desipramine has been researched along with Benign Neoplasms in 7 studies
Desipramine: A tricyclic dibenzazepine compound that potentiates neurotransmission. Desipramine selectively blocks reuptake of norepinephrine from the neural synapse, and also appears to impair serotonin transport. This compound also possesses minor anticholinergic activity, through its affinity to muscarinic receptors.
desipramine : A dibenzoazepine consisting of 10,11-dihydro-5H-dibenzo[b,f]azepine substituted on nitrogen with a 3-(methylamino)propyl group.
| Excerpt | Relevance | Reference |
|---|---|---|
| " In addition, characterization of the UGT1A locus and genetic studies directed at understanding the role of bilirubin glucuronidation and the biochemical basis of the clinical symptoms found in unconjugated hyperbilirubinemia have uncovered the structural gene polymorphisms associated with Crigler-Najjar's and Gilbert's syndrome." | 4.80 | Human UDP-glucuronosyltransferases: metabolism, expression, and disease. ( Strassburg, CP; Tukey, RH, 2000) |
| "LY2603618 is a selective inhibitor of deoxyribonucleic acid damage checkpoint kinase 1 (CHK1) and has been in development for the enhancement of chemotherapeutic agents." | 2.80 | Evaluation of the likelihood of a selective CHK1 inhibitor (LY2603618) to inhibit CYP2D6 with desipramine as a probe substrate in cancer patients. ( Chandler, J; Decker, R; Hynes, SM; Mitchell, M; Ott, J; Wickremsinhe, E; Zhang, W, 2015) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 2 (28.57) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 2 (28.57) | 29.6817 |
| 2010's | 3 (42.86) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Tukey, RH | 1 |
| Strassburg, CP | 1 |
| Shaughnessy, R | 1 |
| Retamal, C | 1 |
| Oyanadel, C | 1 |
| Norambuena, A | 1 |
| López, A | 1 |
| Bravo-Zehnder, M | 1 |
| Montecino, FJ | 1 |
| Metz, C | 1 |
| Soza, A | 1 |
| González, A | 1 |
| Hynes, SM | 1 |
| Wickremsinhe, E | 1 |
| Zhang, W | 1 |
| Decker, R | 1 |
| Ott, J | 1 |
| Chandler, J | 1 |
| Mitchell, M | 1 |
| Ma, J | 1 |
| Hou, LN | 1 |
| Rong, ZX | 1 |
| Liang, P | 1 |
| Fang, C | 1 |
| Li, HF | 1 |
| Qi, H | 1 |
| Chen, HZ | 1 |
| Thangathurai, D | 1 |
| Roffey, P | 1 |
| Mogos, M | 1 |
| Riad, M | 1 |
| Mikhail, M | 1 |
| Ansuategui Sánchez, M | 1 |
| Rodríguez Hernández, JL | 1 |
| López Manzanero, L | 1 |
| González Miranda, F | 1 |
| Ziebarth, D | 1 |
1 review available for desipramine and Benign Neoplasms
| Article | Year |
|---|---|
Human UDP-glucuronosyltransferases: metabolism, expression, and disease.
Topics: Autoimmunity; Chromosome Mapping; Glucuronides; Glucuronosyltransferase; Humans; Hyperbilirubinemia; | 2000 |
1 trial available for desipramine and Benign Neoplasms
| Article | Year |
|---|---|
Evaluation of the likelihood of a selective CHK1 inhibitor (LY2603618) to inhibit CYP2D6 with desipramine as a probe substrate in cancer patients.
Topics: Adolescent; Adult; Aged; Antineoplastic Agents; Area Under Curve; Checkpoint Kinase 1; Computer Simu | 2015 |
5 other studies available for desipramine and Benign Neoplasms
| Article | Year |
|---|---|
Epidermal growth factor receptor endocytic traffic perturbation by phosphatidate phosphohydrolase inhibition: new strategy against cancer.
Topics: Desipramine; Endocytosis; Endosomes; Enzyme Inhibitors; ErbB Receptors; HeLa Cells; Humans; Ligands; | 2014 |
Antidepressant desipramine leads to C6 glioma cell autophagy: implication for the adjuvant therapy of cancer.
Topics: Animals; Antidepressive Agents; Autophagy; Cell Death; Chemotherapy, Adjuvant; Desipramine; Glioma; | 2013 |
Usefulness of desipramine in ICU cancer patients for acute depression.
Topics: Acute Disease; Antidepressive Agents, Tricyclic; Critical Care; Depressive Disorder; Desipramine; Hu | 2004 |
[Analgesia with desipramide in neoplastic chronic pains].
Topics: Adult; Aged; Desipramine; Drug Evaluation; Female; Humans; Male; Middle Aged; Neoplasms; Pain, Intra | 1980 |
[Comparative studies of the nitrosation behavior of drugs by constant pH value and under simulated stomach conditions].
Topics: Aminopyrine; Ampicillin; Biotransformation; Clomipramine; Desipramine; Dipyrone; Ethambutol; Gastric | 1982 |