desipramine has been researched along with Cardiac Failure in 13 studies
Desipramine: A tricyclic dibenzazepine compound that potentiates neurotransmission. Desipramine selectively blocks reuptake of norepinephrine from the neural synapse, and also appears to impair serotonin transport. This compound also possesses minor anticholinergic activity, through its affinity to muscarinic receptors.
desipramine : A dibenzoazepine consisting of 10,11-dihydro-5H-dibenzo[b,f]azepine substituted on nitrogen with a 3-(methylamino)propyl group.
| Excerpt | Relevance | Reference |
|---|---|---|
| "We reported recently that inhibition of neuronal reuptake of norepinephrine (NE) by desipramine prevented the reduction of sympathetic neurotransmitters in the failing right ventricle of right heart failure animals." | 7.72 | Desipramine attenuates loss of cardiac sympathetic neurotransmitters produced by congestive heart failure and NE infusion. ( Himura, Y; Kashiki, M; Liang, CS; Stevens, SY; Yatani, A, 2003) |
| "Elevated plasma norepinephrine (NE) in congestive heart failure (CHF) is caused by increased NE spillover and decreased NE clearance." | 5.28 | Effects of desipramine on norepinephrine clearance in congestive heart failure. ( Baily, RG; Clemson, B; Davis, D; Zelis, R, 1990) |
| "We reported recently that inhibition of neuronal reuptake of norepinephrine (NE) by desipramine prevented the reduction of sympathetic neurotransmitters in the failing right ventricle of right heart failure animals." | 3.72 | Desipramine attenuates loss of cardiac sympathetic neurotransmitters produced by congestive heart failure and NE infusion. ( Himura, Y; Kashiki, M; Liang, CS; Stevens, SY; Yatani, A, 2003) |
| "34 patients with chronic congestive heart failure, 6 patients with pure autonomic failure and 9 recent heart transplant recipients were used to investigate the possible effects of chronic sympathetic nervous system overactivity and sympathetic underactivity and denervation on peripheral MHPG production and plasma MHPG concentration." | 1.29 | Regional origins of 3-methoxy-4-hydroxyphenylglycol in plasma: effects of chronic sympathetic nervous activation and denervation, and acute reflex sympathetic stimulation. ( Cox, HS; Esler, MD; Jennings, GL; Kaye, DM; Lambert, GW; Turner, AG; Vaz, M, 1995) |
| "Elevated plasma norepinephrine (NE) in congestive heart failure (CHF) is caused by increased NE spillover and decreased NE clearance." | 1.28 | Effects of desipramine on norepinephrine clearance in congestive heart failure. ( Baily, RG; Clemson, B; Davis, D; Zelis, R, 1990) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 3 (23.08) | 18.7374 |
| 1990's | 6 (46.15) | 18.2507 |
| 2000's | 3 (23.08) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 1 (7.69) | 2.80 |
| Authors | Studies |
|---|---|
| Blanco-Rivero, J | 1 |
| Couto, GK | 1 |
| Paula, SM | 1 |
| Fontes, MT | 1 |
| Rossoni, LV | 1 |
| Liang, CS | 2 |
| Himura, Y | 2 |
| Kashiki, M | 2 |
| Stevens, SY | 2 |
| Yatani, A | 1 |
| HALL, GF | 1 |
| Meredith, IT | 1 |
| Eisenhofer, G | 2 |
| Lambert, GW | 2 |
| Dewar, EM | 1 |
| Jennings, GL | 2 |
| Esler, MD | 3 |
| Kaye, DM | 1 |
| Vaz, M | 1 |
| Cox, HS | 2 |
| Turner, AG | 1 |
| Du, XJ | 1 |
| Dart, AM | 1 |
| Leineweber, K | 1 |
| Seyfarth, T | 1 |
| Brodde, OE | 1 |
| Zelis, R | 2 |
| Clemson, B | 2 |
| Baily, R | 1 |
| Davis, D | 2 |
| Esler, M | 1 |
| Chin, J | 1 |
| Jennings, G | 1 |
| Meredith, I | 1 |
| Cox, H | 1 |
| Lambert, G | 1 |
| Thompson, J | 1 |
| Dart, A | 1 |
| Baily, RG | 1 |
| Reidenberg, MM | 1 |
| Affrime, M | 1 |
| Greeff, K | 1 |
| Wagner, J | 1 |
13 other studies available for desipramine and Cardiac Failure
| Article | Year |
|---|---|
Enhanced sympathetic neurotransduction in the superior mesenteric artery in a rat model of heart failure: role of noradrenaline and ATP.
