desipramine has been researched along with Alcohol Drinking in 19 studies
Desipramine: A tricyclic dibenzazepine compound that potentiates neurotransmission. Desipramine selectively blocks reuptake of norepinephrine from the neural synapse, and also appears to impair serotonin transport. This compound also possesses minor anticholinergic activity, through its affinity to muscarinic receptors.
desipramine : A dibenzoazepine consisting of 10,11-dihydro-5H-dibenzo[b,f]azepine substituted on nitrogen with a 3-(methylamino)propyl group.
Alcohol Drinking: Behaviors associated with the ingesting of ALCOHOLIC BEVERAGES, including social drinking.
| Excerpt | Relevance | Reference |
|---|---|---|
| " The current study assessed whether paliperidone, a dopamine D2 receptor and adrenergic alpha-2 receptor antagonist like clozapine, would attenuate alcohol drinking in the alcohol-preferring P rat and the Syrian golden hamster, and whether desipramine, a norepinephrine reuptake inhibitor, would potentiate the ability of paliperidone to attenuate alcohol drinking in the P rat and the Syrian golden hamster." | 7.81 | Desipramine enhances the ability of paliperidone to decrease alcohol drinking. ( Chau, DT; Dawson, R; Green, AI; Gulick, D; Khokhar, JY, 2015) |
| " To create a safer clozapine-like drug, we tested whether the antipsychotic iloperidone, a drug that combines a weak dopamine D2 receptor blockade and a potent norepinephrine alpha-2 receptor blockade would reduce alcohol drinking, and whether its effect on alcohol drinking could be increased if combined with an agent to facilitate norepinephrine activity." | 5.43 | Effects of iloperidone, combined with desipramine, on alcohol drinking in the Syrian golden hamster. ( Green, AI; Khokhar, JY, 2016) |
| "Desipramine pretreatment reduced the time spent immobile in rats of the 2 alcohol-nonpreferring lines (i." | 5.30 | Comparison of rats selectively bred for high and low ethanol intake in a forced-swim-test model of depression: effects of desipramine. ( Froehlich, JC; Godfrey, CD; Li, TK; Murphy, JM; Stewart, RB, 1997) |
| "We recreated a clozapine-like drug to reduce alcohol drinking in the Syrian golden hamster by combining low dose haloperidol with a norepinephrine α-2 receptor antagonist, idazoxan, and a norepinephrine reuptake inhibitor, desipramine." | 3.81 | Clozapine reconstructed: Haloperidol's ability to reduce alcohol intake in the Syrian golden hamster can be enhanced through noradrenergic modulation by desipramine and idazoxan. ( Chau, DT; Dawson, R; Green, AI; Khokhar, JY, 2015) |
| " The current study assessed whether paliperidone, a dopamine D2 receptor and adrenergic alpha-2 receptor antagonist like clozapine, would attenuate alcohol drinking in the alcohol-preferring P rat and the Syrian golden hamster, and whether desipramine, a norepinephrine reuptake inhibitor, would potentiate the ability of paliperidone to attenuate alcohol drinking in the P rat and the Syrian golden hamster." | 3.81 | Desipramine enhances the ability of paliperidone to decrease alcohol drinking. ( Chau, DT; Dawson, R; Green, AI; Gulick, D; Khokhar, JY, 2015) |
| "The atypical antipsychotic clozapine reduces alcohol drinking in patients with schizophrenia." | 3.80 | Desipramine enhances the ability of risperidone to decrease alcohol intake in the Syrian golden hamster. ( Chau, DT; Dawson, R; Green, AI; Gulick, D; Khokhar, JY, 2014) |
