desipramine has been researched along with Aging in 64 studies
Desipramine: A tricyclic dibenzazepine compound that potentiates neurotransmission. Desipramine selectively blocks reuptake of norepinephrine from the neural synapse, and also appears to impair serotonin transport. This compound also possesses minor anticholinergic activity, through its affinity to muscarinic receptors.
desipramine : A dibenzoazepine consisting of 10,11-dihydro-5H-dibenzo[b,f]azepine substituted on nitrogen with a 3-(methylamino)propyl group.
Aging: The gradual irreversible changes in structure and function of an organism that occur as a result of the passage of time.
| Excerpt | Relevance | Reference |
|---|---|---|
| "The cardiovascular effects of desipramine were assessed in 74 young women with bulimia nervosa participating in a 6-week double-blind, placebo-controlled study." | 9.07 | Increased pulse and blood pressure associated with desipramine treatment of bulimia nervosa. ( Hadigan, CM; Walsh, BT; Wong, LM, 1992) |
| "Thirty outpatients between the ages of 60 and 85 with DSM-III Major Depression entered an 8 week randomized, double-blind comparison of desipramine and adinazolam mesylate, a triazolobenzodiazepine derivative." | 9.06 | A controlled trial of adinazolam versus desipramine in geriatric depression. ( Boyer, WF; Doroski, VS; Feighner, JP; Hendrickson, GG; Pambakian, RA, 1990) |
| " Desipramine is a typical tricyclic antidepressant, and can provide neuroprotection and counteract depression-like behaviors." | 7.85 | Desipramine rescues age-related phenotypes in depression-like rats induced by chronic mild stress. ( Chen, Y; Fu, Z; Huang, L; Ma, L; Shen, Q; Wang, Q; Wu, T; Xie, X, 2017) |
| " The purpose of this study was to assess the effects of the long-term administration of the tricyclic antidepressant desipramine and the reversibility of this treatment following a 15 d washout period on specific salivary proteins, composition of oral microbiota, and oral health (gingivitis) of aging female F344 rats." | 7.70 | Desipramine induced changes in salivary proteins, cultivable oral microbiota and gingival health in aging female NIA Fischer 344 rats. ( Humphreys-Beher, MG; Koller, MM; Maeda, N; Purushotham, KR; Scarpace, PJ, 2000) |
| "The cardiovascular effects of desipramine were assessed in 74 young women with bulimia nervosa participating in a 6-week double-blind, placebo-controlled study." | 5.07 | Increased pulse and blood pressure associated with desipramine treatment of bulimia nervosa. ( Hadigan, CM; Walsh, BT; Wong, LM, 1992) |
| "Thirty outpatients between the ages of 60 and 85 with DSM-III Major Depression entered an 8 week randomized, double-blind comparison of desipramine and adinazolam mesylate, a triazolobenzodiazepine derivative." | 5.06 | A controlled trial of adinazolam versus desipramine in geriatric depression. ( Boyer, WF; Doroski, VS; Feighner, JP; Hendrickson, GG; Pambakian, RA, 1990) |
