desipramine has been researched along with Asialia in 9 studies
Desipramine: A tricyclic dibenzazepine compound that potentiates neurotransmission. Desipramine selectively blocks reuptake of norepinephrine from the neural synapse, and also appears to impair serotonin transport. This compound also possesses minor anticholinergic activity, through its affinity to muscarinic receptors.
desipramine : A dibenzoazepine consisting of 10,11-dihydro-5H-dibenzo[b,f]azepine substituted on nitrogen with a 3-(methylamino)propyl group.
| Excerpt | Relevance | Reference |
|---|---|---|
| "This single-center, 12-week, double-blind, prospective, controlled-concentration study randomized 121 chronic back pain patients without major depression to active placebo (benztropine mesylate) or to predetermined low, medium, or high concentrations of desipramine (targets were 50, 110, and 150 ng/mL, respectively) or fluoxetine (targets were 100, 200, and 400 ng/mL, respectively)." | 5.12 | Efficacy of noradrenergic and serotonergic antidepressants in chronic back pain: a preliminary concentration-controlled trial. ( Abramson, I; Atkinson, JH; Capparelli, EV; Garfin, SR; Matthews, SC; Slater, MA; Wallace, MS; Zisook, S, 2007) |
| "A common and significant side-effect of the antidepressant desipramine is xerostomia (dry mouth)." | 3.73 | Desipramine inhibits Na+/H+ exchanger in human submandibular cells. ( Choi, SY; Jo, SH; Kim, JS; Lee, JH; Lee, SJ; Li, J; Oh, SB; Park, K, 2006) |
| "Somatic side effects of antidepressant medications and of depression and anxiety were quantified in depressed patients before and after 4 weeks of treatment with amitriptyline (N = 11), or desipramine (N = 12)." | 3.66 | Somatic symptoms in depression and antidepressants. ( Claghorn, JL; Mathew, RJ; Reck, JJ; Thapar, R; Weinman, ML, 1983) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 6 (66.67) | 18.7374 |
| 1990's | 1 (11.11) | 18.2507 |
| 2000's | 2 (22.22) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| KRAKOWSKI, AJ | 1 |
| Choi, SY | 1 |
| Li, J | 1 |
| Jo, SH | 1 |
| Lee, SJ | 1 |
| Oh, SB | 1 |
| Kim, JS | 1 |
| Lee, JH | 1 |
| Park, K | 1 |
| Atkinson, JH | 1 |
| Slater, MA | 1 |
| Capparelli, EV | 1 |
| Wallace, MS | 1 |
| Zisook, S | 1 |
| Abramson, I | 1 |
| Matthews, SC | 1 |
| Garfin, SR | 1 |
| Jackson, SH | 1 |
| Turner, P | 1 |
| Ehsanullah, RS | 1 |
| Nelson, JC | 1 |
| Jatlow, PI | 1 |
| Quinlan, DM | 1 |
| Garvey, MJ | 1 |
| Tuason, VB | 1 |
| Johnson, RA | 1 |
| Valentine, RH | 1 |
| Cooper, TB | 1 |
| Mathew, RJ | 1 |
| Weinman, ML | 1 |
| Thapar, R | 1 |
| Reck, JJ | 1 |
| Claghorn, JL | 1 |
| Salah, RS | 1 |
| Cameron, OG | 1 |
| Watt, DC | 1 |
| Crammer, JL | 1 |
| Elkes, A | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Efficacy of Antidepressants in Chronic Back Pain[NCT00018200] | Phase 2 | 130 participants (Actual) | Interventional | 1999-04-30 | Completed | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
3 trials available for desipramine and Asialia
| Article | Year |
|---|---|
Efficacy of noradrenergic and serotonergic antidepressants in chronic back pain: a preliminary concentration-controlled trial.
Topics: Adrenergic Uptake Inhibitors; Adult; Aged; Back Pain; Capsules; Chronic Disease; Constipation; Desip | 2007 |
A comparison of diclofensine and desmethylimipramine using tyramine pressor tests in normal subjects.
Topics: Adult; Antidepressive Agents; Blood Pressure; Desipramine; Humans; Isoquinolines; Male; Norepinephri | 1983 |
Metabolism, anticholinergic effects, and therapeutic outcome of desmethylimipramine in depressive illness.
Topics: Adult; Aged; Body Weight; Clinical Trials as Topic; Depression; Desipramine; Dose-Response Relations | 1972 |
6 other studies available for desipramine and Asialia
| Article | Year |
|---|---|
TREATMENT OF SEVERE DEPRESSION WITH DESIPRAMINE: LONG-TERM TRIAL AND FOLLOW-UP.
Topics: Constipation; Depression; Depressive Disorder; Depressive Disorder, Major; Desipramine; Drug Hyperse | 1964 |
Desipramine inhibits Na+/H+ exchanger in human submandibular cells.
Topics: Adult; Aged; Antidepressive Agents, Tricyclic; Cell Line; Desipramine; Humans; Hydrogen-Ion Concentr | 2006 |
Subjective complaints during desipramine treatment. Relative importance of plasma drug concentrations and the severity of depression.
Topics: Attitude to Health; Depressive Disorder; Desipramine; Dizziness; Female; Hospitalization; Humans; Ma | 1984 |
Elevated plasma tricyclic levels with therapeutic doses of imipramine.
Topics: Adult; Depressive Disorder; Desipramine; Electrocardiography; Female; Humans; Hydroxylation; Imipram | 1984 |
Somatic symptoms in depression and antidepressants.
Topics: Adult; Amitriptyline; Anxiety; Autonomic Nervous System Diseases; Constipation; Depressive Disorder; | 1983 |
Pilocarpine for anticholinergic adverse effects associated with desipramine treatment.
Topics: Antidepressive Agents, Tricyclic; Constipation; Depressive Disorder; Desipramine; Humans; Male; Midd | 1996 |