desipramine has been researched along with Burkitt Lymphoma in 1 studies
Desipramine: A tricyclic dibenzazepine compound that potentiates neurotransmission. Desipramine selectively blocks reuptake of norepinephrine from the neural synapse, and also appears to impair serotonin transport. This compound also possesses minor anticholinergic activity, through its affinity to muscarinic receptors.
desipramine : A dibenzoazepine consisting of 10,11-dihydro-5H-dibenzo[b,f]azepine substituted on nitrogen with a 3-(methylamino)propyl group.
Burkitt Lymphoma: A form of undifferentiated malignant LYMPHOMA usually found in central Africa, but also reported in other parts of the world. It is commonly manifested as a large osteolytic lesion in the jaw or as an abdominal mass. B-cell antigens are expressed on the immature cells that make up the tumor in virtually all cases of Burkitt lymphoma. The Epstein-Barr virus (HERPESVIRUS 4, HUMAN) has been isolated from Burkitt lymphoma cases in Africa and it is implicated as the causative agent in these cases; however, most non-African cases are EBV-negative.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Imipramine dimers were only found to be moderate inhibitors of the human serotonin transporter (hSERT) having IC(50) values in the micromolar region whilst the induction of cell death occurred independently of hSERT expression." | 1.39 | Basic N-interlinked imipramines show apoptotic activity against malignant cells including Burkitt's lymphoma. ( Bright, SA; Brinkø, A; Jensen, HH; Larsen, MT; Sinning, S; Williams, DC, 2013) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 1 (100.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Bright, SA | 1 |
| Brinkø, A | 1 |
| Larsen, MT | 1 |
| Sinning, S | 1 |
| Williams, DC | 1 |
| Jensen, HH | 1 |
1 other study available for desipramine and Burkitt Lymphoma
| Article | Year |
|---|---|
Basic N-interlinked imipramines show apoptotic activity against malignant cells including Burkitt's lymphoma.
Topics: Antineoplastic Agents; Apoptosis; Burkitt Lymphoma; Cell Death; Cell Line, Tumor; Cell Survival; Hum | 2013 |