| " Desipramine is a typical tricyclic antidepressant, and can provide neuroprotection and counteract depression-like behaviors." | 3.85 | Desipramine rescues age-related phenotypes in depression-like rats induced by chronic mild stress. ( Chen, Y; Fu, Z; Huang, L; Ma, L; Shen, Q; Wang, Q; Wu, T; Xie, X, 2017) |
| " Here, we investigated the role of aging in the behavioral effects of the antidepressants, desipramine (DMI) (5, 10, and 20 mg/kg) and fluoxetine (FLX) (5, 10, and 20 mg/kg) in young adults (3-5 months), middle-aged (MA, 12-15 months), and senescent (SE, 23-25 months) male rats in the forced-swim test." | 3.83 | Age-related changes in the antidepressant-like effect of desipramine and fluoxetine in the rat forced-swim test. ( Fernández-Guasti, A; Martínez-Mota, L; Olivares-Nazario, M, 2016) |
| " In this study we analyzed the effects of the long-term administration of the tricyclic antidepressant desipramine and the reversibility of this treatment following a 15-day washout period on different parameters in parotid gland function in aging rats." | 3.71 | An analysis of parotid salivary gland function with desipramine and age in female NIA Fischer 344 rats. ( Cowman, RA; Humphreys-Beher, MG; Koller, MM; Scarpace, PJ, 2001) |
| " These include biological factors, such as strain, age, body weight, gender and individual differences between animals; influence of preconditioning before the FST: handling, social isolation or enriched environment, food manipulations, various kinds of stress, endocrine manipulations and surgery; schedule and routes of treatment, dosage and type of the drugs as well as experimental design and laboratory environmental effects." | 2.49 | Factors influencing behavior in the forced swim test. ( Bogdanova, OV; D'Anci, KE; Kanekar, S; Renshaw, PF, 2013) |
| "It is important to understand both the kinetic and the dynamic implications of dosing TCAs and BZs in the elderly, for whom these drugs are frequently prescribed." | 2.37 | Implications of dosing tricyclic antidepressants and benzodiazepines in geriatrics. ( Cutler, NR; Narang, PK, 1984) |
| "We previously verified a physiologically based pharmacokinetic (PBPK) model for mirabegron in healthy subjects using the Simcyp Simulator by incorporating data on the inhibitory effect on cytochrome P450 (CYP) 2D6 and a multi-elimination pathway mediated by CYP3A4, uridine 5'-diphosphate-glucuronosyltransferase (UGT) 2B7 and butyrylcholinesterase (BChE)." | 1.51 | Application of a physiologically based pharmacokinetic model for the prediction of mirabegron plasma concentrations in a population with severe renal impairment. ( Konishi, K; Minematsu, T; Nagasaka, Y; Tabata, K, 2019) |
| "Predicted metabolic drug clearances (CLPT ) were determined using in vitro-in vivo extrapolation coupled with physiological-based pharmacokinetic modelling and simulation (IVIVE-PBPK) in Simcyp®." | 1.39 | Predicted metabolic drug clearance with increasing adult age. ( Doogue, MP; Jensen, BP; Patel, F; Polasek, TM; Sorich, MJ; Wiese, MD, 2013) |
