desipramine has been researched along with Back Ache in 4 studies
Desipramine: A tricyclic dibenzazepine compound that potentiates neurotransmission. Desipramine selectively blocks reuptake of norepinephrine from the neural synapse, and also appears to impair serotonin transport. This compound also possesses minor anticholinergic activity, through its affinity to muscarinic receptors.
desipramine : A dibenzoazepine consisting of 10,11-dihydro-5H-dibenzo[b,f]azepine substituted on nitrogen with a 3-(methylamino)propyl group.
| Excerpt | Relevance | Reference |
|---|---|---|
| "This clinical trial evaluated the independent and combined effects of a tricyclic antidepressant (desipramine) and cognitive behavioral therapy (CBT) for chronic back pain relative to an active placebo treatment." | 9.34 | A randomized placebo-controlled trial of desipramine, cognitive behavioral therapy, and active placebo therapy for low back pain. ( Atkinson, JH; Capparelli, EV; Chircop-Rollick, T; D'Andrea, J; Funk, SD; Garfin, S; Gould, HM; Patel, SM; Penzien, DB; Rutledge, T; Slater, M; Wallace, M; Weickgenanta, AL, 2020) |
| "Doxepin and desipramine at final doses of 188 and 173 mg/day, respectively, were compared in 36 volunteers with major affective or dysthymic disorder and chronic back pain." | 9.05 | Antidepressants in concomitant chronic back pain and depression: doxepin and desipramine compared. ( Benedetti, C; Bokan, JA; Butler, S; Phillips, M; Spengler, D; Ward, N, 1984) |
| "This clinical trial evaluated the independent and combined effects of a tricyclic antidepressant (desipramine) and cognitive behavioral therapy (CBT) for chronic back pain relative to an active placebo treatment." | 5.34 | A randomized placebo-controlled trial of desipramine, cognitive behavioral therapy, and active placebo therapy for low back pain. ( Atkinson, JH; Capparelli, EV; Chircop-Rollick, T; D'Andrea, J; Funk, SD; Garfin, S; Gould, HM; Patel, SM; Penzien, DB; Rutledge, T; Slater, M; Wallace, M; Weickgenanta, AL, 2020) |
| "This single-center, 12-week, double-blind, prospective, controlled-concentration study randomized 121 chronic back pain patients without major depression to active placebo (benztropine mesylate) or to predetermined low, medium, or high concentrations of desipramine (targets were 50, 110, and 150 ng/mL, respectively) or fluoxetine (targets were 100, 200, and 400 ng/mL, respectively)." | 5.12 | Efficacy of noradrenergic and serotonergic antidepressants in chronic back pain: a preliminary concentration-controlled trial. ( Abramson, I; Atkinson, JH; Capparelli, EV; Garfin, SR; Matthews, SC; Slater, MA; Wallace, MS; Zisook, S, 2007) |
| "Patients with chronic low-back pain and depression were treated double blind with desipramine or doxepin." | 5.06 | Tricyclic antidepressants for chronic low-back pain. Mechanisms of action and predictors of response. ( Ward, NG, 1986) |
| "Doxepin and desipramine at final doses of 188 and 173 mg/day, respectively, were compared in 36 volunteers with major affective or dysthymic disorder and chronic back pain." | 5.05 | Antidepressants in concomitant chronic back pain and depression: doxepin and desipramine compared. ( Benedetti, C; Bokan, JA; Butler, S; Phillips, M; Spengler, D; Ward, N, 1984) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 2 (50.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 1 (25.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 1 (25.00) | 2.80 |
| Authors | Studies |
|---|---|
| Gould, HM | 1 |
| Atkinson, JH | 2 |
| Chircop-Rollick, T | 1 |
| D'Andrea, J | 1 |
| Garfin, S | 1 |
| Patel, SM | 1 |
| Funk, SD | 1 |
| Capparelli, EV | 2 |
| Penzien, DB | 1 |
| Wallace, M | 1 |
| Weickgenanta, AL | 1 |
| Slater, M | 1 |
| Rutledge, T | 1 |
| Slater, MA | 1 |
| Wallace, MS | 1 |
| Zisook, S | 1 |
| Abramson, I | 1 |
| Matthews, SC | 1 |
| Garfin, SR | 1 |
| Ward, N | 1 |
| Bokan, JA | 1 |
| Phillips, M | 1 |
| Benedetti, C | 1 |
| Butler, S | 1 |
| Spengler, D | 1 |
| Ward, NG | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Efficacy of Antidepressants in Chronic Back Pain[NCT00964886] | Phase 2 | 142 participants (Actual) | Interventional | 2010-01-31 | Completed | ||
| Efficacy of Antidepressants in Chronic Back Pain[NCT00018200] | Phase 2 | 130 participants (Actual) | Interventional | 1999-04-30 | Completed | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
"The DDS is self-report measure of current pain intensity of chronic back pain. Participants rate pain on a 20 point scale as being greater or less intense relative to 12 adjectival descriptor words which serve as anchors (eg, greater or less than faint, moderate, strong). Scores range from 0 to 20 with higher scores indicating higher pain intensity. The analysis evaluated the 'as randomized' sample at 12 weeks after baseline or last observation carried forward, after co-varying for baseline (pre-treatment) values." (NCT00964886)
Timeframe: 12 weeks after baseline (or last observation carried forward)
| Intervention | units on a scale (Mean) |
|---|---|
| Arm 1 + Arm 3 | 8.3 |
| Arm 2 + Arm 4 | 8.1 |
| Arm 2 + Arm 3 | 8.0 |
| Arm 1 + Arm 4 | 8.4 |
"This questionnaire measures disability in everyday function due to back pain. It is a 24-item checklist asking patients to endorse whether or not back pain limits activities they normally do (eg, I stay at home most of the time because of my back). Scores range from 0 to 24, with higher scores indicating greater disability in everyday function due to back pain. The analysis evaluated the 'as randomized' sample at 12 weeks after baseline, after co-varying for baseline (pre-treatment) values." (NCT00964886)
Timeframe: 12 weeks after baseline (or last observation carried forward)
| Intervention | Units on a scale. (Mean) |
|---|---|
| Arm 1 + Arm 3 | 8.7 |
| Arm 2 + Arm 4 | 8.9 |
| Arm 2 + Arm 3 | 8.7 |
| Arm 1 + Arm 4 | 8.9 |
4 trials available for desipramine and Back Ache
| Article | Year |
|---|---|
A randomized placebo-controlled trial of desipramine, cognitive behavioral therapy, and active placebo therapy for low back pain.
Topics: Back Pain; Chronic Pain; Cognitive Behavioral Therapy; Desipramine; Humans; Low Back Pain; Treatment | 2020 |
Efficacy of noradrenergic and serotonergic antidepressants in chronic back pain: a preliminary concentration-controlled trial.
Topics: Adrenergic Uptake Inhibitors; Adult; Aged; Back Pain; Capsules; Chronic Disease; Constipation; Desip | 2007 |
Antidepressants in concomitant chronic back pain and depression: doxepin and desipramine compared.
Topics: Adult; Anxiety Disorders; Back Pain; beta-Endorphin; Chronic Disease; Clinical Trials as Topic; Depr | 1984 |
Tricyclic antidepressants for chronic low-back pain. Mechanisms of action and predictors of response.
Topics: Adult; Back Pain; Chronic Disease; Clinical Trials as Topic; Depressive Disorder; Desipramine; Doubl | 1986 |