comorbidity; Desipramine; Humans; Male; Methadone;

1994
Psychotherapy and pharmacotherapy for ambulatory cocaine abusers.
    Archives of general psychiatry, 1994, Volume: 51, Issue:3

    Topics: Adult; Ambulatory Care; Analysis of Variance; Cocaine; Cognitive Behavioral Therapy; Combined Modali

1994
Blind man's bluff: effectiveness and significance of psychotherapy and pharmacotherapy blinding procedures in a clinical trial.
    Journal of consulting and clinical psychology, 1994, Volume: 62, Issue:2

    Topics: Cocaine; Combined Modality Therapy; Desipramine; Double-Blind Method; Humans; Psychotherapy; Substan

1994
The effect of a history of conduct disorder in adult major depression.
    Journal of affective disorders, 1996, Feb-12, Volume: 37, Issue:1

    Topics: Adolescent; Adult; Alcoholism; Antidepressive Agents, Tricyclic; Child; Child Behavior Disorders; Cl

1996
Treatment of cocaine dependence in methadone maintenance clients: a pilot study comparing the efficacy of desipramine and amantadine.
    The International journal of the addictions, 1992, Volume: 27, Issue:7

    Topics: Adolescent; Adult; Amantadine; Baltimore; Cocaine; Desipramine; Female; Follow-Up Studies; Humans; M

1992
Weighing up the pros and cons: help-seeking by drug misusers in Baltimore, USA.
    Drug and alcohol dependence, 1992, Volume: 31, Issue:1

    Topics: Adult; Bromocriptine; Buprenorphine; Cocaine; Desipramine; Fear; Female; Fluoxetine; Humans; Male; M

1992
Intravenous cocaine challenges during desipramine maintenance.
    Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology, 1992, Volume: 7, Issue:3

    Topics: Adult; Cardiovascular System; Cocaine; Desipramine; Dose-Response Relationship, Drug; Female; Humans

1992
Desipramine treatment of cocaine dependence in methadone-maintained patients.
    Archives of general psychiatry, 1992, Volume: 49, Issue:11

    Topics: Adult; Cocaine; Comorbidity; Desipramine; Double-Blind Method; Drug Therapy, Combination; Follow-Up

1992
Pharmacotherapy for cocaine-abusing methadone-maintained patients using amantadine or desipramine.
    Archives of general psychiatry, 1992, Volume: 49, Issue:11

    Topics: Adult; Amantadine; Cocaine; Desipramine; Double-Blind Method; Female; Humans; Male; Methadone; Opioi

1992
The impact of prior substance abuse on treatment outcome for bulimia nervosa.
    Addictive behaviors, 1992, Volume: 17, Issue:4

    Topics: Adolescent; Adult; Body Weight; Bulimia; Depressive Disorder; Desipramine; Double-Blind Method; Fema

1992
Depression as a prognostic factor for pharmacological treatment of cocaine dependence.
    Psychopharmacology bulletin, 1991, Volume: 27, Issue:3

    Topics: Adult; Amantadine; Cocaine; Depression; Desipramine; Female; Humans; Male; Prognosis; Psychiatric St

1991
Comparison of amantadine and desipramine combined with psychotherapy for treatment of cocaine dependence.
    The American journal of drug and alcohol abuse, 1991, Volume: 17, Issue:2

    Topics: Adult; Amantadine; Cocaine; Combined Modality Therapy; Desipramine; Dose-Response Relationship, Drug

1991
Amantadine and desipramine in the treatment of cocaine abusing methadone maintained patients.
    NIDA research monograph, 1990, Volume: 105

    Topics: Adult; Amantadine; Cocaine; Desipramine; Double-Blind Method; Female; Humans; Male; Methadone; Opioi

1990
Psychological reactions and retention by cocaine addicts during treatment according to HIV-serostatus: a matched-control study.
    The American journal of drug and alcohol abuse, 1991, Volume: 17, Issue:3

    Topics: Adaptation, Psychological; Adult; Affect; AIDS Serodiagnosis; Amantadine; Baltimore; Cocaine; Combin

1991
Hyperprolactinemia and risk for relapse of cocaine abuse.
    Biological psychiatry, 1990, Nov-01, Volume: 28, Issue:9

    Topics: Adult; Cocaine; Desipramine; Double-Blind Method; Female; Humans; Hyperprolactinemia; Male; Prolacti

1990
Desipramine facilitation of initial cocaine abstinence.
    Archives of general psychiatry, 1989, Volume: 46, Issue:2

    Topics: Adult; Ambulatory Care; Clinical Trials as Topic; Cocaine; Desipramine; Double-Blind Method; Female;

