desipramine has been researched along with Anxiety Disorders in 39 studies
Desipramine: A tricyclic dibenzazepine compound that potentiates neurotransmission. Desipramine selectively blocks reuptake of norepinephrine from the neural synapse, and also appears to impair serotonin transport. This compound also possesses minor anticholinergic activity, through its affinity to muscarinic receptors.
desipramine : A dibenzoazepine consisting of 10,11-dihydro-5H-dibenzo[b,f]azepine substituted on nitrogen with a 3-(methylamino)propyl group.
Anxiety Disorders: Persistent and disabling ANXIETY.
| Excerpt | Relevance | Reference |
|---|---|---|
| "To evaluate whether serotonin reuptake inhibition is critical to the treatment of obsessive-compulsive disorder, 40 outpatients with a principal diagnosis of obsessive-compulsive disorder were randomized in a double-blind fashion to 8 weeks of treatment with either the serotonin reuptake inhibitor fluvoxamine maleate (n = 21) or the norepinephrine reuptake inhibitor desipramine hydrochloride (n = 19)." | 9.06 | Specificity of serotonin reuptake inhibitors in the treatment of obsessive-compulsive disorder. Comparison of fluvoxamine and desipramine. ( Charney, DS; Delgado, PL; Goodman, WK; Heninger, GR; Krystal, JH; Nagy, LM; Palumbo, J; Price, LH; Rasmussen, SA, 1990) |
| "Doxepin and desipramine at final doses of 188 and 173 mg/day, respectively, were compared in 36 volunteers with major affective or dysthymic disorder and chronic back pain." | 9.05 | Antidepressants in concomitant chronic back pain and depression: doxepin and desipramine compared. ( Benedetti, C; Bokan, JA; Butler, S; Phillips, M; Spengler, D; Ward, N, 1984) |
| "To evaluate whether serotonin reuptake inhibition is critical to the treatment of obsessive-compulsive disorder, 40 outpatients with a principal diagnosis of obsessive-compulsive disorder were randomized in a double-blind fashion to 8 weeks of treatment with either the serotonin reuptake inhibitor fluvoxamine maleate (n = 21) or the norepinephrine reuptake inhibitor desipramine hydrochloride (n = 19)." | 5.06 | Specificity of serotonin reuptake inhibitors in the treatment of obsessive-compulsive disorder. Comparison of fluvoxamine and desipramine. ( Charney, DS; Delgado, PL; Goodman, WK; Heninger, GR; Krystal, JH; Nagy, LM; Palumbo, J; Price, LH; Rasmussen, SA, 1990) |
| "Doxepin and desipramine at final doses of 188 and 173 mg/day, respectively, were compared in 36 volunteers with major affective or dysthymic disorder and chronic back pain." | 5.05 | Antidepressants in concomitant chronic back pain and depression: doxepin and desipramine compared. ( Benedetti, C; Bokan, JA; Butler, S; Phillips, M; Spengler, D; Ward, N, 1984) |
| " Among the more important recent discoveries are the efficacy of the tricyclic antidepressants for panic disorder and agoraphobia with panic attacks; the use of the monoamine oxidase inhibitors for the above disorders and for atypical depression and hysteroid dysphoria; the use of propranolol for anxiety disorders and for uncontrollable violent outbursts; the antianxiety and antipanic effects of clonidine; and the usefulness of lithium in treating schizophrenia and schizoaffective disorder and for emotionally unstable character disorders." | 4.76 | Newer uses for older psychotropic medications. ( Liebowitz, MR, 1982) |
