desipramine has been researched along with Arrhythmia in 40 studies
Desipramine: A tricyclic dibenzazepine compound that potentiates neurotransmission. Desipramine selectively blocks reuptake of norepinephrine from the neural synapse, and also appears to impair serotonin transport. This compound also possesses minor anticholinergic activity, through its affinity to muscarinic receptors.
desipramine : A dibenzoazepine consisting of 10,11-dihydro-5H-dibenzo[b,f]azepine substituted on nitrogen with a 3-(methylamino)propyl group.
| Excerpt | Relevance | Reference |
|---|---|---|
| "The incidence of halothane-epinephrine arrhythmias increases after the short-term administration of imipramine, probably because of enhanced noradrenergic transmission." | 7.67 | Halothane-epinephrine arrhythmias and adrenergic responsiveness after chronic imipramine administration in dogs. ( Maze, M; Smith, CM; Spiss, CK, 1984) |
| "Desipramine was given to 34 outpatients aged 20 to 51 years who had primary major depressive disorder but who were otherwise in good health." | 5.07 | 2-Hydroxydesipramine and desipramine plasma levels and electrocardiographic effects in depressed younger adults. ( Cooper, TB; Johnson, MH; Nelson, LD; Ribner, HS; Stern, SL; Suckow, RF, 1991) |
| "The administration of CaCl2 or 4-aminopyridine did not reverse tricyclic antidepressant-induced hypotension in rats." | 3.69 | Effect of calcium chloride and 4-aminopyridine therapy on desipramine toxicity in rats. ( Keyler, DE; Pentel, PR; Wananukul, W, 1996) |
| "In view of the importance of sympathetic nervous system in the genesis of cardiac arrhythmias during reperfusion following coronary occlusion, the role of noradrenaline uptake inhibitor desipramine in the prevention of reperfusion arrhythmias was investigated in intact rabbit heart and isolated rat heart." | 3.69 | Role of noradrenaline uptake inhibition and alpha-adrenoceptors in reperfusion ventricular arrhythmias in vivo and in vitro. ( Pandhi, P; Sharma, PL; Shekher, A; Singh, M, 1996) |
| "The incidence of halothane-epinephrine arrhythmias increases after the short-term administration of imipramine, probably because of enhanced noradrenergic transmission." | 3.67 | Halothane-epinephrine arrhythmias and adrenergic responsiveness after chronic imipramine administration in dogs. ( Maze, M; Smith, CM; Spiss, CK, 1984) |
| "The use of desipramine in treating major depressive disorder in the hospitalized medically ill patient is described." | 3.67 | Use of desipramine in the medically ill. ( Cavanaugh, SV, 1984) |
| "The antiarrhythmic plasma-concentration range of imipramine with desmethylimipramine was determined in 15 cardiac patients with ventricular arrhythmias." | 3.66 | Antiarrhythmic plasma-concentration range of imipramine against ventricular premature depolarizations. ( Alchevsky, D; Bigger, JT; Brem, R; Giardina, EG; Louie, M, 1983) |
| "The electrocardiographic effects of imipramine hydrochloride at therapeutic plasma concentrations were determined in 44 depressed patients during a 6-week clinical outcome study of depression." | 3.66 | The electrocardiographic and antiarrhythmic effects of imipramine hydrochloride at therapeutic plasma concentrations. ( Bigger, JT; Giardina, EG; Glassman, AH; Kantor, SJ; Perel, JM, 1979) |
| " Subjects were then treated with DMI, titrated to an average DMI dosage of 3 mg/kg, and underwent repeated exercise testing." | 2.69 | Cardiovascular effects of desipramine in children and adults during exercise testing. ( Bigger, JT; Bilich, K; Giardina, EG; Greenhill, LL; Sloan, RP; Walsh, BT; Waslick, BD, 1999) |
