Page last updated: 2024-10-25

desipramine and Aging

desipramine has been researched along with Aging in 64 studies

Desipramine: A tricyclic dibenzazepine compound that potentiates neurotransmission. Desipramine selectively blocks reuptake of norepinephrine from the neural synapse, and also appears to impair serotonin transport. This compound also possesses minor anticholinergic activity, through its affinity to muscarinic receptors.
desipramine : A dibenzoazepine consisting of 10,11-dihydro-5H-dibenzo[b,f]azepine substituted on nitrogen with a 3-(methylamino)propyl group.

Aging: The gradual irreversible changes in structure and function of an organism that occur as a result of the passage of time.

Research Excerpts

ExcerptRelevanceReference
"The cardiovascular effects of desipramine were assessed in 74 young women with bulimia nervosa participating in a 6-week double-blind, placebo-controlled study."9.07Increased pulse and blood pressure associated with desipramine treatment of bulimia nervosa. ( Hadigan, CM; Walsh, BT; Wong, LM, 1992)
"Thirty outpatients between the ages of 60 and 85 with DSM-III Major Depression entered an 8 week randomized, double-blind comparison of desipramine and adinazolam mesylate, a triazolobenzodiazepine derivative."9.06A controlled trial of adinazolam versus desipramine in geriatric depression. ( Boyer, WF; Doroski, VS; Feighner, JP; Hendrickson, GG; Pambakian, RA, 1990)
" Desipramine is a typical tricyclic antidepressant, and can provide neuroprotection and counteract depression-like behaviors."7.85Desipramine rescues age-related phenotypes in depression-like rats induced by chronic mild stress. ( Chen, Y; Fu, Z; Huang, L; Ma, L; Shen, Q; Wang, Q; Wu, T; Xie, X, 2017)
" The purpose of this study was to assess the effects of the long-term administration of the tricyclic antidepressant desipramine and the reversibility of this treatment following a 15 d washout period on specific salivary proteins, composition of oral microbiota, and oral health (gingivitis) of aging female F344 rats."7.70Desipramine induced changes in salivary proteins, cultivable oral microbiota and gingival health in aging female NIA Fischer 344 rats. ( Humphreys-Beher, MG; Koller, MM; Maeda, N; Purushotham, KR; Scarpace, PJ, 2000)
"The cardiovascular effects of desipramine were assessed in 74 young women with bulimia nervosa participating in a 6-week double-blind, placebo-controlled study."5.07Increased pulse and blood pressure associated with desipramine treatment of bulimia nervosa. ( Hadigan, CM; Walsh, BT; Wong, LM, 1992)
"Thirty outpatients between the ages of 60 and 85 with DSM-III Major Depression entered an 8 week randomized, double-blind comparison of desipramine and adinazolam mesylate, a triazolobenzodiazepine derivative."5.06A controlled trial of adinazolam versus desipramine in geriatric depression. ( Boyer, WF; Doroski, VS; Feighner, JP; Hendrickson, GG; Pambakian, RA, 1990)
" Desipramine is a typical tricyclic antidepressant, and can provide neuroprotection and counteract depression-like behaviors."3.85Desipramine rescues age-related phenotypes in depression-like rats induced by chronic mild stress. ( Chen, Y; Fu, Z; Huang, L; Ma, L; Shen, Q; Wang, Q; Wu, T; Xie, X, 2017)
