desipramine has been researched along with Aura in 12 studies
Desipramine: A tricyclic dibenzazepine compound that potentiates neurotransmission. Desipramine selectively blocks reuptake of norepinephrine from the neural synapse, and also appears to impair serotonin transport. This compound also possesses minor anticholinergic activity, through its affinity to muscarinic receptors.
desipramine : A dibenzoazepine consisting of 10,11-dihydro-5H-dibenzo[b,f]azepine substituted on nitrogen with a 3-(methylamino)propyl group.
| Excerpt | Relevance | Reference |
|---|---|---|
| " In this present study we have investigated the effects of DMI and ketamine on both NMDA-induced and spontaneous depolarizing shifts in cortical wedges prepared from genetically epilepsy-prone mice (DBA/2)." | 3.68 | Desmethylimipramine potentiates NMDA responses in a mouse cortical slice preparation. ( Davies, JA; Lancaster, JM, 1991) |
| "Pretreatment with prazosin (1 microgram/side) significantly diminished the anticonvulsant effectiveness of methoxamine and nisoxetine while prazosin, by itself, had no effects on the seizure intensity." | 1.30 | Anticonvulsant effect of enhancement of noradrenergic transmission in the superior colliculus in genetically epilepsy-prone rats (GEPRs): a microinjection study. ( Dailey, JW; Jobe, PC; Steenbergen, JL; Yan, QS, 1998) |
| "According to our convulsion intensity scoring system, these animals have an audiogenic response score (ARS) of 3 and the colony is designated the GEPR-3 colony." | 1.27 | Anticonvulsant drugs and the genetically epilepsy-prone rat. ( Dailey, JW; Jobe, PC, 1985) |
| "Amitriptyline was the most effective antidepressant, attenuating both seizure severity and afterdischarge duration." | 1.27 | Acute effects of antidepressants on hippocampal seizures. ( Clifford, DB; Hicks, FG; Rutherford, JL; Zorumski, CF, 1985) |
| "On the average, seizures were observed at 40 mg/kg and were seen after desmethylimipramine (50 mg/kg), mianserin (30 mg/kg), amitriptyline (20 mg/kg), imipramine (40 mg/kg), maprotiline (40 mg/kg), and zimelidine (50 mg/kg)." | 1.27 | Comparison of the (pro)convulsive properties of fluvoxamine and clovoxamine with eight other antidepressants in an animal model. ( Bradford, D; Krijzer, F; Snelder, M, 1984) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 7 (58.33) | 18.7374 |
| 1990's | 5 (41.67) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| LAMONT, ES | 1 |
| Krijzer, F | 1 |
| Snelder, M | 1 |
| Bradford, D | 1 |
| Yan, QS | 3 |
| Jobe, PC | 4 |
| Dailey, JW | 4 |
| Spina, E | 1 |
| Avenoso, A | 1 |
| Campo, GM | 1 |
| Caputi, AP | 1 |
| Perucca, E | 1 |
| Steenbergen, JL | 1 |
| Lancaster, JM | 1 |
| Davies, JA | 1 |
| Fogel, BS | 1 |
| Haltzman, S | 1 |
| Clifford, DB | 1 |
| Rutherford, JL | 1 |
| Hicks, FG | 1 |
| Zorumski, CF | 1 |
| Sjöqvist, F | 1 |
| Milner, G | 1 |
| Hills, NF | 1 |
2 trials available for desipramine and Aura
| Article | Year |
|---|---|
Phenobarbital induces the 2-hydroxylation of desipramine.
Topics: Adult; Anticonvulsants; Antidepressive Agents, Tricyclic; Cytochrome P-450 CYP2D6; Cytochrome P-450 | 1996 |
A double-blind assessment of antidepressants in the treatment of 212 enuretic patients.
Topics: Clinical Trials as Topic; Desipramine; Enuresis; Epilepsy; Female; Humans; Humidity; Imipramine; Mal | 1968 |
10 other studies available for desipramine and Aura
| Article | Year |
|---|---|
SIDE-EFFECTS OF PERTOFRAN.
Topics: Depression; Desipramine; Drug Therapy; Epilepsy; Epilepsy, Tonic-Clonic; Seizures; Toxicology | 1965 |
Comparison of the (pro)convulsive properties of fluvoxamine and clovoxamine with eight other antidepressants in an animal model.
Topics: Amitriptyline; Animals; Antidepressive Agents; Desipramine; Disease Models, Animal; Dose-Response Re | 1984 |
Thalamic deficiency in norepinephrine release detected via intracerebral microdialysis: a synaptic determinant of seizure predisposition in the genetically epilepsy-prone rat.
Topics: Analysis of Variance; Animals; Desipramine; Dialysis; Epilepsy; Female; Norepinephrine; Potassium Ch | 1993 |
Noradrenergic mechanisms for the anticonvulsant effects of desipramine and yohimbine in genetically epilepsy-prone rats: studies with microdialysis.
Topics: Animals; Anticonvulsants; Desipramine; Dialysis; Disease Susceptibility; Epilepsy; Female; Male; Mic | 1993 |
Anticonvulsant effect of enhancement of noradrenergic transmission in the superior colliculus in genetically epilepsy-prone rats (GEPRs): a microinjection study.
Topics: Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Adrenergic Uptake Inhibitors; Animals; Anti | 1998 |
Desmethylimipramine potentiates NMDA responses in a mouse cortical slice preparation.
Topics: Action Potentials; Animals; Anticonvulsants; Cerebral Cortex; Convulsants; Corpus Callosum; Desipram | 1991 |
Desipramine and phenytoin: a potential drug interaction of therapeutic relevance.
Topics: Adult; Depressive Disorder; Desipramine; Drug Interactions; Epilepsy; Female; Humans; Male; Phenytoi | 1987 |
Anticonvulsant drugs and the genetically epilepsy-prone rat.
Topics: Acoustic Stimulation; Amitriptyline; Animals; Anticonvulsants; Carbamazepine; Desipramine; Disease M | 1985 |
Acute effects of antidepressants on hippocampal seizures.
Topics: Amitriptyline; Animals; Anticonvulsants; Antidepressive Agents; Bupropion; Desipramine; Epilepsy; Hi | 1985 |
[Differences between individuals in human pharmacokinetics. Clinical significance].
Topics: Binding Sites; Desipramine; Epilepsy; Female; Humans; Male; Nortriptyline; Pharmacogenetics; Phenyto | 1972 |