Topics: Adenosine Triphosphate; Adrenergic alpha-Antagonists; Adrenergic Uptake Inhibitors; Animals; Desipra | 2021 |
Differential pre- and postsynaptic effects of desipramine on cardiac sympathetic nerve terminals in RHF.
Topics: Adrenergic alpha-Agonists; Adrenergic Uptake Inhibitors; Animals; Blood Pressure; Cardiotonic Agents | 2002 |
Desipramine attenuates loss of cardiac sympathetic neurotransmitters produced by congestive heart failure and NE infusion.
Topics: Adrenergic alpha-Agonists; Adrenergic Fibers; Adrenergic Uptake Inhibitors; Animals; Blood Pressure; | 2003 |
COMBINING ANTIDEPRESSANT DRUGS.
Topics: Antidepressive Agents; Coronary Disease; Desipramine; Heart Failure; Phenelzine; Toxicology | 1965 |
Cardiac sympathetic nervous activity in congestive heart failure. Evidence for increased neuronal norepinephrine release and preserved neuronal uptake.
Topics: Coronary Disease; Desipramine; Dihydroxyphenylalanine; Heart; Heart Failure; Humans; Male; Middle Ag | 1993 |
Regional origins of 3-methoxy-4-hydroxyphenylglycol in plasma: effects of chronic sympathetic nervous activation and denervation, and acute reflex sympathetic stimulation.
Topics: Adrenergic Uptake Inhibitors; Adult; Desipramine; Female; Heart Failure; Heart Transplantation; Huma | 1995 |
Sympathetic activation triggers ventricular arrhythmias in rat heart with chronic infarction and failure.
Topics: Adrenergic beta-Antagonists; Adrenergic Uptake Inhibitors; Analysis of Variance; Animals; Atenolol; | 1999 |
Chamber-specific alterations of noradrenaline uptake (uptake(1)) in right ventricles of monocrotaline-treated rats.
Topics: Adrenergic Uptake Inhibitors; Animals; Binding, Competitive; Cocaine; Desipramine; Dopamine Uptake I | 2000 |
Regulation of tissue noradrenaline in the rat myocardial infarction model of chronic heart failure.
Topics: alpha-Methyltyrosine; Animals; Arteries; Desipramine; Disease Models, Animal; Heart Failure; Kidney | 1992 |
Is adrenaline released by sympathetic nerves in man?
Topics: Adrenal Gland Neoplasms; Adult; Catecholamines; Desipramine; Epinephrine; Exercise; Heart Failure; H | 1991 |
Effects of desipramine on norepinephrine clearance in congestive heart failure.
Topics: Adult; Blood Pressure; Desipramine; Female; Heart Failure; Heart Rate; Humans; Infusions, Intravenou | 1990 |
Influence of disease on binding of drugs to plasma proteins.
Topics: Arrhythmias, Cardiac; Arteriosclerosis; Blood Proteins; Blood Urea Nitrogen; Carbon Radioisotopes; C | 1973 |
[Animal experiments to study the cardiotoxic effect of thymoleptics].
Topics: Amitriptyline; Animals; Blood Pressure; Cats; Desipramine; Drug Synergism; Epinephrine; Heart; Heart | 1971 |