" Here, we investigated the role of aging in the behavioral effects of the antidepressants, desipramine (DMI) (5, 10, and 20 mg/kg) and fluoxetine (FLX) (5, 10, and 20 mg/kg) in young adults (3-5 months), middle-aged (MA, 12-15 months), and senescent (SE, 23-25 months) male rats in the forced-swim test."3.83Age-related changes in the antidepressant-like effect of desipramine and fluoxetine in the rat forced-swim test. ( Fernández-Guasti, A; Martínez-Mota, L; Olivares-Nazario, M, 2016)
" In this study we analyzed the effects of the long-term administration of the tricyclic antidepressant desipramine and the reversibility of this treatment following a 15-day washout period on different parameters in parotid gland function in aging rats."3.71An analysis of parotid salivary gland function with desipramine and age in female NIA Fischer 344 rats. ( Cowman, RA; Humphreys-Beher, MG; Koller, MM; Scarpace, PJ, 2001)
" These include biological factors, such as strain, age, body weight, gender and individual differences between animals; influence of preconditioning before the FST: handling, social isolation or enriched environment, food manipulations, various kinds of stress, endocrine manipulations and surgery; schedule and routes of treatment, dosage and type of the drugs as well as experimental design and laboratory environmental effects."2.49Factors influencing behavior in the forced swim test. ( Bogdanova, OV; D'Anci, KE; Kanekar, S; Renshaw, PF, 2013)
"It is important to understand both the kinetic and the dynamic implications of dosing TCAs and BZs in the elderly, for whom these drugs are frequently prescribed."2.37Implications of dosing tricyclic antidepressants and benzodiazepines in geriatrics. ( Cutler, NR; Narang, PK, 1984)
"We previously verified a physiologically based pharmacokinetic (PBPK) model for mirabegron in healthy subjects using the Simcyp Simulator by incorporating data on the inhibitory effect on cytochrome P450 (CYP) 2D6 and a multi-elimination pathway mediated by CYP3A4, uridine 5'-diphosphate-glucuronosyltransferase (UGT) 2B7 and butyrylcholinesterase (BChE)."1.51Application of a physiologically based pharmacokinetic model for the prediction of mirabegron plasma concentrations in a population with severe renal impairment. ( Konishi, K; Minematsu, T; Nagasaka, Y; Tabata, K, 2019)
"Predicted metabolic drug clearances (CLPT ) were determined using in vitro-in vivo extrapolation coupled with physiological-based pharmacokinetic modelling and simulation (IVIVE-PBPK) in Simcyp®."1.39Predicted metabolic drug clearance with increasing adult age. ( Doogue, MP; Jensen, BP; Patel, F; Polasek, TM; Sorich, MJ; Wiese, MD, 2013)
"Desipramine pretreatment, to block 6-OHDA uptake and prevent sympathectomy, completely blocked the 6-OHDA-induced effects, demonstrating that the destruction of NA nerve fibers is required."1.31Alterations in T lymphocyte activity following chemical sympathectomy in young and old Fischer 344 rats. ( Bellinger, DL; Felten, DL; Madden, KS; Stevens, SY, 2000)
" The study shows that it is possible to obtain a good estimation of individual dosage needs from one or more serum concentrations obtained at steady state."1.28Predictive techniques applied to imipramine therapeutic drug monitoring. ( Domínguez-Gil, A; Fernandez de Gatta, MM; Garcia, MJ; Montojo, C; Ramón Gutierrez, J; Rey, F; Tamayo, M, 1989)
"Imipramine treatment elicited a significantly greater decrease in these adrenergic sites in the aged (39."1.27The effect of imipramine treatment on brain serotonin receptors and beta-adrenoceptors and on pineal beta-adrenergic function in adult and aged rats. ( Cooper, T; Friedman, E; Yocca, F, 1986)