1989
Desipramine treatment of cocaine abuse in methadone maintenance patients.
    NIDA research monograph, 1989, Volume: 95

    Topics: Clinical Trials as Topic; Cocaine; Combined Modality Therapy; Desipramine; Double-Blind Method; Huma

1989
Comparison of amantadine and desipramine combined with psychotherapy for treatment of cocaine dependence.
    NIDA research monograph, 1989, Volume: 95

    Topics: Amantadine; Clinical Trials as Topic; Cocaine; Combined Modality Therapy; Desipramine; Follow-Up Stu

1989
Desipramine treatment for relapse prevention in cocaine dependence.
    NIDA research monograph, 1989, Volume: 95

    Topics: Adult; Cocaine; Desipramine; Double-Blind Method; Female; Humans; Length of Stay; Male; Personality

1989
Evaluation of treatment for cocaine dependence.
    NIDA research monograph, 1989, Volume: 95

    Topics: Adult; Behavior Therapy; Cocaine; Combined Modality Therapy; Desipramine; Double-Blind Method; Human

1989
Double-blind comparison of desipramine and placebo for treatment of phencyclidine or amphetamine dependence.
    NIDA research monograph, 1986, Volume: 67

    Topics: Amphetamines; Clinical Trials as Topic; Desipramine; Double-Blind Method; Humans; Phencyclidine; Pla

1986
Pharmacological and behavioral treatments of cocaine dependence: controlled studies.
    The Journal of clinical psychiatry, 1988, Volume: 49 Suppl

    Topics: Animals; Behavior Therapy; Clinical Trials as Topic; Cocaine; Conditioning, Classical; Desipramine;

1988
Bromocriptine-desipramine protocol in treatment of cocaine addiction.
    Journal of clinical pharmacology, 1987, Volume: 27, Issue:8

    Topics: Adult; Bromocriptine; Clinical Trials as Topic; Cocaine; Desipramine; Drug Therapy, Combination; Hum

1987
Treatment of depression in chronic cocaine and phencyclidine abuse with desipramine.
    Journal of clinical pharmacology, 1986, Volume: 26, Issue:3

    Topics: Adult; Clinical Trials as Topic; Cocaine; Depression; Desipramine; Humans; Male; Phencyclidine; Plac

1986

Other Studies

39 other studies available for desipramine and Chemical Dependence

ArticleYear
Evaluation of the reinforcing effects of monoamine reuptake inhibitors under a concurrent schedule of food and i.v. drug delivery in rhesus monkeys.
    Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology, 2005, Volume: 30, Issue:4

    Topics: Adrenergic Uptake Inhibitors; Animals; Atomoxetine Hydrochloride; Attention Deficit Disorder with Hy

2005
Excess fatality from desipramine in children and adolescents.
    Journal of the American Academy of Child and Adolescent Psychiatry, 2006, Volume: 45, Issue:1

    Topics: Adolescent; Amitriptyline; Child; Desipramine; Doxepin; Humans; Imipramine; Incidence; Mortality; No

2006
Cocaine and amphetamine dependence treated with desipramine.
    NIDA research monograph, 1983, Volume: 43

    Topics: Adult; Amphetamine; Cocaine; Desipramine; Female; Humans; Male; Substance-Related Disorders

1983
Desipramine in the treatment of hypersomnolence following abrupt cessation of cocaine use.
    The American journal of psychiatry, 1983, Volume: 140, Issue:11

    Topics: Adult; Cocaine; Desipramine; Female; Humans; Sleep Wake Disorders; Substance Withdrawal Syndrome; Su

1983
Withdrawal from chronic phencyclidine (PCP) dependence with desipramine.
    The American journal of psychiatry, 1981, Volume: 138, Issue:6

    Topics: Adolescent; Adult; Desipramine; Female; Humans; Male; Phencyclidine; Substance Withdrawal Syndrome;

1981
Identification of misused drugs in the clinical laboratory. I. Tricyclics.
    Clinical biochemistry, 1980, Volume: 13, Issue:1

    Topics: Adult; Amitriptyline; Antidepressive Agents, Tricyclic; Chromatography, Gas; Chromatography, Thin La

1980
Cocaine craving.
    Journal of the American Academy of Child and Adolescent Psychiatry, 1994, Volume: 33, Issue:4

    Topics: Adolescent; Amitriptyline; Cocaine; Desipramine; Humans; Hypotension, Orthostatic; Male; Risk Factor

1994
Clinical trials of pharmacologic treatments in pregnant women--methodologic considerations.
    NIDA research monograph, 1995, Volume: 149