| "Desipramine has an antiarrhythmic effect in patients with chronic ventricular ectopy, but its clinical utility is limited by adverse effects." | 2.66 | Antiarrhythmic efficacy of desipramine. ( Bressler, R; Fenster, PE; Kipps, J, 1989) |
| "No significant arrhythmias or tachycardias were observed." | 1.29 | ECG changes in pediatric patients on tricyclic antidepressants, desipramine, and imipramine. ( Giuffre, RM; Johnson, A; O'Malley, K, 1996) |
| "Five of the 10 patients had arrhythmias and two of these died." | 1.25 | Cardiac abnormalities in poisoning with tricyclic antidepressants. ( Beattie, RR; Freeman, JW; Mundy, GR; Ryan, C, 1969) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 25 (62.50) | 18.7374 |
| 1990's | 13 (32.50) | 18.2507 |
| 2000's | 2 (5.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Jia, L | 1 |
| Sun, H | 1 |
| Pierog, JE | 1 |
| Kane, KE | 1 |
| Kane, BG | 1 |
| Donovan, JW | 1 |
| Helmick, T | 1 |
| Spiss, CK | 1 |
| Smith, CM | 1 |
| Maze, M | 1 |
| Cavanaugh, SV | 1 |
| Nilius, B | 1 |
| Giardina, EG | 4 |
| Louie, M | 1 |
| Bigger, JT | 4 |
| Brem, R | 1 |
| Alchevsky, D | 1 |
| Marshall, JB | 1 |
| Forker, AD | 1 |
| Pariser, SF | 1 |
| Reynolds, JC | 1 |
| Falko, JM | 1 |
| Jones, BA | 1 |
| Mencer, DL | 1 |
| Werry, JS | 2 |
| Biederman, J | 2 |
| Thisted, R | 1 |
| Greenhill, L | 1 |
| Ryan, N | 1 |
| Filippelli, A | 1 |
| Cuparencu, B | 1 |
| Falciani, M | 1 |
| de Novellis, V | 1 |
| Safta, L | 1 |
| Arustei, V | 1 |
| Rossi, F | 1 |
| Baldessarini, RJ | 1 |
| Goldblatt, A | 1 |
| Lapey, KA | 1 |
| Doyle, A | 1 |
| Hesslein, PS | 1 |
| Lambe, J | 1 |
| Johnson, A | 1 |
| Giuffre, RM | 1 |
| O'Malley, K | 1 |
| Wananukul, W | 1 |
| Keyler, DE | 1 |
| Pentel, PR | 1 |
| Shekher, A | 1 |
| Sharma, PL | 1 |
| Pandhi, P | 1 |
| Singh, M | 1 |
| Waslick, BD | 2 |
| Walsh, BT | 2 |
| Greenhill, LL | 2 |
| Sloan, RP | 2 |
| Bilich, K | 2 |
| Wolk, S | 1 |
| Bagiella, E | 1 |
| Glassman, AH | 1 |
| Perel, JM | 1 |
| Kantor, SJ | 1 |
| Biamino, G | 1 |
| Fenner, H | 1 |
| Schüren, KP | 1 |
| Neye, J | 1 |
| Ramdohr, B | 1 |
| Lohmann, RW | 1 |
| Allonen, H | 1 |
| Iisalo, E | 1 |
| Nuortio, L | 1 |
| Silva, OA | 1 |
| Carvalho Lemos, JM | 1 |
| López, M | 1 |
| Tingelstad, JB | 1 |
| Katz, MR | 1 |
| Stern, SL | 1 |
| Ribner, HS | 1 |
| Cooper, TB | 1 |
| Nelson, LD | 1 |
| Johnson, MH | 1 |
| Suckow, RF | 1 |
| Pohl, R | 1 |
| Bridges, M | 1 |
| Rainey, JM | 1 |
| Boudoulas, H | 1 |
| Yeragani, VK | 1 |
| Fenster, PE | 1 |
| Bressler, R | 1 |
| Kipps, J | 1 |
| Schroeder, JS | 1 |
| Mullin, AV | 1 |
| Elliott, GR | 1 |
| Steiner, H | 1 |
| Nichols, M | 1 |
| Gordon, A | 1 |
| Paulos, M | 1 |
| Daugherty, A | 1 |
| Frayn, KN | 1 |
| Redfern, WS | 1 |
| Woodward, B | 1 |
| Czartorysky, B | 1 |
| Harding, J | 1 |
| Yamaguchi, N | 1 |
| Lamontagne, D | 1 |
| Boudreau, G | 1 |
| Nadeau, R | 1 |
| de Champlain, J | 1 |
| Smith, DB | 1 |
| Tyznik, JW | 1 |
| Mahapatra, RK | 1 |
| Paul, SK | 1 |
| Mahapatra, D | 1 |
| Winter, S | 1 |
| Barth, N | 2 |
| Muscholl, E | 1 |
| Reidenberg, MM | 1 |
| Affrime, M | 1 |
| Chahine, RA | 1 |
| Castellanos, A | 1 |
| Brown, TC | 1 |
| Dwyer, ME | 1 |
| Stocks, JG | 1 |
| Bucher, HW | 1 |
| Stucki, P | 1 |
| Freeman, JW | 1 |
| Mundy, GR | 1 |
| Beattie, RR | 1 |
| Ryan, C | 1 |
1 review available for desipramine and Arrhythmia
| Article | Year |
|---|---|
Cardiovascular effects of tricyclic antidepressant drugs: therapeutic usage, overdose, and management of complications.
Topics: Adult; Aged; Amitriptyline; Antidepressive Agents, Tricyclic; Arrhythmias, Cardiac; Cardiovascular S | 1982 |
4 trials available for desipramine and Arrhythmia
| Article | Year |
|---|---|
Cardiovascular effects of desipramine in children and adults during exercise testing.