Research

Studies (64)

TimeframeStudies, this research(%)All Research%
pre-199029 (45.31)18.7374
1990's16 (25.00)18.2507
2000's12 (18.75)29.6817
2010's7 (10.94)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Petrascheck, M1
Ye, X1
Buck, LB1
Xie, X1
Chen, Y1
Wang, Q1
Shen, Q1
Ma, L1
Huang, L1
Wu, T1
Fu, Z1
Konishi, K1
Minematsu, T1
Nagasaka, Y1
Tabata, K1
Bogdanova, OV1
Kanekar, S1
D'Anci, KE1
Renshaw, PF1
Olivares-Nazario, M1
Fernández-Guasti, A2
Martínez-Mota, L1
Tomii, T1
Honjo, O1
Matsumoto, T1
Tachibana, H1
Fujii, Y1
Ishino, K1
Ogasawara, Y1
Sano, S1
Francis, BM1
Yang, J1
Hajderi, E1
Brown, ME1
Michalski, B1
McLaurin, J1
Fahnestock, M1
Mount, HT1
Polasek, TM1
Patel, F1
Jensen, BP1
Sorich, MJ1
Wiese, MD1
Doogue, MP1
Dorne, JL1
Walton, K1
Slob, W1
Renwick, AG1
Leineweber, K1
Wangemann, T1
Giessler, C1
Bruck, H1
Dhein, S1
Kostelka, M1
Mohr, FW1
Silber, RE1
Brodde, OE1
Ulloa, RE1
Nicolini, H1
HAASE, HJ1
KOESTER, H1
KOENIG, M1
BLEKER, A1
Nap, A1
Mathy, MJ1
Pfaffendorf, M1
van Zwieten, PA1
Leenen, FH1
Coletta, E1
Fourney, A1
White, R1
Kozisek, ME1
Middlemas, D1
Bylund, DB1
Burchinsky, SG1
Wilson, MA2
Roy, EJ2
Hoffman, DW2
Marchi, M1
Giacobini, E2
Cutler, NR2
Narang, PK1
Schmidt, RH1
Björklund, A1
Lindvall, O1
Lorén, I1
Kitanaka, I1
Ross, RJ1
Zavadil, AP1
Potter, WZ1
Adrien, J1
Bourgoin, S1
Laguzzi, R1
Hamon, M1
Scarpace, PJ4
Koller, MM4
Rajakumar, G1
Madden, KS2
Ackerman, KD1
Livnat, S1
Felten, SY1
Felten, DL2
Smith, JE1
Lakoski, JM1
Hebert, MA2
Gerhardt, GA2
Snyder, DL2
Aloyo, VJ2
Wang, W1
Roberts, J2
Schiffman, SS1
Graham, BG1
Suggs, MS1
Sattely-Miller, EA1
Stevens, SY1
Bellinger, DL1
Laudenslager, ML1
Clarke, AS1
Cowman, RA2
Humphreys-Beher, MG3
Purushotham, KR1
Maeda, N1
Peters, DA1
Pappas, BA1
Taub, H1
Saari, M1
Eastgate, SM1
Wright, JJ1
Werry, JS1
Greenberg, LH2
Weiss, B2
Breese, GR2
Mueller, RA2
Vogel, RA1
Stoof, JC1
Duijkstra, H1
Hillegers, JP1
Appelbaum, PS1
Vasile, RG1
Orsulak, PJ1
Schildkraut, JJ1
Roffler-Tarlov, S1
Pickel, VM1
Johnson, E1
Carson, M1
Chan, J1
McIlvain, HB1
Johnson, MD1
Markus, RP1
Werneck de Avellar, MC1
Johnson, BJ1
Bruno, JP1
Walsh, BT1
Hadigan, CM1
Wong, LM1
Stromberg, JS1
Linares, OA1
Supiano, MA1
Smith, MJ1
Foster, AH1
Halter, JB1
Kuchel, GA1
Zigmond, RE1
Drago, F1
Pulvirenti, L1
Spadaro, F1
Pennisi, G1
Feighner, JP1
Boyer, WF1
Hendrickson, GG1
Pambakian, RA1
Doroski, VS1
Brunello, N1
Riva, M1
Rovescalli, AC1
Galimberti, R1
Racagni, G1
Dyke, AC1
Angus, JA1
Korner, PI1
Fernandez de Gatta, MM1
Tamayo, M1
Garcia, MJ1
Montojo, C1
Ramón Gutierrez, J1
Rey, F1
Domínguez-Gil, A1
Brunswick, DJ1
Friedman, E1
Cooper, T1
Yocca, F1
Bickford-Wimer, PC2
Parfitt, K2
Hoffer, BJ2
Freedman, R2
Marshall, JF1
Altar, CA1
Rose, G1
Rigal, JG1
Albin, HC1
Duchier, AR1
D'Aulnay, JM1
Fenelon, JH1
Vincon, GA1
Demotes-Mainard, FM1
Rapp, PR1
Fanelli, RF1
McGuire, M1
Rosenberg, RA1
Gallagher, M1
Sachs, C1
de Champlain, J1
Malmfors, T1
Olson, L1

Reviews

3 reviews available for desipramine and Aging

ArticleYear
Factors influencing behavior in the forced swim test.
    Physiology & behavior, 2013, Jun-13, Volume: 118

    Topics: Aging; Animals; Antidepressive Agents; Behavior, Animal; Body Weight; Conditioning, Psychological; D