    Topics: Bromocriptine; Buprenorphine; Clinical Trials as Topic; Desipramine; Dopamine Agonists; Female; Huma

1995
Effects of proposed treatments for cocaine addiction on hemodynamic responsiveness to cocaine in conscious rats.
    The Journal of pharmacology and experimental therapeutics, 1997, Volume: 283, Issue:2

    Topics: Animals; Bromocriptine; Buprenorphine; Cocaine; Desipramine; Diazepam; Dizocilpine Maleate; Hemodyna

1997
Predictive validity of the extinction/reinstatement model of drug craving.
    Psychopharmacology, 1998, Volume: 135, Issue:2

    Topics: Adrenergic Uptake Inhibitors; Animals; Cocaine; Desipramine; Male; Rats; Rats, Sprague-Dawley; Self

1998
Psychiatric issues in the management of patients with HIV infection.
    JAMA, 2001, Dec-12, Volume: 286, Issue:22

    Topics: Adult; Antidepressive Agents; Attention Deficit Disorder with Hyperactivity; Depressive Disorder, Ma

2001
Tricyclic antidepressant overdoses in adolescent patients.
    Pediatrics, 1977, Volume: 59, Issue:2

    Topics: Adolescent; Affective Symptoms; Amitriptyline; Antidepressive Agents, Tricyclic; Desipramine; Dose-R

1977
Desipramine facilitation of cocaine abstinence in an adolescent.
    Journal of the American Academy of Child and Adolescent Psychiatry, 1992, Volume: 31, Issue:2

    Topics: Adolescent; Cocaine; Depressive Disorder; Desipramine; Humans; Male; Personality Inventory; Substanc

1992
Assessment of dopamine release by in vivo microdialysis in the nucleus accumbens of rats following acute and chronic administration of desipramine.
    Annals of the New York Academy of Sciences, 1992, Jun-28, Volume: 654

    Topics: 3,4-Dihydroxyphenylacetic Acid; Animals; Desipramine; Dialysis; Dopamine; Homovanillic Acid; Hydroxy

1992
A laboratory model for evaluating potential treatment medications in humans.
    NIDA research monograph, 1992, Volume: 119

    Topics: Cocaine; Desipramine; Humans; Models, Theoretical; Substance-Related Disorders

1992
Research on desipramine in the treatment of cocaine abuse: a critique of Levin and Lehman's meta-analysis.
    Journal of clinical psychopharmacology, 1992, Volume: 12, Issue:5

    Topics: Clinical Trials as Topic; Cocaine; Desipramine; Humans; Meta-Analysis as Topic; Research Design; Sub

1992
Adjunctive desipramine in the treatment of cocaine abusing schizophrenics.
    Psychopharmacology bulletin, 1992, Volume: 28, Issue:3

    Topics: Adult; Cocaine; Desipramine; Female; Humans; Male; Schizophrenia; Schizophrenic Psychology; Substanc

1992
Self-administration of cocaine by humans: a laboratory perspective.
    Ciba Foundation symposium, 1992, Volume: 166

    Topics: Choice Behavior; Cocaine; Desipramine; Humans; Laboratories; Self Administration; Substance-Related

1992
Low dose desipramine treatment of cocaine-related panic attacks.
    The Journal of nervous and mental disease, 1991, Volume: 179, Issue:12

    Topics: Adult; Cocaine; Desipramine; Drug Administration Schedule; Drug Evaluation; Female; Humans; Male; Mi

1991
Innovations in use of pharmacological treatments.
    The American journal of psychiatry, 1991, Volume: 148, Issue:8

    Topics: Cocaine; Desipramine; Humans; Peer Review; Psychiatry; Psychotropic Drugs; Substance-Related Disorde

1991
Concurrent effects of acute intravenous cocaine in context of chronic desipramine in humans.
    NIDA research monograph, 1990, Volume: 105

    Topics: Adult; Blood Pressure; Cocaine; Desipramine; Drug Interactions; Heart Rate; Humans; Injections, Intr

1990
Chronic cocaine administration alters corticotropin-releasing factor receptors in the rat brain.
    Brain research, 1990, Oct-29, Volume: 531, Issue:1-2

    Topics: Animals; Autoradiography; Brain; Cerebral Ventricles; Cocaine; Corticotropin-Releasing Hormone; Desi

1990
Use of unproven and unapproved drugs to treat cocaine addiction.
    The American journal of psychiatry, 1990, Volume: 147, Issue:11

    Topics: Clinical Protocols; Cocaine; Desipramine; Drugs, Investigational; Humans; Informed Consent; Substanc