| " However, we report the successful treatment of a case with desipramine and suggest that, because there is a link between depersonalization and anxiety disorders, tricyclic antidepressants may prove effective for depersonalization." | 3.67 | Desipramine: a possible treatment for depersonalization disorder. ( Kuperman, S; Noyes, R; Olson, SB, 1987) |
| "Ten cases are presented--two in detail--in which clonazepam was used successfully in patients with treatment-resistant panic disorder with or without agoraphobia." | 3.67 | Successful use of clonazepam in patients with treatment-resistant panic disorder. ( Rosenbaum, JF; Tesar, GE, 1986) |
| "Concerning the comorbid substance use, all the studies have included patients with alcohol use, none of them have dealt with cocaine, cannabis or nicotine use." | 2.82 | Clinical practice guideline on pharmacological and psychological management of adult patients with an anxiety disorder and comorbid substance use. ( Arranz, B; Arrojo, M; Becoña, E; Bernardo, M; Castells, X; Cunill, R; Flórez, G; Fonseca, F; Garriga, M; Goikolea, JM; González-Pinto, A; López, A; Sáiz, PA; San, L; Tirado-Muñoz, J; Torrens, M; Zorrilla, I, 2022) |
| "Desipramine-treated subjects showed gradual improvement over the course of the study, and the improvement in week 1 was not so strongly predictive of overall improvement." | 2.67 | Antidepressant or antianxiety? A study of the efficacy of antidepressant medication. ( Edwards, J; Fawcett, J; Fogg, L; Kravitz, HM, 1990) |
| "It is important to understand both the kinetic and the dynamic implications of dosing TCAs and BZs in the elderly, for whom these drugs are frequently prescribed." | 2.37 | Implications of dosing tricyclic antidepressants and benzodiazepines in geriatrics. ( Cutler, NR; Narang, PK, 1984) |
| "Global transient cerebral ischemia was performing with the four-vessels occlusion method." | 1.35 | Behavioral effects of four antidepressants on an ischemic rat model of emotional disturbances. ( Bantsiele, GB; Bentué-Ferrer, D; Bourin, M; Laviolle, B; Reymann, JM; Saïkali, S, 2009) |
| "Imipramine has been shown to reduce anxiety in patients with generalized anxiety disorder (GAD)." | 1.31 | Therapeutic effects of imipramine are counteracted by its metabolite, desipramine, in patients with generalized anxiety disorder. ( Clark, CM; Hoehn-Saric, R; Kowalski, PA; McLeod, DR; Porges, SW, 2000) |
| "Desipramine was associated with a much higher frequency of jitteriness than was imipramine." | 1.27 | The jitteriness syndrome in panic disorder patients treated with antidepressants. ( Balon, R; Lycaki, H; Pohl, R; Yeragani, VK, 1988) |
| "In a 39-year-old man with Parkinson's disease and a history of anxiety disorders, anxiety-provoking situations such as group psychotherapy precipitated panic attacks and caused pronounced worsening of the parkinsonian symptoms." | 1.27 | Parkinson's disease complicated by anxiety. ( Ahlskog, JE; Black, JL; Routh, LC, 1987) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 17 (43.59) | 18.7374 |
| 1990's | 14 (35.90) | 18.2507 |
| 2000's | 4 (10.26) | 29.6817 |
| 2010's | 3 (7.69) | 24.3611 |
| 2020's | 1 (2.56) | 2.80 |
| Authors | Studies |
|---|---|
| Sáiz, PA | 1 |
| Flórez, G | 1 |
| Arrojo, M | 1 |
| Bernardo, M | 1 |
| González-Pinto, A | 1 |
| Goikolea, JM | 1 |
| Zorrilla, I | 1 |
| Cunill, R | 1 |
| Castells, X | 1 |
| Becoña, E | 1 |
| López, A | 1 |
| Torrens, M | 1 |
| Fonseca, F | 1 |
| Tirado-Muñoz, J | 1 |
| Arranz, B | 1 |
| Garriga, M | 1 |
| San, L | 1 |
| Villas-Boas, CB | 1 |
| Chierrito, D | 1 |
| Fernandez-Llimos, F | 1 |
| Tonin, FS | 1 |
| Sanches, ACC | 1 |
| Ipser, JC | 1 |