2013
Neurotransmitter receptors in the central nervous system and aging: pharmacological aspect (review).
    Experimental gerontology, 1984, Volume: 19, Issue:4

    Topics: Adenylyl Cyclases; Aging; Animals; Brain; Desipramine; Dopamine; Dopamine Antagonists; Female; Fluph

1984
Implications of dosing tricyclic antidepressants and benzodiazepines in geriatrics.
    The Psychiatric clinics of North America, 1984, Volume: 7, Issue:4

    Topics: Adipose Tissue; Adult; Aged; Aging; Amitriptyline; Antidepressive Agents, Tricyclic; Anxiety Disorde

1984

Trials

3 trials available for desipramine and Aging

ArticleYear
Aging and cardiac responses to epinephrine in humans: role of neuronal uptake.
    American journal of physiology. Heart and circulatory physiology, 2005, Volume: 288, Issue:5

    Topics: Adrenergic beta-Agonists; Adrenergic Uptake Inhibitors; Adult; Aged; Aging; Baroreflex; Blood Pressu

2005
Increased pulse and blood pressure associated with desipramine treatment of bulimia nervosa.
    Journal of clinical psychopharmacology, 1992, Volume: 12, Issue:3

    Topics: Adolescent; Adult; Aging; Bulimia; Desipramine; Dose-Response Relationship, Drug; Double-Blind Metho

1992
A controlled trial of adinazolam versus desipramine in geriatric depression.
    International clinical psychopharmacology, 1990, Volume: 5, Issue:3

    Topics: Administration, Oral; Aged; Aged, 80 and over; Aging; Anti-Anxiety Agents; Antidepressive Agents; Be

1990

Other Studies

58 other studies available for desipramine and Aging

ArticleYear
An antidepressant that extends lifespan in adult Caenorhabditis elegans.
    Nature, 2007, Nov-22, Volume: 450, Issue:7169

    Topics: Aging; Animals; Antidepressive Agents; Caenorhabditis elegans; Caloric Restriction; Humans; Longevit

2007
Desipramine rescues age-related phenotypes in depression-like rats induced by chronic mild stress.
    Life sciences, 2017, Nov-01, Volume: 188

    Topics: Aging; Animals; Antidepressive Agents, Tricyclic; Behavior, Animal; Depression; Desipramine; Eating;

2017
Application of a physiologically based pharmacokinetic model for the prediction of mirabegron plasma concentrations in a population with severe renal impairment.
    Biopharmaceutics & drug disposition, 2019, Volume: 40, Issue:5-6

    Topics: Acetanilides; Adolescent; Adrenergic beta-3 Receptor Agonists; Adult; Aged; Aging; Butyrylcholineste

2019
Age-related changes in the antidepressant-like effect of desipramine and fluoxetine in the rat forced-swim test.
    Behavioural pharmacology, 2016, Volume: 27, Issue:1

    Topics: Aging; Animals; Antidepressive Agents; Depressive Disorder; Desipramine; Disease Models, Animal; Dos

2016
Impact of chronic cyanosis and reoxygenation on the microheterogeneity of the myocardial blood flow: digital radiographic study in neonatal rats.
    General thoracic and cardiovascular surgery, 2011, Volume: 59, Issue:10

    Topics: Age Factors; Aging; Animals; Animals, Newborn; Chronic Disease; Coronary Circulation; Cyanosis; Desi

2011
Reduced tissue levels of noradrenaline are associated with behavioral phenotypes of the TgCRND8 mouse model of Alzheimer's disease.
    Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology, 2012, Volume: 37, Issue:8

    Topics: Adrenergic alpha-2 Receptor Antagonists; Adrenergic Uptake Inhibitors; Aging; Alzheimer Disease; Amy

2012
Predicted metabolic drug clearance with increasing adult age.
    British journal of clinical pharmacology, 2013, Volume: 75, Issue:4

    Topics: Adult; Aged; Aged, 80 and over; Aging; Caffeine; Computer Simulation; Desipramine; Female; Humans; M

2013
Human variability in polymorphic CYP2D6 metabolism: is the kinetic default uncertainty factor adequate?
    Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association, 2002, Volume: 40, Issue:11