| "Desipramine pretreatment, to block 6-OHDA uptake and prevent sympathectomy, completely blocked the 6-OHDA-induced effects, demonstrating that the destruction of NA nerve fibers is required." | 1.31 | Alterations in T lymphocyte activity following chemical sympathectomy in young and old Fischer 344 rats. ( Bellinger, DL; Felten, DL; Madden, KS; Stevens, SY, 2000) |
| " The study shows that it is possible to obtain a good estimation of individual dosage needs from one or more serum concentrations obtained at steady state." | 1.28 | Predictive techniques applied to imipramine therapeutic drug monitoring. ( Domínguez-Gil, A; Fernandez de Gatta, MM; Garcia, MJ; Montojo, C; Ramón Gutierrez, J; Rey, F; Tamayo, M, 1989) |
| "Imipramine treatment elicited a significantly greater decrease in these adrenergic sites in the aged (39." | 1.27 | The effect of imipramine treatment on brain serotonin receptors and beta-adrenoceptors and on pineal beta-adrenergic function in adult and aged rats. ( Cooper, T; Friedman, E; Yocca, F, 1986) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 29 (45.31) | 18.7374 |
| 1990's | 16 (25.00) | 18.2507 |
| 2000's | 12 (18.75) | 29.6817 |
| 2010's | 7 (10.94) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Petrascheck, M | 1 |
| Ye, X | 1 |
| Buck, LB | 1 |
| Xie, X | 1 |
| Chen, Y | 1 |
| Wang, Q | 1 |
| Shen, Q | 1 |
| Ma, L | 1 |
| Huang, L | 1 |
| Wu, T | 1 |
| Fu, Z | 1 |
| Konishi, K | 1 |
| Minematsu, T | 1 |
| Nagasaka, Y | 1 |
| Tabata, K | 1 |
| Bogdanova, OV | 1 |
| Kanekar, S | 1 |
| D'Anci, KE | 1 |
| Renshaw, PF | 1 |
| Olivares-Nazario, M | 1 |
| Fernández-Guasti, A | 2 |
| Martínez-Mota, L | 1 |
| Tomii, T | 1 |
| Honjo, O | 1 |
| Matsumoto, T | 1 |
| Tachibana, H | 1 |
| Fujii, Y | 1 |
| Ishino, K | 1 |
| Ogasawara, Y | 1 |
| Sano, S | 1 |
| Francis, BM | 1 |
| Yang, J | 1 |
| Hajderi, E | 1 |
| Brown, ME | 1 |
| Michalski, B | 1 |
| McLaurin, J | 1 |
| Fahnestock, M | 1 |
| Mount, HT | 1 |
| Polasek, TM | 1 |
| Patel, F | 1 |
| Jensen, BP | 1 |
| Sorich, MJ | 1 |
| Wiese, MD | 1 |
| Doogue, MP | 1 |
| Dorne, JL | 1 |
| Walton, K | 1 |
| Slob, W | 1 |
| Renwick, AG | 1 |
| Leineweber, K | 1 |
| Wangemann, T | 1 |
| Giessler, C | 1 |
| Bruck, H | 1 |
| Dhein, S | 1 |
| Kostelka, M | 1 |
| Mohr, FW | 1 |
| Silber, RE | 1 |
| Brodde, OE | 1 |
| Ulloa, RE | 1 |
| Nicolini, H | 1 |
| HAASE, HJ | 1 |
| KOESTER, H | 1 |
| KOENIG, M | 1 |
| BLEKER, A | 1 |
| Nap, A | 1 |
| Mathy, MJ | 1 |
| Pfaffendorf, M | 1 |
| van Zwieten, PA | 1 |
| Leenen, FH | 1 |
| Coletta, E | 1 |
| Fourney, A | 1 |
| White, R | 1 |
| Kozisek, ME | 1 |
| Middlemas, D | 1 |
| Bylund, DB | 1 |
| Burchinsky, SG | 1 |
| Wilson, MA | 2 |
| Roy, EJ | 2 |
| Hoffman, DW | 2 |
| Marchi, M | 1 |
| Giacobini, E | 2 |
| Cutler, NR | 2 |
| Narang, PK | 1 |
| Schmidt, RH | 1 |
| Björklund, A | 1 |
| Lindvall, O | 1 |
| Lorén, I | 1 |
| Kitanaka, I | 1 |
| Ross, RJ | 1 |
| Zavadil, AP | 1 |
| Potter, WZ | 1 |
| Adrien, J | 1 |
| Bourgoin, S | 1 |