| Wilson, D | 1 |
| Akindipe, TO | 1 |
| Sager, C | 1 |
| Stein, DJ | 1 |
| Shah, AP | 1 |
| Carreno, FR | 1 |
| Wu, H | 1 |
| Chung, YA | 1 |
| Frazer, A | 1 |
| Bantsiele, GB | 1 |
| Bentué-Ferrer, D | 1 |
| Saïkali, S | 1 |
| Laviolle, B | 1 |
| Bourin, M | 1 |
| Reymann, JM | 1 |
| Kurpius, MP | 1 |
| Alexander, B | 1 |
| Monteggia, LM | 1 |
| Luikart, B | 1 |
| Barrot, M | 1 |
| Theobold, D | 1 |
| Malkovska, I | 1 |
| Nef, S | 1 |
| Parada, LF | 1 |
| Nestler, EJ | 1 |
| Liebowitz, MR | 3 |
| Ward, N | 1 |
| Bokan, JA | 1 |
| Phillips, M | 1 |
| Benedetti, C | 1 |
| Butler, S | 1 |
| Spengler, D | 1 |
| Rosenbaum, JF | 3 |
| Cutler, NR | 1 |
| Narang, PK | 1 |
| Grant, B | 1 |
| Katon, W | 1 |
| Beitman, B | 1 |
| Breier, A | 1 |
| Ginsberg, EM | 1 |
| Charney, DS | 2 |
| Fyer, AJ | 1 |
| Gorman, JM | 1 |
| Dillon, D | 2 |
| Appleby, IL | 1 |
| Levy, G | 1 |
| Anderson, S | 1 |
| Levitt, M | 2 |
| Palij, M | 1 |
| Davies, SO | 1 |
| Sheehan, DV | 1 |
| Rifkin, A | 1 |
| Klein, DF | 1 |
| Sovner, RD | 1 |
| Campbell, JL | 1 |
| Thomas, HM | 1 |
| Gabrielli, W | 1 |
| Liskow, BI | 1 |
| Powell, BJ | 1 |
| Hogarty, GE | 1 |
| McEvoy, JP | 1 |
| Ulrich, RF | 1 |
| DiBarry, AL | 1 |
| Bartone, P | 1 |
| Cooley, S | 1 |
| Hammill, K | 1 |
| Carter, M | 1 |
| Munetz, MR | 1 |
| Perel, J | 1 |
| Wilens, TE | 1 |
| Biederman, J | 2 |
| Prince, J | 1 |
| Spencer, TJ | 1 |
| Faraone, SV | 1 |
| Warburton, R | 1 |
| Schleifer, D | 1 |
| Harding, M | 1 |
| Linehan, C | 1 |
| Geller, D | 1 |
| Wamboldt, MZ | 1 |
| Yancey, AG | 1 |
| Roesler, TA | 1 |
| Levitt, AJ | 1 |
| Joffe, RT | 1 |
| Sokolov, ST | 1 |
| McLeod, DR | 1 |
| Hoehn-Saric, R | 1 |
| Porges, SW | 1 |
| Kowalski, PA | 1 |
| Clark, CM | 1 |
| Kleber, RJ | 1 |
| Bajwa, WK | 2 |
| Asnis, GM | 3 |
| Kalus, O | 2 |
| Rubinson, E | 2 |
| Kahn, R | 1 |
| Friedman, JM | 1 |
| Iqbal, N | 2 |
| Grosz, D | 2 |
| van Praag, H | 1 |
| Cahn, W | 1 |
| Warnock, JK | 1 |
| Sieg, K | 1 |
| Willsie, D | 1 |
| Stevenson, EK | 1 |
| Kestenbaum, T | 1 |
| Bartels, MG | 1 |
| Varley, CK | 1 |
| Mitchell, J | 1 |
| Stamm, SJ | 1 |
| Goodman, WK | 1 |
| Price, LH | 1 |
| Delgado, PL | 1 |
| Palumbo, J | 1 |
| Krystal, JH | 1 |
| Nagy, LM | 1 |
| Rasmussen, SA | 1 |
| Heninger, GR | 1 |
| Harkavy Friedman, JM | 1 |
| van Praag, HM | 1 |
| Cooper, TB | 1 |
| Kravitz, HM | 1 |
| Fogg, L | 1 |
| Fawcett, J | 1 |
| Edwards, J | 1 |
| Bystritsky, A | 1 |
| Pasnau, RO | 1 |
| Fava, M | 1 |
| Anderson, K | 1 |
| Gonzalez, E | 1 |
| Bronstein, B | 1 |
| De Monaco, H | 1 |
| Wright, V | 1 |
| Pohl, R | 1 |
| Yeragani, VK | 1 |
| Balon, R | 1 |
| Lycaki, H | 1 |
| Noyes, R | 1 |
| Kuperman, S | 1 |
| Olson, SB | 1 |
| Routh, LC | 1 |
| Black, JL | 1 |
| Ahlskog, JE | 1 |
| Tesar, GE | 1 |
| Stewart, JW | 1 |
| McGrath, PJ | 1 |
| Harrison, W | 1 |
| Quitkin, F | 1 |
| Rabkin, JG | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| [NCT00005461] | 0 participants | Observational | 1991-04-30 | Completed | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
8 reviews available for desipramine and Anxiety Disorders
| Article | Year |
|---|---|
Clinical practice guideline on pharmacological and psychological management of adult patients with an anxiety disorder and comorbid substance use.
Topics: Adult; Anxiety Disorders; Desipramine; Humans; Naltrexone; Paroxetine; Substance-Related Disorders | 2022 |
Pharmacological treatment of attention-deficit hyperactivity disorder comorbid with an anxiety disorder: a systematic review.