    Topics: Adult; Aged; Aging; Benzhydryl Compounds; Cresols; Cyclohexanols; Cytochrome P-450 CYP2D6; Debrisoqu

2002
Age-dependent changes of cardiac neuronal noradrenaline reuptake transporter (uptake1) in the human heart.
    Journal of the American College of Cardiology, 2002, Oct-16, Volume: 40, Issue:8

    Topics: Adolescent; Adrenergic Uptake Inhibitors; Adult; Age Factors; Aged; Aging; Atrial Function; Child; C

2002
Age differences in the sensitivity to clomipramine in an animal model of obsessive-compulsive disorder.
    Psychopharmacology, 2003, Volume: 166, Issue:3

    Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Aging; Animals; Antidepressive Agents, Tricyclic; Clomiprami

2003
[ON THE METHODOLOGY OF RESEARCH ON ANTIDEPRESSIVE DRUGS WITH SPECIAL REFERENCE TO IMIPRAMINE (TOFRANIL) AND DESMETHYLIMIPRAMINE (PERTOFRAN)].
    Archiv fur Psychiatrie und Nervenkrankheiten, 1963, Sep-18, Volume: 204

    Topics: Aging; Antidepressive Agents; Bipolar Disorder; Body Constitution; Desipramine; Humans; Imipramine;

1963
Different prejunctional and postjunctional responses to angiotensin II and AT1-receptor inhibition: influence of maturation.
    Journal of cardiovascular pharmacology, 2004, Volume: 43, Issue:3

    Topics: Acrylates; Aging; Angiotensin II Type 1 Receptor Blockers; Angiotensin Receptor Antagonists; Animals

2004
The differential regulation of BDNF and TrkB levels in juvenile rats after four days of escitalopram and desipramine treatment.
    Neuropharmacology, 2008, Volume: 54, Issue:2

    Topics: Aging; Animals; Antidepressive Agents, Tricyclic; Brain-Derived Neurotrophic Factor; Chromatography,

2008
Age alters the observed response of imipramine binding sites to chronic antidepressant treatment in female rats.
    European journal of pharmacology, 1984, Nov-13, Volume: 106, Issue:2

    Topics: Aging; Animals; Carrier Proteins; Desipramine; Female; Hypothalamus; Imipramine; Kinetics; Preoptic

1984
Norepinephrine uptake in aging adrenergic nerve terminals.
    Neurobiology of aging, 1980,Summer, Volume: 1, Issue:1

    Topics: Aging; Animals; Chickens; Desipramine; Female; Iris; Male; Metanephrine; Norepinephrine; Ouabain; Re

1980
Prefrontal cortex: dense dopaminergic input in the newborn rat.
    Brain research, 1982, Volume: 281, Issue:2

    Topics: Aging; Animals; Animals, Newborn; Axons; Biological Transport; Cerebral Cortex; Desipramine; Dopamin

1982
Altered hydroxydesipramine concentrations in elderly depressed patients.
    Clinical pharmacology and therapeutics, 1982, Volume: 31, Issue:1

    Topics: Adult; Aged; Aging; Depression; Desipramine; Female; Humans; Kidney; Male; Middle Aged

1982
[Effects of intraventricular injection of 5,7-dihydroxytryptamine on monoamines and sleep in the kitten (author's transl)].
    Journal de physiologie, 1981, Volume: 77, Issue:2-3

    Topics: 5,7-Dihydroxytryptamine; Aging; Animals; Brain; Brain Stem; Cats; Desipramine; Dihydroxytryptamines;

1981
Characteristics of norepinephrine uptake in developing peripheral nerve terminals.
    Brain research, 1980, Nov-10, Volume: 201, Issue:1

    Topics: Aging; Animals; Chick Embryo; Chickens; Cocaine; Desipramine; Iris; Kinetics; Norepinephrine; Ouabai

1980
Desipramine desensitizes beta-adrenergic signal transduction in salivary glands: differential regulation with age.
    European journal of pharmacology, 1993, Sep-15, Volume: 247, Issue:1

    Topics: Adenylyl Cyclases; Aging; Analysis of Variance; Animals; Cerebral Cortex; Desipramine; Down-Regulati