| Laguzzi, R | 1 |
| Hamon, M | 1 |
| Scarpace, PJ | 4 |
| Koller, MM | 4 |
| Rajakumar, G | 1 |
| Madden, KS | 2 |
| Ackerman, KD | 1 |
| Livnat, S | 1 |
| Felten, SY | 1 |
| Felten, DL | 2 |
| Smith, JE | 1 |
| Lakoski, JM | 1 |
| Hebert, MA | 2 |
| Gerhardt, GA | 2 |
| Snyder, DL | 2 |
| Aloyo, VJ | 2 |
| Wang, W | 1 |
| Roberts, J | 2 |
| Schiffman, SS | 1 |
| Graham, BG | 1 |
| Suggs, MS | 1 |
| Sattely-Miller, EA | 1 |
| Stevens, SY | 1 |
| Bellinger, DL | 1 |
| Laudenslager, ML | 1 |
| Clarke, AS | 1 |
| Cowman, RA | 2 |
| Humphreys-Beher, MG | 3 |
| Purushotham, KR | 1 |
| Maeda, N | 1 |
| Peters, DA | 1 |
| Pappas, BA | 1 |
| Taub, H | 1 |
| Saari, M | 1 |
| Eastgate, SM | 1 |
| Wright, JJ | 1 |
| Werry, JS | 1 |
| Greenberg, LH | 2 |
| Weiss, B | 2 |
| Breese, GR | 2 |
| Mueller, RA | 2 |
| Vogel, RA | 1 |
| Stoof, JC | 1 |
| Duijkstra, H | 1 |
| Hillegers, JP | 1 |
| Appelbaum, PS | 1 |
| Vasile, RG | 1 |
| Orsulak, PJ | 1 |
| Schildkraut, JJ | 1 |
| Roffler-Tarlov, S | 1 |
| Pickel, VM | 1 |
| Johnson, E | 1 |
| Carson, M | 1 |
| Chan, J | 1 |
| McIlvain, HB | 1 |
| Johnson, MD | 1 |
| Markus, RP | 1 |
| Werneck de Avellar, MC | 1 |
| Johnson, BJ | 1 |
| Bruno, JP | 1 |
| Walsh, BT | 1 |
| Hadigan, CM | 1 |
| Wong, LM | 1 |
| Stromberg, JS | 1 |
| Linares, OA | 1 |
| Supiano, MA | 1 |
| Smith, MJ | 1 |
| Foster, AH | 1 |
| Halter, JB | 1 |
| Kuchel, GA | 1 |
| Zigmond, RE | 1 |
| Drago, F | 1 |
| Pulvirenti, L | 1 |
| Spadaro, F | 1 |
| Pennisi, G | 1 |
| Feighner, JP | 1 |
| Boyer, WF | 1 |
| Hendrickson, GG | 1 |
| Pambakian, RA | 1 |
| Doroski, VS | 1 |
| Brunello, N | 1 |
| Riva, M | 1 |
| Rovescalli, AC | 1 |
| Galimberti, R | 1 |
| Racagni, G | 1 |
| Dyke, AC | 1 |
| Angus, JA | 1 |
| Korner, PI | 1 |
| Fernandez de Gatta, MM | 1 |
| Tamayo, M | 1 |
| Garcia, MJ | 1 |
| Montojo, C | 1 |
| Ramón Gutierrez, J | 1 |
| Rey, F | 1 |
| Domínguez-Gil, A | 1 |
| Brunswick, DJ | 1 |
| Friedman, E | 1 |
| Cooper, T | 1 |
| Yocca, F | 1 |
| Bickford-Wimer, PC | 2 |
| Parfitt, K | 2 |
| Hoffer, BJ | 2 |
| Freedman, R | 2 |
| Marshall, JF | 1 |
| Altar, CA | 1 |
| Rose, G | 1 |
| Rigal, JG | 1 |
| Albin, HC | 1 |
| Duchier, AR | 1 |
| D'Aulnay, JM | 1 |
| Fenelon, JH | 1 |
| Vincon, GA | 1 |
| Demotes-Mainard, FM | 1 |
| Rapp, PR | 1 |
| Fanelli, RF | 1 |
| McGuire, M | 1 |
| Rosenberg, RA | 1 |
| Gallagher, M | 1 |
| Sachs, C | 1 |
| de Champlain, J | 1 |
| Malmfors, T | 1 |
| Olson, L | 1 |
3 reviews available for desipramine and Aging
| Article | Year |
|---|---|
Factors influencing behavior in the forced swim test.
Topics: Aging; Animals; Antidepressive Agents; Behavior, Animal; Body Weight; Conditioning, Psychological; D | 2013 |
Neurotransmitter receptors in the central nervous system and aging: pharmacological aspect (review).
Topics: Adenylyl Cyclases; Aging; Animals; Brain; Desipramine; Dopamine; Dopamine Antagonists; Female; Fluph | 1984 |
Implications of dosing tricyclic antidepressants and benzodiazepines in geriatrics.