Topics: Adolescent; Adult; Anxiety Disorders; Atomoxetine Hydrochloride; Attention Deficit Disorder with Hyp | 2019 |
Pharmacotherapy for anxiety and comorbid alcohol use disorders.
Topics: Alcohol-Related Disorders; Anxiety; Anxiety Disorders; Buspirone; Comorbidity; Desipramine; Humans; | 2015 |
Newer uses for older psychotropic medications.
Topics: Adrenergic beta-Antagonists; Agoraphobia; Anxiety Disorders; Bipolar Disorder; Clonidine; Depressive | 1982 |
Treatment of outpatients with desipramine.
Topics: Ambulatory Care; Anxiety Disorders; Body Weight; Depressive Disorder; Desipramine; Drug Administrati | 1984 |
Implications of dosing tricyclic antidepressants and benzodiazepines in geriatrics.
Topics: Adipose Tissue; Adult; Aged; Aging; Amitriptyline; Antidepressive Agents, Tricyclic; Anxiety Disorde | 1984 |
Current concepts in psychiatry. Panic attacks and phobias.
Topics: Adolescent; Adult; Agoraphobia; Antidepressive Agents; Anxiety Disorders; Behavior Therapy; Clinical | 1982 |
Cardiovascular effects of tricyclic antidepressants in childhood asthma: a case series and review.
Topics: Adolescent; Anti-Inflammatory Agents; Antidepressive Agents, Tricyclic; Anxiety Disorders; Asthma; B | 1997 |
14 trials available for desipramine and Anxiety Disorders
| Article | Year |
|---|---|
Antidepressants in concomitant chronic back pain and depression: doxepin and desipramine compared.
Topics: Adult; Anxiety Disorders; Back Pain; beta-Endorphin; Chronic Disease; Clinical Trials as Topic; Depr | 1984 |
Current concepts in psychiatry. Panic attacks and phobias.
Topics: Adolescent; Adult; Agoraphobia; Antidepressive Agents; Anxiety Disorders; Behavior Therapy; Clinical | 1982 |
Impact of desipramine or carbamazepine on patient retention in outpatient cocaine treatment: preliminary findings.
Topics: Ambulatory Care; Antisocial Personality Disorder; Anxiety Disorders; Carbamazepine; Cocaine; Combine | 1994 |
Pharmacotherapy of impaired affect in recovering schizophrenic patients.
Topics: Adolescent; Adult; Ambulatory Care; Antipsychotic Agents; Anxiety Disorders; Basal Ganglia Diseases; | 1995 |
Six-week, double-blind, placebo-controlled study of desipramine for adult attention deficit hyperactivity disorder.
Topics: Adolescent; Adult; Age Factors; Ambulatory Care; Anxiety Disorders; Attention Deficit Disorder with | 1996 |
Does the chronological relationship between the onset of dysthymia and major depression influence subsequent response to antidepressants?
Topics: Adolescent; Adult; Aged; Ambulatory Care; Antidepressive Agents; Anxiety Disorders; Comorbidity; Dep | 1998 |
A double-blind comparative study of desipramine hydrochloride and diazepam in the control of mixed anxiety/depression symptomatology.
Topics: Adjustment Disorders; Adolescent; Adult; Anxiety Disorders; Clinical Trials as Topic; Desipramine; D | 1979 |
Desipramine treatment in panic disorder.
Topics: Adult; Agoraphobia; Anxiety Disorders; Arousal; Desipramine; Female; Humans; Male; Panic; Personalit | 1991 |
Pediatric cardiovascular effects of imipramine and desipramine.
Topics: Adolescent; Anxiety Disorders; Child; Depressive Disorder; Desipramine; Double-Blind Method; Electro | 1991 |
Specificity of serotonin reuptake inhibitors in the treatment of obsessive-compulsive disorder. Comparison of fluvoxamine and desipramine.
Topics: Adult; Anxiety Disorders; Basal Ganglia; Depressive Disorder; Desipramine; Dopamine; Double-Blind Me | 1990 |
The drug-free period: a methodological issue.
Topics: Anxiety Disorders; Clinical Trials as Topic; Depressive Disorder; Desipramine; Drug Administration S | 1990 |
Antidepressant or antianxiety? A study of the efficacy of antidepressant medication.
Topics: Adult; Alprazolam; Anxiety Disorders; Clinical Trials as Topic; Depressive Disorder; Desipramine; Dr | 1990 |
Initial reaction and subsequent response to antidepressants in panic patients.