1993
Neonatal sympathetic denervation alters development of natural killer (NK) cell activity in F344 rats.
    Brain, behavior, and immunity, 1993, Volume: 7, Issue:4

    Topics: Aging; Animals; Animals, Newborn; Cytotoxicity, Immunologic; Desipramine; Female; Killer Cells, Natu

1993
Electrophysiological study of the effects of the reuptake inhibitor duloxetine on serotonergic responses in the aging hippocampus.
    Pharmacology, 1997, Volume: 55, Issue:2

    Topics: Action Potentials; Aging; Animals; Antidepressive Agents, Second-Generation; Desipramine; Duloxetine

1997
Normal and drug-induced locomotor behavior in aging: comparison to evoked DA release and tissue content in fischer 344 rats.
    Brain research, 1998, Jun-22, Volume: 797, Issue:1

    Topics: 3,4-Dihydroxyphenylacetic Acid; Adrenergic Uptake Inhibitors; Aging; Animals; Brain Chemistry; Chrom

1998
Influence of age and dietary restriction on norepinephrine uptake into cardiac synaptosomes.
    Journal of cardiovascular pharmacology, 1998, Volume: 32, Issue:6

    Topics: Adrenergic Uptake Inhibitors; Aging; Animals; Carrier Proteins; Desipramine; Diet; Dose-Response Rel

1998
Age-related changes in the capacity, rate, and modulation of dopamine uptake within the striatum and nucleus accumbens of Fischer 344 rats: an in vivo electrochemical study.
    The Journal of pharmacology and experimental therapeutics, 1999, Volume: 288, Issue:2

    Topics: Adrenergic Uptake Inhibitors; Aging; Animals; Citalopram; Corpus Striatum; Desipramine; Dopamine; Do

1999
Effect of psychotropic drugs on taste responses in young and elderly persons.
    Annals of the New York Academy of Sciences, 1998, Nov-30, Volume: 855

    Topics: Adult; Aged; Aging; Amitriptyline; Clomipramine; Desipramine; Doxepin; Female; Humans; Imipramine; M

1998
Alterations in T lymphocyte activity following chemical sympathectomy in young and old Fischer 344 rats.
    Journal of neuroimmunology, 2000, Mar-01, Volume: 103, Issue:2

    Topics: Aging; Animals; Cell Division; Cells, Cultured; Concanavalin A; Desipramine; Dose-Response Relations

2000
Antidepressant treatment during social challenge prior to 1 year of age affects immune and endocrine responses in adult macaques.
    Psychiatry research, 2000, Jul-24, Volume: 95, Issue:1

    Topics: Adolescent; Adrenergic Uptake Inhibitors; Aging; Animals; Antibody Formation; Antidepressive Agents,

2000
An analysis of submandibular salivary gland function with desipramine and age in female NIA Fischer 344 rats.
    Mechanisms of ageing and development, 2000, Nov-15, Volume: 119, Issue:3

    Topics: Aging; Animals; Antidepressive Agents, Tricyclic; Body Weight; Desipramine; DNA; Female; Organ Size;

2000
An analysis of parotid salivary gland function with desipramine and age in female NIA Fischer 344 rats.
    Experimental gerontology, 2001, Volume: 36, Issue:1

    Topics: Aging; Animals; Antidepressive Agents, Tricyclic; Body Weight; Desipramine; DNA; Female; Organ Size;

2001
Desipramine induced changes in salivary proteins, cultivable oral microbiota and gingival health in aging female NIA Fischer 344 rats.
    Life sciences, 2000, Dec-15, Volume: 68, Issue:4

    Topics: Aging; alpha-Amylases; Animals; Antidepressive Agents, Tricyclic; Blotting, Western; Desipramine; El

2000
Effect of intraventricular injections of 6-hydroxydopamine in neonatal rats on the catecholamine levels and tyrosine hydroxylase activity in brain regions at maturity.
    Biochemical pharmacology, 1977, Dec-01, Volume: 26, Issue:23

    Topics: Aging; Animals; Animals, Newborn; Brain; Brain Chemistry; Catecholamines; Desipramine; Hydroxydopami

1977
Behavioural effects of methylphenidate in 6-hydroxydopamine-treated neonatal rats.
    Psychopharmacology, 1978, Jul-06, Volume: 58, Issue:2