Topics: Adipose Tissue; Adult; Aged; Aging; Amitriptyline; Antidepressive Agents, Tricyclic; Anxiety Disorde | 1984 |
3 trials available for desipramine and Aging
| Article | Year |
|---|---|
Aging and cardiac responses to epinephrine in humans: role of neuronal uptake.
Topics: Adrenergic beta-Agonists; Adrenergic Uptake Inhibitors; Adult; Aged; Aging; Baroreflex; Blood Pressu | 2005 |
Increased pulse and blood pressure associated with desipramine treatment of bulimia nervosa.
Topics: Adolescent; Adult; Aging; Bulimia; Desipramine; Dose-Response Relationship, Drug; Double-Blind Metho | 1992 |
A controlled trial of adinazolam versus desipramine in geriatric depression.
Topics: Administration, Oral; Aged; Aged, 80 and over; Aging; Anti-Anxiety Agents; Antidepressive Agents; Be | 1990 |
58 other studies available for desipramine and Aging
| Article | Year |
|---|---|
An antidepressant that extends lifespan in adult Caenorhabditis elegans.
Topics: Aging; Animals; Antidepressive Agents; Caenorhabditis elegans; Caloric Restriction; Humans; Longevit | 2007 |
Desipramine rescues age-related phenotypes in depression-like rats induced by chronic mild stress.
Topics: Aging; Animals; Antidepressive Agents, Tricyclic; Behavior, Animal; Depression; Desipramine; Eating; | 2017 |
Application of a physiologically based pharmacokinetic model for the prediction of mirabegron plasma concentrations in a population with severe renal impairment.
Topics: Acetanilides; Adolescent; Adrenergic beta-3 Receptor Agonists; Adult; Aged; Aging; Butyrylcholineste | 2019 |
Age-related changes in the antidepressant-like effect of desipramine and fluoxetine in the rat forced-swim test.
Topics: Aging; Animals; Antidepressive Agents; Depressive Disorder; Desipramine; Disease Models, Animal; Dos | 2016 |
Impact of chronic cyanosis and reoxygenation on the microheterogeneity of the myocardial blood flow: digital radiographic study in neonatal rats.
Topics: Age Factors; Aging; Animals; Animals, Newborn; Chronic Disease; Coronary Circulation; Cyanosis; Desi | 2011 |
Reduced tissue levels of noradrenaline are associated with behavioral phenotypes of the TgCRND8 mouse model of Alzheimer's disease.
Topics: Adrenergic alpha-2 Receptor Antagonists; Adrenergic Uptake Inhibitors; Aging; Alzheimer Disease; Amy | 2012 |
Predicted metabolic drug clearance with increasing adult age.
Topics: Adult; Aged; Aged, 80 and over; Aging; Caffeine; Computer Simulation; Desipramine; Female; Humans; M | 2013 |
Human variability in polymorphic CYP2D6 metabolism: is the kinetic default uncertainty factor adequate?
Topics: Adult; Aged; Aging; Benzhydryl Compounds; Cresols; Cyclohexanols; Cytochrome P-450 CYP2D6; Debrisoqu | 2002 |
Age-dependent changes of cardiac neuronal noradrenaline reuptake transporter (uptake1) in the human heart.
Topics: Adolescent; Adrenergic Uptake Inhibitors; Adult; Age Factors; Aged; Aging; Atrial Function; Child; C | 2002 |
Age differences in the sensitivity to clomipramine in an animal model of obsessive-compulsive disorder.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Aging; Animals; Antidepressive Agents, Tricyclic; Clomiprami | 2003 |
[ON THE METHODOLOGY OF RESEARCH ON ANTIDEPRESSIVE DRUGS WITH SPECIAL REFERENCE TO IMIPRAMINE (TOFRANIL) AND DESMETHYLIMIPRAMINE (PERTOFRAN)].
Topics: Aging; Antidepressive Agents; Bipolar Disorder; Body Constitution; Desipramine; Humans; Imipramine; | 1963 |
Different prejunctional and postjunctional responses to angiotensin II and AT1-receptor inhibition: influence of maturation.