Topics: Adolescent; Adult; Age Factors; Antidepressive Agents, Tricyclic; Arrhythmias, Cardiac; Blood Pressu | 1999 |
2-Hydroxydesipramine and desipramine plasma levels and electrocardiographic effects in depressed younger adults.
Topics: Adult; Antidepressive Agents, Tricyclic; Arrhythmias, Cardiac; Depressive Disorder; Desipramine; Ele | 1991 |
Antiarrhythmic efficacy of desipramine.
Topics: Adult; Aged; Aged, 80 and over; Arrhythmias, Cardiac; Chronic Disease; Clinical Trials as Topic; Des | 1989 |
Cardiovascular effects of desipramine in children.
Topics: Arrhythmias, Cardiac; Attention Deficit Disorder with Hyperactivity; Child; Clinical Trials as Topic | 1989 |
35 other studies available for desipramine and Arrhythmia
| Article | Year |
|---|---|
Support vector machines classification of hERG liabilities based on atom types.
Topics: Animals; Arrhythmias, Cardiac; CHO Cells; Computer Simulation; Cricetinae; Cricetulus; Discriminant | 2008 |
Tricyclic antidepressant toxicity treated with massive sodium bicarbonate.
Topics: Antidepressive Agents, Tricyclic; Arrhythmias, Cardiac; Cyclohexanols; Desipramine; Drug Overdose; E | 2009 |
Halothane-epinephrine arrhythmias and adrenergic responsiveness after chronic imipramine administration in dogs.
Topics: Anesthesia; Animals; Arrhythmias, Cardiac; Desipramine; Dogs; Drug Interactions; Epinephrine; Female | 1984 |
Use of desipramine in the medically ill.
Topics: Arrhythmias, Cardiac; Cardiovascular System; Depressive Disorder; Desipramine; Disease; Drug Adminis | 1984 |
Electrophysiological effects of the tricyclic antidepressant desipramine on mammalian myocardium.
Topics: Action Potentials; Animals; Arrhythmias, Cardiac; Atrial Function; Cell Membrane; Desipramine; Femal | 1984 |
Antiarrhythmic plasma-concentration range of imipramine against ventricular premature depolarizations.
Topics: Adult; Aged; Arrhythmias, Cardiac; Desipramine; Dose-Response Relationship, Drug; Drug Evaluation; F | 1983 |
Arrhythmia induced by a tricyclic antidepressant in a patient with undiagnosed mitral valve prolapse.
Topics: Adult; Arrhythmias, Cardiac; Depressive Disorder; Desipramine; Female; Humans; Mitral Valve Prolapse | 1981 |
Resolved: cardiac arrhythmias make desipramine an unacceptable choice in children.
Topics: Antidepressive Agents, Tricyclic; Arrhythmias, Cardiac; Attention Deficit Disorder with Hyperactivit | 1995 |
Effects of the intracerebroventricular administration of ketamine on centrogenic arrhythmias in anesthetized rats.
Topics: Anesthesia; Animals; Arrhythmias, Cardiac; Aspartic Acid; Cerebral Ventricles; Desipramine; Electroc | 1994 |
The safety of desipramine.
Topics: Adolescent; Arrhythmias, Cardiac; Cause of Death; Child; Death, Sudden, Cardiac; Depressive Disorder | 1994 |
A naturalistic study of 24-hour electrocardiographic recordings and echocardiographic findings in children and adolescents treated with desipramine.
Topics: Adolescent; Arrhythmias, Cardiac; Attention Deficit Disorder with Hyperactivity; Child; Child, Presc | 1993 |
Psychotropic drugs.
Topics: Adolescent; Antidepressive Agents, Tricyclic; Arrhythmias, Cardiac; Child; Depressive Disorder; Desi | 1995 |
ECG changes in pediatric patients on tricyclic antidepressants, desipramine, and imipramine.
Topics: Adolescent; Alberta; Antidepressive Agents, Tricyclic; Arrhythmias, Cardiac; Attention Deficit Disor | 1996 |
Effect of calcium chloride and 4-aminopyridine therapy on desipramine toxicity in rats.
Topics: 4-Aminopyridine; Animals; Antidepressive Agents, Tricyclic; Arrhythmias, Cardiac; Blood Pressure; Br | 1996 |
Role of noradrenaline uptake inhibition and alpha-adrenoceptors in reperfusion ventricular arrhythmias in vivo and in vitro.
Topics: Adrenergic Uptake Inhibitors; Animals; Arrhythmias, Cardiac; Desipramine; In Vitro Techniques; Male; | 1996 |
Effects of desipramine on autonomic input to the heart.
