desipramine has been researched along with Bradycardia in 6 studies
Desipramine: A tricyclic dibenzazepine compound that potentiates neurotransmission. Desipramine selectively blocks reuptake of norepinephrine from the neural synapse, and also appears to impair serotonin transport. This compound also possesses minor anticholinergic activity, through its affinity to muscarinic receptors.
desipramine : A dibenzoazepine consisting of 10,11-dihydro-5H-dibenzo[b,f]azepine substituted on nitrogen with a 3-(methylamino)propyl group.
Bradycardia: Cardiac arrhythmias that are characterized by excessively slow HEART RATE, usually below 50 beats per minute in human adults. They can be classified broadly into SINOATRIAL NODE dysfunction and ATRIOVENTRICULAR BLOCK.
| Excerpt | Relevance | Reference |
|---|---|---|
| "The administration of CaCl2 or 4-aminopyridine did not reverse tricyclic antidepressant-induced hypotension in rats." | 3.69 | Effect of calcium chloride and 4-aminopyridine therapy on desipramine toxicity in rats. ( Keyler, DE; Pentel, PR; Wananukul, W, 1996) |
| " Activities of the compounds in antagonizing reserpine-induced ptosis in rabbits and prolongation of alcohol hypnosis in mice give good correlation with their clinical actions, whilst their activities in augmenting excitation of rats by amphetamine and yohimbine toxicity in mice, and in reversing reserpine-induced bradycardia in rats offer further evidence for drug-induced sensitization to adrenergic or tryptaminic mechanisms, which is not however specific for antidepressant agents." | 3.64 | A COMPARISON OF IMIPRAMINE, CHLORPROMAZINE AND RELATED DRUGS IN VARIOUS TESTS INVOLVING AUTONOMIC FUNCTIONS AND ANTAGONISM OF RESERPINE. ( HALLIWELL, G; QUINTON, RM; WILLIAMS, FE, 1964) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 4 (66.67) | 18.7374 |
| 1990's | 2 (33.33) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| FEKETE, M | 1 |
| BORSY, J | 1 |
| HALLIWELL, G | 1 |
| QUINTON, RM | 1 |
| WILLIAMS, FE | 1 |
| LOEW, D | 1 |
| TAESCHLER, M | 1 |
| Sawyer, WT | 1 |
| Caudill, JL | 1 |
| Ellison, MJ | 1 |
| Goodwin, DA | 1 |
| Lally, KP | 1 |
| Null, DM | 1 |
| Wananukul, W | 1 |
| Keyler, DE | 1 |
| Pentel, PR | 1 |
6 other studies available for desipramine and Bradycardia
| Article | Year |
|---|---|
ON THE ANTIARRHYTHMIC EFFECT OF SOME THYMOLEPTICS (AMITRIPTYLINE, IMIPRAMINE, TRIMEPROPIMINE AND DESMETHYLIMIPRAMINE).
Topics: Aconitum; Amitriptyline; Antidepressive Agents; Atrial Fibrillation; Bradycardia; Bretylium Compound | 1964 |
A COMPARISON OF IMIPRAMINE, CHLORPROMAZINE AND RELATED DRUGS IN VARIOUS TESTS INVOLVING AUTONOMIC FUNCTIONS AND ANTAGONISM OF RESERPINE.
Topics: Alcoholic Intoxication; Amitriptyline; Amphetamine; Animals; Antidepressive Agents; Autonomic Nervou | 1964 |
[RESEARCH ON ANTICHOLINERGIC EFFECTS OF ANTIDEPRESSIVE SUBSTANCES IN THE RABBIT].
Topics: Amitriptyline; Animals; Antidepressive Agents; Atropine; Bradycardia; Cholinergic Antagonists; Desip | 1964 |
A case of severe acute desipramine overdose.
Topics: Acute Disease; Adult; Bradycardia; Desipramine; Humans; Male; Respiratory Insufficiency; Seizures; S | 1984 |
Extracorporeal membrane oxygenation support for cardiac dysfunction from tricyclic antidepressant overdose.
Topics: Bradycardia; Desipramine; Drug Overdose; Extracorporeal Membrane Oxygenation; Female; Humans; Infant | 1993 |
Effect of calcium chloride and 4-aminopyridine therapy on desipramine toxicity in rats.
Topics: 4-Aminopyridine; Animals; Antidepressive Agents, Tricyclic; Arrhythmias, Cardiac; Blood Pressure; Br | 1996 |