Topics: Acrylates; Aging; Angiotensin II Type 1 Receptor Blockers; Angiotensin Receptor Antagonists; Animals | 2004 |
The differential regulation of BDNF and TrkB levels in juvenile rats after four days of escitalopram and desipramine treatment.
Topics: Aging; Animals; Antidepressive Agents, Tricyclic; Brain-Derived Neurotrophic Factor; Chromatography, | 2008 |
Age alters the observed response of imipramine binding sites to chronic antidepressant treatment in female rats.
Topics: Aging; Animals; Carrier Proteins; Desipramine; Female; Hypothalamus; Imipramine; Kinetics; Preoptic | 1984 |
Norepinephrine uptake in aging adrenergic nerve terminals.
Topics: Aging; Animals; Chickens; Desipramine; Female; Iris; Male; Metanephrine; Norepinephrine; Ouabain; Re | 1980 |
Prefrontal cortex: dense dopaminergic input in the newborn rat.
Topics: Aging; Animals; Animals, Newborn; Axons; Biological Transport; Cerebral Cortex; Desipramine; Dopamin | 1982 |
Altered hydroxydesipramine concentrations in elderly depressed patients.
Topics: Adult; Aged; Aging; Depression; Desipramine; Female; Humans; Kidney; Male; Middle Aged | 1982 |
[Effects of intraventricular injection of 5,7-dihydroxytryptamine on monoamines and sleep in the kitten (author's transl)].
Topics: 5,7-Dihydroxytryptamine; Aging; Animals; Brain; Brain Stem; Cats; Desipramine; Dihydroxytryptamines; | 1981 |
Characteristics of norepinephrine uptake in developing peripheral nerve terminals.
Topics: Aging; Animals; Chick Embryo; Chickens; Cocaine; Desipramine; Iris; Kinetics; Norepinephrine; Ouabai | 1980 |
Desipramine desensitizes beta-adrenergic signal transduction in salivary glands: differential regulation with age.
Topics: Adenylyl Cyclases; Aging; Analysis of Variance; Animals; Cerebral Cortex; Desipramine; Down-Regulati | 1993 |
Neonatal sympathetic denervation alters development of natural killer (NK) cell activity in F344 rats.
Topics: Aging; Animals; Animals, Newborn; Cytotoxicity, Immunologic; Desipramine; Female; Killer Cells, Natu | 1993 |
Electrophysiological study of the effects of the reuptake inhibitor duloxetine on serotonergic responses in the aging hippocampus.
Topics: Action Potentials; Aging; Animals; Antidepressive Agents, Second-Generation; Desipramine; Duloxetine | 1997 |
Normal and drug-induced locomotor behavior in aging: comparison to evoked DA release and tissue content in fischer 344 rats.
Topics: 3,4-Dihydroxyphenylacetic Acid; Adrenergic Uptake Inhibitors; Aging; Animals; Brain Chemistry; Chrom | 1998 |
Influence of age and dietary restriction on norepinephrine uptake into cardiac synaptosomes.
Topics: Adrenergic Uptake Inhibitors; Aging; Animals; Carrier Proteins; Desipramine; Diet; Dose-Response Rel | 1998 |
Age-related changes in the capacity, rate, and modulation of dopamine uptake within the striatum and nucleus accumbens of Fischer 344 rats: an in vivo electrochemical study.
Topics: Adrenergic Uptake Inhibitors; Aging; Animals; Citalopram; Corpus Striatum; Desipramine; Dopamine; Do | 1999 |
Effect of psychotropic drugs on taste responses in young and elderly persons.
Topics: Adult; Aged; Aging; Amitriptyline; Clomipramine; Desipramine; Doxepin; Female; Humans; Imipramine; M | 1998 |
Alterations in T lymphocyte activity following chemical sympathectomy in young and old Fischer 344 rats.