| " To create a safer clozapine-like drug, we tested whether the antipsychotic iloperidone, a drug that combines a weak dopamine D2 receptor blockade and a potent norepinephrine alpha-2 receptor blockade would reduce alcohol drinking, and whether its effect on alcohol drinking could be increased if combined with an agent to facilitate norepinephrine activity." | 1.43 | Effects of iloperidone, combined with desipramine, on alcohol drinking in the Syrian golden hamster. ( Green, AI; Khokhar, JY, 2016) |
| "Desipramine treatment appeared to result in decreases in alcohol consumption in nonalcoholic patients with depression." | 1.32 | Depressive symptoms and alcohol consumption among nonalcoholic depression patients treated with desipramine. ( Bagby, RM; Goldstein, BI; Joffe, RT; Levitt, A; Schaffer, A; Wesson, V; Zaretsky, A, 2004) |
| "Desipramine pretreatment reduced the time spent immobile in rats of the 2 alcohol-nonpreferring lines (i." | 1.30 | Comparison of rats selectively bred for high and low ethanol intake in a forced-swim-test model of depression: effects of desipramine. ( Froehlich, JC; Godfrey, CD; Li, TK; Murphy, JM; Stewart, RB, 1997) |
| " Chronic administration of desipramine may have therapeutic efficacy in treating cocaine abuse only in subjects attempting to refrain from cocaine who are aided in their passage through a withdrawal phase by desipramine." | 1.28 | Schedule-induced oral self-administration of cocaine and ethanol solutions: lack of effect of chronic desipramine. ( Falk, JL; Tang, M, 1990) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 6 (31.58) | 18.7374 |
| 1990's | 5 (26.32) | 18.2507 |
| 2000's | 4 (21.05) | 29.6817 |
| 2010's | 4 (21.05) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Gulick, D | 2 |
| Chau, DT | 3 |
| Khokhar, JY | 4 |
| Dawson, R | 3 |
| Green, AI | 4 |
| Stevenson, JR | 1 |
| Schroeder, JP | 1 |
| Nixon, K | 1 |
| Besheer, J | 1 |
| Crews, FT | 1 |
| Hodge, CW | 1 |
| Sacharczuk, M | 1 |
| Juszczak, G | 1 |
| Swiergiel, AH | 1 |
| Jaszczak, K | 1 |
| Lipkowski, AW | 1 |
| Sadowski, B | 1 |
| Martijena, ID | 1 |
| Bustos, SG | 1 |
| Bertotto, ME | 1 |
| Molina, VA | 1 |
| Goldstein, BI | 1 |
| Schaffer, A | 1 |
| Levitt, A | 1 |
| Zaretsky, A | 1 |
| Joffe, RT | 1 |
| Wesson, V | 1 |
| Bagby, RM | 1 |
| Foltin, RW | 1 |
| Fischman, MW | 1 |
| Levin, FR | 1 |
| Rosenwasser, AM | 1 |
| Hayes, MJ | 1 |
| Godfrey, CD | 1 |
| Froehlich, JC | 1 |
| Stewart, RB | 1 |
| Li, TK | 2 |
| Murphy, JM | 2 |
| Rockman, GE | 1 |
| Amit, Z | 2 |
| Carr, G | 1 |
| Ogren, SO | 1 |
| Levitan, DE | 1 |
| Brown, ZE | 1 |
| Sutherland, EA | 1 |
| Melchior, CL | 1 |
| Myers, RD | 1 |
| Gallant, D | 1 |
| Tang, M | 1 |
| Falk, JL | 1 |
| Hilakivi, LA | 2 |
| Hilakivi, I | 1 |
| Kiianmaa, K | 2 |
| Stenberg, D | 1 |
| Sinclair, JD | 1 |
| McBride, WJ | 1 |
| Lumeng, L | 1 |
1 review available for desipramine and Alcohol Drinking
| Article | Year |
|---|---|
Cardiovascular effects of cocaine in humans: laboratory studies.
Topics: Alcohol Drinking; Arousal; Blood Pressure; Calcium Channel Blockers; Cannabinoids; Cardiovascular Sy | 1995 |
1 trial available for desipramine and Alcohol Drinking
| Article | Year |
|---|---|
Reduction of ethanol intake by pharmacologic agents--investigational problems.
Topics: Adult; Alcohol Drinking; Alcoholics Anonymous; Alcoholism; Combined Modality Therapy; Depressive Dis | 1992 |
17 other studies available for desipramine and Alcohol Drinking
| Article | Year |
|---|---|
Desipramine enhances the ability of risperidone to decrease alcohol intake in the Syrian golden hamster.
Topics: Alcohol Drinking; Animals; Brain; Clozapine; Desipramine; Dopamine Antagonists; Dose-Response Relati | 2014 |
Clozapine reconstructed: Haloperidol's ability to reduce alcohol intake in the Syrian golden hamster can be enhanced through noradrenergic modulation by desipramine and idazoxan.