Topics: Anxiety Disorders; Desipramine; Dose-Response Relationship, Drug; Drug Administration Schedule; Fluo | 1990 |
Treatment outcome validation of DSM-III depressive subtypes. Clinical usefulness in outpatients with mild to moderate depression.
Topics: Anxiety Disorders; Bipolar Disorder; Clinical Trials as Topic; Depressive Disorder; Desipramine; Dou | 1985 |
18 other studies available for desipramine and Anxiety Disorders
| Article | Year |
|---|---|
Role of TrkB in the anxiolytic-like and antidepressant-like effects of vagal nerve stimulation: Comparison with desipramine.
Topics: Adrenergic Uptake Inhibitors; Animals; Anti-Anxiety Agents; Antidepressive Agents, Tricyclic; Anxiet | 2016 |
Behavioral effects of four antidepressants on an ischemic rat model of emotional disturbances.
Topics: Analysis of Variance; Animals; Antidepressive Agents; Anxiety Disorders; Behavior, Animal; Brain Isc | 2009 |
Rates of in vivo methylation of desipramine and nortriptyline.
Topics: Aged, 80 and over; Antidepressive Agents, Tricyclic; Anxiety Disorders; Depressive Disorder; Desipra | 2006 |
Brain-derived neurotrophic factor conditional knockouts show gender differences in depression-related behaviors.
Topics: Alleles; Animals; Antidepressive Agents, Tricyclic; Anxiety Disorders; Brain-Derived Neurotrophic Fa | 2007 |
Panic disorder.
Topics: Adolescent; Adult; Anxiety Disorders; Desipramine; Diagnosis, Differential; Family Practice; Fear; F | 1983 |
Seminal emission induced by tricyclic antidepressant.
Topics: Anxiety Disorders; Defecation; Depressive Disorder; Desipramine; Double-Blind Method; Ejaculation; H | 1984 |
Lactate provocation of panic attacks. I. Clinical and behavioral findings.
Topics: Adult; Agoraphobia; Anxiety Disorders; Clonidine; Desipramine; Fear; Female; Humans; Imipramine; Lac | 1984 |
Blockade by imipramine or desipramine of panic induced by sodium lactate.
Topics: Anxiety Disorders; Desipramine; Fear; Humans; Imipramine; Lactates; Panic | 1981 |
The clinical characteristics and treatment of atypical depression.
Topics: Adult; Anxiety Disorders; Depressive Disorder; Desipramine; Fatigue; Female; Humans; Imipramine; Mal | 1981 |
Therapeutic effects of imipramine are counteracted by its metabolite, desipramine, in patients with generalized anxiety disorder.
Topics: Adrenergic Uptake Inhibitors; Adult; Anxiety Disorders; Arrhythmia, Sinus; Blood Pressure; Desiprami | 2000 |
Desipramine-induced urticaria: a clinical problem.
Topics: Adult; Ambulatory Care; Anxiety Disorders; Depressive Disorder; Desipramine; Drug Eruptions; Female; | 1991 |
Drug-related alopecia in patients treated with tricyclic antidepressants.
Topics: Adult; Alopecia; Antidepressive Agents, Tricyclic; Anxiety Disorders; Child; Child Behavior Disorder | 1991 |
"Anger attacks": possible variants of panic and major depressive disorders.
Topics: Adult; Anger; Anxiety Disorders; Clomipramine; Clonazepam; Depressive Disorder; Desipramine; Diagnos | 1990 |
Desipramine and cutaneous reactions in pediatric outpatients.
Topics: Adolescent; Adult; Age Factors; Ambulatory Care; Anxiety Disorders; Attention Deficit Disorder with | 1988 |
The jitteriness syndrome in panic disorder patients treated with antidepressants.
Topics: Adult; Akathisia, Drug-Induced; Antidepressive Agents, Tricyclic; Anxiety Disorders; Depressive Diso | 1988 |
Desipramine: a possible treatment for depersonalization disorder.
Topics: Adolescent; Anxiety Disorders; Depersonalization; Desipramine; Humans; Male | 1987 |
Parkinson's disease complicated by anxiety.
Topics: Adult; Anxiety Disorders; Behavior Therapy; Combined Modality Therapy; Desipramine; Humans; Male; Pa | 1987 |
Successful use of clonazepam in patients with treatment-resistant panic disorder.
Topics: Adult; Agoraphobia; Alprazolam; Anxiety Disorders; Benzodiazepines; Benzodiazepinones; Clonazepam; D | 1986 |