Topics: Aging; Animals; Cell Division; Cells, Cultured; Concanavalin A; Desipramine; Dose-Response Relations | 2000 |
Antidepressant treatment during social challenge prior to 1 year of age affects immune and endocrine responses in adult macaques.
Topics: Adolescent; Adrenergic Uptake Inhibitors; Aging; Animals; Antibody Formation; Antidepressive Agents, | 2000 |
An analysis of submandibular salivary gland function with desipramine and age in female NIA Fischer 344 rats.
Topics: Aging; Animals; Antidepressive Agents, Tricyclic; Body Weight; Desipramine; DNA; Female; Organ Size; | 2000 |
An analysis of parotid salivary gland function with desipramine and age in female NIA Fischer 344 rats.
Topics: Aging; Animals; Antidepressive Agents, Tricyclic; Body Weight; Desipramine; DNA; Female; Organ Size; | 2001 |
Desipramine induced changes in salivary proteins, cultivable oral microbiota and gingival health in aging female NIA Fischer 344 rats.
Topics: Aging; alpha-Amylases; Animals; Antidepressive Agents, Tricyclic; Blotting, Western; Desipramine; El | 2000 |
Effect of intraventricular injections of 6-hydroxydopamine in neonatal rats on the catecholamine levels and tyrosine hydroxylase activity in brain regions at maturity.
Topics: Aging; Animals; Animals, Newborn; Brain; Brain Chemistry; Catecholamines; Desipramine; Hydroxydopami | 1977 |
Behavioural effects of methylphenidate in 6-hydroxydopamine-treated neonatal rats.
Topics: Aging; Animals; Animals, Newborn; Behavior, Animal; Desipramine; Hydroxydopamines; Methylphenidate; | 1978 |
Ability of aged rats to alter beta adrenergic receptors of brain in response to repeated administration of reserpine and desmethylimipramine.
Topics: Aging; Animals; Brain; Cerebellum; Cerebral Cortex; Desipramine; Male; Pineal Gland; Rats; Receptors | 1979 |
Alterations in the neurocytotoxicity of 5,7-dihydroxytryptamine by pharmacologic agents in adult and developing rats.
Topics: 5,7-Dihydroxytryptamine; Aging; Animals; Animals, Newborn; Central Nervous System Agents; Desipramin | 1978 |
Biochemical and behavioral alterations in developing rats treated with 5,7-dihydroxytryptamine.
Topics: 5-Hydroxytryptophan; 5,7-Dihydroxytryptamine; Aging; Animals; Avoidance Learning; Behavior, Animal; | 1978 |
Changes in the behavioral response to a novel environment following lesioning of the central dopaminergic system in rat pups.
Topics: Aging; Animals; Behavior, Animal; Brain Chemistry; Catecholamines; Desipramine; Dopamine; Environmen | 1978 |
Clinical utility of tricyclic antidepressant blood levels: a case report.
Topics: Aged; Aging; Depression; Desipramine; Drug Therapy, Combination; Female; Humans; Imipramine; Phenoth | 1979 |
Differences between the effects of acute and long-term treatment with desmethylimipramine on reserpine-induced release of amines from rat brain.
Topics: Administration, Oral; Aging; Animals; Brain; Brain Chemistry; Catecholamines; Desipramine; Dopamine; | 1975 |
Ultrastructure of spared dopamine terminals in caudate-putamen nuclei of adult rats neonatally treated with intranigral 6-hydroxydopamine.
Topics: Aging; Animals; Axons; Caudate Nucleus; Desipramine; Dopamine; Immunoenzyme Techniques; Immunohistoc | 1992 |
Effect of age on potassium- and tyramine-induced release of norepinephrine from cardiac synaptosomes in male F344 rats.
Topics: Adrenergic Fibers; Aging; Animals; Desipramine; Heart; Male; Myocardium; Norepinephrine; Oxidopamine | 1992 |
Effect of ageing on the number of neuronal noradrenaline uptake sites in the rat vas deferens.