Topics: Adrenergic alpha-2 Receptor Antagonists; Adrenergic Uptake Inhibitors; Adult; Alcohol Drinking; Anim | 2015 |
Desipramine enhances the ability of paliperidone to decrease alcohol drinking.
Topics: Adrenergic alpha-2 Receptor Antagonists; Adrenergic Uptake Inhibitors; Alcohol Deterrents; Alcohol D | 2015 |
Effects of iloperidone, combined with desipramine, on alcohol drinking in the Syrian golden hamster.
Topics: Adrenergic Uptake Inhibitors; Alcohol Drinking; Animals; Antipsychotic Agents; Clozapine; Cricetinae | 2016 |
Abstinence following alcohol drinking produces depression-like behavior and reduced hippocampal neurogenesis in mice.
Topics: Alcohol Drinking; Animals; Antidepressive Agents, Tricyclic; Behavior, Animal; Cell Survival; Centra | 2009 |
Alcohol reverses depressive and pronociceptive effects of chronic stress in mice with enhanced activity of the opioid system.
Topics: Alcohol Drinking; Analgesics, Opioid; Analysis of Variance; Animals; Antidepressive Agents, Tricycli | 2009 |
Antidepressants attenuate both the enhanced ethanol intake and ethanol-induced anxiolytic effects in diazepam withdrawn rats.
Topics: Alcohol Drinking; Analysis of Variance; Animals; Anti-Anxiety Agents; Antidepressive Agents; Anxiety | 2005 |
Depressive symptoms and alcohol consumption among nonalcoholic depression patients treated with desipramine.
Topics: Adult; Alcohol Drinking; Antidepressive Agents, Tricyclic; Depressive Disorder, Major; Desipramine; | 2004 |
Neonatal desipramine treatment alters free-running circadian drinking rhythms in rats.
Topics: Alcohol Drinking; Animals; Animals, Newborn; Circadian Rhythm; Desipramine; Drinking Behavior; Light | 1994 |
Comparison of rats selectively bred for high and low ethanol intake in a forced-swim-test model of depression: effects of desipramine.
Topics: Alcohol Drinking; Animals; Behavior, Animal; Depression; Desipramine; Disease Models, Animal; Male; | 1997 |
Attenuation of ethanol intake by 5-hydroxytryptamine uptake blockade in laboratory rats: II. Possible interaction with brain norepinephrine.
Topics: Alcohol Drinking; Animals; Brain Chemistry; Desipramine; Male; Norepinephrine; Rats; Serotonin; Sero | 1979 |
Catecholaminergic involvement in alcohol's rewarding properties: implications for a treatment model for alcoholics.
Topics: Alcohol Drinking; Alcoholism; Alkaloids; Animals; Desipramine; Dopamine; Ethanol; Humans; Hydroxydop | 1977 |
Genetic differences in ethanol drinking of the rat following injection of 6-OHDA, 5,6-DHT or 5,7-DHT into the cerebral ventricles.
Topics: 5,6-Dihydroxytryptamine; Alcohol Drinking; Animals; Body Weight; Brain Chemistry; Desipramine; Dopam | 1976 |
Schedule-induced oral self-administration of cocaine and ethanol solutions: lack of effect of chronic desipramine.
Topics: Alcohol Drinking; Alcoholism; Animals; Cocaine; Desipramine; Dose-Response Relationship, Drug; Drug | 1990 |
Neonatal antidepressant administration suppresses concurrent active (REM) sleep and increases adult alcohol consumption in rats.
Topics: 3,4-Dihydroxyphenylacetic Acid; Alcohol Drinking; Animals; Animals, Newborn; Brain Chemistry; Desipr | 1987 |
Neonatal desipramine or zimeldine treatment causes long-lasting changes in brain monoaminergic systems and alcohol related behavior in rats.
Topics: Alcohol Drinking; Animals; Animals, Newborn; Behavior, Animal; Biogenic Amines; Brain; Desipramine; | 1987 |
Effects of Ro 15-4513, fluoxetine and desipramine on the intake of ethanol, water and food by the alcohol-preferring (P) and -nonpreferring (NP) lines of rats.
Topics: Alcohol Drinking; Alcoholism; Animals; Azides; Benzodiazepines; Desipramine; Drinking Behavior; Feed | 1988 |