    Topics: Aging; Animals; Animals, Newborn; Behavior, Animal; Desipramine; Hydroxydopamines; Methylphenidate;

1978
Ability of aged rats to alter beta adrenergic receptors of brain in response to repeated administration of reserpine and desmethylimipramine.
    The Journal of pharmacology and experimental therapeutics, 1979, Volume: 211, Issue:2

    Topics: Aging; Animals; Brain; Cerebellum; Cerebral Cortex; Desipramine; Male; Pineal Gland; Rats; Receptors

1979
Alterations in the neurocytotoxicity of 5,7-dihydroxytryptamine by pharmacologic agents in adult and developing rats.
    Annals of the New York Academy of Sciences, 1978, Jun-12, Volume: 305

    Topics: 5,7-Dihydroxytryptamine; Aging; Animals; Animals, Newborn; Central Nervous System Agents; Desipramin

1978
Biochemical and behavioral alterations in developing rats treated with 5,7-dihydroxytryptamine.
    The Journal of pharmacology and experimental therapeutics, 1978, Volume: 205, Issue:3

    Topics: 5-Hydroxytryptophan; 5,7-Dihydroxytryptamine; Aging; Animals; Avoidance Learning; Behavior, Animal;

1978
Changes in the behavioral response to a novel environment following lesioning of the central dopaminergic system in rat pups.
    Psychopharmacology, 1978, Apr-28, Volume: 57, Issue:2

    Topics: Aging; Animals; Behavior, Animal; Brain Chemistry; Catecholamines; Desipramine; Dopamine; Environmen

1978
Clinical utility of tricyclic antidepressant blood levels: a case report.
    The American journal of psychiatry, 1979, Volume: 136, Issue:3

    Topics: Aged; Aging; Depression; Desipramine; Drug Therapy, Combination; Female; Humans; Imipramine; Phenoth

1979
Differences between the effects of acute and long-term treatment with desmethylimipramine on reserpine-induced release of amines from rat brain.
    Biochemical pharmacology, 1975, Jul-15, Volume: 24, Issue:13-14

    Topics: Administration, Oral; Aging; Animals; Brain; Brain Chemistry; Catecholamines; Desipramine; Dopamine;

1975
Ultrastructure of spared dopamine terminals in caudate-putamen nuclei of adult rats neonatally treated with intranigral 6-hydroxydopamine.
    Brain research. Developmental brain research, 1992, Nov-20, Volume: 70, Issue:1

    Topics: Aging; Animals; Axons; Caudate Nucleus; Desipramine; Dopamine; Immunoenzyme Techniques; Immunohistoc

1992
Effect of age on potassium- and tyramine-induced release of norepinephrine from cardiac synaptosomes in male F344 rats.
    Journal of gerontology, 1992, Volume: 47, Issue:6

    Topics: Adrenergic Fibers; Aging; Animals; Desipramine; Heart; Male; Myocardium; Norepinephrine; Oxidopamine

1992
Effect of ageing on the number of neuronal noradrenaline uptake sites in the rat vas deferens.
    Naunyn-Schmiedeberg's archives of pharmacology, 1992, Volume: 346, Issue:4

    Topics: Aging; Animals; Binding Sites; Desipramine; Kinetics; Lithium; Male; Neurons; Norepinephrine; Rats;

1992
D-1 and D-2 receptor mediation of sensorimotor behavior in rats depleted of dopamine during development.
    Behavioural brain research, 1992, Mar-15, Volume: 47, Issue:1

    Topics: Afferent Pathways; Aging; Animals; Attention; Corpus Striatum; Desipramine; Dopamine; Hippocampus; M

1992
Effect of desipramine on norepinephrine metabolism in humans: interaction with aging.
    The American journal of physiology, 1991, Volume: 261, Issue:6 Pt 2

    Topics: Adult; Aged; Aging; Desipramine; Female; Humans; Kinetics; Male; Metabolic Clearance Rate; Middle Ag

1991
Functional recovery and collateral neuronal sprouting examined in young and aged rats following a partial neural lesion.
    Brain research, 1991, Feb-01, Volume: 540, Issue:1-2