Topics: Aging; Animals; Binding Sites; Desipramine; Kinetics; Lithium; Male; Neurons; Norepinephrine; Rats; | 1992 |
D-1 and D-2 receptor mediation of sensorimotor behavior in rats depleted of dopamine during development.
Topics: Afferent Pathways; Aging; Animals; Attention; Corpus Striatum; Desipramine; Dopamine; Hippocampus; M | 1992 |
Effect of desipramine on norepinephrine metabolism in humans: interaction with aging.
Topics: Adult; Aged; Aging; Desipramine; Female; Humans; Kinetics; Male; Metabolic Clearance Rate; Middle Ag | 1991 |
Functional recovery and collateral neuronal sprouting examined in young and aged rats following a partial neural lesion.
Topics: Aging; Animals; Arylamine N-Acetyltransferase; Circadian Rhythm; Desipramine; Functional Laterality; | 1991 |
Effects of TRH and prolactin in the behavioral despair (swim) model of depression in rats.
Topics: Aging; Animals; Behavior, Animal; Depression; Desipramine; Injections, Intraventricular; Injections, | 1990 |
Age-related changes in rat serotonergic and adrenergic systems and in receptor responsiveness to subchronic desipramine treatment.
Topics: Aging; Animals; Brain; Clonidine; Desipramine; Dihydroalprenolol; Hydroxyindoleacetic Acid; Imiprami | 1988 |
A functional study of the development of the cardiac sympathetic neuroeffector junction in the SHR.
Topics: Aging; Animals; Blood Pressure; Clonidine; Desipramine; Dose-Response Relationship, Drug; Electric S | 1989 |
Predictive techniques applied to imipramine therapeutic drug monitoring.
Topics: Adolescent; Adult; Aging; Child; Child, Preschool; Desipramine; False Positive Reactions; Female; Hu | 1989 |
Effect of age on the rate of recovery of beta-adrenergic receptors in rat brain following desmethylimipramine-induced subsensitivity.
Topics: Aging; Animals; Brain; Cerebral Cortex; Desipramine; Dihydroalprenolol; Kinetics; Male; Pineal Gland | 1985 |
The effect of imipramine treatment on brain serotonin receptors and beta-adrenoceptors and on pineal beta-adrenergic function in adult and aged rats.
Topics: Aging; Animals; Brain; Desipramine; Dihydroalprenolol; Imipramine; Indoles; Male; Pineal Gland; Rats | 1986 |
Desipramine and noradrenergic neurotransmission in aging: failure to respond in aged laboratory animals.
Topics: Action Potentials; Aging; Animals; Desipramine; Electric Stimulation; Hydroxydopamines; Male; Norepi | 1987 |
Striatal dopamine uptake and swim performance of the aged rat.
Topics: Aging; Animals; Bupropion; Corpus Striatum; Desipramine; Dopamine; Dopamine Antagonists; Male; Motor | 1986 |
Age-related changes in cerebellar noradrenergic function.
Topics: Aging; Animals; Cerebellum; Desipramine; Dose-Response Relationship, Drug; Electrophysiology; Evoked | 1988 |
Imipramine blood levels and clinical outcome.
Topics: Adult; Aged; Aging; Depressive Disorder; Desipramine; Female; Humans; Imipramine; Male; Middle Aged; | 1987 |
Alterations in [3H]desmethylimipramine binding in the aged rat brain: an in vitro autoradiographic demonstration.
Topics: Aging; Animals; Autoradiography; Brain; Caudate Nucleus; Corpus Striatum; Desipramine; In Vitro Tech | 1987 |
Pharmacokinetics of imipramine are affected by age and sex in rats.
Topics: Aging; Animals; Desipramine; Female; Hypothalamus; Imipramine; Kinetics; Male; Preoptic Area; Rats; | 1986 |
The postnatal development of noradrenaline uptake in the adrenergic nerves of different tissues from the rat.
Topics: Age Factors; Aging; Animals; Desipramine; Dopamine; Duodenum; Growth; Heart Atria; In Vitro Techniqu | 1970 |