1990
Desipramine effects on cocaine self-administration by rhesus monkeys.
    Drug and alcohol dependence, 1990, Volume: 26, Issue:2

    Topics: Animals; Appetitive Behavior; Cocaine; Conditioning, Operant; Desipramine; Dose-Response Relationshi

1990
Evidence for altered desipramine disposition in methadone-maintained patients treated for cocaine abuse.
    The American journal of drug and alcohol abuse, 1990, Volume: 16, Issue:3-4

    Topics: Adult; Cocaine; Depressive Disorder; Desipramine; Dose-Response Relationship, Drug; Female; Humans;

1990
Schedule-induced oral self-administration of cocaine and ethanol solutions: lack of effect of chronic desipramine.
    Drug and alcohol dependence, 1990, Volume: 25, Issue:1

    Topics: Alcohol Drinking; Alcoholism; Animals; Cocaine; Desipramine; Dose-Response Relationship, Drug; Drug

1990
Increase in desipramine serum levels associated with methadone treatment.
    The American journal of psychiatry, 1989, Volume: 146, Issue:12

    Topics: Adult; Cocaine; Desipramine; Drug Interactions; Drug Therapy, Combination; Humans; Male; Methadone;

1989
The treatment of chemical dependence.
    JAMA, 1989, Jun-09, Volume: 261, Issue:22

    Topics: Cocaine; Desipramine; Humans; Substance-Related Disorders

1989
Central stimulant abuse: neurochemistry and pharmacotherapy.
    Advances in alcohol & substance abuse, 1986,Winter, Volume: 6, Issue:2

    Topics: Antipsychotic Agents; Brain; Bromocriptine; Cocaine; Desipramine; Dopamine; Euphoria; Humans; Recept

1986
Involvement of the ventral tegmental dopamine system in opioid and psychomotor stimulant reinforcement.
    NIDA research monograph, 1986, Volume: 67

    Topics: Animals; Cocaine; Desipramine; Dopamine; Heroin; Heroin Dependence; Hydroxydopamines; Oxidopamine; P

1986
Treating cocaine abusing methadone maintenance patients with desipramine.
    NIDA research monograph, 1988, Volume: 81

    Topics: Acquired Immunodeficiency Syndrome; Adult; Cocaine; Desipramine; Female; Heroin Dependence; Humans;

1988
Relapse to cocaine abuse after initiating desipramine treatment.
    JAMA, 1988, Nov-04, Volume: 260, Issue:17

    Topics: Adult; Bulimia; Cocaine; Depressive Disorder; Desipramine; Female; Humans; Male; Recurrence; Substan

1988
Stepwise detoxification from cocaine. A promising regimen.
    Postgraduate medicine, 1988, Volume: 84, Issue:2

    Topics: Adolescent; Adult; Amantadine; Bromocriptine; Cocaine; Desipramine; Drug Therapy, Combination; Femal

1988
Breaking the cycle of addiction.
    Science (New York, N.Y.), 1988, Aug-26, Volume: 241, Issue:4869

    Topics: Behavior Therapy; Cocaine; Desipramine; Humans; Mental Disorders; Psychotherapy; Recurrence; Substan

1988
Desipramine augmentation of cocaine abstinence: initial results.
    Clinical neuropharmacology, 1986, Volume: 9 Suppl 4

    Topics: Cocaine; Desipramine; Double-Blind Method; Drug Evaluation; Humans; Lithium; Psychotherapy; Substanc

1986
A preliminary study of desipramine in the treatment of cocaine abuse in methadone maintenance patients.
    The Journal of clinical psychiatry, 1987, Volume: 48, Issue:11

    Topics: Adult; Antisocial Personality Disorder; Black or African American; Cocaine; Desipramine; Female; Hum

1987
New uses of antidepressants in cocaine abuse.
    Psychosomatics, 1986, Volume: 27, Issue:11 Suppl

    Topics: Antidepressive Agents; Cocaine; Combined Modality Therapy; Desipramine; Humans; Lithium; Substance-R

1986
Enhanced development of dispositional tolerance to methadone by desipramine given together with methadone.
    Life sciences, 1985, Feb-25, Volume: 36, Issue:8

    Topics: Analgesia; Animals; Desipramine; Drug Interactions; Humans; Male; Methadone; Rats; Rats, Inbred Stra

1985
The effect of antidepressants and "tranquilizers" on the response of mice to ethanol.
    British journal of pharmacology, 1968, Volume: 34, Issue:2

    Topics: Accidents, Traffic; Amitriptyline; Animals; Antidepressive Agents; Chlorpromazine; Coma; Desipramine

1968