Topics: Adolescent; Adult; Age Factors; Aged; Antidepressive Agents, Tricyclic; Arrhythmias, Cardiac; Child; | 1999 |
The electrocardiographic and antiarrhythmic effects of imipramine hydrochloride at therapeutic plasma concentrations.
Topics: Adult; Aged; Anti-Arrhythmia Agents; Antidepressive Agents, Tricyclic; Arrhythmias, Cardiac; Bundle- | 1979 |
Cardiovascular side effects of tricyclic antidepressants - a risk in the use of these drugs.
Topics: Acridines; Animals; Antidepressive Agents, Tricyclic; Arrhythmias, Cardiac; Blood Pressure; Cats; De | 1975 |
Effect of reserpine, desipramine and phenytoin on digoxin induced arrhythmias and myocardial uptake of digoxin in guinea pigs.
Topics: Animals; Antibody Specificity; Arrhythmias, Cardiac; Depression, Chemical; Desipramine; Digoxin; Dru | 1975 |
[Electrocardiographic changes in acute poisoning by tricyclic drugs].
Topics: Accidents, Home; Adolescent; Arrhythmias, Cardiac; Child, Preschool; Desipramine; Electrocardiograph | 1975 |
The cardiotoxicity of the tricyclics.
Topics: Antidepressive Agents, Tricyclic; Arrhythmias, Cardiac; Attention Deficit Disorder with Hyperactivit | 1991 |
Raised serum levels of desipramine with the antiarrhythmic propafenone.
Topics: Aged; Arrhythmias, Cardiac; Depressive Disorder; Desipramine; Drug Interactions; Humans; Male; Propa | 1991 |
Effects of trazodone and desipramine on cardiac rate and rhythm in a patient with preexisting cardiovascular disease.
Topics: Arrhythmias, Cardiac; Cardiac Complexes, Premature; Depressive Disorder; Desipramine; Female; Heart | 1986 |
The role of catecholamines in the production of ischaemia-induced ventricular arrhythmias in the rat in vivo and in vitro.
Topics: Adrenal Medulla; Adrenalectomy; Adrenergic alpha-Antagonists; Adrenergic beta-Antagonists; Anesthesi | 1986 |
QRS interval in tricyclic antidepressant overdose.
Topics: Adult; Antidepressive Agents, Tricyclic; Arrhythmias, Cardiac; Desipramine; Electrocardiography; Hea | 1988 |
Effects of yohimbine and desipramine on cardiac noradrenaline release and ventricular arrhythmias during acute coronary artery occlusion and reperfusion in anesthetized dogs.
Topics: Anesthesia; Animals; Arrhythmias, Cardiac; Blood Pressure; Coronary Circulation; Coronary Vessels; D | 1987 |
Desipramine-induced conduction disorder mimicking myocardial infarction.
Topics: Adult; Arrhythmias, Cardiac; Desipramine; Diagnosis, Differential; Female; Humans; Myocardial Infarc | 1987 |
Cardiovascular effects of polycyclic antidepressants.
Topics: Adult; Amitriptyline; Amoxapine; Antidepressive Agents, Tricyclic; Arrhythmias, Cardiac; Depression; | 1986 |
Proceedings: Arrhythmias evoked by infusion of tricyclic antidepressants and noradrenaline on isolated rabbit hearts.
Topics: Animals; Antidepressive Agents; Arrhythmias, Cardiac; Desipramine; Dose-Response Relationship, Drug; | 1974 |
The effects of the tricyclic antidepressants desipramine, doxepin and iprindole on the isolated perfused rabbit heart.
Topics: Animals; Antidepressive Agents; Arrhythmias, Cardiac; Atropine; Autonomic Fibers, Postganglionic; Co | 1974 |
Influence of disease on binding of drugs to plasma proteins.
Topics: Arrhythmias, Cardiac; Arteriosclerosis; Blood Proteins; Blood Urea Nitrogen; Carbon Radioisotopes; C | 1973 |
Myocardial toxicity produced by desipramine overdosage.
Topics: Adult; Arrhythmias, Cardiac; Desipramine; Drug Overdose; Female; Heart; Humans; Suicide, Attempted | 1971 |
Antidepressant overdosage in children--a new menace.
Topics: Accidents, Home; Adolescent; Amitriptyline; Antidepressive Agents; Arrhythmias, Cardiac; Child; Chil | 1971 |
[Cardiac complications in poisoning with desipramine (Pertofran)].
Topics: Adult; Arrhythmias, Cardiac; Depression; Desipramine; Electrocardiography; Female; Humans; Suicide | 1967 |
Cardiac abnormalities in poisoning with tricyclic antidepressants.
Topics: Adult; Amitriptyline; Antidepressive Agents; Arrhythmias, Cardiac; Desipramine; Electrocardiography; | 1969 |