desipramine has been researched along with Autistic Disorder in 2 studies
Desipramine: A tricyclic dibenzazepine compound that potentiates neurotransmission. Desipramine selectively blocks reuptake of norepinephrine from the neural synapse, and also appears to impair serotonin transport. This compound also possesses minor anticholinergic activity, through its affinity to muscarinic receptors.
desipramine : A dibenzoazepine consisting of 10,11-dihydro-5H-dibenzo[b,f]azepine substituted on nitrogen with a 3-(methylamino)propyl group.
Autistic Disorder: A disorder beginning in childhood. It is marked by the presence of markedly abnormal or impaired development in social interaction and communication and a markedly restricted repertoire of activity and interest. Manifestations of the disorder vary greatly depending on the developmental level and chronological age of the individual. (DSM-V)
| Excerpt | Relevance | Reference |
|---|---|---|
| "To determine whether clomipramine hydrochloride, a serotonin reuptake blocker with unique anti-obsessional properties, is differentially effective for obsessive-compulsive and stereotyped motor behaviors in autistic disorder compared with placebo and with the noradrenergic tricyclic antidepressant agent, desipramine hydrochloride." | 9.07 | A double-blind comparison of clomipramine, desipramine, and placebo in the treatment of autistic disorder. ( Gordon, CT; Hamburger, SD; Nelson, JE; Rapoport, JL; State, RC, 1993) |
| "Clomipramine, a serotonin reuptake blocker that has unique antiobsessional properties, was hypothesized to have a different effect from that of desipramine, a tricyclic antidepressant with selective adrenergic effects, for the stereotyped, repetitive behaviors in autism." | 9.07 | Differential response of seven subjects with autistic disorder to clomipramine and desipramine. ( Gordon, CT; Hamburger, SD; Mannheim, GB; Rapoport, JL; State, RC, 1992) |
| "To determine whether clomipramine hydrochloride, a serotonin reuptake blocker with unique anti-obsessional properties, is differentially effective for obsessive-compulsive and stereotyped motor behaviors in autistic disorder compared with placebo and with the noradrenergic tricyclic antidepressant agent, desipramine hydrochloride." | 5.07 | A double-blind comparison of clomipramine, desipramine, and placebo in the treatment of autistic disorder. ( Gordon, CT; Hamburger, SD; Nelson, JE; Rapoport, JL; State, RC, 1993) |
| "Clomipramine, a serotonin reuptake blocker that has unique antiobsessional properties, was hypothesized to have a different effect from that of desipramine, a tricyclic antidepressant with selective adrenergic effects, for the stereotyped, repetitive behaviors in autism." | 5.07 | Differential response of seven subjects with autistic disorder to clomipramine and desipramine. ( Gordon, CT; Hamburger, SD; Mannheim, GB; Rapoport, JL; State, RC, 1992) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 2 (100.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Gordon, CT | 2 |
| State, RC | 2 |
| Nelson, JE | 1 |
| Hamburger, SD | 2 |
| Rapoport, JL | 2 |
| Mannheim, GB | 1 |
2 trials available for desipramine and Autistic Disorder
| Article | Year |
|---|---|
A double-blind comparison of clomipramine, desipramine, and placebo in the treatment of autistic disorder.
Topics: Adolescent; Adult; Ambulatory Care; Autistic Disorder; Child; Clomipramine; Desipramine; Double-Blin | 1993 |
Differential response of seven subjects with autistic disorder to clomipramine and desipramine.
Topics: Adolescent; Anger; Autistic Disorder; Child; Clomipramine; Compulsive Behavior; Desipramine; Double- | 1992 |