    Topics: Aging; Animals; Arylamine N-Acetyltransferase; Circadian Rhythm; Desipramine; Functional Laterality;

1991
Effects of TRH and prolactin in the behavioral despair (swim) model of depression in rats.
    Psychoneuroendocrinology, 1990, Volume: 15, Issue:5-6

    Topics: Aging; Animals; Behavior, Animal; Depression; Desipramine; Injections, Intraventricular; Injections,

1990
Age-related changes in rat serotonergic and adrenergic systems and in receptor responsiveness to subchronic desipramine treatment.
    Pharmacology & toxicology, 1988, Volume: 63, Issue:3

    Topics: Aging; Animals; Brain; Clonidine; Desipramine; Dihydroalprenolol; Hydroxyindoleacetic Acid; Imiprami

1988
A functional study of the development of the cardiac sympathetic neuroeffector junction in the SHR.
    Journal of hypertension, 1989, Volume: 7, Issue:5

    Topics: Aging; Animals; Blood Pressure; Clonidine; Desipramine; Dose-Response Relationship, Drug; Electric S

1989
Predictive techniques applied to imipramine therapeutic drug monitoring.
    DICP : the annals of pharmacotherapy, 1989, Volume: 23, Issue:5

    Topics: Adolescent; Adult; Aging; Child; Child, Preschool; Desipramine; False Positive Reactions; Female; Hu

1989
Effect of age on the rate of recovery of beta-adrenergic receptors in rat brain following desmethylimipramine-induced subsensitivity.
    Brain research, 1985, Feb-25, Volume: 328, Issue:1

    Topics: Aging; Animals; Brain; Cerebral Cortex; Desipramine; Dihydroalprenolol; Kinetics; Male; Pineal Gland

1985
The effect of imipramine treatment on brain serotonin receptors and beta-adrenoceptors and on pineal beta-adrenergic function in adult and aged rats.
    European journal of pharmacology, 1986, Apr-29, Volume: 123, Issue:3

    Topics: Aging; Animals; Brain; Desipramine; Dihydroalprenolol; Imipramine; Indoles; Male; Pineal Gland; Rats

1986
Desipramine and noradrenergic neurotransmission in aging: failure to respond in aged laboratory animals.
    Neuropharmacology, 1987, Volume: 26, Issue:6

    Topics: Action Potentials; Aging; Animals; Desipramine; Electric Stimulation; Hydroxydopamines; Male; Norepi

1987
Striatal dopamine uptake and swim performance of the aged rat.
    Brain research, 1986, Jul-30, Volume: 379, Issue:1

    Topics: Aging; Animals; Bupropion; Corpus Striatum; Desipramine; Dopamine; Dopamine Antagonists; Male; Motor

1986
Age-related changes in cerebellar noradrenergic function.
    Annals of the New York Academy of Sciences, 1988, Volume: 515

    Topics: Aging; Animals; Cerebellum; Desipramine; Dose-Response Relationship, Drug; Electrophysiology; Evoked

1988
Imipramine blood levels and clinical outcome.
    Journal of clinical psychopharmacology, 1987, Volume: 7, Issue:4

    Topics: Adult; Aged; Aging; Depressive Disorder; Desipramine; Female; Humans; Imipramine; Male; Middle Aged;

1987
Alterations in [3H]desmethylimipramine binding in the aged rat brain: an in vitro autoradiographic demonstration.
    Neuroscience letters, 1987, Aug-18, Volume: 79, Issue:1-2

    Topics: Aging; Animals; Autoradiography; Brain; Caudate Nucleus; Corpus Striatum; Desipramine; In Vitro Tech

1987
Pharmacokinetics of imipramine are affected by age and sex in rats.
    Life sciences, 1986, Feb-24, Volume: 38, Issue:8

    Topics: Aging; Animals; Desipramine; Female; Hypothalamus; Imipramine; Kinetics; Male; Preoptic Area; Rats;

1986
The postnatal development of noradrenaline uptake in the adrenergic nerves of different tissues from the rat.
    European journal of pharmacology, 1970, Volume: 9, Issue:1

    Topics: Age Factors; Aging; Animals; Desipramine; Dopamine; Duodenum; Growth; Heart Atria; In Vitro Techniqu

1970